ONTOLOGY REPORT - ANNOTATIONS
Term: benoxaprofen
Accession: CHEBI:76114
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Definition: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
Synonyms: exact_synonym: 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
related_synonym: (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid; 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; 2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; DL-benoxaprofen; Formula=C16H12ClNO3; InChI=1S/C16H12ClNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20); InChIKey=MITFXPHMIHQXPI-UHFFFAOYSA-N; Lilly 90459; SMILES=CC(C(O)=O)c1ccc2oc(nc2c1)-c1ccc(Cl)cc1; benoxaprofene; benoxaprofeno; benoxaprofenum
xref: CAS:51234-28-7 "ChemIDplus"; CAS:51234-28-7 "KEGG DRUG"; CAS:51234-28-7 "NIST Chemistry WebBook"; DrugBank:DB04812; Drug_Central:311 "DrugCentral"; KEGG:D03080
xref_mesh: MESH:C011677
xref: PMID:19439485 "Europe PMC"; PMID:19773537 "Europe PMC"; PMID:21128314 "Europe PMC"; PMID:22514582 "Europe PMC"; PMID:23250699 "Europe PMC"; PMID:2413686 "Europe PMC"; PMID:2833969 "Europe PMC"; PMID:2947294 "Europe PMC"; PMID:3981515 "Europe PMC"; PMID:6407402 "Europe PMC"; PMID:6526401 "Europe PMC"; PMID:6645654 "Europe PMC"; PMID:6813936 "Europe PMC"; PMID:6993669 "Europe PMC"; PMID:6993670 "Europe PMC"; PMID:6993671 "Europe PMC"; PMID:6993672 "Europe PMC"; PMID:7044799 "Europe PMC"; PMID:7044801 "Europe PMC"; PMID:7084283 "Europe PMC"; PMID:7084287 "Europe PMC"; PMID:7221526 "Europe PMC"; Patent:DE2324443; Patent:US3912748; Patent:US4391814; Patent:US6338855; Patent:WO2008020270; Reaxys:1085080 "Reaxys"; Wikipedia:Benoxaprofen
G
Alb
albumin
14
19,176,275
19,191,793
RGD:6480464
G
Alox12
arachidonate 12-lipoxygenase, 12S type
10
56,851,734
56,864,049
RGD:6480464
G
Alox5
arachidonate 5-lipoxygenase
4
148,398,004
148,446,308
RGD:6480464
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
8
62,472,087
62,478,122
RGD:6480464
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
8
62,451,360
62,458,244
RGD:6480464
G
Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
5
134,492,734
134,507,158
RGD:6480464
G
Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
11
82,945,104
82,978,364
RGD:6480464
G
Gusb
glucuronidase, beta
12
30,202,066
30,215,583
RGD:6480464
G
Lhb
luteinizing hormone subunit beta
1
101,409,992
101,413,725
RGD:6480464
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
9
95,285,592
95,302,822
RGD:6480464
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
9
95,161,157
95,302,822
RGD:6480464
G
Ugt2b7
UDP glucuronosyltransferase family 2 member B7
14
22,597,103
22,619,968
RGD:6480464
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