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Accession:CHEBI:77829 term browser browse the term
Definition:A racemate comprising (1R,2S)- and (1S,2R)-nortilidine. The synthetic narcotic analgesic tilidine is a prodrug for nortilidine, being metabolised to it in the liver. Virtually all of the opioid analgesic effects of racemic nortilidine, which are comparable to those of morphine, are due to the (1S,2R) enantiomer.
Synonyms:exact_synonym: rac-ethyl (1R,2S)-2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate;   rac-ethyl (1S,2R)-2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate
 related_synonym: (+-)-ethyl trans-2-methylamino-1-phenyl-3-cyclohexene-trans-1-carboxylate;   nortilidine
 xref: CAS:38677-94-0 "ChemIDplus";   PMID:12412825 "Europe PMC";   PMID:18516595 "Europe PMC";   PMID:21140136 "Europe PMC";   PMID:22349139 "Europe PMC";   PMID:22381043 "Europe PMC";   PMID:639277 "Europe PMC";   Reaxys:4145877 "Reaxys";   Wikipedia:Nortilidine

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Term Annotations click to browse term
  CHEBI ontology 19734
    chemical entity 19732
      chemical substance 11495
        mixture 10817
          racemate 9696
            rac-nortilidine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        amino acid 12446
                                          non-proteinogenic amino acid 1733
                                            beta-amino acid 172
                                              beta-amino acid ester 128
                                                ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate 0
                                                  (1S,2R)-nortilidine 0
                                                    rac-nortilidine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.