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Accession:CHEBI:7569 term browser browse the term
Definition:A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.
Synonyms:exact_synonym: (2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-{(2S,2'R,3'S,5R,5'R)-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid
 related_synonym: Azalomycin M;   Formula=C40H68O11;   Helixin C;   InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+/m0/s1;   InChIKey=DANUORFCFTYTSZ-SJSJOXFOSA-N;   Polyetherin A;   SMILES=[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C(O)=O)C[C@@H]1C[C@@H](OC)[C@@H](C)[C@]2(O1)O[C@@](C)(C[C@H]2C)[C@@]1([H])CC[C@](C)(O1)[C@]1([H])O[C@]([H])(C[C@@H]1C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C
 alt_id: CHEBI:530451
 xref: Beilstein:74670 "Beilstein";   CAS:28380-24-7 "ChemIDplus";   CAS:28380-24-7 "KEGG COMPOUND";   KEGG:C11609;   KNApSAcK:C00018750
 xref_mesh: MESH:D009550
 xref: PMID:10341035 "Europe PMC";   PMID:10516103 "Europe PMC";   PMID:10996433 "Europe PMC";   PMID:15595852 "Europe PMC";   PMID:17618633 "Europe PMC";   PMID:20678563 "Europe PMC";   PMID:20709811 "Europe PMC";   PMID:20951746 "Europe PMC";   PMID:21257734 "Europe PMC";   PMID:22327078 "Europe PMC";   PMID:22493436 "Europe PMC";   PMID:7592045 "Europe PMC";   PMID:7638257 "Europe PMC";   PMID:7829226 "Europe PMC";   PMID:8010949 "Europe PMC";   PMID:8076364 "Europe PMC";   PMID:8717427 "Europe PMC";   PMID:8895841 "Europe PMC";   PMID:8913333 "Europe PMC";   PMID:9018148 "Europe PMC";   PMID:9178132 "Europe PMC";   PMID:9770325 "Europe PMC";   Patent:US3555150;   Reaxys:74670 "Reaxys";   VSDB:2572;   Wikipedia:Nigericin

show annotations for term's descendants       view all columns           Sort by:
nigericin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp9 aquaporin 9 JBrowse link 8 77,559,621 77,599,781 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Dpp7 dipeptidylpeptidase 7 JBrowse link 3 2,569,135 2,573,387 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:6480464
G Nnat neuronatin JBrowse link 3 154,043,873 154,046,334 RGD:6480464
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:6480464
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        antimicrobial agent 17143
          nigericin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            heteroorganic entity 18990
                              organochalcogen compound 18705
                                organooxygen compound 18615
                                  ether 15755
                                    cyclic ether 6382
                                      polycyclic ether 1218
                                        nigericin 9
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.