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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor
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Accession:CHEBI:77758 term browser browse the term
Definition:An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of a 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53).
Synonyms:related_synonym: 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitor;   3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitors;   3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitors;   3',5'-cyclic-AMP phosphodiesterase inhibitor;   3',5'-cyclic-AMP phosphodiesterase inhibitors;   EC 3.1.4.53 inhibitor;   EC 3.1.4.53 inhibitors;   cAMP-specific PDE inhibitor;   cAMP-specific PDE inhibitors;   cAMP-specific phosphodiesterase inhibitor;   cAMP-specific phosphodiesterase inhibitors
 xref: Wikipedia:3'\,5'-cyclic-AMP_phosphodiesterase


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etazolate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:6480464
piclamilast term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Epx eosinophil peroxidase JBrowse link 10 75,160,690 75,171,774 RGD:6480464
roflumilast term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Pde3a phosphodiesterase 3A JBrowse link 4 175,431,904 175,703,844 RGD:6480464
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:6480464
G Pde4a phosphodiesterase 4A JBrowse link 8 22,189,533 22,234,036 RGD:6480464
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:6480464
G Pde4c phosphodiesterase 4C JBrowse link 16 20,442,305 20,466,386 RGD:6480464
G Pde4d phosphodiesterase 4D JBrowse link 2 40,219,999 41,468,551 RGD:6480464
G Pde7a phosphodiesterase 7A JBrowse link 2 104,042,124 104,134,101 RGD:6480464
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:6480464
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
SCH-351591 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amy2a3 amylase 2a3 JBrowse link 2 216,373,674 216,382,260 RGD:6480464
G Ctrl chymotrypsin-like JBrowse link 19 37,905,864 37,907,714 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Dbp D-box binding PAR bZIP transcription factor JBrowse link 1 101,687,896 101,692,845 RGD:6480464
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 JBrowse link 10 86,683,875 86,690,815 RGD:6480464
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 JBrowse link 15 8,730,871 8,757,165 RGD:6480464
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:6480464
G Prss1 serine protease 1 JBrowse link 4 70,776,046 70,779,249 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      biological role 19678
        biochemical role 19177
          enzyme inhibitor 18082
            EC 3.* (hydrolase) inhibitor 17564
              EC 3.1.* (ester hydrolase) inhibitor 12786
                EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 1326
                  EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor 28
                    phosphodiesterase IV inhibitor + 28
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.