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ONTOLOGY REPORT - ANNOTATIONS


Term:nitroflurbiprofen
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Accession:CHEBI:77428 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2.
Synonyms:exact_synonym: 4-(nitrooxy)butyl 2-(2-fluorobiphenyl-4-yl)propanoate
 related_synonym: 4-(Nitrooxy)butyl 2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetate;   Flurbinitroxybutylester;   Formula=C19H20FNO5;   InChI=1S/C19H20FNO5/c1-14(19(22)25-11-5-6-12-26-21(23)24)16-9-10-17(18(20)13-16)15-7-3-2-4-8-15/h2-4,7-10,13-14H,5-6,11-12H2,1H3;   InChIKey=DLWSRGHNJVLJAH-UHFFFAOYSA-N;   Nitroxybutyl flurbiprofen;   SMILES=C=1C=C(C=CC1)C2=C(F)C=C(C(C(=O)OCCCCO[N+](=O)[O-])C)C=C2
 xref: CAS:158836-71-6
 xref_mesh: MESH:C095631
 xref: PMID:11746392;   PMID:12835894;   PMID:14729123;   PMID:15202730;   PMID:15470334;   PMID:16491094;   PMID:17122968;   PMID:17258737;   PMID:17482436;   PMID:18465650;   PMID:7495106;   PMID:7545516;   PMID:8528547;   PMID:8938015;   PMID:8982652;   PMID:9203938;   PMID:9343749;   PMID:9530274;   PMID:9974120;   Reaxys:8433798


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nitroflurbiprofen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19789
    role 19735
      application 19381
        anti-inflammatory agent 14972
          anti-inflammatory drug 13619
            non-steroidal anti-inflammatory drug 12700
              nitroflurbiprofen 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19789
    subatomic particle 19787
      composite particle 19787
        hadron 19787
          baryon 19787
            nucleon 19787
              atomic nucleus 19787
                atom 19787
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19569
                        carbon atom 19558
                          organic molecular entity 19558
                            organic group 18473
                              organic divalent group 18467
                                organodiyl group 18467
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18038
                                        monocarboxylic acid 17290
                                          fatty acid 15827
                                            saturated fatty acid 15794
                                              propionic acid 3669
                                                flurbiprofen 108
                                                  nitroflurbiprofen 7
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