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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PhIP
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Accession:CHEBI:76290 term browser browse the term
Definition:An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Synonyms:exact_synonym: 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine
 related_synonym: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine;   Formula=C13H12N4;   InChI=1S/C13H12N4/c1-17-11-7-10(9-5-3-2-4-6-9)8-15-12(11)16-13(17)14/h2-8H,1H3,(H2,14,15,16);   InChIKey=UQVKZNNCIHJZLS-UHFFFAOYSA-N;   SMILES=Cn1c(N)nc2ncc(cc12)-c1ccccc1
 xref: CAS:105650-23-5;   HMDB:HMDB0041008;   KEGG:C16038
 xref_mesh: MESH:C049584
 xref: PDBeChem:PIQ;   PMID:10944558;   PMID:11921178;   PMID:20036730;   PMID:23265474;   PMID:23306951;   PMID:23313794;   PMID:23466459;   PMID:24128508;   Reaxys:5951264;   Wikipedia:2-Amino-1-methyl-6-phenylimidazo(4\,5-b)pyridine


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PhIP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of A2M mRNA CTD PMID:15059925 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport
affects metabolic processing
multiple interactions
ISO ABCB1A protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCB1A protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCB1A protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCB1A protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
CTD PMID:18322075, PMID:30701287 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects metabolic processing
multiple interactions
ISO ABCB1B protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCB1B protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCB1B protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
CTD PMID:30701287 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCC1 mRNA CTD PMID:18680760 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport
affects metabolic processing
multiple interactions
affects transport
increases expression
ISO
EXP
ABCC2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCC2 protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
ABCC2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[Cyclosporine results in decreased activity of ABCC2 protein] which affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCC2 mRNA
CTD PMID:11306678, PMID:15057744, PMID:16356829, PMID:16611851, PMID:18680760, PMID:30701287 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects metabolic processing
multiple interactions
ISO ABCC3 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCC3 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCC3 protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
CTD PMID:30701287 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression
multiple interactions
affects metabolic processing
decreases transport
increases expression
increases transport
affects transport
increases secretion
affects abundance
affects response to substance
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ABCG2 protein
[ABCG2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCG2 protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
ABCG2 gene polymorphism results in decreased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCG2 protein results in decreased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCG2 mRNA
ABCG2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 protein results in increased secretion of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; Beclomethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Dexamethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Estradiol inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Triamcinolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
ABCG2 protein affects the abundance of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
ABCG2 affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:14559835, PMID:15365089, PMID:15722455, PMID:18322075, PMID:18680760, PMID:18710444, PMID:21544799, PMID:22892056, PMID:23081912, PMID:26907376, PMID:30701287 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACTA1 mRNA CTD PMID:29877212 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
decreases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTA2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACTA2 mRNA
CTD PMID:15059925, PMID:15215175 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTB mRNA CTD PMID:15215175 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTG1 mRNA CTD PMID:15215175 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACTG2 mRNA CTD PMID:15059925, PMID:29877212 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Actn4 actinin alpha 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTN4 mRNA CTD PMID:12376462 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Adcy5 adenylate cyclase 5 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ADCY5 mRNA CTD PMID:12376462 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adssl1 adenylosuccinate synthase like 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ADSSL1 mRNA CTD PMID:15215175 NCBI chr 6:137,184,818...137,206,694
Ensembl chr 6:137,184,820...137,206,693
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects response to substance
ISO [3'-methoxy-4'-nitroflavone results in decreased activity of AHR protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]
AHR protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:20816883, PMID:23208499 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor affects response to substance ISO AHRR protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:23208499 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of AKAP12 mRNA CTD PMID:20816883 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Alb albumin affects binding
increases expression
decreases expression
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to ALB protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALB mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALB mRNA
CTD PMID:8921513, PMID:15215175, PMID:27028147 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDH3A1 mRNA CTD PMID:20816883 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ALDOA mRNA CTD PMID:15215175 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ALOX5 mRNA CTD PMID:20816883 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Amelx amelogenin, X-linked increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of AMELX mRNA CTD PMID:15215175 NCBI chr  X:26,439,197...26,450,495
Ensembl chr  X:26,439,197...26,450,495
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions
increases methylation
EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA; [decitabine co-treated with trichostatin A] inhibits the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of ANGPTL4 promoter] which results in decreased expression of ANGPTL4 mRNA] CTD PMID:21489049 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Anxa1 annexin A1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ANXA1 mRNA CTD PMID:12376462 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of APAF1 mRNA CTD PMID:20816883 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apc APC regulator of WNT signaling pathway increases mutagenesis
multiple interactions
affects response to substance
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC gene
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APC gene
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased mutagenesis of APC gene
APC protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:7846077, PMID:8608549, PMID:9163695, PMID:9202738, PMID:11181456, PMID:11323404, PMID:11420398, PMID:11756241, PMID:12034317, PMID:14507667, PMID:14706516 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Apoc2 apolipoprotein C2 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of APOC2 mRNA CTD PMID:15215175 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
JBrowse link
G App amyloid beta precursor protein increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of APP protein; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of APP protein modified form CTD PMID:32169473 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aprt adenine phosphoribosyl transferase multiple interactions ISO [CYP1A2 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of APRT gene CTD PMID:2023932 NCBI chr19:55,387,288...55,389,256
Ensembl chr19:55,387,288...55,389,256
JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of AQP1 mRNA CTD PMID:12376462 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Arhgef1 Rho guanine nucleotide exchange factor 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ARHGEF1 mRNA CTD PMID:15215175 NCBI chr 1:81,769,212...81,797,237
Ensembl chr 1:81,779,380...81,797,236
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ARHGEF3 mRNA CTD PMID:15215175 NCBI chr16:2,743,714...3,026,768
Ensembl chr16:2,743,823...3,026,760
JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ASCL2 mRNA CTD PMID:15059925 NCBI chr 1:216,154,002...216,156,409
Ensembl chr 1:216,154,002...216,156,409
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATF4 mRNA CTD PMID:20702593 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf7ip activating transcription factor 7 interacting protein increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATF7IP mRNA CTD PMID:20816883 NCBI chr 4:170,476,998...170,563,063
Ensembl chr 4:170,518,673...170,559,532
JBrowse link
G Atl1 atlastin GTPase 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATL1 mRNA CTD PMID:20816883 NCBI chr 6:92,229,764...92,370,428
Ensembl chr 6:92,229,686...92,370,421
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP2A1 mRNA CTD PMID:15215175 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5F1B mRNA CTD PMID:15215175 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATPIF1 mRNA CTD PMID:12376462 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5MC1 mRNA CTD PMID:15215175 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5MC3 mRNA CTD PMID:15215175 NCBI chr 3:60,811,218...60,813,903
Ensembl chr 3:60,811,210...60,813,869
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATP5PB mRNA CTD PMID:15215175 NCBI chr 2:208,566,385...208,577,147
Ensembl chr 2:208,566,385...208,577,146
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
affects expression
ISO myricetin affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of ATR mRNA] CTD PMID:32342131 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G B4galnt2 beta-1,4-N-acetyl-galactosaminyl transferase 2 increases mutagenesis ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of B4GALNT2 CTD PMID:9202738 NCBI chr10:83,677,768...83,701,487 JBrowse link
G Bace1 beta-secretase 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BACE1 protein CTD PMID:32169473 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bag1 BAG cochaperone 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAG1 mRNA CTD PMID:15215175 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BASP1 mRNA CTD PMID:12376462 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein
Hexachlorocyclohexane promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein]
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein
CTD PMID:11751460, PMID:16120219, PMID:18174961 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcas3 BCAS3, microtubule associated cell migration factor decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BCAS3 mRNA CTD PMID:22100608 NCBI chr10:72,756,548...73,271,851 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BCL2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BCL2 protein
CTD PMID:11751460, PMID:18174961, PMID:23810796 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bnc2 basonuclin 2 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BNC2 mRNA CTD PMID:20816883 NCBI chr 5:102,407,508...102,807,389
Ensembl chr 5:102,415,847...102,786,331
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BRCA1 protein CTD PMID:12203372 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Btf3 basic transcription factor 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BTF3 mRNA CTD PMID:15215175 NCBI chr 2:28,417,316...28,424,436
Ensembl chr 2:28,417,579...28,423,762
JBrowse link
G Btn1a1 butyrophilin, subfamily 1, member A1 increases expression
decreases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BTN1A1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of BTN1A1 mRNA
CTD PMID:15215175 NCBI chr17:43,899,155...43,909,042
Ensembl chr17:43,900,450...43,909,627
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Bysl bystin-like increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BYSL mRNA CTD PMID:15215175 NCBI chr 9:15,393,461...15,403,212
Ensembl chr 9:15,393,330...15,403,117
JBrowse link
G Bzw2 basic leucine zipper and W2 domains 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BZW2 mRNA CTD PMID:15215175 NCBI chr 6:55,586,754...55,647,650
Ensembl chr 6:55,586,346...55,647,665
JBrowse link
G C1qtnf3 C1q and TNF related 3 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of C1QTNF3 mRNA CTD PMID:20816883 NCBI chr 2:60,920,160...60,942,586
Ensembl chr 2:60,920,257...60,942,500
JBrowse link
G Ca4 carbonic anhydrase 4 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CAR4 mRNA CTD PMID:15059925 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067
JBrowse link
G Cab39l calcium binding protein 39-like decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CAB39L mRNA CTD PMID:20816883 NCBI chr15:39,745,124...39,849,022
Ensembl chr15:39,759,257...39,870,208
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CACNA2D1 mRNA CTD PMID:15059925 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Capg capping actin protein, gelsolin like decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CAPG mRNA CTD PMID:15215175 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446
JBrowse link
G Caprin1 cell cycle associated protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CAPRIN1 mRNA CTD PMID:15215175 NCBI chr 3:93,701,830...93,789,580
Ensembl chr 3:93,702,487...93,789,617
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CA2 mRNA CTD PMID:15215175 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CASK mRNA CTD PMID:12376462 NCBI chr  X:9,815,652...10,156,155
Ensembl chr  X:9,815,652...10,156,155
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased activity of CASP3 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CASP3 protein
CTD PMID:18616682, PMID:20307560 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CASP8 mRNA CTD PMID:20816883 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP
ISO
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein
CTD PMID:23313794, PMID:32113805 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCL20 mRNA CTD PMID:15059925 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNA2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNA2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CCNA2 protein
CTD PMID:10728688, PMID:16120219, PMID:29877212 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNB1 protein CTD PMID:16120219 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNB2 mRNA CTD PMID:29877212 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CCND1 mRNA; Plant Preparations inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND1 protein
CTD PMID:12097258, PMID:12376462, PMID:14522882, PMID:18283038, PMID:21081470, PMID:23466459 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCND2 mRNA CTD PMID:15059925 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnh cyclin H increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNH mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCNH protein CTD PMID:12606953 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT2 mRNA CTD PMID:15215175 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT4 mRNA CTD PMID:15215175 NCBI chr14:107,767,392...107,780,270
Ensembl chr14:107,767,392...107,780,270
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT5 mRNA CTD PMID:15215175 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT7 mRNA CTD PMID:15215175 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCT8 mRNA CTD PMID:15215175 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
JBrowse link
G Cd24 CD24 molecule increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD24A mRNA CTD PMID:15215175 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd27 CD27 molecule increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD27 mRNA CTD PMID:20816883 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
JBrowse link
G Cd74 CD74 molecule decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CD74 mRNA CTD PMID:15215175 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cd81 Cd81 molecule increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD81 mRNA CTD PMID:15215175 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdc45 cell division cycle 45 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDCA3 mRNA CTD PMID:29877212 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH1 protein] CTD PMID:22307971, PMID:22581815 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh26 cadherin 26 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH26 mRNA CTD PMID:20816883 NCBI chr 3:173,969,004...174,020,867
Ensembl chr 3:173,969,273...174,019,766
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
increases expression
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDK1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK1 mRNA
CTD PMID:20816883, PMID:29877212 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK13 mRNA CTD PMID:20816883 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdk2ap1 cyclin-dependent kinase 2 associated protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK2AP1 mRNA CTD PMID:15215175 NCBI chr12:37,668,369...37,677,067
Ensembl chr12:37,668,369...37,677,063
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK4 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDK4 protein CTD PMID:12376462, PMID:14522882 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDK9 mRNA CTD PMID:20816883 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDKN1A mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDKN1A protein CTD PMID:11425520, PMID:15635149, PMID:17156947, PMID:23810796, PMID:29877212 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDKN2A mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDKN2A protein CTD PMID:23313794 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects response to substance
increases phosphorylation
ISO CEBPB protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of CEBPB protein
CTD PMID:23208499 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cenpf centromere protein F increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CENPF mRNA CTD PMID:16120219 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CEP290 mRNA CTD PMID:20816883 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Cfhr2 complement factor H-related 2 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CFHR4 mRNA CTD PMID:20816883 NCBI chr13:56,641,657...56,713,305
Ensembl chr13:56,642,365...56,693,968
JBrowse link
G Chat choline O-acetyltransferase increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CHAT mRNA CTD PMID:20816883 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CHRNB2 mRNA CTD PMID:15215175 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Ckap2 cytoskeleton associated protein 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CKAP2 mRNA CTD PMID:29877212 NCBI chr16:74,752,655...74,779,184
Ensembl chr16:74,752,655...74,779,184
JBrowse link
G Ckm creatine kinase, M-type increases expression
decreases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CKM mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CKM mRNA
CTD PMID:15059925, PMID:15215175 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CKS2 mRNA CTD PMID:29877212 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Cldn14 claudin 14 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CLDN14 mRNA CTD PMID:20816883 NCBI chr11:34,132,581...34,142,813
Ensembl chr11:34,132,581...34,142,753
JBrowse link
G Cldn3 claudin 3 multiple interactions EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CLDN3 mRNA CTD PMID:12097258 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Clk2 CDC-like kinase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CLK2 mRNA CTD PMID:15215175 NCBI chr 2:188,476,789...188,488,809
Ensembl chr 2:188,476,820...188,496,191
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CNBP mRNA CTD PMID:15215175 NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765
JBrowse link
G Cnn1 calponin 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CNN1 mRNA CTD PMID:15215175 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761
JBrowse link
G Cnn3 calponin 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CNN3 mRNA CTD PMID:12376462 NCBI chr 2:225,005,069...225,036,179
Ensembl chr 2:225,005,019...225,036,188
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL12A1 mRNA CTD PMID:15215175 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL1A1 mRNA CTD PMID:15215175 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL1A2 mRNA CTD PMID:15215175 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COL2A1 mRNA CTD PMID:15215175 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Col5a1 collagen type V alpha 1 chain decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of COL5A1 mRNA CTD PMID:12376462 NCBI chr 3:6,430,180...6,581,010
Ensembl chr 3:6,430,201...6,578,882
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance EXP COMT protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:12901791 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Coro1a coronin 1A increases methylation
multiple interactions
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of CORO1A promoter
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of CORO1A promoter] which results in decreased expression of CORO1A mRNA
CTD PMID:21489049 NCBI chr 1:198,123,883...198,128,890
Ensembl chr 1:198,123,884...198,128,857
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COX6C mRNA CTD PMID:15215175 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COX7A2 mRNA CTD PMID:15215175 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of COX7C mRNA CTD PMID:15215175 NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903
JBrowse link
G Cryab crystallin, alpha B decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CRYAB mRNA CTD PMID:15059925 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Csn1s1 casein alpha s1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CSN1S1 mRNA CTD PMID:15215175 NCBI chr14:21,993,450...22,009,308
Ensembl chr14:21,993,427...22,009,308
JBrowse link
G Csn2 casein beta multiple interactions
increases expression
decreases expression
EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] affects the expression of CSN2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CSN2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CSN2 mRNA
CTD PMID:9879772, PMID:15215175 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Csn3 casein kappa decreases expression
increases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CSN3 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CSN3 mRNA
CTD PMID:15215175 NCBI chr14:21,803,738...21,810,291
Ensembl chr14:21,803,735...21,810,314
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
increases mutagenesis
ISO
EXP
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased expression of CTNNB1 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased mutagenesis of CTNNB1 gene; CTNNB1 gene mutant form results in increased susceptibility to [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate]
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] affects the localization of CTNNB1 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CTNNB1 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of CTNNB1 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased mutagenesis of CTNNB1 gene; Plant Preparations inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTNNB1 mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTNNB1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTNNB1 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of CTNNB1 gene
CTD PMID:9515794, PMID:10965019, PMID:11756241, PMID:14507667, PMID:15459021, PMID:18283038, PMID:18616682, PMID:21081470, PMID:23466459, PMID:27664423 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
EXP
ISO
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of CTSD mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CTSD protein
CTD PMID:12097258, PMID:20951759 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CXCL10 mRNA CTD PMID:15059925 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CXCR3 mRNA CTD PMID:20816883 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Ethanol] results in increased activity of CYP19A1 protein CTD PMID:32113805 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
affects metabolic processing
increases expression
multiple interactions
increases hydroxylation
increases metabolic processing
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CYP1A1 protein; CYP1A1 results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A1 gene SNP affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA
CYP1A1 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 protein]
CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; [[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [Benzo(a)pyrene co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]
CTD PMID:1913651, PMID:2334931, PMID:8902619, PMID:15598703, PMID:16167840, PMID:17052995, PMID:17279779, PMID:20307560, PMID:20816883, PMID:22131055, PMID:22138251, PMID:23810796, PMID:26091049, PMID:31542801 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
affects metabolic processing
increases expression
multiple interactions
affects oxidation
increases activity
increases response to substance
increases metabolic processing
affects response to substance
increases oxidation
ISO
EXP
CYP1A2 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 gene SNP affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA
[1-Naphthylisothiocyanate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in decreased expression of CYP1A2 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 1-Naphthylisothiocyanate] results in decreased expression of CYP1A2 protein; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]
CYP1A2 affects the oxidation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein
CYP1A2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP1A2 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of APRT gene; [CYP1A2 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein polymorphism results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CYP1A2 results in increased oxidation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [CYP1A2 protein results in decreased ethylation of Phenacetin]; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with CYP1A2 protein] results in increased mutagenesis of HPRT1 gene; [[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine metabolite; AHR mutant form inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased hydroxylation of and results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; CYP1A2 protein results in increased oxidation of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; furafylline inhibits the reaction [CYP1A2 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
CTD PMID:1913651, PMID:1943715, PMID:2023932, PMID:2334931, PMID:8020169, PMID:8625468, PMID:8902619, PMID:9202738, PMID:9581821, PMID:10503887, PMID:10503888, PMID:12706856, PMID:12949046, PMID:14725854, PMID:15110095, PMID:15310245, PMID:15598703, PMID:15944213, PMID:16167840, PMID:17279779, PMID:20192249, PMID:20307560, PMID:20816883, PMID:22131055, PMID:22138251, PMID:23810796, PMID:28160022, PMID:29362861, PMID:31515600, PMID:31542801 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases metabolic processing
increases activity
increases expression
decreases expression
ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1B1 mRNA; [CYP1B1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP1B1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]; IL6 protein promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of CYP1B1 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYP1B1 mRNA
CTD PMID:17279779, PMID:20307560, PMID:20702593, PMID:20816883, PMID:29362861, PMID:31515600 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYP27B1 mRNA CTD PMID:20816883 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2B2 protein CTD PMID:15598703 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine; [CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:17279779 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine
CTD PMID:17279779 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; 5,15-diphenylporphyrin inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]; Ethanol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]; fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]
CTD PMID:29362861 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP CYP3A4 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:1913651 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Dab2 DAB adaptor protein 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DAB2 mRNA CTD PMID:15215175 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dag1 dystroglycan 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DAG1 mRNA CTD PMID:15215175 NCBI chr 8:116,980,501...116,993,182
Ensembl chr 8:116,980,497...116,993,193
JBrowse link
G Dapk3 death-associated protein kinase 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DAPK3 mRNA CTD PMID:15215175 NCBI chr 7:11,392,436...11,400,855
Ensembl chr 7:11,392,437...11,400,805
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DBI mRNA CTD PMID:12376462 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Dcaf1 DDB1 and CUL4 associated factor 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DCAF1 mRNA CTD PMID:20816883 NCBI chr 8:115,538,365...115,615,282
Ensembl chr 8:115,546,712...115,615,282
JBrowse link
G Dcn decorin increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DCN mRNA CTD PMID:15215175 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Ddc dopa decarboxylase decreases activity ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of DDC protein CTD PMID:2243617 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Defal1 defensin alpha-like 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DEFAL1 mRNA CTD PMID:15059925 NCBI chr16:75,366,925...75,367,985
Ensembl chr16:75,366,929...75,367,906
JBrowse link
G Des desmin decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DES mRNA CTD PMID:12376462 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DHRS2 mRNA CTD PMID:20816883 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Dhx15 DEAH-box helicase 15 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DHX15 mRNA CTD PMID:15215175 NCBI chr14:61,136,740...61,174,880
Ensembl chr14:61,136,746...61,174,880
JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DIAPH3 mRNA CTD PMID:20816883 NCBI chr15:69,928,507...70,400,077
Ensembl chr15:70,039,424...70,399,924
JBrowse link
G Dido1 death inducer-obliterator 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DIDO1 mRNA CTD PMID:20816883 NCBI chr 3:176,162,886...176,216,868
Ensembl chr 3:176,162,886...176,197,753
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DLG4 protein CTD PMID:32169473 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of DMBT1 mRNA CTD PMID:15059925 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705
JBrowse link
G Dnah11 dynein, axonemal, heavy chain 11 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNAH11 mRNA CTD PMID:15215175 NCBI chr 6:145,784,893...146,099,212
Ensembl chr 6:145,785,275...146,099,053
JBrowse link
G Dnajb8 DnaJ heat shock protein family (Hsp40) member B8 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNAJB8 mRNA CTD PMID:20816883 NCBI chr 4:120,156,640...120,159,708
Ensembl chr 4:120,156,659...120,159,265
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression
multiple interactions
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNMT1 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of DNMT1 mRNA
CTD PMID:12097258, PMID:22581815 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Edn1 endothelin 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EDN1 mRNA CTD PMID:15215175 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EEF1A1 mRNA CTD PMID:12376462 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EFEMP1 mRNA CTD PMID:12376462 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Egf epidermal growth factor decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EGF mRNA CTD PMID:20816883 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EGFR mRNA CTD PMID:8603490 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EGR1 mRNA CTD PMID:20816883 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ehf ets homologous factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EHF mRNA CTD PMID:15215175 NCBI chr 3:93,176,257...93,216,484
Ensembl chr 3:93,178,163...93,216,495
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EIF5A mRNA CTD PMID:15215175 NCBI chr10:56,527,075...56,531,615
Ensembl chr10:56,527,085...56,531,483
JBrowse link
G Eno1 enolase 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ENO1 mRNA CTD PMID:12376462 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EPHX1 mRNA CTD PMID:12376462 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Eps8l3 EPS8 like 3 affects response to substance ISO EPS8L3 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:19223546 NCBI chr 2:210,668,249...210,681,930
Ensembl chr 2:210,668,403...210,681,796
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ERBB2 mRNA CTD PMID:8603490 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ERCC1 mRNA CTD PMID:22100608 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Erh ERH, mRNA splicing and mitosis factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ERH mRNA CTD PMID:15215175 NCBI chr 6:104,280,390...104,290,905
Ensembl chr 6:104,280,408...104,290,579
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ERP44 mRNA CTD PMID:15215175 NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects response to substance
increases expression
increases activity
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to and results in increased activity of ESR1 protein; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; [fulvestrant results in decreased expression of ESR1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; Estradiol inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to ESR1 protein]; fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of ESR1 protein]
ESR1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR1 protein
CTD PMID:15319301, PMID:15637090, PMID:16533016, PMID:23208499 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ESR2 protein CTD PMID:15637090 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ezr ezrin increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EZR mRNA CTD PMID:12376462 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of F2R mRNA CTD PMID:20816883 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of FHIT mRNA CTD PMID:22100608 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Fn1 fibronectin 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of FN1 mRNA CTD PMID:12376462 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fnbp1l formin binding protein 1-like increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FNBP1L mRNA CTD PMID:20816883 NCBI chr 2:226,691,435...226,742,081
Ensembl chr 2:226,688,844...226,779,440
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP
ISO
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FOS mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FOS protein CTD PMID:20816883, PMID:23313794 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of FURIN mRNA CTD PMID:12376462 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G G0s2 G0/G1switch 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of G0S2 mRNA CTD PMID:15215175 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gab1 GRB2-associated binding protein 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GAB1 mRNA CTD PMID:20816883 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GADD45A mRNA CTD PMID:23810796 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GAP43 mRNA CTD PMID:15059925 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gda guanine deaminase decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GDA mRNA CTD PMID:12376462 NCBI chr 1:238,982,542...239,057,663
Ensembl chr 1:238,982,392...239,057,732
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GGT1 mRNA CTD PMID:12376462 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Glul glutamate-ammonia ligase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GLUL mRNA CTD PMID:15215175 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gna13 G protein subunit alpha 13 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GNA13 mRNA CTD PMID:20816883 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GNAI2 mRNA CTD PMID:15215175 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnat1 G protein subunit alpha transducin 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GNAT1 mRNA CTD PMID:20816883 NCBI chr 8:116,433,302...116,438,038
Ensembl chr 8:116,433,302...116,438,038
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GNMT mRNA CTD PMID:22100608 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Golga4 golgin A4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GOLGA4 mRNA CTD PMID:15215175 NCBI chr 8:127,171,221...127,248,938
Ensembl chr 8:127,171,537...127,248,538
JBrowse link
G Gpc3 glypican 3 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GPC3 mRNA CTD PMID:15215175 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gpr135 G protein-coupled receptor 135 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GPR135 mRNA CTD PMID:20816883 NCBI chr 6:94,816,976...94,818,349
Ensembl chr 6:94,816,976...94,818,349
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX2 protein CTD PMID:18056462 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GPX4 mRNA CTD PMID:15215175 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Grm3 glutamate metabotropic receptor 3 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GRM3 mRNA CTD PMID:20816883 NCBI chr 4:21,316,761...21,567,561
Ensembl chr 4:21,317,695...21,560,490
JBrowse link
G Grm4 glutamate metabotropic receptor 4 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GRM4 mRNA CTD PMID:20816883 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Gspt1 G1 to S phase transition 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSPT1 mRNA CTD PMID:15215175 NCBI chr10:4,313,100...4,347,661
Ensembl chr10:4,312,863...4,446,200
JBrowse link
G Gss glutathione synthetase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSS mRNA CTD PMID:12376462 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects response to substance
multiple interactions
decreases expression
ISO GSTA1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTA1 mRNA
CTD PMID:14601045, PMID:22138251 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA3 mRNA CTD PMID:15215175 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:22564066 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTM5 mRNA CTD PMID:15059925 NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases expression
affects response to substance
EXP
ISO
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of GSTP1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTP1 protein
GSTP1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:12097258, PMID:19223546, PMID:22581815 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects response to substance ISO GSTT1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:22564066 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GUCY1A1 mRNA CTD PMID:15059925 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H3f3b H3.3 histone B increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of H3F3B mRNA CTD PMID:15215175 NCBI chr10:104,573,666...104,575,890
Ensembl chr10:104,573,664...104,575,890
JBrowse link
G H3f4 H3.4 histone decreases methylation
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased methylation of H3-4 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein
CTD PMID:17468514 NCBI chr10:45,304,696...45,305,106 JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HBA1 mRNA CTD PMID:12376462 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions
decreases expression
affects response to substance
ISO
EXP
kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Quercetin inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HBB mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HBB-B1 mRNA
HBB protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:14691983, PMID:15215175, PMID:29877212 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hccs holocytochrome c synthase decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HCCS mRNA CTD PMID:20816883 NCBI chr  X:26,294,028...26,303,461
Ensembl chr  X:26,294,066...26,303,461
JBrowse link
G Hemk1 HemK methyltransferase family member 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HEMK1 mRNA CTD PMID:20816883 NCBI chr 8:116,081,858...116,092,872
Ensembl chr 8:116,082,005...116,092,763
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HIF1A protein CTD PMID:22307971 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb2 high mobility group box 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGB2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGB2 protein CTD PMID:29877212 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HMGCS2 mRNA CTD PMID:15059925 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmgn1 high mobility group nucleosome binding domain 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGN1 mRNA CTD PMID:15215175 NCBI chr11:36,474,028...36,479,947
Ensembl chr11:36,474,840...36,479,868
JBrowse link
G Hmgn2 high mobility group nucleosomal binding domain 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGN2 mRNA CTD PMID:15215175 NCBI chr 5:152,195,359...152,198,813
Ensembl chr 5:152,195,361...152,198,813
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of HMOX1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMOX1 mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of HMOX1 mRNA
CTD PMID:12097258, PMID:20307560 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1b HNF1 homeobox B decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HNF1B mRNA CTD PMID:20816883 NCBI chr10:71,159,863...71,218,902
Ensembl chr10:71,159,869...71,218,902
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis
multiple interactions
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 intron
Ascorbic Acid inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]; beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]; Vitamin E inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with CYP1A2 protein] results in increased mutagenesis of HPRT1 gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of HPRT1 gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased mutagenesis of HPRT1 gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 intron] which affects the splicing of HPRT1 mRNA
CTD PMID:7728948, PMID:8625468, PMID:10728688, PMID:10987307, PMID:11289141, PMID:12467141 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression
increases mutagenesis
multiple interactions
affects response to substance
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HRAS mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HRAS protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of and results in increased activity of HRAS; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of HRAS gene; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene] which results in increased activity of HRAS protein; Dietary Fats affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene]
HRAS protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein]
CTD PMID:8039140, PMID:9433479, PMID:11165753, PMID:12507937, PMID:15132766, PMID:22307971 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSD17B10 mRNA CTD PMID:15215175 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSP90AA1 mRNA CTD PMID:15215175 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSP90AB1 mRNA CTD PMID:15215175 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPA1A mRNA CTD PMID:29877212 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HSPA2 mRNA CTD PMID:15059925 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPA5 mRNA CTD PMID:15215175 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPA8 mRNA CTD PMID:15215175 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HSPB1 mRNA CTD PMID:15059925 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of HSPD1 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of HSPD1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPD1 mRNA
CTD PMID:12097258, PMID:15215175 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions
increases expression
EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of HSPE1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPE1 mRNA
CTD PMID:12097258, PMID:15215175 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPH1 mRNA CTD PMID:15215175 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of ICAM1 mRNA CTD PMID:12097258 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID2 mRNA CTD PMID:15215175 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression
increases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ID3 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID3 mRNA
CTD PMID:12376462, PMID:15059925 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Id4 inhibitor of DNA binding 4, HLH protein increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID4 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID4 protein CTD PMID:14633621 NCBI chr17:16,692,557...16,695,126
Ensembl chr17:16,692,557...16,695,126
JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IFNAR2 mRNA CTD PMID:15215175 NCBI chr11:31,527,790...31,559,834
Ensembl chr11:31,539,016...31,558,851
JBrowse link
G Ifng interferon gamma increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IFNG mRNA CTD PMID:20702593 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IGFBP1 mRNA CTD PMID:15059925 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression
decreases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IGFBP2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IGFBP2 mRNA
CTD PMID:15215175 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IL1B mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL1B mRNA
CTD PMID:15059925, PMID:20702593 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases secretion
decreases expression
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased secretion of IL2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IL2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]
CTD PMID:16168555 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL6 mRNA
[IL6 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in decreased expression of MIR27B mRNA; IL6 protein promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]
CTD PMID:20702593, PMID:31515600 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 signal transducer increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL6ST mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IL6ST protein CTD PMID:12606953 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IMPDH2 mRNA CTD PMID:15215175 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form CTD PMID:11751460 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of INSIG1 mRNA CTD PMID:12376462 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Itga7 integrin subunit alpha 7 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ITGA7 mRNA CTD PMID:15059925 NCBI chr 7:3,355,079...3,383,886
Ensembl chr 7:3,355,116...3,384,675
JBrowse link
G Jak2 Janus kinase 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of JAK2 mRNA CTD PMID:29362861 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of JUN mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of JUN protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of JUN mRNA
CTD PMID:18283038, PMID:23313794 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kat6b lysine acetyltransferase 6B increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KAT6B mRNA CTD PMID:20816883 NCBI chr15:2,811,933...2,966,833
Ensembl chr15:2,813,537...2,966,576
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KCNK1 mRNA CTD PMID:15215175 NCBI chr19:58,823,836...58,862,926
Ensembl chr19:58,823,814...58,862,926
JBrowse link
G Kctd2 potassium channel tetramerization domain containing 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KCTD2 mRNA CTD PMID:20816883 NCBI chr10:103,972,700...103,984,398
Ensembl chr10:103,972,888...103,984,402
JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of and affects the localization of KDM1A protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein CTD PMID:17468514 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kif20a kinesin family member 20A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KIF20A mRNA CTD PMID:29877212 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Klf10 Kruppel-like factor 10 multiple interactions EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of KLF10 mRNA CTD PMID:12097258 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Krt19 keratin 19 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KRT19 mRNA CTD PMID:15215175 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt5 keratin 5 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of KRT5 mRNA CTD PMID:12376462 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LAPTM4B mRNA CTD PMID:15215175 NCBI chr 7:72,924,911...72,968,099
Ensembl chr 7:72,924,799...72,968,101
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LCN2 mRNA CTD PMID:15215175 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LIN7A mRNA CTD PMID:12376462 NCBI chr 7:49,429,613...49,627,835
Ensembl chr 7:49,385,705...49,656,856
JBrowse link
G Lmo4 LIM domain only 4 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LMO4 mRNA CTD PMID:15215175 NCBI chr 2:250,218,635...250,235,435
Ensembl chr 2:250,218,641...250,241,673
JBrowse link
G LOC100909569 zinc finger protein 91-like decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ZNF624 mRNA CTD PMID:20816883 NCBI chr 7:10,580,737...10,734,314 JBrowse link
G Loxl2 lysyl oxidase-like 2 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LOXL2 mRNA CTD PMID:29877212 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Lpl lipoprotein lipase decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LPL mRNA CTD PMID:12376462, PMID:15059925 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp1 LDL receptor related protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LRP1 mRNA CTD PMID:15215175 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrriq3 leucine-rich repeats and IQ motif containing 3 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LRRIQ3 mRNA CTD PMID:20816883 NCBI chr 2:261,403,040...261,499,893
Ensembl chr 2:261,402,980...261,499,891
JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LSR mRNA CTD PMID:12376462 NCBI chr 1:89,383,515...89,399,041
Ensembl chr 1:89,383,519...89,399,041
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LTBP3 mRNA CTD PMID:15215175 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096
JBrowse link
G Lum lumican increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LUM mRNA CTD PMID:15215175 NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MANF mRNA CTD PMID:15215175 NCBI chr 8:115,623,175...115,626,408
Ensembl chr 8:115,623,178...115,626,380
JBrowse link
G Maob monoamine oxidase B decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MAOB mRNA CTD PMID:15059925 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAP2K1 protein CTD PMID:22307971 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAP2K2 protein CTD PMID:22307971 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases expression
ISO fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK1 protein modified form]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]
CTD PMID:15319301, PMID:18056474, PMID:18845389, PMID:22307971 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of MAPK14 mRNA CTD PMID:20702593 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
increases expression
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]
fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK3 protein modified form]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein]
CTD PMID:15319301, PMID:18056474, PMID:18845389, PMID:22307971 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPT protein modified form CTD PMID:32169473 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MAT2A mRNA CTD PMID:20816883 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Matr3 matrin 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MATR3 mRNA CTD PMID:15215175 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM7 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM7 protein CTD PMID:16120219 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 3:125,470,499...125,500,795
Ensembl chr 3:125,470,551...125,500,795
JBrowse link
G Mdh2 malate dehydrogenase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDH2 mRNA CTD PMID:12376462 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Mdk midkine increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDK mRNA CTD PMID:15215175 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDM2 protein CTD PMID:15635149 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Melk maternal embryonic leucine zipper kinase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MELK mRNA CTD PMID:29877212 NCBI chr 5:59,783,835...59,844,356
Ensembl chr 5:59,783,890...59,844,356
JBrowse link
G Mep1a meprin A subunit alpha decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MEP1A mRNA CTD PMID:15059925 NCBI chr 9:20,048,163...20,077,678
Ensembl chr 9:20,048,121...20,077,702
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MFGE8 mRNA CTD PMID:15215175 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MGMT mRNA CTD PMID:12706856, PMID:15215175, PMID:29877212 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mgp matrix Gla protein increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MGP mRNA CTD PMID:12376462 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Mif macrophage migration inhibitory factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MIF mRNA CTD PMID:12376462 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir106b microRNA 106b decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR106B mRNA CTD PMID:24877718 NCBI chr12:19,307,752...19,307,833
Ensembl chr12:19,307,752...19,307,833
JBrowse link
G Mir141 microRNA 141 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR141 mRNA CTD PMID:24877718 NCBI chr 4:157,236,346...157,236,439
Ensembl chr 4:157,236,346...157,236,439
JBrowse link
G Mir200c microRNA 200c decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR200C mRNA CTD PMID:24877718 NCBI chr 4:157,236,786...157,236,854 JBrowse link
G Mir21 microRNA 21 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR21 mRNA CTD PMID:24877718 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir27b microRNA 27b multiple interactions ISO [IL6 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in decreased expression of MIR27B mRNA CTD PMID:31515600 NCBI chr17:823,461...823,557
Ensembl chr17:823,461...823,557
JBrowse link
G Mir30d microRNA 30d decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR30D mRNA CTD PMID:24877718 NCBI chr 7:109,286,463...109,286,544
Ensembl chr 7:109,286,463...109,286,544
JBrowse link
G Mir330 microRNA 330 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR330 mRNA CTD PMID:24877718 NCBI chr 1:80,092,681...80,092,777
Ensembl chr 1:80,092,681...80,092,777
JBrowse link
G Mir494 microRNA 494 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MIR494 mRNA CTD PMID:24877718 NCBI chr 6:133,864,370...133,864,452
Ensembl chr 6:133,864,369...133,864,453
JBrowse link
G Mir615 microRNA 615 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MIR615 mRNA CTD PMID:24877718 NCBI chr 7:144,629,019...144,629,110
Ensembl chr 7:144,629,019...144,629,110
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
increases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MKI67 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MKI67 protein
CTD PMID:23535288, PMID:29877212 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MKNK2 mRNA CTD PMID:15215175 NCBI chr 7:11,908,107...11,919,161
Ensembl chr 7:11,908,107...11,919,156
JBrowse link
G Mlh1 mutL homolog 1 affects response to substance ISO MLH1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:11425520, PMID:16256150 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP12 mRNA CTD PMID:15059925 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
ISO U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP2 protein] CTD PMID:22307971 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP7 mRNA CTD PMID:15059925 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases secretion
increases expression
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased secretion of MMP9 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP9 protein
U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP9 protein]
CTD PMID:20951759, PMID:22307971 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Morc4 MORC family CW-type zinc finger 4 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MORC4 mRNA CTD PMID:29877212 NCBI chr  X:111,143,537...111,191,993
Ensembl chr  X:111,142,602...111,191,936
JBrowse link
G Msh2 mutS homolog 2 affects response to substance ISO
EXP
MSH2 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:11593414, PMID:12901791 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Msh6 mutS homolog 6 affects response to substance
increases expression
ISO MSH6 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MSH6 protein
CTD PMID:11425520, PMID:26091049 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of COX1 mRNA CTD PMID:12376462 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CYTB mRNA CTD PMID:20816883 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt1 metallothionein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MT1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MT1A mRNA CTD PMID:15215175, PMID:29877212 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression
decreases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MT2A mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MT2A mRNA
CTD PMID:15215175 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mutyh mutY DNA glycosylase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MUTYH mRNA CTD PMID:15215175 NCBI chr 5:135,663,328...135,675,348
Ensembl chr 5:135,663,371...135,675,344
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC protein; [Dietary Fats co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of MYC mRNA; Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA]; Plant Preparations promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYC protein alternative form
CTD PMID:8603490, PMID:15059925, PMID:15319301, PMID:18283038, PMID:18616682, PMID:21081470 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh11 myosin heavy chain 11 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYH11 mRNA CTD PMID:15215175 NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184
JBrowse link
G Myl6 myosin light chain 6 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MYL6 mRNA CTD PMID:15215175 NCBI chr 7:2,906,137...2,909,193
Ensembl chr 7:2,906,137...2,909,179
JBrowse link
G N4bp1 Nedd4 binding protein 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of N4BP1 mRNA CTD PMID:20816883 NCBI chr19:21,218,123...21,268,539
Ensembl chr19:21,218,465...21,266,964
JBrowse link
G Nat1 N-acetyltransferase 1 affects response to substance
increases expression
ISO NAT1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAT1 mRNA
CTD PMID:18499698, PMID:31542801 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 increases activity
increases expression
decreases expression
ISO NAT2 protein polymorphism results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; NAT2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAT2 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NAT2 mRNA
CTD PMID:15110095, PMID:22138251, PMID:29549414 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nav2 neuron navigator 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NAV2 mRNA CTD PMID:20816883 NCBI chr 1:104,575,765...104,941,554
Ensembl chr 1:104,576,589...104,941,552
JBrowse link
G Ndn necdin, MAGE family member multiple interactions
increases methylation
EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of NDN promoter] which results in decreased expression of NDN mRNA CTD PMID:21489049 NCBI chr 1:122,981,755...122,983,354
Ensembl chr 1:122,981,755...122,983,351
JBrowse link
G Ndrg2 NDRG family member 2 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NDRG2 mRNA CTD PMID:15059925 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NDUFA2 mRNA CTD PMID:15215175 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Nek2 NIMA-related kinase 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NFE2L2 mRNA
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of NFE2L2 mRNA
CTD PMID:20307560 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfe2l3 nuclear factor, erythroid 2-like 3 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NFE2L3 mRNA CTD PMID:15215175 NCBI chr 4:81,205,214...81,233,068
Ensembl chr 4:81,205,404...81,232,813
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NFKB1 CTD PMID:20715105 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nkg7 natural killer cell granule protein 7 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NKG7 mRNA CTD PMID:20816883 NCBI chr 1:98,492,873...98,493,940
Ensembl chr 1:98,492,828...98,493,978
JBrowse link
G Nme9 NME/NM23 family member 9 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NME9 mRNA CTD PMID:20816883 NCBI chr 8:107,698,612...107,720,758 JBrowse link
G Nnat neuronatin increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NNAT mRNA CTD PMID:15215175 NCBI chr 3:154,043,873...154,046,334
Ensembl chr 3:154,043,873...154,046,330
JBrowse link
G Nop10 NOP10 ribonucleoprotein increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOP10 mRNA CTD PMID:15215175 NCBI chr 3:103,747,654...103,748,739
Ensembl chr 3:103,747,654...103,748,739
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased expression of NOS2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOS2 protein
CTD PMID:15459021, PMID:21081470 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 increases expression
affects response to substance
multiple interactions
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein
NOX1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; [diphenyleneiodonium results in decreased activity of NOX1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]; NOX1 protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]
CTD PMID:20715105, PMID:22307971 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX4 CTD PMID:20715105 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Npm1 nucleophosmin 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NPM1 mRNA CTD PMID:15215175 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NSMF mRNA CTD PMID:12376462 NCBI chr 3:2,262,173...2,270,996
Ensembl chr 3:2,262,253...2,270,995
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NTRK1 mRNA CTD PMID:20816883 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Numb NUMB, endocytic adaptor protein increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NUMB mRNA CTD PMID:15215175 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NUSAP1 mRNA CTD PMID:29877212 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:9581821, PMID:10503888 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Odf4 outer dense fiber of sperm tails 4 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ODF4 mRNA CTD PMID:20816883 NCBI chr10:55,510,333...55,516,315
Ensembl chr10:55,510,340...55,515,885
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Osm oncostatin M increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of OSM mRNA CTD PMID:20816883 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Padi4 peptidyl arginine deiminase 4 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PADI4 mRNA CTD PMID:12376462 NCBI chr 5:159,260,675...159,293,906
Ensembl chr 5:159,260,675...159,293,673
JBrowse link
G Papola poly (A) polymerase alpha increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PAPOLA mRNA CTD PMID:15215175 NCBI chr 6:129,609,068...129,662,002
Ensembl chr 6:129,609,074...129,661,531
JBrowse link
G Paqr7 progestin and adipoQ receptor family member 7 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PAQR7 mRNA CTD PMID:20816883 NCBI chr 5:152,708,782...152,720,230
Ensembl chr 5:152,708,775...152,720,229
JBrowse link
G Pbk PDZ binding kinase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PBK mRNA CTD PMID:29877212 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Pcbp1 poly(rC) binding protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCBP1 mRNA CTD PMID:15215175 NCBI chr 4:118,327,185...118,329,223
Ensembl chr 4:118,327,533...118,328,602
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCK1 mRNA CTD PMID:15215175 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pclaf PCNA clamp associated factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCLAF mRNA CTD PMID:29877212 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PCNA mRNA CTD PMID:15215175 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcp4 Purkinje cell protein 4 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PCP4 mRNA CTD PMID:15059925 NCBI chr11:36,851,035...36,912,272
Ensembl chr11:36,851,038...36,912,229
JBrowse link
G Pdcd1 programmed cell death 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PDCD1 mRNA CTD PMID:20816883 NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
JBrowse link
G Pde10a phosphodiesterase 10A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDE10A mRNA CTD PMID:15215175 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDGFA mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDGFA protein CTD PMID:12376462, PMID:15215175 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDIA4 mRNA CTD PMID:15215175 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pdzd7 PDZ domain containing 7 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDZD7 mRNA CTD PMID:20816883 NCBI chr 1:264,776,393...264,796,206
Ensembl chr 1:264,776,398...264,794,938
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PEBP1 mRNA CTD PMID:12376462 NCBI chr12:45,026,948...45,031,148
Ensembl chr12:45,026,886...45,031,145
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR protein alternative form
fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR protein alternative form]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR protein
CTD PMID:15319301, PMID:15637090 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phb prohibitin increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHB mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHB protein CTD PMID:12376462 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHGDH mRNA CTD PMID:15215175 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PIK3R1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PIK3R1 protein CTD PMID:12606953 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase affects response to substance ISO PIM1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:8895492 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PKM mRNA CTD PMID:15215175 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PLCB1 mRNA CTD PMID:15059925 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plk2 polo-like kinase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PLK2 mRNA CTD PMID:12376462 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Polh DNA polymerase eta affects activity ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the activity of POLH protein CTD PMID:19628463 NCBI chr 9:17,163,354...17,198,006
Ensembl chr 9:17,163,354...17,197,132
JBrowse link
G Polk DNA polymerase kappa affects activity ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the activity of POLK protein CTD PMID:19628463 NCBI chr 2:27,305,718...27,364,906
Ensembl chr 2:27,305,728...27,364,906
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:9581821, PMID:10503888 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Poted POTE ankyrin domain family member D decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of POTED mRNA CTD PMID:20816883 NCBI chr17:66,634,457...66,668,342
Ensembl chr17:66,657,755...66,667,853
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PPARA mRNA CTD PMID:11137312 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppic peptidylprolyl isomerase C increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PPIC mRNA CTD PMID:15215175 NCBI chr18:48,372,039...48,384,645
Ensembl chr18:48,372,041...48,384,645
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRC1 mRNA CTD PMID:29877212 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prcc proline rich mitotic checkpoint control factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRCC mRNA CTD PMID:15215175 NCBI chr 2:187,232,458...187,258,140
Ensembl chr 2:187,232,458...187,258,140
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRDX2 mRNA CTD PMID:15215175 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PRKAR2B mRNA CTD PMID:20816883 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383
JBrowse link
G Prl prolactin multiple interactions ISO
EXP
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of BCL2 protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased secretion of PRL protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of and results in increased secretion of PRL protein; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of and results in increased secretion of PRL protein]
CTD PMID:11751460, PMID:17909072 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Psat1 phosphoserine aminotransferase 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PSAT1 mRNA CTD PMID:29877212 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Psma2 proteasome 20S subunit alpha 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMA2 mRNA CTD PMID:15215175 NCBI chr17:53,091,937...53,102,324
Ensembl chr17:53,091,933...53,102,342
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMA6 mRNA CTD PMID:15215175 NCBI chr 6:76,174,460...76,205,429
Ensembl chr 6:76,174,452...76,205,426
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB1 mRNA CTD PMID:15215175 NCBI chr 1:57,470,878...57,491,359
Ensembl chr 1:57,470,632...57,489,727
JBrowse link
G Psmb2 proteasome 20S subunit beta 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB2 mRNA CTD PMID:15215175 NCBI chr 5:144,702,004...144,734,220
Ensembl chr 5:144,701,949...144,734,257
JBrowse link
G Psmb4 proteasome 20S subunit beta 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB4 mRNA CTD PMID:15215175 NCBI chr 2:196,043,546...196,046,320
Ensembl chr 2:196,043,618...196,046,311
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB6 mRNA CTD PMID:15215175 NCBI chr10:57,131,339...57,133,685
Ensembl chr10:57,131,386...57,133,637
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSMB9 mRNA CTD PMID:15215175 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Psme1 proteasome activator subunit 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PSME1 mRNA CTD PMID:15215175 NCBI chr15:34,256,071...34,258,947
Ensembl chr15:34,256,071...34,258,947
JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTBP1 mRNA CTD PMID:12376462 NCBI chr 7:12,663,965...12,673,723
Ensembl chr 7:12,663,965...12,673,718
JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PTEN protein CTD PMID:22581815 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptger1 prostaglandin E receptor 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGER1 mRNA CTD PMID:11751431 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Ptges3 prostaglandin E synthase 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGES3 mRNA CTD PMID:15215175 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:11159734 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing
multiple interactions
increases expression
ISO PTGS2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGS2 protein
fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGS2 protein]
CTD PMID:11159734, PMID:15459021, PMID:20951759, PMID:21081470 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptprm protein tyrosine phosphatase, receptor type, M decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PTPRM mRNA CTD PMID:29877212 NCBI chr 9:114,846,095...115,555,261
Ensembl chr 9:114,846,095...115,555,261
JBrowse link
G Qk quaking increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of QK mRNA CTD PMID:15215175 NCBI chr 1:50,983,647...51,050,692 JBrowse link
G Rab11a RAB11a, member RAS oncogene family increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB11A mRNA CTD PMID:15215175 NCBI chr 8:70,192,975...70,215,719
Ensembl chr 8:70,192,975...70,215,719
JBrowse link
G Rab1a RAB1A, member RAS oncogene family increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB1A mRNA CTD PMID:15215175 NCBI chr14:104,475,082...104,500,176
Ensembl chr14:104,475,082...104,501,020
JBrowse link
G Rab1b RAB1B, member RAS oncogene family increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB1B mRNA CTD PMID:15215175 NCBI chr 1:220,483,529...220,491,469
Ensembl chr 1:220,480,834...220,491,469
JBrowse link
G Rab2a RAB2A, member RAS oncogene family increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAB2 mRNA CTD PMID:15215175 NCBI chr 5:21,632,654...21,696,721
Ensembl chr 5:21,632,926...21,695,519
JBrowse link
G Rac2 Rac family small GTPase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAC2 mRNA CTD PMID:15215175 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RACGAP1 mRNA CTD PMID:29877212 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Rack1 receptor for activated C kinase 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RACK1 mRNA CTD PMID:15215175 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RAD23B mRNA CTD PMID:20816883 NCBI chr 5:72,103,704...72,141,701
Ensembl chr 5:72,103,704...72,141,700
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases phosphorylation ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of RAF1 protein CTD PMID:22307971 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Ralb RAS like proto-oncogene B increases expression
decreases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RALB mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RALB mRNA
CTD PMID:15215175 NCBI chr13:35,494,716...35,531,503
Ensembl chr13:35,494,721...35,511,020
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RAN mRNA CTD PMID:12376462, PMID:15215175 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RAPGEF1 mRNA CTD PMID:20816883 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G Rasa1 RAS p21 protein activator 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RASA1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RASA1 protein CTD PMID:12606953 NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
JBrowse link
G Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RASGRF2 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RASGRF2 protein CTD PMID:12606953 NCBI chr 2:21,460,041...21,698,937 JBrowse link
G RatNP-3b defensin RatNP-3 precursor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RATNP-3B mRNA CTD PMID:15059925 NCBI chr16:75,528,348...75,530,511
Ensembl chr16:75,497,832...75,530,517
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
increases expression
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased phosphorylation of RB1 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RB1 protein modified form
CTD PMID:14522882, PMID:15635149 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBBP4 mRNA CTD PMID:15215175 NCBI chr 5:147,499,880...147,535,240
Ensembl chr 5:147,499,882...147,535,240
JBrowse link
G Rbm14 RNA binding motif protein 14 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RBM14 mRNA CTD PMID:20816883 NCBI chr 1:220,048,740...220,067,124
Ensembl chr 1:220,048,873...220,067,124
JBrowse link
G Rbp1 retinol binding protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBP1 mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBP1 protein CTD PMID:12376462 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Rbp7 retinol binding protein 7 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RBP7 mRNA CTD PMID:15215175 NCBI chr 5:166,278,214...166,282,832
Ensembl chr 5:166,278,187...166,282,831
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RELA CTD PMID:20715105 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RHOA mRNA CTD PMID:15215175 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhoj ras homolog family member J decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RHOJ mRNA CTD PMID:15059925 NCBI chr 6:98,284,361...98,367,122
Ensembl chr 6:98,284,170...98,367,756
JBrowse link
G Rims4 regulating synaptic membrane exocytosis 4 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RIMS4 mRNA CTD PMID:20816883 NCBI chr 3:160,237,659...160,301,792
Ensembl chr 3:160,241,619...160,301,552
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RND3 mRNA CTD PMID:15215175 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Rnf186 ring finger protein 186 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RNF186 mRNA CTD PMID:20816883 NCBI chr 5:157,416,897...157,418,121
Ensembl chr 5:157,416,897...157,418,121
JBrowse link
G Rnf34 ring finger protein 34 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RNF34 mRNA CTD PMID:20816883 NCBI chr12:39,164,290...39,185,209
Ensembl chr12:39,164,290...39,185,168
JBrowse link
G Rpgr retinitis pigmentosa GTPase regulator decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RPGR mRNA CTD PMID:20816883 NCBI chr  X:14,271,012...14,331,745
Ensembl chr  X:14,271,017...14,331,486
JBrowse link
G Rpgrip1 RPGR interacting protein 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPGRIP1 mRNA CTD PMID:20816883 NCBI chr15:28,521,287...28,575,046
Ensembl chr15:28,522,737...28,574,737
JBrowse link
G Rpl10a ribosomal protein L10A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL10A mRNA CTD PMID:15215175 NCBI chr20:7,908,309...7,910,867
Ensembl chr20:7,908,304...7,910,867
JBrowse link
G Rpl12 ribosomal protein L12 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL12 mRNA CTD PMID:15215175 NCBI chr 3:12,009,578...12,011,952
Ensembl chr 3:12,009,578...12,011,666
JBrowse link
G Rpl13 ribosomal protein L13 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL13 mRNA CTD PMID:15215175 NCBI chr19:55,917,489...55,920,040
Ensembl chr19:55,917,736...55,919,996
JBrowse link
G Rpl13a ribosomal protein L13A increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL13A mRNA CTD PMID:15215175 NCBI chr 1:101,120,325...101,123,401
Ensembl chr 1:101,120,325...101,123,402
JBrowse link
G Rpl19 ribosomal protein L19 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL19 mRNA CTD PMID:15215175 NCBI chr10:85,978,691...85,981,979
Ensembl chr10:85,978,691...85,981,979
JBrowse link
G Rpl21 ribosomal protein L21 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL21 mRNA CTD PMID:15215175 NCBI chr12:9,996,919...9,999,998
Ensembl chr 3:91,870,208...91,870,690
Ensembl chr12:91,870,208...91,870,690
Ensembl chr  X:91,870,208...91,870,690
Ensembl chr13:91,870,208...91,870,690
JBrowse link
G Rpl22 ribosomal protein L22 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL22 mRNA CTD PMID:15215175 NCBI chr 5:169,506,150...169,512,875
Ensembl chr 5:169,506,138...169,512,871
JBrowse link
G Rpl26 ribosomal protein L26 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL26 mRNA CTD PMID:15215175 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
JBrowse link
G Rpl27a ribosomal protein L27a increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL27A mRNA CTD PMID:15215175 NCBI chr 1:174,132,798...174,135,816
Ensembl chr 1:174,132,798...174,135,816
JBrowse link
G Rpl28 ribosomal protein L28 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL28 mRNA CTD PMID:15215175 NCBI chr 1:72,619,282...72,621,941
Ensembl chr 1:72,619,282...72,621,519
JBrowse link
G Rpl3 ribosomal protein L3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL3 mRNA CTD PMID:15215175 NCBI chr 7:121,297,365...121,302,739
Ensembl chr 7:121,297,355...121,311,565
JBrowse link
G Rpl35 ribosomal protein L35 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL35 mRNA CTD PMID:15215175 NCBI chr 3:23,294,813...23,297,774
Ensembl chr 3:23,294,814...23,297,774
JBrowse link
G Rpl35a ribosomal protein L35a increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL35A mRNA CTD PMID:15215175 NCBI chr11:70,963,223...70,967,146
Ensembl chr12:7,186,473...7,186,873
Ensembl chr 5:7,186,473...7,186,873
Ensembl chr 1:7,186,473...7,186,873
Ensembl chr 6:7,186,473...7,186,873
Ensembl chr12:7,186,473...7,186,873
JBrowse link
G Rpl36 ribosomal protein L36 decreases expression
increases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RPL36 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL36 mRNA
CTD PMID:15215175 NCBI chr 9:10,441,228...10,441,981
Ensembl chr 9:10,441,259...10,441,834
JBrowse link
G Rpl37a ribosomal protein L37a increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL37A mRNA CTD PMID:15215175 NCBI chr 9:80,002,892...80,004,995 JBrowse link
G Rpl41 ribosomal protein L41 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL41 mRNA CTD PMID:15215175 NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977
JBrowse link
G Rpl6 ribosomal protein L6 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL6 mRNA CTD PMID:12376462, PMID:15215175 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rpl7 ribosomal protein L7 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL7 mRNA CTD PMID:15215175 NCBI chr 5:2,633,517...2,636,525
Ensembl chr 5:2,632,712...2,640,021
JBrowse link
G Rpl8 ribosomal protein L8 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL8 mRNA CTD PMID:15215175 NCBI chr 7:117,967,608...117,969,886
Ensembl chr 7:118,507,224...118,509,256
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPLP0 mRNA CTD PMID:15215175 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rplp1 ribosomal protein lateral stalk subunit P1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPLP1 mRNA CTD PMID:15215175 NCBI chr 8:66,862,143...66,863,476
Ensembl chr 8:66,862,143...66,863,476
JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPLP2 mRNA CTD PMID:15215175 NCBI chr 1:214,428,280...214,430,551
Ensembl chr 1:214,428,526...214,430,515
JBrowse link
G Rps11 ribosomal protein S11 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS11 mRNA CTD PMID:15215175 NCBI chr 1:101,116,641...101,118,749
Ensembl chr 1:101,116,635...101,118,825
JBrowse link
G Rps14 ribosomal protein S14 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS14 mRNA CTD PMID:15215175 NCBI chr18:56,042,532...56,047,316
Ensembl chr18:56,044,369...56,047,316
JBrowse link
G Rps15 ribosomal protein S15 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS15 mRNA CTD PMID:15215175 NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608
JBrowse link
G Rps17 ribosomal protein S17 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS17 mRNA CTD PMID:15215175 NCBI chr 1:143,167,329...143,169,915
Ensembl chr 1:143,167,362...143,169,657
JBrowse link
G Rps19 ribosomal protein S19 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS19 mRNA CTD PMID:15215175 NCBI chr 1:81,750,873...81,756,629
Ensembl chr 1:81,750,928...81,756,627
JBrowse link
G Rps2 ribosomal protein S2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS2 mRNA CTD PMID:15215175 NCBI chr10:14,088,171...14,090,020
Ensembl chr10:14,088,319...14,089,979
JBrowse link
G Rps23 ribosomal protein S23 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS23 mRNA CTD PMID:15215175 NCBI chr 2:19,823,234...19,824,804
Ensembl chr 2:19,823,234...19,824,804
JBrowse link
G Rps24 ribosomal protein S24 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS24 mRNA CTD PMID:15215175 NCBI chr16:757,390...762,091
Ensembl chr16:757,403...762,075
JBrowse link
G Rps29 ribosomal protein S29 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS29 mRNA CTD PMID:15215175 NCBI chr 6:91,455,333...91,456,709
Ensembl chr 6:91,455,333...91,456,696
Ensembl chr 3:91,455,333...91,456,696
Ensembl chr 7:91,455,333...91,456,696
JBrowse link
G Rps3 ribosomal protein S3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS3 mRNA CTD PMID:15215175 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
JBrowse link
G Rps3a ribosomal protein S3a increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS3A mRNA CTD PMID:15215175 NCBI chr 2:185,440,477...185,444,846
Ensembl chr 2:185,440,291...185,444,897
JBrowse link
G Rps5 ribosomal protein S5 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS5 mRNA CTD PMID:15215175 NCBI chr 1:65,660,470...65,664,767
Ensembl chr 1:65,660,470...65,664,767
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases expression
EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of RPS6 mRNA; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of RPS6 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS6 mRNA
CTD PMID:12097258, PMID:15215175 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps7 ribosomal protein S7 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS7 mRNA CTD PMID:15215175 NCBI chr 6:47,899,525...47,904,389
Ensembl chr 6:47,899,525...47,904,437
JBrowse link
G Rpsa ribosomal protein SA increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPSA mRNA CTD PMID:15215175 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RRM2 mRNA CTD PMID:29877212 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RT1-DA mRNA CTD PMID:15215175 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
JBrowse link
G S100a1 S100 calcium binding protein A1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of S100A1 mRNA CTD PMID:20816883 NCBI chr 2:189,900,505...189,905,348
Ensembl chr 2:189,900,667...189,903,219
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of S100A9 mRNA CTD PMID:15059925 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of S1PR1 mRNA CTD PMID:12376462 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SCARB1 mRNA CTD PMID:12376462 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase increases expression
multiple interactions
decreases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SCD mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SCD1 mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of SCD mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SCD1 mRNA
CTD PMID:12097258, PMID:12376462, PMID:15215175 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SCD2 mRNA CTD PMID:15215175 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Sec61g SEC61 translocon subunit gamma increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SEC61G mRNA CTD PMID:15215175 NCBI chr14:99,774,589...99,780,964
Ensembl chr14:99,774,589...99,780,964
JBrowse link
G Selenop selenoprotein P decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SELENOP mRNA CTD PMID:12376462, PMID:15215175 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Sem1 SEM1, 26S proteasome complex subunit increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SEM1 mRNA CTD PMID:15215175 NCBI chr 4:32,067,444...32,087,600
Ensembl chr 4:32,067,444...32,087,600
JBrowse link
G Serpinb5 serpin family B member 5 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SERPINB5 mRNA CTD PMID:15059925 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SERPINH1 mRNA CTD PMID:29877212 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SH3KBP1 mRNA CTD PMID:15059925 NCBI chr  X:37,790,004...38,196,365
Ensembl chr  X:37,790,586...38,196,204
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SIK1 mRNA CTD PMID:20816883 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Slain2 SLAIN motif family, member 2 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SLAIN2 mRNA CTD PMID:20816883 NCBI chr14:37,802,347...37,880,571
Ensembl chr14:37,802,365...37,871,051
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SLC12A2 mRNA CTD PMID:12376462 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SLC17A7 protein CTD PMID:32169473 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SLC22A1 mRNA CTD PMID:15059925 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A2 protein
CTD PMID:30189235 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A3 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
CTD PMID:30189235 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A6 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein] CTD PMID:28629854 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc25a10 solute carrier family 25 member 10 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SLC25A10 mRNA CTD PMID:12376462 NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143
JBrowse link
G Slc25a4 solute carrier family 25 member 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SLC25A4 mRNA CTD PMID:15215175 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc25a5 solute carrier family 25 member 5 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SLC25A5 mRNA CTD PMID:15215175 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc30a4 solute carrier family 30 member 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SLC30A4 mRNA CTD PMID:15215175 NCBI chr 3:114,805,919...114,828,154
Ensembl chr 3:114,805,922...114,828,154
JBrowse link
G Slc5a6 solute carrier family 5 member 6 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SLC5A6 mRNA CTD PMID:15215175 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SLPI mRNA CTD PMID:15215175 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Smyd3 SET and MYND domain containing 3 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SMYD3 mRNA CTD PMID:22100608 NCBI chr13:97,330,120...97,807,813 JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SNRPD1 mRNA CTD PMID:15215175 NCBI chr18:1,866,066...1,876,613
Ensembl chr18:1,866,080...1,876,613
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SNRPE mRNA CTD PMID:15215175 NCBI chr13:50,252,707...50,258,951
Ensembl chr 8:129,371,556...129,371,973
JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SNRPF mRNA CTD PMID:15215175 NCBI chr 7:34,478,331...34,485,034
Ensembl chr 7:34,478,331...34,485,034
JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SNRPG mRNA CTD PMID:15215175 NCBI chr 4:118,167,267...118,174,846
Ensembl chr 4:118,167,294...118,174,842
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SOD2 mRNA CTD PMID:20702593 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SOX9 mRNA CTD PMID:15215175 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SP1 protein CTD PMID:22307971 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SPC25 mRNA CTD PMID:29877212 NCBI chr 3:55,438,534...55,451,961
Ensembl chr 3:55,438,536...55,451,798
JBrowse link
G Spint2 serine peptidase inhibitor, Kunitz type, 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SPINT2 mRNA CTD PMID:15215175 NCBI chr 1:87,199,373...87,221,826
Ensembl chr 1:87,199,313...87,221,892
JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SQSTM1 mRNA CTD PMID:15215175 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SRRM2 mRNA CTD PMID:20816883 NCBI chr10:13,128,820...13,162,956
Ensembl chr10:13,145,099...13,162,343
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SRSF2 mRNA CTD PMID:15215175 NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
JBrowse link
G Ssbp3 single stranded DNA binding protein 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SSBP3 mRNA CTD PMID:15215175 NCBI chr 5:126,511,339...126,649,830
Ensembl chr 5:126,511,350...126,648,661
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Azoxymethane] results in increased expression of STAT1 mRNA CTD PMID:18424890 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STAT3 mRNA] CTD PMID:29362861 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
increases expression
ISO
EXP
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased activity of STAT5A protein; [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in increased expression of STAT5A protein modified form
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STAT5A mRNA; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STAT5A protein
CTD PMID:11751460, PMID:12376462 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stmn1 stathmin 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STMN1 mRNA CTD PMID:12376462, PMID:29877212 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Ston2 stonin 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STON2 mRNA CTD PMID:20816883 NCBI chr 6:115,398,586...115,547,552
Ensembl chr 6:115,399,326...115,513,354
JBrowse link
G Strn4 striatin 4 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STRN4 mRNA CTD PMID:15215175 NCBI chr 1:78,739,930...78,765,696
Ensembl chr 1:78,735,678...78,765,692
JBrowse link
G Sub1 SUB1 regulator of transcription increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SUB1 mRNA CTD PMID:15215175 NCBI chr 2:62,019,902...62,034,704
Ensembl chr 2:62,022,567...62,034,628
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression
increases expression
increases metabolic processing
increases response to substance
increases activity
multiple interactions
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SULT1A1 mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SULT1A1 mRNA
SULT1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
SULT1A1 protein results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
SULT1A1 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]; [2,6-dichloro-4-nitrophenol results in decreased activity of SULT1A1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [SULT1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct; SULT1A1 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:10692228, PMID:14973106, PMID:15059925, PMID:17433394, PMID:21900212, PMID:22006426, PMID:22138251, PMID:26940682, PMID:28160022, PMID:29549414, PMID:31542801 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SULT1B1 mRNA CTD PMID:31542801 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Syn1 synapsin I increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SYN1 mRNA CTD PMID:15215175 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SYNGR3 mRNA CTD PMID:20816883 NCBI chr10:14,051,413...14,056,169
Ensembl chr10:14,051,415...14,056,169
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TAF1 mRNA CTD PMID:20816883 NCBI chr  X:71,412,291...71,486,456
Ensembl chr  X:71,412,289...71,485,085
JBrowse link
G Taf10 TATA-box binding protein associated factor 10 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TAF10 mRNA CTD PMID:15215175 NCBI chr 1:170,585,160...170,586,428
Ensembl chr 1:170,585,167...170,586,603
JBrowse link
G Tagln transgelin decreases expression
increases expression
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TAGLN mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TAGLN mRNA
CTD PMID:15059925, PMID:15215175 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tbc1d2b TBC1 domain family, member 2B decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TBC1D2B mRNA CTD PMID:20816883 NCBI chr 8:97,577,551...97,647,072
Ensembl chr 8:97,577,565...97,647,072
JBrowse link
G Tbpl1 TATA-box binding protein like 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TBPL1 mRNA CTD PMID:15215175 NCBI chr 1:23,977,154...24,002,512
Ensembl chr 1:23,977,688...24,002,506
JBrowse link
G Tcerg1l transcription elongation regulator 1-like decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TCERG1L mRNA CTD PMID:29877212 NCBI chr 1:210,550,668...210,739,600
Ensembl chr 1:210,550,668...210,739,600
JBrowse link
G Tcf19 transcription factor 19 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TCF19 mRNA CTD PMID:15059925 NCBI chr20:3,740,454...3,746,964
Ensembl chr20:3,744,395...3,746,964
JBrowse link
G Tcp1 t-complex 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TCP1 mRNA CTD PMID:15215175 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tf transferrin multiple interactions
increases expression
EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] affects the expression of TF mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TF mRNA
CTD PMID:9879772, PMID:15215175 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfcp2l1 transcription factor CP2-like 1 decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TFCP2L1 mRNA CTD PMID:15215175 NCBI chr13:34,610,689...34,671,617
Ensembl chr13:34,610,684...34,670,124
JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TGFA mRNA CTD PMID:8603490 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of TIMP1 mRNA CTD PMID:12097258 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TIMP3 mRNA CTD PMID:15215175 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tk1 thymidine kinase 1 multiple interactions
increases mutagenesis
ISO [Benzo(a)pyrene co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of TK1 gene
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of TK1 gene
CTD PMID:26091049 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tkt transketolase decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TKT mRNA CTD PMID:12376462 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tle4 TLE family member 4, transcriptional corepressor increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TLE4 mRNA CTD PMID:12376462 NCBI chr 1:231,394,606...231,531,396
Ensembl chr 1:231,393,379...231,530,786
JBrowse link
G Tmc8 transmembrane channel-like 8 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TMC8 mRNA CTD PMID:20816883 NCBI chr10:106,784,819...106,795,307
Ensembl chr10:106,785,077...106,795,299
JBrowse link
G Tmem37 transmembrane protein 37 increases methylation
multiple interactions
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of TMEM37 promoter
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of TMEM37 promoter] which results in decreased expression of TMEM37 mRNA
CTD PMID:21489049 NCBI chr13:36,094,665...36,101,443
Ensembl chr13:36,094,520...36,101,411
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases stability
increases expression
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]; Dactinomycin promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]]; Tetradecanoylphorbol Acetate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]]
U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TNF protein]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased stability of TNF mRNA
CTD PMID:18845389, PMID:22307971 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnnc2 troponin C2, fast skeletal type decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TNNC2 mRNA CTD PMID:29877212 NCBI chr 3:161,243,607...161,246,335
Ensembl chr 3:161,243,587...161,246,351
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
increases expression
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TOP2A mRNA
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TOP2A mRNA
CTD PMID:20816883, PMID:29877212 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tor1aip2 torsin 1A interacting protein 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TOR1AIP2 mRNA CTD PMID:20816883 NCBI chr13:73,704,088...73,735,339
Ensembl chr13:73,708,815...73,735,339
Ensembl chr13:73,708,815...73,735,339
JBrowse link
G Tp53 tumor protein p53 increases expression
affects expression
multiple interactions
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TP53 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of TP53 mRNA
myricetin affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of TP53 mRNA]
CTD PMID:11425520, PMID:15635149, PMID:17156947, PMID:23810796, PMID:32342131 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases methylation
multiple interactions
EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of TP53I3 promoter
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased methylation of TP53I3 promoter] which results in decreased expression of TP53I3 mRNA
CTD PMID:21489049 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tp63 tumor protein p63 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TRP63 protein CTD PMID:22581815 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tpm2 tropomyosin 2 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TPM2 mRNA CTD PMID:15215175 NCBI chr 5:59,016,616...59,025,971
Ensembl chr 5:59,016,622...59,025,631
JBrowse link
G Tpm3 tropomyosin 3 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TPM3 mRNA CTD PMID:12376462, PMID:15215175 NCBI chr 2:189,423,534...189,451,340
Ensembl chr 2:189,423,559...189,451,029
JBrowse link
G Tram1 translocation associated membrane protein 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TRAM1 mRNA CTD PMID:15215175 NCBI chr 5:5,215,196...5,297,337
Ensembl chr 5:5,215,196...5,316,685
JBrowse link
G Trappc9 trafficking protein particle complex 9 decreases expression ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TRAPPC9 mRNA CTD PMID:22100608, PMID:29877212 NCBI chr 7:113,986,363...114,309,090
Ensembl chr 7:113,681,793...114,305,896
JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TTC37 mRNA CTD PMID:20816883 NCBI chr 2:2,891,265...3,037,602
Ensembl chr 2:2,903,492...3,004,553
JBrowse link
G Ttk Ttk protein kinase increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TTK mRNA CTD PMID:16120219 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Ttl tubulin tyrosine ligase increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TTL mRNA CTD PMID:20816883 NCBI chr 3:121,596,773...121,626,581
Ensembl chr 3:121,596,791...121,624,048
JBrowse link
G Tubb2b tubulin, beta 2B class IIb increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TUBB2B mRNA CTD PMID:12376462 NCBI chr17:31,441,640...31,444,687
Ensembl chr17:31,441,630...31,482,759
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UBA1 mRNA CTD PMID:15215175 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UBE2C mRNA CTD PMID:29877212 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UBE2T mRNA CTD PMID:29877212 NCBI chr13:51,790,877...51,801,379
Ensembl chr13:51,795,867...51,801,163
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression
ISO
EXP
UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA] CTD PMID:15708579, PMID:22138251, PMID:23810796, PMID:29877212, PMID:31542801 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions EXP [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Azoxymethane] results in increased expression of VEGFC mRNA CTD PMID:18424890 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Wtap WT1 associated protein decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of WTAP mRNA CTD PMID:20816883 NCBI chr 1:47,942,500...47,967,633
Ensembl chr 1:47,942,500...47,967,631
JBrowse link
G Xdh xanthine dehydrogenase decreases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of XDH mRNA CTD PMID:12376462 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions
affects response to substance
ISO XPA protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]
XPA protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:10755388, PMID:11285198, PMID:16962818 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
G Xpnpep2 X-prolyl aminopeptidase 2 increases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of XPNPEP2 mRNA CTD PMID:20816883 NCBI chr  X:134,940,656...134,969,874
Ensembl chr  X:134,940,615...134,969,996
JBrowse link
G Xpo1 exportin 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of XPO1 mRNA CTD PMID:15215175 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of XRCC1 mRNA CTD PMID:15215175 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Ythdc1 YTH domain containing 1 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of YTHDC1 mRNA CTD PMID:20816883 NCBI chr14:22,971,834...23,002,326
Ensembl chr14:22,971,836...23,002,011
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of YWHAZ mRNA CTD PMID:12376462 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link
G Zbtb17 zinc finger and BTB domain containing 17 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ZBTB17 mRNA CTD PMID:15215175 NCBI chr 5:159,993,799...160,014,899
Ensembl chr 5:159,993,799...160,014,895
JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ZBTB44 mRNA CTD PMID:15215175 NCBI chr 8:32,165,388...32,223,341
Ensembl chr 8:32,165,810...32,217,476
JBrowse link
G Zfp148 zinc finger protein 148 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ZFP148 mRNA CTD PMID:15215175 NCBI chr11:70,509,909...70,618,422
Ensembl chr11:70,514,750...70,618,347
JBrowse link
G Zfp296 zinc finger protein 296 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ZNF296 mRNA CTD PMID:20816883 NCBI chr 1:80,487,193...80,491,422
Ensembl chr 1:80,487,938...80,491,039
JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ZFP367 mRNA CTD PMID:29877212 NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
JBrowse link
G Zfp654 zinc finger protein 654 decreases expression ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ZNF654 mRNA CTD PMID:20816883 NCBI chr11:1,831,378...1,895,814 JBrowse link
N-hydroxy-PhIP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [ABCB1A protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:30701287 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions ISO [ABCB1B protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:30701287 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:30701287 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [ABCC3 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:30701287 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
multiple interactions
ISO ABCG2 protein affects the transport of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[ABCG2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:18322075, PMID:30701287 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
[[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:16167840, PMID:17052995, PMID:17279779 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [[CYP1A2 protein co-treated with CYP1A1 protein] results in increased hydroxylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; [CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine metabolite
[CYP1A2 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:1943715, PMID:16167840, PMID:17279779, PMID:20192249 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [CYP1B1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:17279779 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:17279779 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity
ISO 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of ESR1 protein
CTD PMID:16533016 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA1 protein CTD PMID:17122891 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA3 protein CTD PMID:17122891 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA4 protein CTD PMID:17122891 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTM1 protein CTD PMID:17122891 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
decreases response to substance
ISO
EXP
[GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTP1 protein
GSTP1 protein results in decreased susceptibility to 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:11196146, PMID:17122891 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
increases metabolic processing
ISO NAT1 protein affects the acetylation of and affects the activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
NAT1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:11505221, PMID:29596660 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
increases metabolic processing
increases acetylation
EXP
ISO
4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
NAT2 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:12222688, PMID:18842621, PMID:29596660 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 affects expression
multiple interactions
EXP 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of PDIA3 protein
[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of PDIA3 protein
CTD PMID:19639176 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Rab7a RAB7A, member RAS oncogene family affects expression
multiple interactions
EXP 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of RAB7A protein
[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of RAB7A protein
CTD PMID:19639176 NCBI chr 4:119,910,461...119,963,065
Ensembl chr 4:119,910,478...119,959,173
JBrowse link
G Rps7 ribosomal protein S7 multiple interactions
affects expression
EXP [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of RPS7 protein
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of RPS7 protein
CTD PMID:19639176 NCBI chr 6:47,899,525...47,904,389
Ensembl chr 6:47,899,525...47,904,437
JBrowse link
G Sar1a secretion associated, Ras related GTPase 1A affects expression
multiple interactions
EXP 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of SAR1A protein
[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of SAR1A protein
CTD PMID:19639176 NCBI chr20:31,298,269...31,310,676
Ensembl chr20:31,265,483...31,310,674
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases metabolic processing
ISO SULT1A1 protein results in increased metabolism of and results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
SULT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:12067565, PMID:29596660 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
affects metabolic processing
increases metabolic processing
increases glucuronidation
ISO UGT1A1 promoter polymorphism affects the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]; UGT1A1 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A1 promoter polymorphism affects the metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A1 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A1 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:11442279, PMID:15310245, PMID:15769885, PMID:15986396 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:15310245 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases metabolic processing
multiple interactions
increases glucuronidation
ISO UGT1A4 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A4 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]
UGT1A4 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:15310245, PMID:15986396 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation
multiple interactions
increases metabolic processing
ISO UGT1A8 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A8 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]
UGT1A8 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:15310245, PMID:15986396 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions
increases metabolic processing
increases glucuronidation
ISO UGT1A9 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine binds to Glucuronides]
UGT1A9 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
UGT1A9 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
CTD PMID:11375903, PMID:15310245, PMID:15986396 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            PhIP 585
              N-hydroxy-PhIP 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        primary amino compound 7872
                                          PhIP 585
                                            N-hydroxy-PhIP 27
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.