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Accession:CHEBI:7577 term browser browse the term
Definition:A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
Synonyms:exact_synonym: rac-methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: (+-)-isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate;   1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester;   Baymycard;   Sular;   Syscor;   Zadipina;   nisoldipino;   nisoldipinum
 xref: CAS:63675-72-9 "ChemIDplus";   CAS:63675-72-9 "KEGG COMPOUND";   CAS:63675-72-9 "NIST Chemistry WebBook";   DrugBank:DB00401;   HMDB:HMDB0014545;   KEGG:C07699;   KEGG:D00618
 xref_mesh: MESH:D015737
 xref: PMID:23841582 "Europe PMC";   PMID:2667729 "Europe PMC";   PMID:3154674 "Europe PMC";   PMID:8150600 "Europe PMC";   PMID:8429113 "Europe PMC";   PMID:8592476 "Europe PMC";   Patent:DE2549568;   Patent:US4154839;   Reaxys:454188 "Reaxys";   Wikipedia:Nisoldipine

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nisoldipine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    chemical entity 19677
      chemical substance 10728
        mixture 9933
          racemate 8662
            nisoldipine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      chalcogen 19242
                        oxygen atom 19196
                          oxygen molecular entity 19196
                            hydroxides 18973
                              organic hydroxy compound 18516
                                alcohol 14919
                                  aliphatic alcohol 11053
                                    alkyl alcohol 11006
                                      methanol 2948
                                        methyl ester 2939
                                          methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 8
                                            (R)-nisoldipine 8
                                              nisoldipine 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.