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Accession:CHEBI:77363 term browser browse the term
Definition:A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
Synonyms:exact_synonym: (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
 related_synonym: Formula=C21H28N2O5;   InChI=1S/C21H28N2O5/c1-13(22-16(20(25)26)11-10-14-6-3-2-4-7-14)19(24)23-17-9-5-8-15(17)12-18(23)21(27)28/h2-4,6-7,13,15-18,22H,5,8-12H2,1H3,(H,25,26)(H,27,28)/t13-,15-,16-,17-,18-/m0/s1;   InChIKey=KEDYTOTWMPBSLG-HILJTLORSA-N;   SMILES=C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N1[C@H]2CCC[C@H]2C[C@H]1C(O)=O;   ramiprilate;   ramiprilatum
 xref: CAS:87269-97-4 "ChemIDplus";   HMDB:HMDB0060579
 xref_mesh: MESH:C052549
 xref: PDBeChem:X92;   PMID:1650863 "Europe PMC";   PMID:19795361 "Europe PMC";   PMID:21147310 "Europe PMC";   PMID:21535409 "Europe PMC";   PMID:21545343 "Europe PMC";   PMID:22022329 "Europe PMC";   PMID:22076778 "Europe PMC";   PMID:23372044 "Europe PMC";   PMID:23591995 "Europe PMC";   PMID:2483427 "Europe PMC";   PMID:2485060 "Europe PMC";   PMID:7768254 "Europe PMC";   PMID:8118952 "Europe PMC";   Patent:EP2277519;   Patent:NZ571901;   Patent:US2011263619;   Reaxys:4212094 "Reaxys"

show annotations for term's descendants       view all columns           Sort by:
ramiprilat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:6480464
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      application 19336
        pharmaceutical 19211
          drug 19211
            protective agent 16345
              cardioprotective agent 1171
                ramiprilat 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        carboacyl group 17074
                                          univalent carboacyl group 17074
                                            carbamoyl group 16804
                                              carboxamide 16804
                                                peptide 9318
                                                  oligopeptide 1076
                                                    dipeptide 255
                                                      ramiprilat 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.