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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.10 (IkappaB kinase) inhibitor
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Accession:CHEBI:77113 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of IkappaB kinase (EC 2.7.11.10).
Synonyms:related_synonym: ATP:[IkappaB protein] phosphotransferase;   ATP:[IkappaB protein] phosphotransferase inhibitor;   CHUK inhibitor;   CHUK inhibitors;   EC 2.7.11.10 (IkappaB kinase) inhibitors;   EC 2.7.11.10 inhibitor;   EC 2.7.11.10 inhibitors;   IKBKA inhibitor;   IKBKA inhibitors;   IKBKB inhibitor;   IKBKB inhibitors;   IKK inhibitor;   IKK inhibitors;   IKK-1 inhibitor;   IKK-1 inhibitors;   IKK-2 inhibitor;   IKK-2 inhibitors;   IkappaB kinase inhibitor;   IkappaB kinase inhibitors;   STK12 inhibitor;   STK12 inhibitors;   TANK-binding kinase 1 inhibitor;   TANK-binding kinase 1 inhibitors;   TBK1 inhibitor;   TBK1 inhibitors
 xref: Wikipedia:IkappaB_kinase


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berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression EXP berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 increases expression ISO Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,347...75,787,575
JBrowse link
G ACAN aggrecan decreases expression EXP Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA] CTD PMID:29170048 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACTA2 actin alpha 2, smooth muscle decreases expression ISO Berberine results in decreased expression of ACTA2 protein CTD PMID:17973934 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AHR aryl hydrocarbon receptor increases activity ISO
EXP
Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein
CTD PMID:23954465, PMID:30138605 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AKT2 AKT serine/threonine kinase 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr19:40,230,317...40,285,531
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ALB albumin multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AURKB aurora kinase B decreases expression EXP Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G AURKC aurora kinase C increases expression EXP Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr19:57,230,317...57,235,550
Ensembl chr19:57,230,802...57,235,548
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Niacinamide] results in increased expression of BAX protein; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]
CTD PMID:16505103, PMID:20656010, PMID:25600690, PMID:26712469, PMID:30138605 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression
multiple interactions
EXP Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA
CTD PMID:26712469 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
CTD PMID:16505103, PMID:20656010, PMID:23954465, PMID:24751971, PMID:25600690, PMID:26712469, PMID:30138605 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions
increases expression
EXP [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA
CTD PMID:26712469 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression
multiple interactions
EXP Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]
CTD PMID:26478571 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 affects binding EXP Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
EXP
ISO
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA
CTD PMID:16505103, PMID:20656010, PMID:25600690, PMID:26712469, PMID:30138605 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases cleavage
multiple interactions
EXP
ISO
Berberine results in increased cleavage of CASP9 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein
CTD PMID:16505103, PMID:26712469, PMID:30138605 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein] CTD PMID:20828602, PMID:24751971, PMID:25600690, PMID:30138605 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] CTD PMID:16391493 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 decreases expression EXP Berberine results in decreased expression of CCND1 protein CTD PMID:16505103 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 decreases expression EXP Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNT1 cyclin T1 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr12:48,688,458...48,716,707
Ensembl chr12:48,688,458...48,716,998
JBrowse link
G CD36 CD36 molecule multiple interactions
increases expression
EXP
ISO
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein
CTD PMID:28038998, PMID:29408570 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CDH2 cadherin 2 decreases expression EXP Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP Berberine results in decreased expression of CDK4 protein CTD PMID:16505103 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDK9 cyclin dependent kinase 9 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 9:127,786,034...127,790,792
Ensembl chr 9:127,785,679...127,790,792
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Berberine results in increased expression of CDKN1A protein CTD PMID:16505103, PMID:23747414 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C increases expression EXP Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775
Ensembl chr11:2,883,213...2,885,775
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA
CTD PMID:20564506, PMID:26478571 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases expression
affects phosphorylation
multiple interactions
EXP
ISO
Berberine results in increased expression of CEBPB mRNA
Berberine affects the phosphorylation of CEBPB protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
CTD PMID:28038998 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CHEK1 checkpoint kinase 1 increases expression EXP Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr11:125,624,910...125,676,256
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 increases expression EXP Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G COL10A1 collagen type X alpha 1 chain increases expression EXP Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr 6:116,118,909...116,219,937
Ensembl chr 6:116,118,909...116,158,747
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression EXP Berberine results in increased expression of COL1A1 mRNA CTD PMID:26478571 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression EXP Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREBBP CREB binding protein increases expression EXP Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr16:3,725,054...3,880,727
Ensembl chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CTNNB1 catenin beta 1 increases expression
multiple interactions
EXP Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]
CTD PMID:26478571 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:16391493, PMID:28916288 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic affects localization EXP Berberine affects the localization of CYCS protein CTD PMID:16505103 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:16046213, PMID:22342832, PMID:24583342 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA
CTD PMID:22342832 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
CTD PMID:22342832, PMID:25455889 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
decreases expression
EXP
ISO
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP3A11 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP3A11 mRNA]
Berberine results in decreased expression of CYP3A11 mRNA
CTD PMID:21524698, PMID:22342832 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions EXP DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression EXP Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G DZIP3 DAZ interacting zinc finger protein 3 increases expression EXP Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr 3:108,589,490...108,694,840
Ensembl chr 3:108,589,705...108,694,840
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G EP300 E1A binding protein p300 increases expression EXP Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESRRA estrogen related receptor alpha multiple interactions EXP Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743
Ensembl chr11:64,305,497...64,316,743
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of FABP4 mRNA
Berberine results in increased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]
CTD PMID:26478571, PMID:29408570 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases expression
ISO
EXP
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein
CTD PMID:20564506, PMID:20656010 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand increases expression EXP Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA] CTD PMID:30138605 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOXO1 forkhead box O1 multiple interactions EXP [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G GDF5 growth differentiation factor 5 decreases expression EXP Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr20:35,433,347...35,454,749
Ensembl chr20:35,433,347...35,454,746
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]
CTD PMID:24751971, PMID:25455889, PMID:30138605 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO
EXP
Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]
CTD PMID:20462044, PMID:23954465 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971, PMID:25600690 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G H2AC11 H2A clustered histone 11 decreases expression EXP Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr 6:27,133,043...27,133,535
Ensembl chr 6:27,133,042...27,135,291
JBrowse link
G H2AC12 H2A clustered histone 12 decreases expression EXP Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr 6:27,147,106...27,147,562
Ensembl chr 6:27,147,129...27,147,515
Ensembl chr 6:27,147,129...27,147,515
JBrowse link
G H2AC14 H2A clustered histone 14 decreases expression EXP Berberine results in decreased expression of H2AC14 mRNA CTD PMID:27311644 NCBI chr 6:27,814,302...27,814,777
Ensembl chr 6:27,814,354...27,814,740
Ensembl chr 6:27,814,354...27,814,740
JBrowse link
G H2AC15 H2A clustered histone 15 decreases expression EXP Berberine results in decreased expression of H2AC15 mRNA CTD PMID:27311644 NCBI chr 6:27,837,880...27,838,375
Ensembl chr 6:27,837,947...27,838,339
Ensembl chr 6:27,837,947...27,838,339
JBrowse link
G H2AC17 H2A clustered histone 17 decreases expression EXP Berberine results in decreased expression of H2AC17 mRNA CTD PMID:27311644 NCBI chr 6:27,892,699...27,893,185
Ensembl chr 6:27,892,757...27,893,149
Ensembl chr 6:27,892,757...27,893,149
JBrowse link
G H2AC18 H2A clustered histone 18 decreases expression EXP Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 1:149,842,218...149,842,750
Ensembl chr 1:149,842,188...149,842,736
JBrowse link
G H2AC4 H2A clustered histone 4 decreases expression EXP Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr 6:26,033,092...26,033,618
Ensembl chr 6:26,033,176...26,033,568
Ensembl chr 6:26,033,176...26,033,568
JBrowse link
G H2AC6 H2A clustered histone 6 decreases expression EXP Berberine results in decreased expression of H2AC6 mRNA CTD PMID:27311644 NCBI chr 6:26,124,172...26,124,690
Ensembl chr 6:26,124,145...26,139,116
JBrowse link
G H2AC8 H2A clustered histone 8 decreases expression EXP Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr 6:26,216,921...26,217,483
Ensembl chr 6:26,216,975...26,217,483
JBrowse link
G H2AW H2A.W histone decreases expression EXP Berberine results in decreased expression of H2AW mRNA CTD PMID:27311644 NCBI chr 1:228,457,364...228,457,873
Ensembl chr 1:228,456,979...228,457,873
JBrowse link
G H2AX H2A.X variant histone increases expression
decreases expression
multiple interactions
EXP Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
CTD PMID:23363784, PMID:23747414, PMID:27311644 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G H2BC11 H2B clustered histone 11 decreases expression EXP Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,125,897...27,132,750
Ensembl chr 6:27,125,897...27,132,750
JBrowse link
G H2BC12 H2B clustered histone 12 decreases expression EXP Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr 6:27,138,293...27,146,858
Ensembl chr 6:27,146,418...27,146,798
Ensembl chr 6:27,146,418...27,146,798
JBrowse link
G H2BC13 H2B clustered histone 13 decreases expression EXP Berberine results in decreased expression of H2BC13 mRNA CTD PMID:27311644 NCBI chr 6:27,807,479...27,807,929
Ensembl chr 6:27,807,444...27,807,931
JBrowse link
G H2BC14 H2B clustered histone 14 decreases expression EXP Berberine results in decreased expression of H2BC14 mRNA CTD PMID:27311644 NCBI chr 6:27,815,022...27,815,489
Ensembl chr 6:27,815,044...27,815,424
Ensembl chr 6:27,815,044...27,815,424
JBrowse link
G H2BC15 H2B clustered histone 15 decreases expression EXP Berberine results in decreased expression of H2BC15 mRNA CTD PMID:27311644 NCBI chr 6:27,838,569...27,839,110
Ensembl chr 6:27,837,760...27,865,798
JBrowse link
G H2BC17 H2B clustered histone 17 decreases expression EXP Berberine results in decreased expression of H2BC17 mRNA CTD PMID:27311644 NCBI chr 6:27,893,425...27,893,891
Ensembl chr 6:27,893,463...27,893,843
Ensembl chr 6:27,893,463...27,893,843
JBrowse link
G H2BC4 H2B clustered histone 4 decreases expression EXP Berberine results in decreased expression of H2BC4 mRNA CTD PMID:27311644 NCBI chr 6:26,113,170...26,123,926
Ensembl chr 6:26,114,873...26,123,926
JBrowse link
G H2BC5 H2B clustered histone 5 decreases expression EXP Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr 6:26,158,008...26,171,349
Ensembl chr 6:26,158,146...26,171,349
JBrowse link
G H2BC6 H2B clustered histone 6 decreases expression EXP Berberine results in decreased expression of H2BC6 mRNA CTD PMID:27311644 NCBI chr 6:26,183,761...26,184,230
Ensembl chr 6:26,172,059...26,184,655
JBrowse link
G H2BC7 H2B clustered histone 7 decreases expression EXP Berberine results in decreased expression of H2BC7 mRNA CTD PMID:27311644 NCBI chr 6:26,199,516...26,199,988
Ensembl chr 6:26,199,520...26,200,715
JBrowse link
G H2BC8 H2B clustered histone 8 decreases expression EXP Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr 6:26,216,200...26,216,688
Ensembl chr 6:26,215,159...26,216,692
JBrowse link
G H2BC9 H2B clustered histone 9 decreases expression EXP Berberine results in decreased expression of H2BC9 mRNA CTD PMID:27311644 NCBI chr 6:26,251,614...26,252,075
Ensembl chr 6:26,251,651...26,253,710
JBrowse link
G H2BW2 H2B.W histone 2 decreases expression EXP Berberine results in decreased expression of H2BW2 mRNA CTD PMID:27311644 NCBI chr  X:104,039,753...104,042,454
Ensembl chr  X:104,039,916...104,042,454
Ensembl chr  X:104,039,916...104,042,454
JBrowse link
G H3-3A H3.3 histone A decreases expression EXP Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr 1:226,061,831...226,072,019
Ensembl chr 1:226,061,851...226,073,212
Ensembl chr 1:226,061,851...226,073,212
JBrowse link
G H3-4 H3.4 histone decreases expression EXP Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,325
Ensembl chr 1:228,424,845...228,425,325
JBrowse link
G H3C1 H3 clustered histone 1 decreases expression EXP Berberine results in decreased expression of H3C1 mRNA CTD PMID:27311644 NCBI chr 6:26,020,451...26,020,958
Ensembl chr 6:26,020,490...26,020,900
Ensembl chr 6:26,020,490...26,020,900
JBrowse link
G H3C10 H3 clustered histone 10 decreases expression EXP Berberine results in decreased expression of H3C10 mRNA CTD PMID:27311644 NCBI chr 6:27,810,051...27,810,536
Ensembl chr 6:27,810,064...27,811,300
JBrowse link
G H3C12 H3 clustered histone 12 decreases expression EXP Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr 6:27,890,315...27,890,826
Ensembl chr 6:27,890,382...27,893,106
Ensembl chr 6:27,890,382...27,893,106
JBrowse link
G H3C2 H3 clustered histone 2 decreases expression EXP Berberine results in decreased expression of H3C2 mRNA CTD PMID:27311644 NCBI chr 6:26,031,589...26,032,099
Ensembl chr 6:26,031,594...26,032,099
Ensembl chr 6:26,031,594...26,032,099
JBrowse link
G H3C4 H3 clustered histone 4 decreases expression EXP Berberine results in decreased expression of H3C4 mRNA CTD PMID:27311644 NCBI chr 6:26,196,784...26,199,293
Ensembl chr 6:26,196,840...26,197,250
Ensembl chr 6:26,196,840...26,197,250
JBrowse link
G H3C7 H3 clustered histone 7 decreases expression EXP Berberine results in decreased expression of H3C7 mRNA CTD PMID:27311644 NCBI chr 6:26,250,142...26,250,635
Ensembl chr 6:26,250,195...26,250,605
Ensembl chr 6:26,250,195...26,250,605
JBrowse link
G H3C8 H3 clustered histone 8 decreases expression EXP Berberine results in decreased expression of H3C8 mRNA CTD PMID:27311644 NCBI chr 6:26,270,918...26,271,413
Ensembl chr 6:26,269,405...26,271,815
JBrowse link
G H4C14 H4 clustered histone 14 decreases expression EXP Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr 1:149,832,657...149,833,052
Ensembl chr 1:149,832,659...149,839,767
JBrowse link
G H4C2 H4 clustered histone 2 decreases expression EXP Berberine results in decreased expression of H4C2 mRNA CTD PMID:27311644 NCBI chr 6:26,026,896...26,027,283
Ensembl chr 6:26,026,815...26,027,252
JBrowse link
G H4C3 H4 clustered histone 3 decreases expression EXP Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr 6:26,103,933...26,104,337
Ensembl chr 6:26,103,876...26,104,310
Ensembl chr 6:26,103,876...26,104,310
JBrowse link
G H4C8 H4 clustered histone 8 decreases expression EXP Berberine results in decreased expression of H4C8 mRNA CTD PMID:27311644 NCBI chr 6:26,285,126...26,285,534
Ensembl chr 6:26,277,609...26,285,638
JBrowse link
G H4C9 H4 clustered histone 9 decreases expression EXP Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr 6:27,139,282...27,139,678
Ensembl chr 6:27,138,588...27,139,881
JBrowse link
G HAT1 histone acetyltransferase 1 increases expression EXP Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 2:171,922,425...171,983,686
Ensembl chr 2:171,922,448...171,983,686
JBrowse link
G HDAC2 histone deacetylase 2 decreases expression EXP Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
JBrowse link
G HDAC5 histone deacetylase 5 increases expression EXP Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G HDAC8 histone deacetylase 8 decreases expression EXP Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:72,329,516...72,573,099
Ensembl chr  X:72,329,516...72,573,101
JBrowse link
G HDAC9 histone deacetylase 9 decreases expression
increases expression
EXP Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA
CTD PMID:27311644 NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416
JBrowse link
G HGF hepatocyte growth factor multiple interactions
increases expression
ISO
EXP
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein
CTD PMID:29408570 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP Berberine results in increased expression of HMOX1 protein
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]
CTD PMID:23954465 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha multiple interactions ISO Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]
CTD PMID:18563319, PMID:25455889 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression EXP Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945
JBrowse link
G IFNG interferon gamma multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions
increases expression
EXP Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein
CTD PMID:23954465 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IL10 interleukin 10 multiple interactions
increases expression
ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA
Berberine results in increased expression of IL10 mRNA
CTD PMID:21867779, PMID:30138605 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]
CTD PMID:16391493, PMID:29170048, PMID:30138605 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 increases expression ISO Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL23A interleukin 23 subunit alpha multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr12:56,334,159...56,340,410
Ensembl chr12:56,334,174...56,340,410
JBrowse link
G IL4 interleukin 4 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA
CTD PMID:21867779 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]
Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]
CTD PMID:28916288, PMID:29170048, PMID:30138605, PMID:30240693 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGA1 integrin subunit alpha 1 increases expression EXP Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr 5:52,787,916...52,959,209
Ensembl chr 5:52,787,916...52,959,209
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit affects localization
multiple interactions
ISO Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]
CTD PMID:18294404 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]
CTD PMID:30086269 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KDM1A lysine demethylase 1A increases expression EXP Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 1:23,019,443...23,083,691
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
G KDM4A lysine demethylase 4A increases expression EXP Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 1:43,650,149...43,705,518
Ensembl chr 1:43,650,149...43,705,518
JBrowse link
G KDM5B lysine demethylase 5B increases expression EXP Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr 1:202,724,495...202,809,470
Ensembl chr 1:202,724,495...202,808,487
Ensembl chr 1:202,724,495...202,808,487
JBrowse link
G KDM6A lysine demethylase 6A increases expression EXP Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:44,873,182...45,112,779
Ensembl chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
JBrowse link
G KDM6B lysine demethylase 6B increases expression EXP Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr17:7,834,210...7,854,796
Ensembl chr17:7,839,904...7,854,796
JBrowse link
G KMT5A lysine methyltransferase 5A increases expression EXP Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr12:123,384,132...123,409,353
Ensembl chr12:123,383,773...123,409,353
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
CTD PMID:18640378, PMID:20564506 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr 6:136,557,046...136,793,098
Ensembl chr 6:136,557,046...136,792,477
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]
CTD PMID:18294404, PMID:20462044 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MCM2 minichromosome maintenance complex component 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436
JBrowse link
G MIR19A microRNA 19a decreases expression EXP Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr13:91,350,891...91,350,972
Ensembl chr13:91,350,891...91,350,972
JBrowse link
G MIR92A1 microRNA 92a-1 decreases expression EXP Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr13:91,351,314...91,351,391
Ensembl chr13:91,351,314...91,351,391
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression EXP Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP14 matrix metallopeptidase 14 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,027
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
EXP
ISO
Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
CTD PMID:18294404 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MTTP microsomal triglyceride transfer protein multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,563,761...99,623,999
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
affects localization
ISO arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase multiple interactions
decreases expression
EXP [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr 7:106,248,298...106,284,983
Ensembl chr 7:106,248,298...106,286,326
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
increases activity
multiple interactions
EXP
ISO
Berberine results in increased expression of NFE2L2 protein
Berberine results in increased activity of NFE2L2 protein
Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]
CTD PMID:23523906, PMID:23954465, PMID:30818834 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:21963898 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NGF nerve growth factor multiple interactions EXP Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]
CTD PMID:21095217, PMID:23523906 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Berberine reverses reaction [Carbontetrachloride decreases Nqo1 mRNA in liver] RGD PMID:31432116 RGD:25823187 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 decreases expression EXP Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr 4:1,871,393...1,982,207
Ensembl chr 4:1,871,393...1,982,207
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G OMD osteomodulin increases expression EXP Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr 9:92,412,380...92,424,471
Ensembl chr 9:92,414,245...92,424,461
JBrowse link
G P2RX7 purinergic receptor P2X 7 multiple interactions EXP Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr12:121,132,819...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein
CTD PMID:16505103, PMID:26712469 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:25455889 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases response to substance
increases expression
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
PPARG mRNA results in increased susceptibility to Berberine
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine results in increased expression of PPARG mRNA
Berberine results in decreased expression of PPARG mRNA
CTD PMID:20564506, PMID:26478571, PMID:29408570 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRG4 proteoglycan 4 decreases expression EXP Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr 1:186,296,273...186,314,567
Ensembl chr 1:186,296,279...186,314,562
Ensembl chr 1:186,296,279...186,314,562
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 5:40,759,379...40,798,195
Ensembl chr 5:40,759,379...40,798,374
JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions
decreases activity
ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G PRMT1 protein arginine methyltransferase 1 decreases expression EXP Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr19:49,676,166...49,688,447
Ensembl chr19:49,675,786...49,689,029
JBrowse link
G PRMT2 protein arginine methyltransferase 2 increases expression EXP Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr21:46,635,156...46,665,685
Ensembl chr21:46,635,595...46,665,124
JBrowse link
G PRMT5 protein arginine methyltransferase 5 increases expression EXP Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr14:22,920,526...22,929,392
Ensembl chr14:22,920,525...22,929,408
JBrowse link
G PRMT6 protein arginine methyltransferase 6 increases expression EXP Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 1:107,056,674...107,059,294
Ensembl chr 1:107,056,674...107,067,636
JBrowse link
G PRMT7 protein arginine methyltransferase 7 increases expression EXP Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr16:68,310,982...68,360,876
Ensembl chr16:68,310,974...68,358,584
Ensembl chr16:68,310,974...68,358,584
JBrowse link
G PRMT8 protein arginine methyltransferase 8 increases expression EXP Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr12:3,381,349...3,593,973
Ensembl chr12:3,381,349...3,593,973
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions
increases expression
ISO ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
Berberine results in increased expression of PTEN protein
CTD PMID:29408570 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RBP4 retinol binding protein 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein] CTD PMID:23523906 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RLN1 relaxin 1 affects binding
increases expression
multiple interactions
ISO Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA
CTD PMID:22363579 NCBI chr 9:5,334,930...5,339,876
Ensembl chr 9:5,334,930...5,339,876
JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation EXP Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions
increases expression
EXP CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SETD1B SET domain containing 1B, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr12:121,803,665...121,832,656
Ensembl chr12:121,804,180...121,832,584
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 3:47,016,431...47,164,113
Ensembl chr 3:47,016,429...47,164,113
Ensembl chr 3:47,016,429...47,164,113
JBrowse link
G SETD3 SET domain containing 3, actin histidine methyltransferase increases expression EXP Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr14:99,397,746...99,486,458
Ensembl chr14:99,397,748...99,480,889
JBrowse link
G SETD5 SET domain containing 5 increases expression EXP Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 3:9,397,615...9,478,154
Ensembl chr 3:9,397,615...9,479,240
JBrowse link
G SETD6 SET domain containing 6, protein lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr16:58,515,479...58,523,842
Ensembl chr16:58,515,479...58,521,181
Ensembl chr16:58,515,479...58,521,181
JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 4:139,492,974...139,556,219
Ensembl chr 4:139,495,941...139,606,699
JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 increases expression EXP Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 1:150,926,263...150,964,737
Ensembl chr 1:150,926,263...150,964,744
JBrowse link
G SETDB2 SET domain bifurcated histone lysine methyltransferase 2 increases expression EXP Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr13:49,444,274...49,495,003
Ensembl chr13:49,444,374...49,495,003
JBrowse link
G SI sucrase-isomaltase decreases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]
CTD PMID:20229011 NCBI chr 3:164,978,898...165,078,496
Ensembl chr 3:164,978,898...165,078,496
JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions
EXP Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]
CTD PMID:26712469 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT2 sirtuin 2 multiple interactions EXP [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G SIRT3 sirtuin 3 multiple interactions
increases expression
decreases expression
EXP [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein
CTD PMID:26712469, PMID:27311644 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC27A5 solute carrier family 27 member 5 decreases expression EXP Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr19:58,498,333...58,512,028
Ensembl chr19:58,479,512...58,512,413
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC6A19 solute carrier family 6 member 19 multiple interactions ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr 5:1,201,595...1,225,111
Ensembl chr 5:1,201,595...1,225,111
JBrowse link
G SMYD3 SET and MYND domain containing 3 affects expression EXP Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr 1:245,749,342...246,507,279
Ensembl chr 1:245,749,342...246,507,312
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA] CTD PMID:21095217, PMID:22775417 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]
CTD PMID:22775417, PMID:24751971 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX9 SRY-box transcription factor 9 decreases expression EXP Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SP7 Sp7 transcription factor increases expression EXP Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315
JBrowse link
G SPARC secreted protein acidic and cysteine rich increases expression EXP Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975
JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression
multiple interactions
EXP Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]
CTD PMID:26478571 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA
CTD PMID:20564506, PMID:26478571 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G TERT telomerase reverse transcriptase decreases activity EXP Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
CTD PMID:17973934, PMID:23523906, PMID:30138605 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:21963898, PMID:30240693 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP
ISO
Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:16391493, PMID:20656010, PMID:21095217, PMID:21867779, PMID:23523906, PMID:25600690, PMID:28533128, PMID:29170048, PMID:30240693 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TOP1 DNA topoisomerase I decreases activity EXP Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487
JBrowse link
G TOP2A DNA topoisomerase II alpha multiple interactions
affects response to substance
EXP TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine
CTD PMID:23747414 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein
CTD PMID:20656010, PMID:26712469 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRAF1 TNF receptor associated factor 1 increases expression EXP Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173
JBrowse link
G TRAF2 TNF receptor associated factor 2 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 9:136,881,933...136,926,615
Ensembl chr 9:136,881,912...136,926,607
JBrowse link
G TSTD1 thiosulfate sulfurtransferase like domain containing 1 increases expression EXP Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr 1:161,037,631...161,038,964
Ensembl chr 1:161,037,631...161,038,977
JBrowse link
G UBE2A ubiquitin conjugating enzyme E2 A decreases expression EXP Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:119,574,563...119,584,423
Ensembl chr  X:119,574,536...119,591,083
JBrowse link
G UBE2B ubiquitin conjugating enzyme E2 B decreases expression EXP Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr 5:134,371,569...134,392,108
Ensembl chr 5:134,371,469...134,392,108
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA] CTD PMID:28533128 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G VEGFC vascular endothelial growth factor C increases expression EXP Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                  EC 2.7.11.10 (IkappaB kinase) inhibitor 225
                    (E)-3-tosylacrylonitrile 0
                    berberine 225
Path 2
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                protein kinase inhibitor 14047
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                    EC 2.7.11.10 (IkappaB kinase) inhibitor 225
                      (E)-3-tosylacrylonitrile 0
                      berberine 225
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.