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ONTOLOGY REPORT - ANNOTATIONS


Term:macitentan
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Accession:CHEBI:76607 term browser browse the term
Definition:A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension.
Synonyms:exact_synonym: N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]-N'-propylsulfuric diamide
 related_synonym: ACT 064992;   ACT064992;   Formula=C19H20Br2N6O4S;   InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27);   InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N;   OPSUMIT;   SMILES=CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1;   macitentanum
 xref: CAS:441798-33-0 "ChemIDplus";   CAS:441798-33-0 "KEGG DRUG";   Drug_Central:4809 "DrugCentral";   KEGG:D10135
 xref_mesh: MESH:C533860
 xref: PMID:21403842 "Europe PMC";   PMID:22189899 "Europe PMC";   PMID:22311911 "Europe PMC";   PMID:22348175 "Europe PMC";   PMID:22458347 "Europe PMC";   PMID:22525377 "Europe PMC";   PMID:22862294 "Europe PMC";   PMID:23068290 "Europe PMC";   PMID:23077657 "Europe PMC";   PMID:23192269 "Europe PMC";   PMID:23204120 "Europe PMC";   PMID:23353592 "Europe PMC";   PMID:23568224 "Europe PMC";   PMID:23682110 "Europe PMC";   PMID:23817130 "Europe PMC";   PMID:23830395 "Europe PMC";   PMID:23900878 "Europe PMC";   PMID:23984728 "Europe PMC";   PMID:23997048 "Europe PMC";   PMID:24122306 "Europe PMC";   PMID:24122797 "Europe PMC";   PMID:24249746 "Europe PMC";   PMID:24261583 "Europe PMC";   PMID:24297706 "Europe PMC";   Patent:US2008233188;   Patent:WO2007119214;   Patent:WO2008026156;   Reaxys:11340634 "Reaxys";   Wikipedia:Macitentan


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macitentan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        solvent 16081
          ethylene glycol 105
            macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      chalcogen 19301
                        oxygen atom 19261
                          oxygen molecular entity 19261
                            hydroxides 19013
                              oxoacid 18094
                                chalcogen oxoacid 11401
                                  sulfur oxoacid 10992
                                    sulfuric acid 7914
                                      sulfuric acid derivative 7914
                                        sulfuric amide 17
                                          sulfamides 17
                                            ACT-132577 4
                                              macitentan 4
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