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ONTOLOGY REPORT - ANNOTATIONS


Term:oxyphenbutazone
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Accession:CHEBI:76258 term browser browse the term
Definition:A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.
Synonyms:related_synonym: 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine;   1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine;   3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene;   4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione;   4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione;   4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine;   Formula=C19H20N2O3;   Hydroxyphenylbutazon;   InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3;   InChIKey=HFHZKZSRXITVMK-UHFFFAOYSA-N;   Oxi-fenibutol;   Oxifenylbutazon;   Oxiphenbutazonum;   Oxyphenylbutazone;   SMILES=CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1;   oxifenbutazona;   oxyphenbutazonum;   p-Hydroxyphenylbutazone;   p-Oxyphenylbutazone
 xref: CAS:129-20-4 "ChemIDplus";   CAS:129-20-4 "KEGG COMPOUND";   CAS:129-20-4 "KEGG DRUG";   CAS:129-20-4 "NIST Chemistry WebBook";   DrugBank:DB03585;   Drug_Central:2036 "DrugCentral";   KEGG:C19494;   KEGG:D08324;   LINCS:LSM-5029
 xref_mesh: MESH:D010113
 xref: PMID:1222682 "Europe PMC";   PMID:141661 "Europe PMC";   PMID:14345781 "Europe PMC";   PMID:18963985 "Europe PMC";   PMID:19161668 "Europe PMC";   PMID:20299217 "Europe PMC";   PMID:21428758 "Europe PMC";   PMID:23012453 "Europe PMC";   PMID:23983013 "Europe PMC";   PMID:2862290 "Europe PMC";   PMID:380595 "Europe PMC";   PMID:501546 "Europe PMC";   PMID:546857 "Europe PMC";   PMID:6617711 "Europe PMC";   PMID:6860567 "Europe PMC";   PMID:6894379 "Europe PMC";   PMID:7001487 "Europe PMC";   PMID:7309664 "Europe PMC";   PMID:7368966 "Europe PMC";   PMID:766157 "Europe PMC";   PMID:835859 "Europe PMC";   Patent:EP642336;   Patent:US2008014272;   Patent:WO2005107748;   Reaxys:307474 "Reaxys";   Wikipedia:Oxyphenbutazone


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oxyphenbutazone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        antimicrobial agent 17215
          oxyphenbutazone 1
            oxyphenbutazone hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic molecule 19431
                              organic cyclic compound 19197
                                organic heterocyclic compound 18267
                                  organic heteromonocyclic compound 16348
                                    diazolidine 565
                                      pyrazolidines 28
                                        phenylbutazone 20
                                          oxyphenbutazone 1
                                            oxyphenbutazone hydrate 0
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