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ONTOLOGY REPORT - ANNOTATIONS


Term:nitrazepam
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Accession:CHEBI:7581 term browser browse the term
Definition:A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).
Synonyms:related_synonym: 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one;   7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;   Apodorm;   Atempol;   Benzalin;   Calsmin;   Dormicum;   Eatan;   Eunoctin;   Formula=C15H11N3O3;   Gerson;   Hipnax;   Hipsal;   Ibrovek;   Imeson;   Imesont;   InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19);   InChIKey=KJONHKAYOJNZEC-UHFFFAOYSA-N;   Mogadon;   N-desmethylnimetazepam;   Nelbon;   Nelmat;   Neozepam;   Neuchlonic;   Nitrados;   Paxisyn;   Pelson;   Persopit;   Radedorm;   Relact;   Remnos;   Ro 4-5360;   Ro 5-3059;   SMILES=[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1;   Somitran;   Sonebon;   Sonnolin;   Surem;   Trazenin;   Unisomnia;   nitrazepamum
 xref: CAS:146-22-5 "ChemIDplus";   CAS:146-22-5 "KEGG COMPOUND";   CAS:146-22-5 "NIST Chemistry WebBook";   DrugBank:DB01595;   Drug_Central:1945 "DrugCentral";   HMDB:HMDB0015534;   KEGG:C07487;   KEGG:D00531;   LINCS:LSM-5681
 xref_mesh: MESH:D009567
 xref: PMID:10030438 "Europe PMC";   PMID:15637997 "Europe PMC";   PMID:18603831 "Europe PMC";   PMID:19557123 "Europe PMC";   PMID:23085494 "Europe PMC";   PMID:23245766 "Europe PMC";   PMID:331868 "Europe PMC";   PMID:578380 "Europe PMC";   PMID:6143468 "Europe PMC";   PMID:6926838 "Europe PMC";   PMID:6988458 "Europe PMC";   PMID:7037262 "Europe PMC";   Patent:US3121076;   Reaxys:757185 "Reaxys";   Wikipedia:Nitrazepam


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nitrazepam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c18 aldo-keto reductase family 1, member C18 JBrowse link 13 4,132,615 4,150,646 RGD:6480464
G Akr1c21 aldo-keto reductase family 1, member C21 JBrowse link 13 4,574,075 4,586,543 RGD:6480464
G Akr1c6 aldo-keto reductase family 1, member C6 JBrowse link 13 4,434,311 4,457,530 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp7 caspase 7 JBrowse link 19 56,396,833 56,442,348 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Esr1 estrogen receptor 1 (alpha) JBrowse link 10 4,611,989 5,005,633 RGD:6480464
nimetazepam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp7 caspase 7 JBrowse link 19 56,396,833 56,442,348 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 JBrowse link 17 12,584,189 12,628,489 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20932
    role 20913
      biological role 20911
        biophysical role 12321
          membrane transport modulator 12052
            GABA modulator 4799
              nitrazepam 8
                nimetazepam 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20932
    subatomic particle 20926
      composite particle 20926
        hadron 20926
          baryon 20926
            nucleon 20926
              atomic nucleus 20926
                atom 20926
                  main group element atom 20765
                    p-block element atom 20765
                      carbon group element atom 20504
                        carbon atom 20481
                          organic molecular entity 20481
                            organic molecule 20338
                              organic cyclic compound 20022
                                organic heterocyclic compound 18940
                                  organonitrogen heterocyclic compound 17268
                                    benzodiazepine 535
                                      1,4-benzodiazepinone 113
                                        nitrazepam 8
                                          nimetazepam 4
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