Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.10 (IkappaB kinase) inhibitor
go back to main search page
Accession:CHEBI:77113 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of IkappaB kinase (EC 2.7.11.10).
Synonyms:related_synonym: ATP:[IkappaB protein] phosphotransferase;   ATP:[IkappaB protein] phosphotransferase inhibitor;   CHUK inhibitor;   CHUK inhibitors;   EC 2.7.11.10 (IkappaB kinase) inhibitors;   EC 2.7.11.10 inhibitor;   EC 2.7.11.10 inhibitors;   IKBKA inhibitor;   IKBKA inhibitors;   IKBKB inhibitor;   IKBKB inhibitors;   IKK inhibitor;   IKK inhibitors;   IKK-1 inhibitor;   IKK-1 inhibitors;   IKK-2 inhibitor;   IKK-2 inhibitors;   IkappaB kinase inhibitor;   IkappaB kinase inhibitors;   STK12 inhibitor;   STK12 inhibitors;   TANK-binding kinase 1 inhibitor;   TANK-binding kinase 1 inhibitors;   TBK1 inhibitor;   TBK1 inhibitors
 xref: Wikipedia:IkappaB_kinase


show annotations for term's descendants           Sort by:
 
berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 increases expression EXP berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases expression ISO Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B increases expression ISO Berberine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632
JBrowse link
G Acan aggrecan decreases expression ISO Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA] CTD PMID:29170048 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta decreases expression ISO Berberine results in decreased expression of ACTA2 protein CTD PMID:17973934 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Ahr aryl-hydrocarbon receptor increases activity ISO Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
ISO Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein
CTD PMID:23954465, PMID:30138605 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826
JBrowse link
G Alb albumin multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr11:69,045,624...69,051,664
Ensembl chr11:69,045,647...69,051,664
JBrowse link
G Aurkc aurora kinase C increases expression ISO Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr 7:6,995,347...7,003,091
Ensembl chr 7:6,995,300...7,003,091
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO [Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Niacinamide] results in increased expression of BAX protein; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]
CTD PMID:16505103, PMID:20656010, PMID:25600690, PMID:26712469, PMID:30138605 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
multiple interactions
ISO Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA
CTD PMID:26712469 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
increases expression
multiple interactions
ISO Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
CTD PMID:16505103, PMID:20656010, PMID:23954465, PMID:24751971, PMID:25600690, PMID:26712469, PMID:30138605 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) multiple interactions
increases expression
ISO [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA
CTD PMID:26712469 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression
multiple interactions
ISO Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]
CTD PMID:26478571 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA
CTD PMID:16505103, PMID:20656010, PMID:25600690, PMID:26712469, PMID:30138605 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases activity ISO Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO Berberine results in increased cleavage of CASP9 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein
CTD PMID:16505103, PMID:26712469, PMID:30138605 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein] CTD PMID:20828602, PMID:24751971, PMID:25600690, PMID:30138605 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] CTD PMID:16391493 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Berberine results in decreased expression of CCND1 protein CTD PMID:16505103 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr15:98,538,690...98,567,736
Ensembl chr15:98,538,689...98,570,923
JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression
ISO
EXP
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein
CTD PMID:28038998, PMID:29408570 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression ISO Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Berberine results in decreased expression of CDK4 protein CTD PMID:16505103 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 2:32,705,782...32,712,784
Ensembl chr 2:32,705,784...32,713,076
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO Berberine results in increased expression of CDKN1A protein CTD PMID:16505103, PMID:23747414 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) increases expression ISO Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr 7:143,458,339...143,461,059
Ensembl chr 7:143,458,339...143,461,050
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha multiple interactions
decreases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA
CTD PMID:20564506, PMID:26478571 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta affects phosphorylation
increases expression
multiple interactions
EXP
ISO
Berberine affects the phosphorylation of CEBPB protein
Berberine results in increased expression of CEBPB mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
CTD PMID:28038998 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Col10a1 collagen, type X, alpha 1 increases expression ISO Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr10:34,389,981...34,397,085
Ensembl chr10:34,389,981...34,397,085
JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression ISO Berberine results in increased expression of COL1A1 mRNA CTD PMID:26478571 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Crebbp CREB binding protein increases expression ISO Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr16:4,081,334...4,213,957
Ensembl chr16:4,081,328...4,213,997
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 increases expression
multiple interactions
ISO Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]
CTD PMID:26478571 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:16391493, PMID:28916288 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Berberine affects the localization of CYCS protein CTD PMID:16505103 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
multiple interactions
ISO
EXP
Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:16046213, PMID:22342832, PMID:24583342 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases expression
EXP Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA
CTD PMID:22342832 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 multiple interactions
increases expression
EXP Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B9 mRNA]; Berberine promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]
Berberine results in increased expression of CYP2B9 mRNA
CTD PMID:22342832 NCBI chr 7:26,173,350...26,210,661
Ensembl chr 7:26,173,411...26,210,661
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
EXP Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
CTD PMID:22342832, PMID:25455889 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
decreases expression
EXP
ISO
Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP3A11 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP3A11 mRNA]
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Berberine results in decreased expression of CYP3A11 mRNA
CTD PMID:21524698, PMID:22342832 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions
decreases expression
EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A10 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A10 mRNA]
Berberine results in decreased expression of CYP4A10 mRNA
CTD PMID:22342832 NCBI chr 4:115,518,287...115,533,649
Ensembl chr 4:115,518,264...115,533,649
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions
decreases expression
EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A14 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A14 mRNA]
Berberine results in decreased expression of CYP4A14 mRNA
CTD PMID:22342832 NCBI chr 4:115,486,200...115,496,158
Ensembl chr 4:115,486,200...115,496,142
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr19:30,545,876...30,549,496
Ensembl chr19:30,545,863...30,549,665
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 decreases expression ISO Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression ISO Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Dzip3 DAZ interacting protein 3, zinc finger increases expression ISO Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr16:48,924,228...48,994,142
Ensembl chr16:48,924,232...48,994,165
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr19:6,910,977...6,922,048
Ensembl chr19:6,910,977...6,921,813
Ensembl chr19:6,910,977...6,921,813
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression
increases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of FABP4 mRNA
Berberine results in increased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]
CTD PMID:26478571, PMID:29408570 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
increases expression
EXP
ISO
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein
CTD PMID:20564506, PMID:20656010 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA] CTD PMID:30138605 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr 2:155,941,023...155,945,367
Ensembl chr 2:155,941,023...155,945,367
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP
ISO
Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]
CTD PMID:24751971, PMID:25455889, PMID:30138605 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
EXP
ISO
Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]
CTD PMID:20462044, PMID:23954465 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gsr glutathione reductase multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971, PMID:25600690 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G H2ac10 H2A clustered histone 10 decreases expression ISO Berberine results in decreased expression of H2AC14 mRNA CTD PMID:27311644 NCBI chr13:23,533,875...23,534,378
Ensembl chr13:23,533,906...23,534,304
JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr13:22,035,122...22,035,643
Ensembl chr13:22,035,164...22,035,568
JBrowse link
G H2ac18 H2A clustered histone 18 decreases expression ISO Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 3:96,245,497...96,246,052
Ensembl chr 3:96,245,497...96,246,082
JBrowse link
G H2ac22 H2A clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr13:21,786,774...21,787,248
Ensembl chr13:21,786,826...21,787,218
JBrowse link
G H2ac4 H2A clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr13:23,751,088...23,751,592
Ensembl chr13:23,751,126...23,751,598
JBrowse link
G H2ac6 H2A clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2AC15 mRNA CTD PMID:27311644 NCBI chr13:23,683,473...23,683,959
Ensembl chr13:23,681,467...23,683,948
JBrowse link
G H2ac7 H2A clustered histone 7 decreases expression ISO Berberine results in decreased expression of H2AC17 mRNA CTD PMID:27311644 NCBI chr13:23,574,381...23,574,915
Ensembl chr13:23,574,381...23,574,952
JBrowse link
G H2ac8 H2A clustered histone 8 decreases expression ISO Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr13:23,570,663...23,571,220
Ensembl chr13:23,570,517...23,571,220
JBrowse link
G H2aw H2A.W histone decreases expression ISO Berberine results in decreased expression of H2AW mRNA CTD PMID:27311644 NCBI chr11:58,954,685...58,955,192
Ensembl chr11:58,954,685...58,956,830
JBrowse link
G H2ax H2A.X variant histone increases expression
decreases expression
multiple interactions
ISO Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
CTD PMID:23363784, PMID:23747414, PMID:27311644 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr13:22,035,821...22,036,320
Ensembl chr13:22,035,870...22,036,345
JBrowse link
G H2bc13 H2B clustered histone 13 decreases expression ISO Berberine results in decreased expression of H2BC6 mRNA CTD PMID:27311644 NCBI chr13:21,715,711...21,716,183
Ensembl chr13:21,715,763...21,716,143
JBrowse link
G H2bc14 H2B clustered histone 14 decreases expression ISO Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr13:21,722,044...21,722,526
Ensembl chr13:21,722,044...21,722,567
JBrowse link
G H2bc15 H2B clustered histone 15 decreases expression ISO Berberine results in decreased expression of H2BC15 mRNA CTD PMID:27311644 NCBI chr13:21,754,076...21,754,553
Ensembl chr13:21,754,123...21,754,503
JBrowse link
G H2bc21 H2B clustered histone 21 decreases expression ISO Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 3:96,221,072...96,223,738
Ensembl chr 3:96,221,119...96,223,738
JBrowse link
G H2bc22 H2B clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2BC17 mRNA CTD PMID:27311644 NCBI chr13:21,787,483...21,801,561
Ensembl chr13:21,787,461...21,789,213
JBrowse link
G H2bc4 H2B clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2BC4 mRNA CTD PMID:27311644 NCBI chr13:23,684,199...23,692,480
Ensembl chr13:23,684,199...23,692,908
JBrowse link
G H2bc6 H2B clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2BC7 mRNA CTD PMID:27311644 NCBI chr13:23,583,670...23,621,124
Ensembl chr13:23,583,670...23,621,124
JBrowse link
G H2bc7 H2B clustered histone 7 decreases expression ISO Berberine results in decreased expression of H2BC13 mRNA CTD PMID:27311644 NCBI chr13:23,573,760...23,574,207
Ensembl chr13:23,573,736...23,574,196
JBrowse link
G H2bw2 H2B.W histone 2 decreases expression ISO Berberine results in decreased expression of H2BW2 mRNA CTD PMID:27311644 NCBI chr  X:136,927,325...136,928,373
Ensembl chr  X:136,927,325...136,928,376
JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO Berberine results in decreased expression of H3C10 mRNA CTD PMID:27311644 NCBI chr13:23,761,885...23,762,386
Ensembl chr13:23,761,853...23,762,386
JBrowse link
G H3c10 H3 clustered histone 10 decreases expression ISO Berberine results in decreased expression of H3C4 mRNA CTD PMID:27311644 NCBI chr13:21,717,628...21,718,115
Ensembl chr13:21,717,659...21,718,069
JBrowse link
G H3c11 H3 clustered histone 11 decreases expression ISO Berberine results in decreased expression of H3C7 mRNA CTD PMID:27311644 NCBI chr13:21,782,915...21,783,397
Ensembl chr13:21,782,960...21,783,370
JBrowse link
G H3c8 H3 clustered histone 8 decreases expression ISO Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr13:23,535,418...23,535,909
Ensembl chr13:23,535,422...23,535,951
JBrowse link
G H3f3a H3.3 histone A decreases expression ISO Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr 1:180,802,560...180,813,605
Ensembl chr 1:180,800,832...180,813,943
JBrowse link
G H3f4 H3.4 histone decreases expression ISO Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr11:58,961,711...58,962,273
Ensembl chr11:58,961,812...58,962,222
JBrowse link
G H4c12 H4 clustered histone 12 decreases expression ISO Berberine results in decreased expression of H4C8 mRNA CTD PMID:27311644 NCBI chr13:21,750,145...21,750,553
Ensembl chr13:21,750,194...21,750,505
JBrowse link
G H4c2 H4 clustered histone 2 decreases expression ISO Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr13:23,756,937...23,757,386
Ensembl chr13:23,757,013...23,757,409
JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr13:23,698,084...23,698,458
Ensembl chr13:23,697,635...23,698,454
JBrowse link
G H4c9 H4 clustered histone 9 decreases expression ISO Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr13:22,040,960...22,041,362
Ensembl chr13:22,040,636...22,041,362
JBrowse link
G Hat1 histone aminotransferase 1 increases expression ISO Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 2:71,389,260...71,441,622
Ensembl chr 2:71,388,958...71,441,622
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr10:36,974,297...37,001,889
Ensembl chr10:36,974,544...37,001,889
JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr11:102,195,747...102,230,172
Ensembl chr11:102,194,432...102,230,166
JBrowse link
G Hdac8 histone deacetylase 8 decreases expression ISO Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:102,284,638...102,505,381
Ensembl chr  X:102,284,639...102,505,359
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
increases expression
ISO Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA
CTD PMID:27311644 NCBI chr12:34,047,580...34,917,095
Ensembl chr12:34,047,580...34,917,095
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases expression
ISO
EXP
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein
CTD PMID:29408570 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Berberine results in increased expression of HMOX1 protein
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]
CTD PMID:23954465 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha multiple interactions ISO
EXP
Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]
CTD PMID:18563319, PMID:25455889 NCBI chr 2:163,506,811...163,572,907
Ensembl chr 2:163,506,808...163,572,910
JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha decreases expression ISO Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 9:54,586,511...54,604,662
Ensembl chr 9:54,586,334...54,604,661
JBrowse link
G Ifng interferon gamma multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein
CTD PMID:23954465 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP
ISO
Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA
Berberine results in increased expression of IL10 mRNA
CTD PMID:21867779, PMID:30138605 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]
CTD PMID:16391493, PMID:29170048, PMID:30138605 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 increases expression EXP Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr10:128,296,140...128,298,084
Ensembl chr10:128,296,139...128,298,752
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
EXP Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA
CTD PMID:21867779 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]
Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]
CTD PMID:28916288, PMID:29170048, PMID:30138605, PMID:30240693 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itga1 integrin alpha 1 increases expression ISO Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr13:114,958,079...115,101,964
Ensembl chr13:114,953,096...115,101,964
JBrowse link
G Jun jun proto-oncogene affects localization
multiple interactions
ISO Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]
CTD PMID:18294404 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions
ISO Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]
CTD PMID:30086269 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A increases expression ISO Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 4:136,550,533...136,602,787
Ensembl chr 4:136,550,540...136,602,723
JBrowse link
G Kdm4a lysine (K)-specific demethylase 4A increases expression ISO Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 4:118,136,957...118,180,090
Ensembl chr 4:118,136,957...118,180,043
JBrowse link
G Kdm5b lysine (K)-specific demethylase 5B increases expression ISO Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr 1:134,560,178...134,632,878
Ensembl chr 1:134,560,171...134,635,285
JBrowse link
G Kdm6a lysine (K)-specific demethylase 6A increases expression ISO Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:18,160,862...18,279,936
Ensembl chr  X:18,162,575...18,279,936
JBrowse link
G Kdm6b KDM1 lysine (K)-specific demethylase 6B increases expression ISO Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr11:69,398,508...69,420,367
Ensembl chr11:69,398,508...69,413,675
JBrowse link
G Kmt5a lysine methyltransferase 5A increases expression ISO Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr 5:124,439,930...124,462,311
Ensembl chr 5:124,439,930...124,462,308
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
CTD PMID:18640378, PMID:20564506 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]
CTD PMID:18294404, PMID:20462044 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 6:88,883,474...88,898,780
Ensembl chr 6:88,883,474...88,898,780
JBrowse link
G Mir19a microRNA 19a decreases expression ISO Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr14:115,044,000...115,044,081
Ensembl chr14:115,044,000...115,044,081
JBrowse link
G Mir92-1 microRNA 92-1 decreases expression ISO Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr14:115,044,427...115,044,506
Ensembl chr14:115,044,427...115,044,506
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
CTD PMID:18294404 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 3:138,089,855...138,143,418
Ensembl chr 3:138,089,854...138,144,968
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions
affects localization
ISO arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
decreases expression
ISO [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr12:32,820,335...32,853,369
Ensembl chr12:32,819,545...32,853,349
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
increases activity
multiple interactions
ISO Berberine results in increased expression of NFE2L2 protein
Berberine results in increased activity of NFE2L2 protein
Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]
CTD PMID:23523906, PMID:23954465, PMID:30818834 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:21963898 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]
CTD PMID:21095217, PMID:23523906 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Berberine reverses reaction [Carbontetrachloride decreases Nqo1 mRNA in liver] RGD PMID:31432116 RGD:25823187 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 decreases expression ISO Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr 5:33,820,676...33,897,966
Ensembl chr 5:33,820,725...33,897,975
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505
JBrowse link
G Omd osteomodulin increases expression ISO Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr13:49,582,462...49,592,612
Ensembl chr13:49,582,462...49,592,822
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions ISO Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein
CTD PMID:16505103, PMID:26712469 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:25455889 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases response to substance
increases expression
decreases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
PPARG mRNA results in increased susceptibility to Berberine
Berberine results in increased expression of PPARG mRNA
Berberine results in decreased expression of PPARG mRNA
CTD PMID:20564506, PMID:26478571, PMID:29408570 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Prg4 proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) decreases expression ISO Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr 1:150,449,412...150,466,221
Ensembl chr 1:150,449,412...150,466,165
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation EXP Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases activity
ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr17:86,167,785...86,657,919
Ensembl chr17:86,167,785...86,657,919
JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 decreases expression ISO Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr 7:44,976,755...44,986,420
Ensembl chr 7:44,975,989...44,986,568
JBrowse link
G Prmt2 protein arginine N-methyltransferase 2 increases expression ISO Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr10:76,207,226...76,237,865
Ensembl chr10:76,207,222...76,237,865
JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 increases expression ISO Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr14:54,507,182...54,517,470
Ensembl chr14:54,507,187...54,517,525
JBrowse link
G Prmt6 protein arginine N-methyltransferase 6 increases expression ISO Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 3:110,246,104...110,250,999
Ensembl chr 3:110,246,109...110,250,998
JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 increases expression ISO Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr 8:106,211,054...106,251,694
Ensembl chr 8:106,210,936...106,252,794
JBrowse link
G Prmt8 protein arginine N-methyltransferase 8 increases expression ISO Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr 6:127,689,009...127,769,467
Ensembl chr 6:127,689,011...127,769,472
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
EXP Berberine results in increased expression of PTEN protein
((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
CTD PMID:29408570 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rbp4 retinol binding protein 4, plasma multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr19:38,116,620...38,125,321
Ensembl chr19:38,116,629...38,125,281
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein] CTD PMID:23523906 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rln1 relaxin 1 affects binding
increases expression
multiple interactions
ISO Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA
CTD PMID:22363579 NCBI chr19:29,331,755...29,334,670
Ensembl chr19:29,331,170...29,334,670
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions
increases expression
ISO CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Setd1b SET domain containing 1B increases expression ISO Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr 5:123,142,040...123,168,630
Ensembl chr 5:123,142,193...123,168,629
JBrowse link
G Setd2 SET domain containing 2 increases expression ISO Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 9:110,532,500...110,618,633
Ensembl chr 9:110,532,597...110,618,633
JBrowse link
G Setd3 SET domain containing 3 increases expression ISO Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr12:108,106,431...108,179,345
Ensembl chr12:108,106,431...108,179,314
JBrowse link
G Setd5 SET domain containing 5 increases expression ISO Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 6:113,077,262...113,153,432
Ensembl chr 6:113,077,365...113,153,435
JBrowse link
G Setd6 SET domain containing 6 increases expression ISO Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr 8:95,715,634...95,721,507
Ensembl chr 8:95,715,881...95,719,010
JBrowse link
G Setd7 SET domain containing (lysine methyltransferase) 7 increases expression ISO Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 3:51,515,318...51,560,823
Ensembl chr 3:51,515,319...51,560,879
JBrowse link
G Setdb1 SET domain, bifurcated 1 increases expression ISO Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 3:95,323,525...95,357,202
Ensembl chr 3:95,323,525...95,357,202
JBrowse link
G Setdb2 SET domain, bifurcated 2 increases expression ISO Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr14:59,402,009...59,440,880
Ensembl chr14:59,402,009...59,440,884
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]
CTD PMID:26712469 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr 7:28,766,752...28,788,665
Ensembl chr 7:28,766,735...28,788,661
JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
decreases expression
ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein
CTD PMID:26712469, PMID:27311644 NCBI chr 7:140,863,663...140,882,309
Ensembl chr 7:140,863,666...140,882,309
JBrowse link
G Sis sucrase isomaltase (alpha-glucosidase) decreases expression
multiple interactions
ISO Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]
CTD PMID:20229011 NCBI chr 3:72,888,557...72,967,863
Ensembl chr 3:72,888,557...72,967,863
JBrowse link
G Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 decreases expression ISO Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr 7:12,988,346...12,998,192
Ensembl chr 7:12,988,346...12,998,192
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Slc6a19 solute carrier family 6 (neurotransmitter transporter), member 19 multiple interactions ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr13:73,679,745...73,700,780
Ensembl chr13:73,679,745...73,704,865
JBrowse link
G Smyd3 SET and MYND domain containing 3 affects expression ISO Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr 1:178,951,960...179,518,053
Ensembl chr 1:178,951,960...179,518,041
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA] CTD PMID:21095217, PMID:22775417 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP
ISO
Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]
CTD PMID:22775417, PMID:24751971 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 decreases expression ISO Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Sp7 Sp7 transcription factor 7 increases expression ISO Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr15:102,356,603...102,367,035
Ensembl chr15:102,356,606...102,367,182
JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein increases expression ISO Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr11:55,394,159...55,420,080
Ensembl chr11:55,394,500...55,423,183
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions
ISO Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]
CTD PMID:26478571 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA
CTD PMID:20564506, PMID:26478571 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr13:73,626,911...73,649,843
Ensembl chr13:73,626,911...73,649,843
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
CTD PMID:17973934, PMID:23523906, PMID:30138605 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:21963898, PMID:30240693 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
ISO
EXP
Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:16391493, PMID:20656010, PMID:21095217, PMID:21867779, PMID:23523906, PMID:25600690, PMID:28533128, PMID:29170048, PMID:30240693 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Top1 topoisomerase (DNA) I decreases activity ISO Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 2:160,645,897...160,722,764
Ensembl chr 2:160,645,888...160,722,764
JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions
affects response to substance
ISO TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine
CTD PMID:23747414 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 2:34,941,750...34,961,812
Ensembl chr 2:34,941,750...34,961,772
JBrowse link
G Traf2 TNF receptor-associated factor 2 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 2:25,517,982...25,546,940
Ensembl chr 2:25,517,982...25,546,940
JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions
ISO Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein
CTD PMID:20656010, PMID:26712469 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Tstd1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 increases expression ISO Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr 1:171,419,033...171,420,352
Ensembl chr 1:171,418,872...171,420,352
JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A decreases expression ISO Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:36,874,295...36,884,222
Ensembl chr  X:36,873,900...36,884,222
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr11:51,985,138...52,004,145
Ensembl chr11:51,985,497...52,000,762
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions EXP Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA] CTD PMID:28533128 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr 8:54,077,532...54,186,454
Ensembl chr 8:54,077,606...54,187,096
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21538
    role 21517
      biological role 21516
        inhibitor 19287
          enzyme inhibitor 19203
            EC 2.* (transferase) inhibitor 14258
              EC 2.7.* (P-containing group transferase) inhibitor 13940
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8327
                  EC 2.7.11.10 (IkappaB kinase) inhibitor 221
                    (E)-3-tosylacrylonitrile 0
                    berberine 221
Path 2
Term Annotations click to browse term
  CHEBI ontology 21538
    role 21517
      biological role 21516
        inhibitor 19287
          enzyme inhibitor 19203
            EC 2.* (transferase) inhibitor 14258
              EC 2.7.* (P-containing group transferase) inhibitor 13940
                protein kinase inhibitor 13402
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8327
                    EC 2.7.11.10 (IkappaB kinase) inhibitor 221
                      (E)-3-tosylacrylonitrile 0
                      berberine 221
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.