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ONTOLOGY REPORT - ANNOTATIONS


Term:riociguat
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Accession:CHEBI:76018 term browser browse the term
Definition:A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension
Synonyms:exact_synonym: methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate
 related_synonym: Adempas;   BAY 63-2521;   Formula=C20H19FN8O2;   InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26);   InChIKey=WXXSNCNJFUAIDG-UHFFFAOYSA-N;   Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate;   SMILES=COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12;   riociguatum
 xref: CAS:625115-55-1 "ChemIDplus";   CAS:625115-55-1 "KEGG DRUG";   Drug_Central:4807 "DrugCentral";   KEGG:D09572
 xref_mesh: MESH:C542595
 xref: PMCID:PMC3363218 "Europe PMC";   PMID:19129292 "Europe PMC";   PMID:20424448 "Europe PMC";   PMID:20801938 "Europe PMC";   PMID:20956169 "Europe PMC";   PMID:21391889 "Europe PMC";   PMID:21789188 "Europe PMC";   PMID:22719060 "Europe PMC";   PMID:22900035 "Europe PMC";   PMID:22912874 "Europe PMC";   PMID:22936711 "Europe PMC";   PMID:23204120 "Europe PMC";   PMID:23397304 "Europe PMC";   PMID:23775260 "Europe PMC";   PMID:23883377 "Europe PMC";   PMID:23883378 "Europe PMC";   PMID:23883383 "Europe PMC";   PMID:23939482 "Europe PMC";   PMID:23963798 "Europe PMC";   PMID:23978639 "Europe PMC";   PMID:23997048 "Europe PMC";   PMID:23997053 "Europe PMC";   PMID:24015306 "Europe PMC";   PMID:24092345 "Europe PMC";   Patent:US2009286781;   Patent:WO2007009607;   Patent:WO2011147810;   Reaxys:12581953 "Reaxys";   Wikipedia:Riociguat


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riociguat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Kcnk3 potassium two pore domain channel subfamily K member 3 JBrowse link 6 27,154,274 27,190,209 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        biochemical role 19178
          effector 102
            soluble guanylate cyclase activator 6
              riociguat 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        aromatic amine 13592
                                          aminopyrimidine 1051
                                            riociguat 2
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