Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Penicillium metabolite
go back to main search page
Accession:CHEBI:76964 term browser browse the term
Definition:Any fungal metabolite produced during a metabolic reaction in Penicillium.
Synonyms:related_synonym: Penicillium metabolites
 alt_id: CHEBI:76205;   CHEBI:76963


show annotations for term's descendants           Sort by:
 
(-)-citrinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 protein CTD PMID:29673704 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Citrinin results in increased expression of ATF3 mRNA CTD PMID:21844328 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Citrinin results in increased expression of ATF4 mRNA CTD PMID:21844328 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Citrinin results in increased expression of ATG5 mRNA CTD PMID:22771370 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bag3 BAG cochaperone 3 increases expression
multiple interactions
ISO Citrinin results in increased expression of BAG3 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BAG3 mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of BAG3 mRNA
CTD PMID:30428381 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
ISO Citrinin results in increased expression of BAK1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BAK1 mRNA
CTD PMID:30428381 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
affects expression
ISO Citrinin results in increased expression of BAX protein
Citrinin affects the expression of BAX protein
CTD PMID:21622943, PMID:22771370 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
affects expression
ISO Citrinin results in decreased expression of BCL2 protein
Citrinin affects the expression of BCL2 protein
CTD PMID:21622943, PMID:22771370 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l12 BCL2 like 12 increases expression
multiple interactions
ISO Citrinin results in increased expression of BCL2L12 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BCL2L12 mRNA
CTD PMID:30428381 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Becn1 beclin 1 increases expression ISO Citrinin results in increased expression of BECN1 mRNA CTD PMID:22771370 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp2 caspase 2 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CASP2 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CASP2 mRNA
CTD PMID:30428381 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
ISO
EXP
Citrinin results in increased activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Citrinin results in increased activity of CASP3 protein]; Citrinin inhibits the reaction [ochratoxin A results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Citrinin results in increased activity of CASP3 protein]
[Citrinin results in increased activity of CASP3 protein] which results in increased activity of PAK2 protein; Citrinin results in increased activity of CASP3 protein
Citrinin results in increased expression of CASP3 protein modified form
CTD PMID:18767140, PMID:19361540, PMID:21622943, PMID:22564900, PMID:29673704 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
ISO
EXP
Citrinin results in increased activity of CASP9 protein
Citrinin results in increased expression of CASP9 protein modified form
CTD PMID:21622943, PMID:22564900 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity ISO Citrinin results in increased activity of CAT protein CTD PMID:21622943 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccna2 cyclin A2 increases expression EXP Citrinin results in increased expression of CCNA2 mRNA CTD PMID:23856526 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression
decreases expression
multiple interactions
EXP
ISO
Citrinin results in increased expression of CCNB1 mRNA
Citrinin results in decreased expression of CCNB1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CCNB1 mRNA
CTD PMID:23856526, PMID:30428381 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
decreases expression
EXP
ISO
Citrinin results in increased expression of CCNE1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CCNE1 mRNA
Citrinin results in decreased expression of CCNE1 mRNA
CTD PMID:23856526, PMID:30428381 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CCNG1 mRNA; [Citrinin co-treated with ochratoxin A] results in decreased expression of CCNG1 protein CTD PMID:30428381 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cdc23 cell division cycle 23 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDC23 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC23 mRNA
CTD PMID:30428381 NCBI chr18:27,430,924...27,452,569
Ensembl chr18:27,430,905...27,452,420
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
decreases expression
increases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC25A mRNA
Citrinin results in decreased expression of CDC25A mRNA
Citrinin results in increased expression of CDC25A mRNA
CTD PMID:30428381 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC25C mRNA
Citrinin results in decreased expression of CDC25C mRNA
CTD PMID:30428381 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc26 cell division cycle 26 multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC26 mRNA
Citrinin results in decreased expression of CDC26 mRNA
CTD PMID:30428381 NCBI chr 5:78,252,168...78,267,137
Ensembl chr 5:78,253,397...78,267,063
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC34 mRNA
Citrinin results in decreased expression of CDC34 mRNA
CTD PMID:30428381 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC6 mRNA
Citrinin results in decreased expression of CDC6 mRNA
CTD PMID:30428381 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc7 cell division cycle 7 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDC7 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC7 mRNA
CTD PMID:30428381 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDH1 mRNA; [ochratoxin A co-treated with Citrinin] results in decreased expression of CDH1 protein CTD PMID:29673704 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDK1 protein modified form
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDK1 mRNA
CTD PMID:20929984, PMID:30428381 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk10 cyclin-dependent kinase 10 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDK10 mRNA CTD PMID:30428381 NCBI chr19:56,024,903...56,032,610
Ensembl chr19:56,024,903...56,032,605
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Citrinin results in increased expression of CDKN1A protein CTD PMID:20929984, PMID:21622943 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDKN1B mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDKN1B mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of CDKN1B mRNA
CTD PMID:30428381 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of COL3A1 mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of and results in increased secretion of COL3A1 protein CTD PMID:29673704 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Citrinin affects the localization of CYCS protein CTD PMID:21622943 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Citrinin results in decreased expression of CYP11A1 protein CTD PMID:22564900 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Citrinin results in increased expression of DDIT3 mRNA CTD PMID:21844328 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G E2f1 E2F transcription factor 1 increases expression EXP Citrinin results in increased expression of E2F1 mRNA CTD PMID:23856526 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
ISO Citrinin results in increased expression of EGR1 mRNA; Citrinin results in increased expression of EGR1 protein
U 0126 inhibits the reaction [Citrinin results in increased expression of EGR1 protein]
CTD PMID:19361540 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Citrinin results in increased expression of FOS mRNA; Citrinin results in increased expression of FOS protein
U 0126 inhibits the reaction [Citrinin results in increased expression of FOS protein]
CTD PMID:19361540 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression
multiple interactions
ISO Citrinin results in increased expression of GADD45B mRNA
U 0126 inhibits the reaction [Citrinin results in increased expression of GADD45B mRNA]
CTD PMID:19361540 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Citrinin results in increased expression of HGF mRNA CTD PMID:23856526 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Citrinin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Citrinin results in decreased expression of HSD3B1 protein CTD PMID:22564900
G Ifng interferon gamma decreases expression
increases expression
decreases secretion
ISO Citrinin results in decreased expression of IFNG mRNA
Citrinin results in increased expression of IFNG protein
Citrinin results in decreased secretion of IFNG protein
CTD PMID:12112629, PMID:22771370 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 protein]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL10 protein] CTD PMID:22771370 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL1B mRNA]
Citrinin results in decreased expression of IL1B mRNA
CTD PMID:22771370 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Citrinin results in increased expression of JUN mRNA; Citrinin results in increased expression of JUN protein CTD PMID:19361540 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Citrinin results in increased expression of JUNB mRNA CTD PMID:19361540 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Citrinin results in increased expression of LCN2 mRNA CTD PMID:23856526 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Citrinin results in increased phosphorylation of MAPK1 protein
Citrinin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]; ochratoxin A promotes the reaction [Citrinin results in increased phosphorylation of MAPK1 protein]
CTD PMID:19361540, PMID:23856526, PMID:29673704 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
Citrinin results in increased phosphorylation of MAPK3 protein
Citrinin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein]; ochratoxin A promotes the reaction [Citrinin results in increased phosphorylation of MAPK3 protein]
CTD PMID:19361540, PMID:23856526, PMID:29673704 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Citrinin results in increased phosphorylation of MAPK8 protein CTD PMID:19361540 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Citrinin results in increased phosphorylation of MAPK9 protein CTD PMID:19361540 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mir1 microRNA 1 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of MIR1 mRNA
[Citrinin co-treated with ochratoxin A] results in increased expression of MIR1 mRNA
CTD PMID:30428381 NCBI chr18:2,054,933...2,055,019 JBrowse link
G Mir107 microRNA 107 decreases expression ISO Citrinin results in decreased expression of MIR107 mRNA CTD PMID:30428381 NCBI chr 1:253,128,250...253,128,336
Ensembl chr 1:253,128,250...253,128,336
JBrowse link
G Mir122 microRNA 122 multiple interactions
increases expression
ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR122 mRNA
Citrinin results in increased expression of MIR122 mRNA
CTD PMID:30428381 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir132 microRNA 132 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR132 mRNA CTD PMID:30428381 NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
JBrowse link
G Mir139 microRNA 139 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR139 mRNA CTD PMID:30428381 NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612
JBrowse link
G Mir142 microRNA 142 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR142 mRNA CTD PMID:30428381 NCBI chr10:75,050,839...75,050,925
Ensembl chr10:75,050,832...75,050,942
JBrowse link
G Mir144 microRNA 144 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR144 mRNA CTD PMID:30428381 NCBI chr10:65,291,365...65,291,447
Ensembl chr10:65,291,365...65,291,447
JBrowse link
G Mir152 microRNA 152 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR152 mRNA CTD PMID:30428381 NCBI chr10:84,719,319...84,719,403
Ensembl chr10:84,719,319...84,719,403
JBrowse link
G Mir184 microRNA 184 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR184 mRNA CTD PMID:30428381 NCBI chr 8:97,175,657...97,175,733
Ensembl chr 8:97,175,657...97,175,733
JBrowse link
G Mir187 microRNA 187 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR187 mRNA CTD PMID:30428381 NCBI chr18:16,390,507...16,390,610
Ensembl chr18:16,390,507...16,390,610
JBrowse link
G Mir190b microRNA 190b multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR190B mRNA CTD PMID:30428381 NCBI chr 2:189,421,137...189,421,214
Ensembl chr 2:189,421,137...189,421,214
JBrowse link
G Mir200b microRNA 200b multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR200B mRNA CTD PMID:30428381 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
JBrowse link
G Mir200c microRNA 200c multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR200C mRNA CTD PMID:30428381 NCBI chr 4:157,236,786...157,236,854 JBrowse link
G Mir295-1 microRNA 295-1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR372 mRNA CTD PMID:30428381 NCBI chr 1:64,536,623...64,536,703
Ensembl chr 1:64,536,623...64,536,703
JBrowse link
G Mir301a microRNA 301a decreases expression ISO Citrinin results in decreased expression of MIR301A mRNA CTD PMID:30428381 NCBI chr10:74,417,746...74,417,845
Ensembl chr10:74,417,746...74,417,845
JBrowse link
G Mir32 microRNA 32 decreases expression ISO Citrinin results in decreased expression of MIR32 mRNA CTD PMID:30428381 NCBI chr 5:73,934,255...73,934,324
Ensembl chr 5:73,934,255...73,934,324
JBrowse link
G Mir34a microRNA 34a decreases expression ISO Citrinin results in decreased expression of MIR34A mRNA CTD PMID:30428381 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mir34b microRNA 34b multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR34B mRNA
Citrinin results in decreased expression of MIR34B mRNA
CTD PMID:30428381 NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
JBrowse link
G Mir34c microRNA 34c decreases expression
multiple interactions
ISO Citrinin results in decreased expression of MIR34C mRNA
[Citrinin co-treated with ochratoxin A] results in increased expression of MIR34C mRNA
CTD PMID:30428381 NCBI chr 8:55,492,024...55,492,100
Ensembl chr 8:55,492,024...55,492,100
JBrowse link
G Mir374b microRNA 374b decreases expression ISO Citrinin results in decreased expression of MIR374B mRNA CTD PMID:30428381 NCBI chr  X:74,443,648...74,443,715
Ensembl chr  X:74,443,648...74,443,715
JBrowse link
G Mir449a microRNA 449a multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR449A mRNA CTD PMID:30428381 NCBI chr 2:44,897,601...44,897,691
Ensembl chr 2:44,897,601...44,897,691
JBrowse link
G Mir449c microRNA 449c multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR449C mRNA CTD PMID:30428381 NCBI chr 2:44,896,066...44,896,164
Ensembl chr 2:44,896,066...44,896,164
JBrowse link
G Mir92a1 microRNA 92a-1 decreases expression ISO Citrinin results in decreased expression of MIR92A1 mRNA CTD PMID:30428381 NCBI chr15:100,180,586...100,180,663
Ensembl chr15:100,180,586...100,180,663
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression
multiple interactions
ISO Citrinin results in increased expression of MMP3 mRNA
pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]
CTD PMID:19361540 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases activity ISO [Citrinin results in increased activity of CASP3 protein] which results in increased activity of PAK2 protein; Citrinin results in increased activity of PAK2 protein CTD PMID:18767140 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of PDCD4 mRNA
Citrinin results in decreased expression of PDCD4 mRNA
CTD PMID:30428381 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO Citrinin results in decreased activity of PPARG protein CTD PMID:27481073 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Citrinin results in increased expression of PPP1R15A mRNA CTD PMID:21844328 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 mRNA; [ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 protein CTD PMID:29673704 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP Citrinin inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A] CTD PMID:10336520 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of SLC5A1 mRNA CTD PMID:29673704 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Citrinin results in decreased expression of STAR protein CTD PMID:22564900 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased activity of THRB protein CTD PMID:27481073 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Citrinin results in increased expression of TLR2 mRNA CTD PMID:22771370 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr3 toll-like receptor 3 decreases expression ISO Citrinin results in decreased expression of TLR3 mRNA CTD PMID:22771370 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Citrinin promotes the reaction [CPG-oligonucleotide results in increased expression of TNF mRNA]; Citrinin promotes the reaction [CPG-oligonucleotide results in increased expression of TNF protein]
[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of TNF protein; pyrazolanthrone inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]; U 0126 inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]
CTD PMID:22771370, PMID:29673704 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip1 TNF alpha induced protein 1 increases expression
multiple interactions
ISO Citrinin results in increased expression of TNFAIP1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of TNFAIP1 mRNA
CTD PMID:30428381 NCBI chr10:65,791,002...65,805,693
Ensembl chr10:65,791,003...65,805,693
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression
multiple interactions
ISO Citrinin results in increased expression of TNFRSF12A mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of TNFRSF12A mRNA
CTD PMID:30428381 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of TNFRSF1A mRNA CTD PMID:30428381 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 multiple interactions
increases expression
ISO [ochratoxin A co-treated with Citrinin] results in increased expression of TNFRSF10D mRNA
Citrinin results in increased expression of TNFRSF10D mRNA
CTD PMID:30428381 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tp53 tumor protein p53 increases expression ISO
EXP
Citrinin results in increased expression of TP53 protein
Citrinin results in increased expression of TP53 protein modified form
Citrinin results in increased expression of TRP53 protein
CTD PMID:20929984, PMID:21622943, PMID:22564900 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vim vimentin multiple interactions ISO [ochratoxin A co-treated with Citrinin] results in decreased expression of VIM mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of VIM protein CTD PMID:29673704 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
2,5-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing ISO ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde CTD PMID:11744614 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
andrastin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of CSF2 protein CTD PMID:28535995 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TGFB1 protein CTD PMID:28535995 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO andrastin A results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
brefeldin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Brefeldin A inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:15525798 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
EXP Brefeldin A inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]
Brefeldin A results in decreased phosphorylation of AKT1 protein
CTD PMID:15525798, PMID:24090963 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Brefeldin A results in increased expression of ATF4 protein CTD PMID:24865413, PMID:27358234 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein] CTD PMID:20493918 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Brefeldin A inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO Brefeldin A inhibits the reaction [Copper affects the localization of ATP7B protein] CTD PMID:10982773 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Casp12 caspase 12 increases activity
multiple interactions
ISO Brefeldin A results in increased activity of CASP12 protein
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP12 protein]
CTD PMID:20493918 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp2 caspase 2 multiple interactions ISO Bortezomib promotes the reaction [Brefeldin A results in increased cleavage of and results in increased activity of CASP2 protein]; Brefeldin A promotes the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP2 protein]; Brefeldin A results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:18723477 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Brefeldin A results in increased activity of CASP3 protein
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein]
CTD PMID:20150630, PMID:20493918 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity
multiple interactions
ISO Brefeldin A results in decreased activity of CFTR protein
Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium results in increased activity of CFTR protein mutant form]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat results in increased activity of CFTR protein mutant form]
CTD PMID:15371258, PMID:18230692 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Brefeldin A inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:22167199 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Brefeldin A results in increased expression of DDIT3 mRNA; Brefeldin A results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]
CTD PMID:19428936, PMID:20493918, PMID:20626587, PMID:24865413, PMID:27358234 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Brefeldin A results in increased expression of EIF2AK3 protein CTD PMID:24865413 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation
ISO Apigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein] CTD PMID:20493918 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fhl1 four and a half LIM domains 1 multiple interactions EXP Brefeldin A inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] CTD PMID:17161435 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein] CTD PMID:20493918 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]
Brefeldin A results in increased expression of HSPA5 mRNA; Brefeldin A results in increased expression of HSPA5 protein
bortezomib inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]
CTD PMID:12147617, PMID:18723477, PMID:19428936, PMID:20493918, PMID:20626587, PMID:27358234 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il6 interleukin 6 decreases secretion
multiple interactions
ISO Brefeldin A results in decreased secretion of IL6 protein
Brefeldin A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:11216681, PMID:22102721, PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
EXP Brefeldin A results in decreased phosphorylation of MAPK1 protein
Brefeldin A inhibits the reaction [Levodopa results in increased phosphorylation of MAPK1 protein]
CTD PMID:24090963, PMID:25044243 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
EXP Brefeldin A results in decreased phosphorylation of MAPK3 protein
Brefeldin A inhibits the reaction [Levodopa results in increased phosphorylation of MAPK3 protein]
CTD PMID:24090963, PMID:25044243 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 multiple interactions ISO Brefeldin A affects the reaction [sodium arsenite affects the localization of NFE2L1 protein] CTD PMID:20805060 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Brefeldin A inhibits the reaction [sodium arsenite results in increased activity of NFE2L2 protein] CTD PMID:20805060 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases expression ISO Brefeldin A results in decreased expression of NR1I2 mRNA CTD PMID:25616597 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein] CTD PMID:20493918 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]] CTD PMID:12608646 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]] CTD PMID:12608646 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO Brefeldin A results in decreased secretion of TNF protein CTD PMID:22102721 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO Brefeldin A inhibits the reaction [Bortezomib results in increased localization of TNFRSF10A protein] CTD PMID:17326159 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Brefeldin A affects the reaction [Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein] CTD PMID:17326159 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO Brefeldin A results in increased expression of TP53BP1 protein CTD PMID:27358234 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion
multiple interactions
increases expression
ISO Brefeldin A results in decreased secretion of VEGFA protein
Brefeldin A inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
Brefeldin A results in increased expression of VEGFA mRNA
CTD PMID:12147617, PMID:20850416 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression
increases activity
ISO bortezomib inhibits the reaction [Brefeldin A results in increased activity of XBP1 protein]
Brefeldin A results in increased expression of XBP1 protein
CTD PMID:18723477, PMID:27358234 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
D-gluconic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ALDH1A2 mRNA CTD PMID:16556975 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ARNT2 mRNA CTD PMID:16556975 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ATP6V1F mRNA CTD PMID:16556975 NCBI chr 4:56,744,563...56,747,657
Ensembl chr 4:56,744,561...56,747,656
JBrowse link
G Casp3 caspase 3 multiple interactions ISO gluconic acid promotes the reaction [Zinc Sulfate inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]] CTD PMID:27017951 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [gluconic acid co-treated with Zinc Sulfate] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA] CTD PMID:27017951 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cblb Cbl proto-oncogene B decreases expression EXP gluconic acid results in decreased expression of CBLB mRNA CTD PMID:16556975 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases response to substance ISO CLCN3 protein results in increased susceptibility to gluconic acid CTD PMID:12843258 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP gluconic acid results in increased expression of CRHR1 mRNA CTD PMID:16556975 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CSF1R mRNA CTD PMID:16556975 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CYP4A8 mRNA CTD PMID:16556975 NCBI chr 5:133,978,953...134,008,255
Ensembl chr 5:133,978,954...134,008,255
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases expression EXP gluconic acid results in decreased expression of FYN mRNA CTD PMID:16556975 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:30031400 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of GRK2 mRNA CTD PMID:16556975 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 increases expression EXP gluconic acid results in increased expression of HCN4 mRNA CTD PMID:16556975 NCBI chr 8:63,599,907...63,637,327
Ensembl chr 8:63,600,663...63,639,654
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:30031400 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hoxa1 homeobox A1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of HOXA1 mRNA CTD PMID:16556975 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of KCNC1 mRNA CTD PMID:16556975 NCBI chr 1:102,414,352...102,456,718
Ensembl chr 1:102,414,625...102,456,411
JBrowse link
G Kif3c kinesin family member 3C increases expression EXP gluconic acid results in increased expression of KIF3C mRNA CTD PMID:16556975 NCBI chr 6:27,768,943...27,815,611
Ensembl chr 6:27,768,943...27,815,611
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in decreased expression of LCAT mRNA] CTD PMID:30031400 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of LPL mRNA CTD PMID:16556975 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of MDH1 mRNA CTD PMID:16556975 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Mdh2 malate dehydrogenase 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of MDH2 mRNA CTD PMID:16556975 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO gluconic acid inhibits the reaction [Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT1A mRNA]] CTD PMID:27017951 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO gluconic acid inhibits the reaction [Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT2A mRNA]] CTD PMID:27017951 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of NR1D2 mRNA CTD PMID:16556975 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] affects the reaction [Dietary Fats results in increased expression of NR1H3 mRNA] CTD PMID:30031400 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PAK1 mRNA CTD PMID:16556975 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PGAP2 mRNA CTD PMID:16556975 NCBI chr 1:167,309,021...167,335,550
Ensembl chr 1:167,309,051...167,334,741
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PRKAR1A mRNA CTD PMID:16556975 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PRKCA mRNA CTD PMID:16556975 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptges prostaglandin E synthase multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTGES mRNA CTD PMID:16556975 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTPN2 mRNA CTD PMID:16556975 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RARA mRNA CTD PMID:16556975 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rxrg retinoid X receptor gamma multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RXRG mRNA CTD PMID:16556975 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Sema6c semaphorin 6C multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SEMA6C mRNA CTD PMID:16556975 NCBI chr 2:196,330,777...196,347,218
Ensembl chr 2:196,334,626...196,344,008
JBrowse link
G Sirpa signal-regulatory protein alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SIRPA mRNA CTD PMID:16556975 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SLC15A2 mRNA CTD PMID:16556975 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SLC22A8 mRNA CTD PMID:16556975 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc32a1 solute carrier family 32 member 1 decreases expression EXP gluconic acid results in decreased expression of SLC32A1 mRNA CTD PMID:16556975 NCBI chr 3:155,102,980...155,107,815
Ensembl chr 3:155,103,150...155,107,817
JBrowse link
G Slc6a8 solute carrier family 6 member 8 increases expression EXP gluconic acid results in increased expression of SLC6A8 mRNA CTD PMID:16556975 NCBI chr  X:157,129,987...157,139,321
Ensembl chr  X:157,129,987...157,139,291
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [gluconic acid co-treated with Zinc Sulfate] promotes the reaction [Aflatoxin B1 results in increased expression of SOD1 mRNA] CTD PMID:27017951 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:30031400 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Sstr3 somatostatin receptor 3 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SSTR3 mRNA CTD PMID:16556975 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Tas2r107 taste receptor, type 2, member 107 decreases expression EXP gluconic acid results in decreased expression of TAS2R10 mRNA CTD PMID:16556975 NCBI chr 4:165,773,200...165,774,126
Ensembl chr 4:165,773,200...165,774,126
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of UBE2I mRNA CTD PMID:16556975 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of VAMP2 mRNA CTD PMID:16556975 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link
G Vax2 ventral anterior homeobox 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of VAX2 mRNA CTD PMID:16556975 NCBI chr 4:115,388,839...115,412,515
Ensembl chr 4:115,388,839...115,412,515
JBrowse link
G Vps52 VPS52 subunit of GARP complex increases expression EXP gluconic acid results in increased expression of VPS52 mRNA CTD PMID:16556975 NCBI chr20:5,431,997...5,441,736
Ensembl chr20:5,432,004...5,441,706
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP gluconic acid results in increased expression of WEE1 mRNA CTD PMID:16556975 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
griseofulvin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Griseofulvin results in increased expression of ABCB1A mRNA CTD PMID:8707270 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Griseofulvin results in increased expression of ABCB4 mRNA CTD PMID:8707270 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression ISO Griseofulvin results in decreased expression of ADRB3 mRNA CTD PMID:12735108 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 affects expression
multiple interactions
increases activity
increases expression
ISO Griseofulvin affects the expression of ALAS1 mRNA
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; [Ascorbic Acid co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; Ascorbic Acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]
Griseofulvin results in increased expression of ALAS1 mRNA
CTD PMID:10215191, PMID:12735108, PMID:15793285, PMID:24523661 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Anxa2 annexin A2 increases expression ISO Griseofulvin results in increased expression of ANXA2 mRNA CTD PMID:12735108 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa3 annexin A3 affects expression ISO Griseofulvin affects the expression of ANXA3 mRNA CTD PMID:12735108 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa5 annexin A5 increases expression ISO Griseofulvin results in increased expression of ANXA5 mRNA CTD PMID:12735108 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Anxa6 annexin A6 increases expression ISO Griseofulvin results in increased expression of ANXA6 mRNA CTD PMID:12735108 NCBI chr10:40,320,581...40,375,605
Ensembl chr10:40,320,581...40,375,605
JBrowse link
G Areg amphiregulin increases expression ISO Griseofulvin results in increased expression of AREG protein CTD PMID:19267999 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Btc betacellulin increases expression ISO Griseofulvin results in increased expression of BTC protein CTD PMID:19267999 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO Griseofulvin results in increased activity of CASP3 protein
Griseofulvin results in increased cleavage of CASP3 protein
CTD PMID:23329179, PMID:25412316 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO Griseofulvin results in increased activity of CASP9 protein CTD PMID:23329179 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Griseofulvin affects the expression of CBR1 mRNA CTD PMID:12735108 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cd14 CD14 molecule affects expression ISO Griseofulvin affects the expression of CD14 mRNA CTD PMID:12735108 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd24 CD24 molecule affects expression ISO Griseofulvin affects the expression of CD24A mRNA CTD PMID:12735108 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Griseofulvin results in increased expression of COL1A1 mRNA CTD PMID:12735108 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Griseofulvin results in increased expression of COL3A1 mRNA CTD PMID:12735108 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO Griseofulvin affects the expression of COL4A1 mRNA CTD PMID:12735108 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cstb cystatin B increases expression ISO Griseofulvin results in increased expression of CSTB mRNA CTD PMID:12735108 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression
multiple interactions
ISO Griseofulvin affects the expression of CYP1A2 mRNA
Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]
CTD PMID:9029748, PMID:12735108 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
increases expression
ISO Griseofulvin results in increased activity of CYP2A5 protein
Griseofulvin results in increased expression of CYP2A5 mRNA; Griseofulvin results in increased expression of CYP2A5 protein
CTD PMID:7543189, PMID:9007836, PMID:9698299, PMID:11038160 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO Griseofulvin affects the expression of CYP2B10 mRNA CTD PMID:12735108 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression ISO Griseofulvin affects the expression of CYP2B13 mRNA CTD PMID:12735108 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects expression ISO Griseofulvin affects the expression of CYP2B9 mRNA CTD PMID:12735108 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression ISO Griseofulvin affects the expression of CYP2C29 mRNA CTD PMID:12735108 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Griseofulvin results in decreased expression of CYP7B1 mRNA CTD PMID:12735108 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Eln elastin affects expression ISO Griseofulvin affects the expression of ELN mRNA CTD PMID:12735108 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Ereg epiregulin increases expression ISO Griseofulvin results in increased expression of EREG protein CTD PMID:19267999 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Griseofulvin results in decreased expression of FABP1 mRNA CTD PMID:12735108 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fech ferrochelatase decreases activity
increases expression
multiple interactions
ISO Griseofulvin results in decreased activity of FECH protein
Griseofulvin results in increased expression of FECH mRNA
[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron; heme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]
CTD PMID:10215191, PMID:15078340 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fstl1 follistatin-like 1 affects expression ISO Griseofulvin affects the expression of FSTL1 mRNA CTD PMID:12735108 NCBI chr11:65,791,196...65,845,721
Ensembl chr11:65,782,567...65,845,418
JBrowse link
G G0s2 G0/G1switch 2 decreases expression ISO Griseofulvin results in decreased expression of G0S2 mRNA CTD PMID:12735108 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta affects expression ISO Griseofulvin affects the expression of GADD45B mRNA CTD PMID:12735108 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
ISO Griseofulvin results in increased expression of and results in increased localization of GJA1 protein
Griseofulvin results in increased expression of GJA1 mRNA
CTD PMID:23329179 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects expression ISO Griseofulvin affects the expression of GSTM2 mRNA CTD PMID:12735108 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
ISO Griseofulvin results in increased activity of HMOX1 protein
Griseofulvin results in increased expression of HMOX1 mRNA; Griseofulvin results in increased expression of HMOX1 protein
CTD PMID:10215191, PMID:15793285, PMID:16309571 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ier3 immediate early response 3 affects expression ISO Griseofulvin affects the expression of IER3 mRNA CTD PMID:12735108 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Griseofulvin results in decreased expression of IGF1 mRNA CTD PMID:12735108 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression ISO Griseofulvin results in decreased expression of IGFALS mRNA CTD PMID:12735108 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression ISO Griseofulvin affects the expression of IGFBP2 mRNA CTD PMID:12735108 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] CTD PMID:11367519 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Inhbc inhibin subunit beta C decreases expression ISO Griseofulvin results in decreased expression of INHBC mRNA CTD PMID:12735108 NCBI chr 7:70,648,005...70,661,475
Ensembl chr 7:70,646,519...70,661,891
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 affects expression ISO Griseofulvin affects the expression of IQGAP1 mRNA CTD PMID:12735108 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Itgb2 integrin subunit beta 2 affects expression ISO Griseofulvin affects the expression of ITGB2 mRNA CTD PMID:12735108 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Krt18 keratin 18 multiple interactions
increases expression
decreases response to substance
ISO Griseofulvin promotes the reaction [KRT18 protein binds to KRT18 protein]
Griseofulvin results in increased expression of KRT18 mRNA; Griseofulvin results in increased expression of KRT18 protein
KRT18 protein results in decreased susceptibility to Griseofulvin
CTD PMID:7504119, PMID:8770877, PMID:10952237, PMID:12388748 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 increases expression
increases phosphorylation
ISO Griseofulvin results in increased expression of KRT8 mRNA; Griseofulvin results in increased expression of KRT8 protein
Griseofulvin results in increased phosphorylation of KRT8 protein
CTD PMID:7504119, PMID:10952237, PMID:12735108, PMID:20643122 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lamb1 laminin subunit beta 1 decreases expression ISO Griseofulvin results in decreased expression of LAMB1 protein CTD PMID:1573853 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamb2 laminin subunit beta 2 decreases expression
increases expression
ISO Griseofulvin results in decreased expression of LAMB2 protein
Griseofulvin results in increased expression of LAMB2 mRNA
CTD PMID:1573853 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 affects expression ISO Griseofulvin affects the expression of LILRB4 mRNA CTD PMID:12735108 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579
JBrowse link
G Lpl lipoprotein lipase affects expression ISO Griseofulvin affects the expression of LPL mRNA CTD PMID:12735108 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression ISO Griseofulvin results in increased expression of LY6D mRNA CTD PMID:12735108 NCBI chr 7:115,993,304...115,994,812
Ensembl chr 7:115,993,301...115,994,783
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO Griseofulvin results in increased expression of MAPT mRNA; Griseofulvin results in increased expression of MAPT mRNA alternative form; Griseofulvin results in increased expression of MAPT protein CTD PMID:10051481 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Griseofulvin results in increased expression of MT1 mRNA CTD PMID:12735108 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Npdc1 neural proliferation, differentiation and control, 1 affects expression ISO Griseofulvin affects the expression of NPDC1 mRNA CTD PMID:12735108 NCBI chr 3:2,624,231...2,630,672
Ensembl chr 3:2,625,015...2,630,670
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Griseofulvin results in increased expression of NQO1 mRNA CTD PMID:12735108 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Griseofulvin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 affects expression ISO Griseofulvin affects the expression of PAPSS2 mRNA CTD PMID:12735108 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
JBrowse link
G Pf4 platelet factor 4 affects expression ISO Griseofulvin affects the expression of PF4 mRNA CTD PMID:12735108 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression ISO Griseofulvin affects the expression of POR mRNA CTD PMID:12735108 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Griseofulvin results in decreased expression of PPARA mRNA CTD PMID:9548566 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO Griseofulvin results in increased expression of PPARD mRNA CTD PMID:9548566 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Griseofulvin results in increased expression of PPARG mRNA CTD PMID:9548566 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppl periplakin affects expression ISO Griseofulvin affects the expression of PPL mRNA CTD PMID:12735108 NCBI chr10:10,644,572...10,690,223
Ensembl chr10:10,644,572...10,690,223
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO Griseofulvin results in increased expression of RARA mRNA CTD PMID:9548566 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Griseofulvin results in increased expression of RARB mRNA CTD PMID:9548566 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma increases expression ISO Griseofulvin results in increased expression of RARG mRNA CTD PMID:9548566 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Griseofulvin results in decreased expression of RXRA mRNA CTD PMID:9548566 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrg retinoid X receptor gamma decreases expression ISO Griseofulvin results in decreased expression of RXRG mRNA CTD PMID:9548566 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO Griseofulvin results in increased expression of S100A6 mRNA CTD PMID:12735108 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 affects expression ISO Griseofulvin affects the expression of SCD2 mRNA CTD PMID:12735108 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Sele selectin E multiple interactions ISO Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:11367519 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L decreases expression ISO Griseofulvin results in decreased expression of SELL protein CTD PMID:11367519 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Soat1 sterol O-acyltransferase 1 affects expression ISO Griseofulvin affects the expression of SOAT1 mRNA CTD PMID:12735108 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression ISO Griseofulvin affects the expression of SPP1 mRNA CTD PMID:12735108 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgm2 transglutaminase 2 affects expression ISO Griseofulvin affects the expression of TGM2 mRNA CTD PMID:12735108 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tm4sf4 transmembrane 4 L six family member 4 affects expression ISO Griseofulvin affects the expression of TM4SF4 mRNA CTD PMID:12735108 NCBI chr 2:147,532,032...147,547,254
Ensembl chr 2:147,496,229...147,547,252
JBrowse link
G Tmsb10 thymosin, beta 10 affects expression ISO Griseofulvin affects the expression of TMSB10 mRNA CTD PMID:12735108 NCBI chr 4:100,882,216...100,883,303
Ensembl chr 4:100,882,216...100,883,275
JBrowse link
G Tmsb4x thymosin beta 4, X-linked affects expression ISO Griseofulvin affects the expression of TMSB4X mRNA CTD PMID:12735108 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] CTD PMID:11154858, PMID:11367519 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase affects expression ISO Griseofulvin affects the expression of UGDH mRNA CTD PMID:12735108 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression ISO Griseofulvin affects the expression of UGT1A1 mRNA CTD PMID:12735108 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression
multiple interactions
ISO Griseofulvin affects the expression of VCAM1 mRNA
Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
CTD PMID:11154858, PMID:11367519, PMID:12735108 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vcl vinculin affects localization ISO Griseofulvin affects the localization of VCL protein CTD PMID:25412316 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Wnt3a Wnt family member 3A affects expression ISO Griseofulvin affects the expression of WNT3A mRNA CTD PMID:12735108 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Ybx3 Y box binding protein 3 affects expression ISO Griseofulvin affects the expression of YBX3 mRNA CTD PMID:12735108 NCBI chr 4:165,606,819...165,630,041
Ensembl chr 4:165,606,819...165,630,118
JBrowse link
lovastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression
decreases expression
multiple interactions
ISO Lovastatin results in increased expression of ABCA1 mRNA
lovastatin decreases expression of ABCA1 mRNA in HepG2 cells
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCA1 mRNA
Lovastatin results in decreased expression of ABCA1 mRNA
CTD PMID:19260826, PMID:29852127, PMID:27765770 RGD:18936994 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Lovastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Lovastatin results in decreased activity of ABCB11 protein
CTD PMID:23956101, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
increases transport
ISO Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
Lovastatin analog results in decreased activity of ABCB1 protein
ABCB1 protein results in increased transport of Lovastatin; ABCB1 protein results in increased transport of Lovastatin analog
CTD PMID:15616150 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
ISO Lovastatin results in decreased activity of ABCC1 protein
[Lovastatin results in decreased activity of ABCC1 protein] which results in increased susceptibility to Antimony Sodium Gluconate; Doxorubicin inhibits the reaction [Lovastatin results in increased expression of ABCC1 mRNA]
CTD PMID:18056276, PMID:22712078 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
decreases activity
ISO
EXP
ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Lovastatin results in increased expression of ABCC2 mRNA
Lovastatin analog results in decreased activity of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin promotes the reaction [Cisplatin results in decreased expression of ABCC2 mRNA]
CTD PMID:15616150, PMID:23562342, PMID:26739623 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects expression
multiple interactions
ISO Lovastatin affects the expression of ABCG5 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCG5 mRNA
CTD PMID:27208389, PMID:29852127 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 affects expression ISO Lovastatin affects the expression of ABCG8 mRNA CTD PMID:27208389 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACACA mRNA CTD PMID:29852127 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACOX1 mRNA CTD PMID:29852127 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACSS2 mRNA CTD PMID:29852127 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Lovastatin results in decreased expression of ACTA2 protein
CTD PMID:22129737 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta decreases expression
increases expression
ISO Lovastatin results in decreased expression of ACTB mRNA
Lovastatin results in increased expression of ACTB mRNA
CTD PMID:20493250 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actr3 actin related protein 3 increases expression ISO Lovastatin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression
multiple interactions
EXP
ISO
Lovastatin results in increased expression of ADAM10 protein
[Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein
CTD PMID:29341888 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing affects expression
multiple interactions
ISO Lovastatin affects the expression of ADIPOQ mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ADIPOQ mRNA
CTD PMID:27208389, PMID:29852127 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Lovastatin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akap7 A-kinase anchoring protein 7 decreases response to substance ISO AKAP7 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 1:21,129,213...21,263,850
Ensembl chr 1:21,141,970...21,263,850
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]
Lovastatin results in decreased phosphorylation of AKT1 protein
CTD PMID:16425225, PMID:17472962, PMID:19760159, PMID:20578043 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ank2 ankyrin 2 decreases response to substance ISO ANK2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122
JBrowse link
G Anxa4 annexin A4 decreases expression ISO Lovastatin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Anxa5 annexin A5 decreases expression ISO Lovastatin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [Lovastatin co-treated with Niacin] results in increased expression of APOA1 protein; [Niacin co-treated with Lovastatin] results in increased expression of APOA1 protein CTD PMID:12633795, PMID:17319473 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apob apolipoprotein B multiple interactions
decreases secretion
ISO [Niacin co-treated with Lovastatin] results in decreased expression of APOB protein
Lovastatin results in decreased secretion of APOB protein
CTD PMID:11728391, PMID:12633795 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoe apolipoprotein E affects expression
multiple interactions
ISO Lovastatin affects the expression of APOE mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of APOE mRNA
CTD PMID:27208389, PMID:29852127 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases cleavage
increases secretion
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; TAPI-2 inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; U 0126 inhibits the reaction [Lovastatin results in increased secretion of APP protein]
[APP protein co-treated with Lovastatin] results in increased secretion of APP protein; [Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein; [Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein; [Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein; [Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[APP protein co-treated with Lovastatin] results in increased secretion of APP protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased cleavage of APP protein
Lovastatin results in increased secretion of APP protein; Lovastatin results in increased secretion of APP protein modified form
CTD PMID:19741129, PMID:29341888 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Lovastatin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATM protein modified form] CTD PMID:26739623 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form] CTD PMID:26739623 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bace1 beta-secretase 1 decreases expression
multiple interactions
EXP
ISO
Lovastatin results in decreased expression of BACE1 protein
[Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein
CTD PMID:29341888 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bace2 beta-secretase 2 multiple interactions
increases expression
ISO
EXP
[Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein
Lovastatin results in increased expression of BACE2 protein
CTD PMID:29341888 NCBI chr11:37,798,397...37,880,624
Ensembl chr11:37,798,370...37,880,821
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects localization
ISO
EXP
Lovastatin results in increased expression of BAX protein
Lovastatin promotes the reaction [Cisplatin results in increased expression of BAX mRNA]
Lovastatin affects the localization of BAX protein
CTD PMID:10473109, PMID:15180944, PMID:26739623 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases cleavage
multiple interactions
EXP Lovastatin results in increased cleavage of BCAR1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein]
CTD PMID:16367743 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Lovastatin results in decreased expression of BCL2 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein]
CTD PMID:10473109, PMID:11178870, PMID:12094262 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Lovastatin results in decreased expression of BCL2L1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein]
CTD PMID:11178870 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein] CTD PMID:18766339 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] CTD PMID:24718106 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962, PMID:18815881 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of BRCA2 mRNA] CTD PMID:22712078 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Lovastatin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Calr calreticulin increases expression ISO Lovastatin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Casp2 caspase 2 increases activity
multiple interactions
ISO Lovastatin results in increased activity of CASP2 protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
CTD PMID:12933658, PMID:16234849 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
decreases expression
ISO
EXP
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
Lovastatin analog results in increased cleavage of CASP3 protein
Lovastatin results in increased activity of CASP3 protein
Lovastatin results in decreased expression of CASP3 mRNA
Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
CTD PMID:11720884, PMID:12933658, PMID:15180944, PMID:16367743, PMID:18034278, PMID:18766339, PMID:20493250, PMID:26863638 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases activity ISO Lovastatin results in increased activity of CASP6 protein CTD PMID:11720884 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 increases activity ISO Lovastatin results in increased activity of CASP8 protein CTD PMID:15180944, PMID:15705602 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Lovastatin results in increased activity of CASP9 protein CTD PMID:12933658, PMID:15180944, PMID:15705602 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA] CTD PMID:22712078, PMID:28710503 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO
EXP
Lovastatin results in decreased expression of CCND1 protein
Lovastatin results in increased expression of CCND1 mRNA; Lovastatin results in increased expression of CCND1 protein
CTD PMID:18034278, PMID:20578043 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Lovastatin results in decreased expression of CCND3 protein CTD PMID:10502407 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression ISO Lovastatin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Lovastatin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Lovastatin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO Lovastatin results in decreased expression of CD44 mRNA; Lovastatin results in decreased expression of CD44 protein CTD PMID:21199873 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdc42 cell division cycle 42 increases expression
decreases expression
ISO Lovastatin results in increased expression of CDC42 protein
Lovastatin results in decreased expression of CDC42 mRNA
CTD PMID:18766339, PMID:20493250 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Lovastatin results in decreased activity of CDK2 protein CTD PMID:10502407 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Lovastatin results in decreased expression of CDK4 mRNA; Lovastatin results in decreased expression of CDK4 protein CTD PMID:20578043 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases cleavage EXP Lovastatin results in decreased cleavage of CDK5 protein CTD PMID:19741129 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Lovastatin results in increased expression of CDKN1A protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]
CTD PMID:18034278, PMID:22712078 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP
ISO
Lovastatin results in increased expression of CDKN1B mRNA; Lovastatin results in increased expression of CDKN1B protein CTD PMID:9848777, PMID:10502407, PMID:15118409, PMID:18034278, PMID:20578043 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of CDKN3 protein modified form] CTD PMID:26739623 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cenpf centromere protein F increases expression
multiple interactions
ISO Lovastatin results in increased expression of CENPF protein
Lovastatin promotes the reaction [Paclitaxel results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]
CTD PMID:12467231 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Cfl1 cofilin 1 decreases phosphorylation EXP Lovastatin results in decreased phosphorylation of CFL1 protein CTD PMID:20578043 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO
EXP
Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form]
CTD PMID:17088865, PMID:21356574, PMID:26739623 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form] CTD PMID:26739623 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases expression
ISO
EXP
[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]
Lovastatin results in increased expression of CHRNA7 mRNA; Lovastatin results in increased expression of CHRNA7 protein
U 0126 inhibits the reaction [Lovastatin results in increased expression of CHRNA7 protein]
CTD PMID:29341888 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Lovastatin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression ISO Lovastatin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] CTD PMID:24718106 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases expression ISO Lovastatin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Ctnnb1 catenin beta 1 decreases degradation
increases expression
multiple interactions
EXP
ISO
Lovastatin results in decreased degradation of CTNNB1 protein
Lovastatin results in increased expression of CTNNB1 mRNA
Lovastatin affects the localization of and results in increased expression of CTNNB1 protein
CTD PMID:17234346, PMID:19741129, PMID:24742230 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CYP1A1 mRNA]; Lovastatin results in increased expression of and results in increased activity of CYP1A1 protein
Lovastatin results in increased expression of CYP1A1 mRNA
CTD PMID:1311272, PMID:22712078 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Lovastatin results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO Lovastatin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr 7:70,555,953...70,571,433
Ensembl chr 7:70,556,019...70,572,614
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Lovastatin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588
JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] CTD PMID:24718106 NCBI chr  X:70,596,246...70,648,529
Ensembl chr  X:70,596,576...70,648,532
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Lovastatin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression ISO Lovastatin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 5:117,595,194...117,780,844
Ensembl chr 5:117,596,136...117,780,777
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO Lovastatin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Dstn destrin, actin depolymerizing factor decreases expression ISO Lovastatin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 3:138,024,508...138,051,304
Ensembl chr 3:138,024,508...138,051,298
JBrowse link
G Eaf2 ELL associated factor 2 decreases response to substance ISO EAF2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr11:66,878,658...66,923,092
Ensembl chr11:66,878,658...66,923,092
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Lovastatin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein] CTD PMID:12942316, PMID:19760159 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:12942316, PMID:19760159 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression ISO Lovastatin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 5:147,796,580...147,803,853
Ensembl chr 5:147,796,662...147,803,851
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression
multiple interactions
EXP Lovastatin results in increased expression of ERCC1 mRNA
Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC1 mRNA]
CTD PMID:26739623 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease multiple interactions
increases expression
EXP Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA]
Lovastatin results in increased expression of ERCC5 mRNA
CTD PMID:26739623 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases expression EXP Lovastatin results in increased expression of ERCC6 mRNA CTD PMID:26739623 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO Lovastatin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FADS2 mRNA CTD PMID:29852127 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA] CTD PMID:17088865 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA] CTD PMID:17088865 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase increases expression ISO Lovastatin results in increased expression of FASN mRNA CTD PMID:11728391 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
increases expression
ISO geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]
Lovastatin results in increased expression of FBXO32 mRNA; Lovastatin results in increased expression of FBXO32 protein
CTD PMID:19406843 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases activity ISO Lovastatin results in increased activity of FDFT1 protein CTD PMID:8517861 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FDPS mRNA CTD PMID:29852127 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Flot1 flotillin 1 decreases expression ISO Lovastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr20:3,427,890...3,438,418
Ensembl chr20:3,427,880...3,438,396
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression
EXP
ISO
Lovastatin affects the expression of FOS protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FOS mRNA]
Lovastatin results in decreased expression of FOS
CTD PMID:10412747, PMID:12392621, PMID:22712078 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein] CTD PMID:18434508 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Lovastatin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO Lovastatin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr10:40,812,858...40,846,252
Ensembl chr10:40,812,858...40,846,252
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of G6PD mRNA CTD PMID:29852127 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Lovastatin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
JBrowse link
G Gap43 growth associated protein 43 increases expression ISO Lovastatin results in increased expression of GAP43 protein CTD PMID:20694854 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression ISO Lovastatin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr17:70,299,177...70,325,864
Ensembl chr17:70,299,183...70,325,855
JBrowse link
G Gk glycerol kinase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of GK mRNA CTD PMID:29852127 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Gmps guanine monophosphate synthase increases expression ISO Lovastatin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 2:154,555,967...154,590,662
Ensembl chr 2:154,555,871...154,590,662
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; Lovastatin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:29852127, PMID:30853469 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA] CTD PMID:28710503 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein] CTD PMID:24718106 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
increases phosphorylation
ISO
EXP
Lovastatin results in decreased phosphorylation of GSK3B protein
Lovastatin results in increased phosphorylation of GSK3B protein
CTD PMID:17234346, PMID:19741129 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO
EXP
Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]
CTD PMID:21356574, PMID:22712078, PMID:26739623, PMID:28710503 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Lovastatin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Lovastatin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
affects expression
decreases activity
increases expression
ISO [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate; [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]
[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCR mRNA
Lovastatin affects the expression of HMGCR mRNA
Lovastatin results in increased expression of HMGCR mRNA
CTD PMID:8517861, PMID:8593127, PMID:17208200, PMID:19260826, PMID:19699819, PMID:19856009, PMID:27208389, PMID:29852127 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of HMGCS1 mRNA CTD PMID:29852127 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Lovastatin results in increased expression of HMOX1 protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
CTD PMID:20594940, PMID:21910007, PMID:28710503 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression ISO Lovastatin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr10:34,955,713...34,961,662
Ensembl chr10:34,955,716...34,961,608
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Lovastatin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression ISO Lovastatin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression
ISO Lovastatin results in decreased expression of HNRNPK mRNA
Lovastatin results in increased expression of HNRNPK mRNA
CTD PMID:20493250 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases prenylation
multiple interactions
ISO Lovastatin results in decreased prenylation of HRAS protein
Lovastatin results in decreased prenylation of and results in decreased localization of HRAS protein
CTD PMID:16156861, PMID:19360310 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Lovastatin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Lovastatin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Lovastatin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifng interferon gamma multiple interactions ISO Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO IGF1 protein results in decreased susceptibility to Lovastatin CTD PMID:9525472 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein] CTD PMID:19741129 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein] CTD PMID:18809656, PMID:21430599 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA] CTD PMID:28710503 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]; Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression
multiple interactions
ISO Lovastatin results in increased expression of INSIG1 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG1 mRNA
CTD PMID:19260826, PMID:29852127 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of INSIG2 mRNA CTD PMID:29852127 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Insr insulin receptor multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Ipo5 importin 5 decreases expression ISO Lovastatin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr15:106,243,110...106,293,326
Ensembl chr15:106,257,650...106,292,112
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of IRS1 mRNA CTD PMID:29852127 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of IRS2 mRNA CTD PMID:29852127 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Lovastatin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr16:20,589,497...20,592,333
Ensembl chr16:20,589,481...20,592,449
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Lovastatin results in decreased expression of ITGB1 protein CTD PMID:12405293 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression
EXP
ISO
Lovastatin affects the expression of JUN protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of JUN mRNA]
Lovastatin results in decreased expression of JUN
CTD PMID:10412747, PMID:12392621, PMID:22712078 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO Lovastatin affects the activity of KCNH2 protein CTD PMID:16278312 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases prenylation
increases expression
affects localization
increases activity
ISO Lovastatin results in decreased prenylation of KRAS protein
Lovastatin results in increased expression of KRAS protein
Lovastatin affects the localization of KRAS protein
Lovastatin results in increased activity of KRAS protein
CTD PMID:12106604, PMID:12907238, PMID:16156861, PMID:17005160 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt18 keratin 18 decreases expression ISO Lovastatin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression ISO Lovastatin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA CTD PMID:30853469 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases activity
increases expression
ISO
EXP
OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of LDLR mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]
Lovastatin results in increased activity of LDLR protein
CTD PMID:8593127, PMID:11728391, PMID:12524230, PMID:20578043, PMID:29852127 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 affects localization ISO Lovastatin affects the localization of LEF1 protein CTD PMID:17234346 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Lipc lipase C, hepatic type affects expression ISO Lovastatin affects the expression of LIPC mRNA CTD PMID:27208389 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lmnb1 lamin B1 decreases farnesylation
increases degradation
affects localization
ISO Lovastatin results in decreased farnesylation of LMNB1 protein
Lovastatin results in increased degradation of LMNB1 protein
Lovastatin affects the localization of LMNB1 protein
CTD PMID:10203554, PMID:11720884 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Lpin2 lipin 2 decreases response to substance ISO LPIN2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 9:119,517,101...119,591,533
Ensembl chr 9:119,517,101...119,591,533
JBrowse link
G Lpl lipoprotein lipase affects expression
multiple interactions
ISO Lovastatin affects the expression of LPL mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of LPL mRNA
CTD PMID:27208389, PMID:29852127 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp5 LDL receptor related protein 5 increases expression ISO Lovastatin results in increased expression of LRP5 mRNA CTD PMID:24742230 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK1 protein]
Lovastatin results in decreased activity of MAPK1 protein
[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]
CTD PMID:12213976, PMID:16952276, PMID:19360310, PMID:19760159, PMID:20578043, PMID:24718106, PMID:29341888 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation
ISO
EXP
[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased phosphorylation of MAPK3 protein
Lovastatin results in decreased activity of MAPK3 protein
Lovastatin results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16952276, PMID:18434508, PMID:19360310, PMID:19760159, PMID:20578043, PMID:24718106, PMID:29341888 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK8 protein modified form] CTD PMID:26739623 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK9 protein modified form] CTD PMID:26739623 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mbp myelin basic protein multiple interactions
increases expression
EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA] CTD PMID:20578043 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA] CTD PMID:28710503 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA CTD PMID:30853469 NCBI chr 9:26,795,649...26,795,732
Ensembl chr 9:26,795,649...26,795,732
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA CTD PMID:30853469 NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Lovastatin results in decreased expression of MMP2 protein CTD PMID:19360310 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA] CTD PMID:28710503 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Lovastatin results in decreased expression of MMP9 protein CTD PMID:19360310 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Doxorubicin inhibits the reaction [Lovastatin results in increased expression of NFE2L2 mRNA]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA] CTD PMID:22712078, PMID:28710503 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nmral1 NmrA like redox sensor 1 increases expression ISO Lovastatin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr10:11,045,924...11,055,154
Ensembl chr10:11,046,024...11,055,158
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:18809656 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:28710503 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Lovastatin results in increased expression of NQO1 mRNA CTD PMID:1311272 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases prenylation ISO Lovastatin results in decreased prenylation of NRAS protein CTD PMID:16156861 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Nucb1 nucleobindin 1 increases expression ISO Lovastatin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 1:101,480,160...101,511,029
Ensembl chr 1:101,480,145...101,500,850
JBrowse link
G Oat ornithine aminotransferase decreases expression ISO Lovastatin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Osm oncostatin M multiple interactions ISO OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA] CTD PMID:12524230 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression ISO Lovastatin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Lovastatin analog results in increased cleavage of PARP1 protein CTD PMID:26863638 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parvb parvin, beta decreases response to substance ISO PARVB SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 7:125,189,827...125,275,977
Ensembl chr 7:125,189,827...125,277,689
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of PCK1 mRNA CTD PMID:29852127 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression EXP Lovastatin results in decreased expression of PDGFRA mRNA CTD PMID:20578043 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression
increases expression
ISO Lovastatin results in decreased expression of PDIA3 mRNA
Lovastatin results in increased expression of PDIA3 mRNA
CTD PMID:20493250 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO Lovastatin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression
ISO Lovastatin results in decreased expression of PGAM1 mRNA
Lovastatin results in increased expression of PGAM1 mRNA
CTD PMID:20493250 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Lovastatin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression EXP Lovastatin results in increased expression of PLA2G4A mRNA CTD PMID:20578043 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions
increases secretion
increases expression
EXP
ISO
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]
Lovastatin results in increased secretion of PLAT protein
CTD PMID:10412747, PMID:12405293 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plau plasminogen activator, urokinase decreases secretion ISO Lovastatin results in decreased secretion of PLAU protein CTD PMID:12405293 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis
increases metabolic processing
multiple interactions
ISO PON3 protein results in increased hydrolysis of Lovastatin
PON3 protein results in increased metabolism of Lovastatin
7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]; Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]
CTD PMID:12615656, PMID:15772423 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
affects localization
increases expression
ISO
EXP
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; Lovastatin results in increased expression of and affects the localization of PPARG protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of PPARG mRNA; PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]
CTD PMID:16425225, PMID:20578043, PMID:26863638, PMID:29852127 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA] CTD PMID:28710503 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Lovastatin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Lovastatin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases cleavage
EXP benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein] CTD PMID:16367743 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression ISO Lovastatin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr 6:93,423,029...93,444,223
Ensembl chr 6:93,423,002...93,444,240
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 decreases expression ISO Lovastatin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr 6:76,174,460...76,205,429
Ensembl chr 6:76,174,452...76,205,426
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO Lovastatin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 4:9,867,132...9,881,383
Ensembl chr 4:9,867,101...9,881,484
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO
EXP
Cycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; Lovastatin results in increased expression of and results in increased phosphorylation of PTEN protein; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]
CTD PMID:16425225, PMID:20578043 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
increases expression
multiple interactions
ISO
EXP
Lovastatin results in decreased expression of PTGS2 protein
Lovastatin analog results in increased expression of PTGS2 mRNA; Lovastatin analog results in increased expression of PTGS2 protein
Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]
Lovastatin results in increased expression of PTGS2 mRNA; Lovastatin results in increased expression of PTGS2 protein
CTD PMID:20578043, PMID:21910007, PMID:26863638 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression ISO Lovastatin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr14:104,475,082...104,500,176
Ensembl chr14:104,475,082...104,501,020
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
affects localization
decreases activity
increases expression
ISO geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Lovastatin results in decreased activity of RAC1 protein
Lovastatin results in increased expression of RAC1 protein
CTD PMID:12933658, PMID:18766339, PMID:19360310, PMID:21356574 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
decreases activity
ISO Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein]
Lovastatin results in decreased activity of RAF1 protein
CTD PMID:19360310, PMID:19760159 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family increases expression ISO Lovastatin results in increased expression of RAP1A protein CTD PMID:12467231 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP
ISO
Lovastatin results in decreased phosphorylation of RB1 protein CTD PMID:9848777, PMID:10502407, PMID:15118409 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rhoa ras homolog family member A multiple interactions
decreases expression
decreases prenylation
affects localization
ISO
EXP
geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Lovastatin results in decreased geranoylation of and affects the localization of RHOA protein
Lovastatin results in decreased expression of RHOA mRNA
Lovastatin results in decreased prenylation of RHOA protein
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]
CTD PMID:9398081, PMID:11178870, PMID:12405293, PMID:12933658, PMID:16156861, PMID:20493250, PMID:20578043 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B decreases prenylation
multiple interactions
increases expression
ISO Lovastatin results in decreased prenylation of RHOB protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
Lovastatin results in increased expression of RHOB protein
CTD PMID:12467231, PMID:16156861, PMID:16234849 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rpl27 ribosomal protein L27 increases expression ISO Lovastatin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr10:89,352,864...89,356,563
Ensembl chr10:89,352,835...89,356,547
JBrowse link
G Rpl9 ribosomal protein L9 increases expression ISO Lovastatin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr14:44,524,419...44,527,613
Ensembl chr14:44,524,416...44,527,613
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Lovastatin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Lovastatin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO Lovastatin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 1:101,413,766...101,426,970
Ensembl chr 1:101,413,766...101,426,852
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA CTD PMID:30853469 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA CTD PMID:30853469 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Lovastatin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 1:78,277,524...78,333,281
Ensembl chr 1:78,277,515...78,333,321
JBrowse link
G Scap SREBF chaperone multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SCAP mRNA CTD PMID:29852127 NCBI chr 8:118,551,869...118,628,650
Ensembl chr 8:118,570,503...118,628,651
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
affects expression
ISO [Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
Lovastatin affects the expression of SCARB1 mRNA
CTD PMID:20404351, PMID:27208389 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SCD1 mRNA CTD PMID:29852127 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression ISO Lovastatin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr17:77,312,562...77,340,934
Ensembl chr17:77,312,562...77,340,934
JBrowse link
G Slc31a1 solute carrier family 31 member 1 increases expression EXP Lovastatin results in increased expression of SLC31A1 mRNA CTD PMID:26739623 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Sox10 SRY-box transcription factor 10 multiple interactions
increases expression
EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA] CTD PMID:20578043 NCBI chr 7:120,393,238...120,403,523
Ensembl chr 7:120,393,254...120,403,523
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SREBF1 mRNA CTD PMID:29852127 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases localization
multiple interactions
ISO
EXP
Lovastatin results in increased localization of SREBF2 protein
[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF2 mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]
CTD PMID:11728391, PMID:20578043, PMID:29852127 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Steap2 STEAP2 metalloreductase decreases response to substance ISO STEAP2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 4:25,506,604...25,527,088
Ensembl chr 4:25,507,463...25,527,087
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Lovastatin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] CTD PMID:24718106 NCBI chr20:5,535,434...5,564,657
Ensembl chr20:5,535,432...5,564,437
JBrowse link
G Tcp1 t-complex 1 increases expression ISO Lovastatin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tg thyroglobulin increases secretion ISO Lovastatin results in increased secretion of TG protein CTD PMID:12843138 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO Lovastatin results in increased expression of TH protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]
CTD PMID:20694854 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression ISO Lovastatin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr 7:11,501,145...11,513,576
Ensembl chr 7:11,501,146...11,513,581
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein] CTD PMID:18809656, PMID:21430599, PMID:22712078 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Lovastatin results in increased expression of TNFRSF11B mRNA CTD PMID:24742230 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Lovastatin results in increased susceptibility to TNFSF10 protein CTD PMID:17928957 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Lovastatin results in decreased expression of TNFSF11 mRNA CTD PMID:24742230 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Lovastatin results in increased expression of and results in increased phosphorylation of TP53 protein
Lovastatin inhibits the reaction [Cisplatin results in increased expression of TP53 protein modified form]
Lovastatin results in increased expression of TP53 mRNA
CTD PMID:17088865, PMID:21199873, PMID:26739623 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FSN mRNA CTD PMID:29852127 NCBI chr 6:10,912,383...11,014,279
Ensembl chr 6:10,912,383...11,014,278
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Lovastatin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Tuba1b tubulin, alpha 1B increases expression
decreases expression
ISO Lovastatin results in increased expression of TUBA1B mRNA
Lovastatin results in decreased expression of TUBA1B mRNA
CTD PMID:20493250 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Lovastatin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression ISO Lovastatin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression ISO Lovastatin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 1:72,312,260...72,329,828
Ensembl chr 1:72,312,727...72,329,856
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of UCP2 mRNA CTD PMID:29852127 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases expression ISO Lovastatin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 4:157,332,735...157,347,803
Ensembl chr 4:157,332,740...157,347,803
JBrowse link
G Vcp valosin-containing protein decreases expression
increases expression
ISO Lovastatin results in decreased expression of VCP mRNA
Lovastatin results in increased expression of VCP mRNA
CTD PMID:20493250 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions
increases expression
ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of WEE1 mRNA]
Lovastatin results in increased expression of WEE1 mRNA
CTD PMID:22712078 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP Lovastatin results in increased expression of XIAP mRNA CTD PMID:26739623 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression EXP Lovastatin results in increased expression of XPA mRNA CTD PMID:26739623 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression ISO Lovastatin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link
mevastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 affects expression
decreases expression
multiple interactions
EXP
ISO
mevastatin affects the expression of ABCA1 mRNA
Mevastatin (compactin) decreases expression of abca1 mRNA in rat peripheral fibroblasts
Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]]
CTD PMID:16415093, PMID:17526932, PMID:17526932 RGD:2308820 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO mevastatin inhibits the reaction [BDNF protein results in decreased activity of HU 211] CTD PMID:20554863 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO mevastatin results in increased expression of BMP2 mRNA; mevastatin results in increased expression of BMP2 protein CTD PMID:10814523 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA] CTD PMID:16330322 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO mevastatin results in increased phosphorylation of EIF2AK3 protein CTD PMID:16330322 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA] CTD PMID:16330322 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 multiple interactions
increases expression
ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA] CTD PMID:16330322 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifng interferon gamma multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression
multiple interactions
ISO mevastatin results in increased expression of MSMO1 mRNA
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA]
CTD PMID:16330322 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278, PMID:17041008 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein] CTD PMID:16734383 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rhoa ras homolog family member A decreases lipidation
multiple interactions
ISO mevastatin results in decreased lipidation of RHOA protein
Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]
CTD PMID:17322126 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Sele selectin E multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases cleavage
multiple interactions
EXP
ISO
mevastatin results in decreased expression of SREBF1 protein
mevastatin results in increased cleavage of SREBF1 protein
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]
CTD PMID:16330322, PMID:17526932 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
increases cleavage
EXP
ISO
mevastatin results in increased expression of SREBF2 protein
mevastatin results in increased cleavage of SREBF2 protein
CTD PMID:16330322, PMID:17526932 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Tunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein] CTD PMID:16330322 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
mycophenolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO Mycophenolic Acid results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
JBrowse link
G Adm adrenomedullin multiple interactions EXP Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15063164 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Agt angiotensinogen decreases expression EXP Mycophenolic Acid results in decreased expression of AGT protein alternative form CTD PMID:15213268 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression
multiple interactions
EXP Mycophenolic Acid results in decreased expression of AIF1 mRNA
[Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA
CTD PMID:10688038 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Mycophenolic Acid results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO Mycophenolic Acid results in increased expression of AKT1 protein CTD PMID:21396949 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Mycophenolic Acid binds to ALB protein CTD PMID:26892221 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein] CTD PMID:20302854 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Mycophenolic Acid results in increased expression of BAK1 protein CTD PMID:16505121 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein CTD PMID:21396949 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein; Mycophenolic Acid inhibits the reaction [BCL2 protein results in decreased susceptibility to Dexamethasone] CTD PMID:16505121, PMID:21396949 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp1 caspase 1 increases expression ISO Mycophenolic Acid results in increased expression of CASP1 mRNA CTD PMID:19818335 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Mycophenolic Acid results in increased activity of CASP3 protein
[Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein
CTD PMID:16059982, PMID:16505121, PMID:21396949 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO Mycophenolic Acid results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] CTD PMID:17624267 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CCL20 mRNA
Mycophenolic Acid results in increased expression of CCL20 mRNA
CTD PMID:19818335 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Mycophenolic Acid results in increased expression of CCL22 mRNA CTD PMID:19818335 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 increases expression ISO Mycophenolic Acid results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr12:2,429,492...2,438,928
Ensembl chr12:2,429,509...2,438,817
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
EXP [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of CCL5 mRNA
Mycophenolic Acid results in decreased expression of CCL5 mRNA
CTD PMID:10688038 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression
decreases expression
ISO Mycophenolic Acid results in increased expression of CCL6 mRNA
Mycophenolic Acid results in decreased expression of CCL6 mRNA
CTD PMID:19818335 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO Mycophenolic Acid results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 increases expression ISO Mycophenolic Acid results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr10:89,086,556...89,088,993
Ensembl chr10:89,086,556...89,088,993
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CCR2 mRNA CTD PMID:19818335
G Ccr3 C-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression ISO Mycophenolic Acid results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ccr9 C-C motif chemokine receptor 9 increases expression ISO Mycophenolic Acid results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 8:132,827,325...132,842,130
Ensembl chr 8:132,828,091...132,842,130
JBrowse link
G Cd40lg CD40 ligand increases expression ISO Mycophenolic Acid results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] CTD PMID:12193749 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein] CTD PMID:20302854 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO Mycophenolic Acid results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO Mycophenolic Acid results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCL2 protein CTD PMID:19818335 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
increases expression
ISO Mycophenolic Acid results in decreased expression of CXCL1 mRNA
Mycophenolic Acid results in increased expression of CXCL1 mRNA
CTD PMID:19818335 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO Mycophenolic Acid results in increased expression of CXCR2 mRNA CTD PMID:19818335 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Mycophenolic Acid results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 increases expression ISO Mycophenolic Acid results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr 8:48,835,688...48,852,032
Ensembl chr 8:48,836,957...48,850,671
JBrowse link
G Cycs cytochrome c, somatic increases secretion ISO Mycophenolic Acid results in increased secretion of CYCS protein CTD PMID:16505121 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Mycophenolic Acid results in increased expression of CYP1A1 mRNA
Mycophenolic Acid affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]; Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:25929522 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Mycophenolic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CTD PMID:25929522 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases methylation ISO CYP2C8 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases methylation ISO CYP3A5 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Des desmin multiple interactions EXP Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Mycophenolic Acid results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein] CTD PMID:20302854 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Mycophenolic Acid results in decreased expression of HSPA5 mRNA CTD PMID:24356939 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
EXP
ISO
Mycophenolic Acid results in decreased expression of IFNG mRNA
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD PMID:11562063, PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 decreases expression EXP Mycophenolic Acid results in decreased expression of IL10 mRNA CTD PMID:11562063 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
JBrowse link
G Il11 interleukin 11 increases expression ISO Mycophenolic Acid results in increased expression of IL11 mRNA CTD PMID:19818335 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 decreases expression EXP Mycophenolic Acid results in decreased expression of IL12RB2 mRNA CTD PMID:11562063 NCBI chr 4:98,049,195...98,141,562
Ensembl chr 4:98,052,842...98,141,482
JBrowse link
G Il13 interleukin 13 increases expression ISO Mycophenolic Acid results in increased expression of IL13 mRNA CTD PMID:19818335 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 increases expression ISO Mycophenolic Acid results in increased expression of IL15 mRNA CTD PMID:19818335 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il16 interleukin 16 increases expression ISO Mycophenolic Acid results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il18 interleukin 18 decreases expression ISO Mycophenolic Acid results in decreased expression of IL18 mRNA CTD PMID:19818335 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO Mycophenolic Acid results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO Mycophenolic Acid results in increased expression of IL1R2 mRNA CTD PMID:19818335 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO
EXP
[Mycophenolic Acid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]
Mycophenolic Acid results in decreased expression of IL2 mRNA
CTD PMID:11562063, PMID:12193749, PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO Mycophenolic Acid results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO Mycophenolic Acid results in increased expression of IL2RG mRNA CTD PMID:19818335 NCBI chr  X:71,165,378...71,169,078
Ensembl chr  X:71,162,585...71,169,865
JBrowse link
G Il3 interleukin 3 increases expression ISO Mycophenolic Acid results in increased expression of IL3 mRNA CTD PMID:19818335 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 decreases expression EXP Mycophenolic Acid results in decreased expression of IL4 mRNA CTD PMID:11562063 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha increases expression ISO Mycophenolic Acid results in increased expression of IL5RA mRNA CTD PMID:19818335 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117
JBrowse link
G Il6 interleukin 6 increases expression ISO Mycophenolic Acid results in increased expression of IL6 protein CTD PMID:11981085 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Mycophenolic Acid results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Il6st interleukin 6 signal transducer increases expression ISO Mycophenolic Acid results in increased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 increases expression EXP Mycophenolic Acid results in increased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Mycophenolic Acid results in increased expression of ITGAM mRNA CTD PMID:19818335 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Klrk1 killer cell lectin like receptor K1 decreases expression ISO Mycophenolic Acid results in decreased expression of KLRK1 CTD PMID:20736080 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link
G Krcc1 lysine-rich coiled-coil 1 decreases expression ISO Mycophenolic Acid results in decreased expression of KRCC1 mRNA CTD PMID:24356939 NCBI chr 4:99,133,735...99,148,236
Ensembl chr 4:99,133,842...99,146,827
JBrowse link
G LOC103694381 lymphotoxin-beta increases expression ISO Mycophenolic Acid results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
JBrowse link
G Lrrc37a leucine rich repeat containing 37A decreases expression ISO Mycophenolic Acid results in decreased expression of LRRC37A3 mRNA CTD PMID:24356939 NCBI chr10:91,548,704...91,581,537
Ensembl chr10:91,544,417...91,581,232
JBrowse link
G Lta lymphotoxin alpha increases expression ISO Mycophenolic Acid results in increased expression of LTA mRNA CTD PMID:19818335 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein CTD PMID:15604220 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
Mycophenolic Acid results in decreased expression of MAPK1 protein modified form
CTD PMID:20302854 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases expression
ISO Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
Mycophenolic Acid results in decreased expression of MAPK3 protein modified form
CTD PMID:20302854 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
decreases expression
ISO
EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
Mycophenolic Acid results in decreased expression of MAPK8 protein modified form
CTD PMID:20302854 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases expression
ISO
EXP
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]
Mycophenolic Acid results in decreased expression of MAPK9 protein modified form
CTD PMID:20302854 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Mycophenolic Acid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO Mycophenolic Acid results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 increases expression ISO Mycophenolic Acid results in increased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr 1:282,134,676...282,140,370
Ensembl chr 1:282,134,981...282,135,772
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 decreases expression ISO Mycophenolic Acid results in decreased expression of NCR1 CTD PMID:20736080 NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
JBrowse link
G Ncr2 natural cytotoxicity triggering receptor 2 decreases expression ISO Mycophenolic Acid results in decreased expression of NCR2 CTD PMID:20736080 NCBI chr 9:14,779,496...14,787,872 JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 decreases expression ISO Mycophenolic Acid results in decreased expression of NCR3 CTD PMID:20736080 NCBI chr20:5,170,169...5,175,773
Ensembl chr20:5,170,215...5,175,773
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein] CTD PMID:17624267 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Mycophenolic Acid results in increased activity of NR1I2 protein
[Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Mycophenolic Acid results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Prkca protein kinase C, alpha increases expression ISO Mycophenolic Acid results in increased expression of PRKCA protein CTD PMID:21396949 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Mycophenolic Acid inhibits the reaction [RAC1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:17950325 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
EXP
ISO
Mycophenolic Acid results in decreased expression of RELA protein modified form
Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
CTD PMID:20302854 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Mycophenolic Acid results in increased expression of RGS2 mRNA CTD PMID:24356939 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein CTD PMID:15604220 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mycophenolic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Mycophenolic Acid results in decreased expression of SLC7A11 mRNA CTD PMID:24356939 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mycophenolic Acid results in increased expression of SPP1 mRNA CTD PMID:19818335 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of STAT5A protein CTD PMID:15604220 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Mycophenolic Acid results in decreased expression of TGFB1 mRNA CTD PMID:11562063 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Mycophenolic Acid binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
increases expression
EXP
ISO
Mycophenolic Acid results in decreased expression of TNF mRNA
Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Mycophenolic Acid inhibits the reaction [Mercuric Chloride results in increased secretion of TNF protein]
Mycophenolic Acid results in increased expression of TNF mRNA; Mycophenolic Acid results in increased expression of TNF protein
CTD PMID:11562063, PMID:11912253, PMID:19818335 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Mycophenolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:19818335 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tspoap1 TSPO associated protein 1 decreases expression ISO Mycophenolic Acid results in decreased expression of TSPOAP1 mRNA CTD PMID:24356939 NCBI chr10:75,053,956...75,079,615
Ensembl chr10:75,055,020...75,076,434
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions
affects metabolic processing
ISO UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid
4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]; [4-cresol inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide]] which results in increased abundance of Mycophenolic Acid; [UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid] which results in increased abundance of mycophenolic acid glucuronide
UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid
CTD PMID:18498916, PMID:18816295, PMID:31742356 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression
decreases expression
EXP
ISO
ochratoxin A results in increased expression of A2M mRNA
ochratoxin A results in decreased expression of A2M mRNA
CTD PMID:12700408, PMID:30008028 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Aadac arylacetamide deacetylase affects expression EXP ochratoxin A affects the expression of AADAC mRNA CTD PMID:17483316 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO ochratoxin A results in decreased expression of AARS1 mRNA CTD PMID:30559759 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP ochratoxin A results in decreased expression of ABAT mRNA CTD PMID:18417182 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 affects transport
multiple interactions
ISO ABCA8 protein affects the transport of ochratoxin A
ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:12379217 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP ochratoxin A results in decreased expression of ABCB11 mRNA CTD PMID:12700408 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression EXP ochratoxin A results in decreased expression of ABCB1A mRNA CTD PMID:18417182 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP ochratoxin A results in increased expression of ABCB1B mRNA CTD PMID:16251485 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression ISO ochratoxin A results in decreased expression of ABCB6 mRNA CTD PMID:19287073 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
affects transport
decreases expression
affects export
ISO
EXP
biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]; chrysin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]; Genistein inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]; Polyphenols inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]; Polyphenols metabolite inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]; Quercetin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]; resveratrol inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]
ochratoxin A results in increased expression of ABCC2 mRNA
ABCC2 protein affects the transport of ochratoxin A
ochratoxin A results in decreased expression of ABCC2 mRNA
CTD PMID:15955639, PMID:16251485, PMID:19505989, PMID:23358140, PMID:26505656, PMID:28532671, PMID:29126803 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO ochratoxin A metabolite results in decreased expression of ABCG1 mRNA; ochratoxin A results in decreased expression of ABCG1 mRNA CTD PMID:24356939 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects response to substance
increases transport
increases expression
decreases expression
decreases response to substance
affects transport
decreases transport
ISO
EXP
ABCG2 protein affects the susceptibility to ochratoxin A
ABCG2 protein results in increased transport of ochratoxin A
ochratoxin A results in increased expression of ABCG2 mRNA
ochratoxin A results in decreased expression of ABCG2 mRNA
ABCG2 protein results in decreased susceptibility to ochratoxin A
ABCG2 protein affects the transport of ochratoxin A
ABCG2 protein results in decreased transport of ochratoxin A
CTD PMID:28532671, PMID:29126803, PMID:32470353 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd14a abhydrolase domain containing 14A increases expression EXP ochratoxin A results in increased expression of ABHD14A mRNA CTD PMID:22124623 NCBI chr 8:115,141,575...115,151,222
Ensembl chr 8:115,141,539...115,149,527
JBrowse link
G Abi3 ABI family, member 3 decreases expression ISO ochratoxin A metabolite results in decreased expression of ABI3 mRNA; ochratoxin A results in decreased expression of ABI3 mRNA CTD PMID:26314263 NCBI chr10:83,644,086...83,655,182
Ensembl chr10:83,644,086...83,655,182
JBrowse link
G Abraxas1 abraxas 1, BRCA1 A complex subunit decreases expression EXP ochratoxin A results in decreased expression of ABRAXAS1 mRNA CTD PMID:23358140 NCBI chr14:10,424,674...10,439,010
Ensembl chr14:10,424,674...10,439,003
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A decreases expression ISO
EXP
ochratoxin A results in decreased expression of ACAA1 mRNA
ochratoxin A results in decreased expression of ACAA1A mRNA
CTD PMID:12700408, PMID:19287073 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP ochratoxin A results in increased expression of ACSL1 mRNA CTD PMID:16251485 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases