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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorendic acid
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Accession:CHEBI:76603 term browser browse the term
Definition:A bridged organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with maleic anhydride followed by hydrolysis of the resulting anhydride. A chemical intermediate used in the preparation of fire-retardant polyester resins and plasticisers.
Synonyms:exact_synonym: 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid
 related_synonym: 1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dicarboxylic acid;   1,4,5,6,7,7-Hexachlorobicyclo(2.2.1)-5-heptene-2,3-dicarboxylic acid;   Formula=C9H4Cl6O4;   Hexachloro-endo-methylenetetrahydrophthalic acid;   InChI=1S/C9H4Cl6O4/c10-3-4(11)8(13)2(6(18)19)1(5(16)17)7(3,12)9(8,14)15/h1-2H,(H,16,17)(H,18,19);   InChIKey=DJKGDNKYTKCJKD-UHFFFAOYSA-N;   SMILES=OC(=O)C1C(C(O)=O)C2(Cl)C(Cl)=C(Cl)C1(Cl)C2(Cl)Cl
 xref: CAS:115-28-6;   KEGG:C19204
 xref_mesh: MESH:C035377
 xref: PMID:12748725;   PMID:1367592;   PMID:15318386;   PMID:18961903;   PMID:21089823;   PMID:21850124;   PMID:2197462;   PMID:22584684;   PMID:2629100;   PMID:7120517;   PMID:8792842;   Reaxys:1892213;   Reaxys:8156979;   Wikipedia:Chlorendic_acid


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chlorendic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C6 complement C6 decreases expression EXP chlorendic acid results in decreased expression of C6 mRNA CTD PMID:22584684 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G Ccnb1 cyclin B1 increases expression EXP chlorendic acid results in increased expression of CCNB1 mRNA CTD PMID:22584684 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP chlorendic acid results in increased expression of CCND1 mRNA CTD PMID:22584684 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP chlorendic acid results in increased expression of CDK1 mRNA CTD PMID:22584684 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 increases expression EXP chlorendic acid results in increased expression of CDKN3 mRNA CTD PMID:22584684 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases secretion
increases expression
ISO chlorendic acid results in increased secretion of ENPP2 protein
chlorendic acid results in increased expression of ENPP2 mRNA
CTD PMID:22952646 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions EXP [Diethylnitrosamine co-treated with chlorendic acid] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with chlorendic acid] results in decreased expression of GJB1 protein CTD PMID:1973356 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Kif11 kinesin family member 11 increases expression EXP chlorendic acid results in increased expression of KIF11 mRNA CTD PMID:22584684 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Mir193a microRNA 193a decreases expression EXP chlorendic acid results in decreased expression of MIR193A mRNA CTD PMID:22584684 NCBI chr10:67,065,885...67,065,996
Ensembl chr10:67,065,885...67,065,996
JBrowse link
G Mir200a microRNA 200a increases expression EXP chlorendic acid results in increased expression of MIR200A mRNA CTD PMID:22584684 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir200b microRNA 200b increases expression EXP chlorendic acid results in increased expression of MIR200B mRNA CTD PMID:22584684 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
JBrowse link
G Mir20a microRNA 20a decreases expression EXP chlorendic acid results in decreased expression of MIR20A mRNA CTD PMID:22584684 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir28 microRNA 28 increases expression EXP chlorendic acid results in increased expression of MIR28 mRNA CTD PMID:22584684 NCBI chr11:79,380,523...79,380,608
Ensembl chr11:79,380,523...79,380,608
JBrowse link
G Mir34a microRNA 34a increases expression EXP chlorendic acid results in increased expression of MIR34A mRNA CTD PMID:22584684 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mir3545 microRNA 3545 decreases expression EXP chlorendic acid results in decreased expression of MIR203 mRNA CTD PMID:22584684 NCBI chr 6:136,704,947...136,705,061
Ensembl chr 6:136,704,947...136,705,061
JBrowse link
G Mir429 microRNA 429 increases expression EXP chlorendic acid results in increased expression of MIR429 mRNA CTD PMID:22584684 NCBI chr 5:173,488,331...173,488,415
Ensembl chr 5:173,488,331...173,488,415
JBrowse link
G Mir497 microRNA 497 decreases expression EXP chlorendic acid results in decreased expression of MIR497 mRNA CTD PMID:22584684 NCBI chr10:56,844,977...56,845,045
Ensembl chr10:56,844,977...56,845,045
JBrowse link
G Mir96 microRNA 96 decreases expression EXP chlorendic acid results in decreased expression of MIR96 mRNA CTD PMID:22584684 NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression EXP chlorendic acid results in decreased expression of NAMPT mRNA CTD PMID:22584684 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP chlorendic acid results in increased expression of NUPR1 mRNA CTD PMID:22584684 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions ISO chlorendic acid results in increased cleavage of and results in increased activity of PPP3CA protein CTD PMID:22952646 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Stmn1 stathmin 1 increases expression EXP chlorendic acid results in increased expression of STMN1 mRNA CTD PMID:22584684 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tnf tumor necrosis factor increases expression ISO chlorendic acid results in increased expression of TNF mRNA CTD PMID:22952646 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP chlorendic acid results in increased expression of TOP2A mRNA CTD PMID:22584684 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression EXP chlorendic acid results in increased expression of TP53INP1 mRNA CTD PMID:22584684 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP chlorendic acid results in increased expression of WEE1 mRNA CTD PMID:22584684 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            chlorendic acid 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      dicarboxylic acids and O-substituted derivatives 10279
                                        dicarboxylic acid 10272
                                          chlorendic acid 26
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.