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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:toxaphene
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Accession:CHEBI:77850 term browser browse the term
Definition:A highly complex mixture of several hundred polychlorinated compounds obtained by chlorination of camphene to an overall chlorine content of 67-69% by weight and having an overall empirical formula of C10H10Cl8 (including optical isomers, it could theoretically contain over 32,000 congeners). Toxaphene was used from the mid-1940s as an agricultural insecticide (mostly in the USA, particularly on corn and soybeans). Use increased with the phasing out of DDT in the 1970s (it became the most heavily manufactured pesticide in the US) but it is now banned due to concerns about toxicity and carcinogenicity. Total production since its first use is estimated at around 500,000 tons. In the environment, most of the components of toxaphene get metabolised, but from 10 to >100 resist biodegradation, depending on the medium and the specialisation of the enzyme system. Breathing, drinking or eating high levels of toxaphene can damage the lungs, kidneys, and nervous system.
Synonyms:related_synonym: Toxaphen;   camphechlor;   camphechlore;   chlorinated camphene;   chlorocamphene;   polychlorocamphene
 xref: CAS:8001-35-2;   KEGG:C15470
 xref_mesh: MESH:D014112
 xref: PMID:11254057;   PMID:15295903;   PMID:20221755;   PMID:21470655;   PMID:21863113;   PMID:22162326;   PMID:22366425;   PMID:22498080;   PMID:23859873;   PMID:23939819;   PMID:24056452;   PMID:24164036;   PMID:24274290;   PMID:385896;   Patent:US2565471;   Reaxys:8188730;   Wikipedia:Toxaphene


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toxaphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 increases expression EXP Toxaphene results in increased expression of AGPAT3 mRNA CTD PMID:23153324 NCBI chr20:11,060,584...11,144,806
Ensembl chr20:11,114,164...11,144,806
JBrowse link
G Ar androgen receptor multiple interactions ISO [DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Toxaphene binds to and results in increased activity of AR protein; Toxaphene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Toxaphene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:10696776, PMID:18324785, PMID:21295777, PMID:26022396 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arl4a ADP-ribosylation factor like GTPase 4A decreases expression EXP Toxaphene results in decreased expression of ARL4A mRNA CTD PMID:23153324 NCBI chr 6:59,945,926...59,950,586
Ensembl chr 6:59,948,577...59,950,586
JBrowse link
G Aurkb aurora kinase B decreases expression EXP Toxaphene results in decreased expression of AURKB mRNA CTD PMID:23153324 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Toxaphene results in increased expression of BRCA1 mRNA CTD PMID:12473173 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Cab39l calcium binding protein 39-like decreases expression EXP Toxaphene results in decreased expression of CAB39L mRNA CTD PMID:23153324 NCBI chr15:39,745,124...39,849,022
Ensembl chr15:39,759,257...39,870,208
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Toxaphene results in increased degradation of GSN protein]; CAT protein inhibits the reaction [Toxaphene results in increased degradation of PXN protein]; CAT protein inhibits the reaction [Toxaphene results in increased degradation of VIM protein] CTD PMID:12139946 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression EXP Toxaphene results in decreased expression of CDCA8 mRNA CTD PMID:23153324 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Toxaphene results in decreased expression of CDKN1A protein CTD PMID:12473173 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cfd complement factor D decreases expression EXP Toxaphene results in decreased expression of CFD mRNA CTD PMID:23153324 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression EXP Toxaphene results in increased expression of COL3A1 mRNA CTD PMID:23153324 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Toxaphene results in decreased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Toxaphene results in increased expression of CYP1A1 mRNA
NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A1 mRNA]
CTD PMID:26187448, PMID:28218408 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Toxaphene results in increased expression of CYP1A2 mRNA
NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A2 mRNA]
CTD PMID:26187448, PMID:28218408 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B10 mRNA] CTD PMID:26187448, PMID:28218408 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B9 mRNA] CTD PMID:28218408 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Toxaphene results in decreased expression of DUSP1 mRNA CTD PMID:23153324 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
increases expression
affects binding
ISO
EXP
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; Toxaphene binds to and results in increased activity of ESR1 protein; Toxaphene inhibits the reaction [Estradiol binds to ESR1 protein]
Toxaphene results in increased activity of ESR1 protein
Toxaphene results in increased expression of ESR1 mRNA
Toxaphene binds to ESR1 protein
CTD PMID:9168004, PMID:9860891, PMID:10774817, PMID:11356845, PMID:14579009, PMID:16626760, PMID:21295777, PMID:26022396 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity
multiple interactions
EXP
ISO
Toxaphene results in increased activity of ESR2 protein
Toxaphene binds to and results in increased activity of ESR2 protein
CTD PMID:9860891, PMID:16626760 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
decreases activity
ISO Toxaphene binds to and results in decreased activity of ESRRA protein; Toxaphene binds to and results in increased activity of ESRRA protein mutant form; Toxaphene inhibits the reaction [NCOA2 protein results in increased activity of ESRRA protein]
Toxaphene results in decreased activity of ESRRA protein
CTD PMID:10493499, PMID:11356845, PMID:11850205, PMID:15955695 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Fmn2 formin 2 affects response to substance ISO FMN2 gene SNP affects the susceptibility to Toxaphene CTD PMID:25622337 NCBI chr13:92,569,256...92,887,302 JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Toxaphene results in decreased expression of GJA1 protein CTD PMID:8820588 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glis2 GLIS family zinc finger 2 decreases expression EXP Toxaphene results in decreased expression of GLIS2 mRNA CTD PMID:23153324 NCBI chr10:11,154,459...11,177,063
Ensembl chr10:11,154,658...11,174,861
JBrowse link
G Gsn gelsolin increases degradation
multiple interactions
ISO Toxaphene results in increased degradation of GSN protein
CAT protein inhibits the reaction [Toxaphene results in increased degradation of GSN protein]
CTD PMID:12139946 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G H2ax H2A.X variant histone decreases expression EXP Toxaphene results in decreased expression of H2AX mRNA CTD PMID:23153324 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 decreases expression EXP Toxaphene results in decreased expression of KBTBD2 mRNA CTD PMID:23153324 NCBI chr 4:87,088,759...87,111,576
Ensembl chr 4:87,088,759...87,111,025
JBrowse link
G Kctd9 potassium channel tetramerization domain containing 9 decreases expression EXP Toxaphene results in decreased expression of KCTD9 mRNA CTD PMID:23153324 NCBI chr15:44,411,591...44,439,645
Ensembl chr15:44,411,865...44,439,236
JBrowse link
G Kif22 kinesin family member 22 decreases expression EXP Toxaphene results in decreased expression of KIF22 mRNA CTD PMID:23153324 NCBI chr 1:198,461,406...198,476,430
Ensembl chr 1:198,461,169...198,476,476
JBrowse link
G Ldha lactate dehydrogenase A increases expression EXP Toxaphene results in increased expression of LDHA protein CTD PMID:1269500 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B increases expression EXP Toxaphene results in increased expression of LDHB protein CTD PMID:1269500 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Ldhc lactate dehydrogenase C increases expression EXP Toxaphene results in increased expression of LDHC protein CTD PMID:1269500 NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
JBrowse link
G Ldhd lactate dehydrogenase D decreases expression EXP Toxaphene results in decreased expression of LDHD protein CTD PMID:1269500 NCBI chr19:43,826,989...43,848,937
Ensembl chr19:43,826,993...43,848,937
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component increases expression EXP Toxaphene results in increased expression of LIN7C mRNA CTD PMID:23153324 NCBI chr 3:101,010,923...101,018,235
Ensembl chr 3:101,010,899...101,018,433
JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 increases expression EXP Toxaphene results in increased expression of LRIG3 mRNA CTD PMID:23153324 NCBI chr 7:69,213,098...69,263,251
Ensembl chr 7:69,213,147...69,263,142
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [NR1I2 gene mutant form affects the susceptibility to Toxaphene] which results in increased expression of MYC mRNA CTD PMID:28218408 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Toxaphene inhibits the reaction [NCOA2 protein results in increased activity of ESRRA protein] CTD PMID:10493499 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nnmt nicotinamide N-methyltransferase decreases expression EXP Toxaphene results in decreased expression of NNMT mRNA CTD PMID:23153324 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Toxaphene results in increased activity of NR1I2 protein
[NR1I2 gene mutant form affects the susceptibility to Toxaphene] which results in increased expression of MYC mRNA
CTD PMID:16565514, PMID:25680588, PMID:28218408 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
multiple interactions
ISO NR1I3 gene affects the susceptibility to Toxaphene
NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A2 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B9 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP3A11 mRNA]
CTD PMID:26187448, PMID:28218408 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
affects binding
ISO
EXP
Toxaphene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Toxaphene inhibits the reaction [Progesterone binds to PGR protein]
Toxaphene results in increased expression of PGR mRNA
Toxaphene binds to PGR protein
CTD PMID:10774817, PMID:14579009, PMID:26022396 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Prl prolactin increases expression EXP Toxaphene results in increased expression of PRL mRNA CTD PMID:12804517 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Pxn paxillin multiple interactions
increases degradation
ISO CAT protein inhibits the reaction [Toxaphene results in increased degradation of PXN protein] CTD PMID:12139946 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Pygb glycogen phosphorylase B decreases expression EXP Toxaphene results in decreased expression of PYGB mRNA CTD PMID:23153324 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Rab34 RAB34, member RAS oncogene family decreases expression EXP Toxaphene results in decreased expression of RAB34 mRNA CTD PMID:23153324 NCBI chr10:65,448,111...65,452,178
Ensembl chr10:65,448,950...65,452,177
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Toxaphene results in decreased expression of RB1 protein CTD PMID:10048758 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Sema3c semaphorin 3C decreases expression EXP Toxaphene results in decreased expression of SEMA3C mRNA CTD PMID:23153324 NCBI chr 4:14,318,276...14,490,438
Ensembl chr 4:14,318,274...14,490,446
JBrowse link
G Sesn3 sestrin 3 increases expression EXP Toxaphene results in increased expression of SESN3 mRNA CTD PMID:23153324 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
G Slc10a7 solute carrier family 10, member 7 increases expression EXP Toxaphene results in increased expression of SLC10A7 mRNA CTD PMID:23153324 NCBI chr19:32,857,984...33,081,359
Ensembl chr19:32,855,343...33,080,998
JBrowse link
G Slmap sarcolemma associated protein decreases expression EXP Toxaphene results in decreased expression of SLMAP mRNA CTD PMID:23153324 NCBI chr16:2,112,271...2,227,336
Ensembl chr16:2,112,274...2,227,309
JBrowse link
G Tbc1d13 TBC1 domain family, member 13 increases expression EXP Toxaphene results in increased expression of TBC1D13 mRNA CTD PMID:23153324 NCBI chr 3:8,701,849...8,718,400
Ensembl chr 3:8,701,855...8,717,515
JBrowse link
G Tenm2 teneurin transmembrane protein 2 affects response to substance ISO TENM2 gene SNP affects the susceptibility to Toxaphene CTD PMID:25622337 NCBI chr10:20,846,091...21,791,771
Ensembl chr10:20,844,899...21,265,026
JBrowse link
G Tff1 trefoil factor 1 decreases expression
increases expression
decreases secretion
ISO Toxaphene results in decreased expression of TFF1 mRNA
Toxaphene results in increased expression of TFF1 mRNA
Toxaphene results in decreased secretion of TFF1 protein
CTD PMID:9276643, PMID:12473173 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tmem63a transmembrane protein 63a increases expression EXP Toxaphene results in increased expression of TMEM63A mRNA CTD PMID:23153324 NCBI chr13:99,219,585...99,253,176
Ensembl chr13:99,220,510...99,253,316
JBrowse link
G Trim29 tripartite motif-containing 29 decreases expression EXP Toxaphene results in decreased expression of TRIM29 mRNA CTD PMID:23153324 NCBI chr 8:47,674,321...47,699,065
Ensembl chr 8:47,674,321...47,699,065
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression EXP Toxaphene results in increased expression of TSHB protein CTD PMID:8933632 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression EXP Toxaphene results in decreased expression of TUBB6 mRNA CTD PMID:23153324 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Ube4b ubiquitination factor E4B increases expression EXP Toxaphene results in increased expression of UBE4B mRNA CTD PMID:23153324 NCBI chr 5:166,156,033...166,259,069
Ensembl chr 5:166,156,033...166,259,069
JBrowse link
G Upb1 beta-ureidopropionase 1 affects response to substance ISO UPB1 gene SNP affects the susceptibility to Toxaphene CTD PMID:25622337 NCBI chr20:14,167,383...14,193,724
Ensembl chr20:14,167,586...14,193,690
JBrowse link
G Vim vimentin increases degradation
multiple interactions
ISO Toxaphene results in increased degradation of VIM protein
CAT protein inhibits the reaction [Toxaphene results in increased degradation of VIM protein]
CTD PMID:12139946 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 decreases expression EXP Toxaphene results in decreased expression of WSB1 mRNA CTD PMID:23153324 NCBI chr10:66,586,905...66,602,984
Ensembl chr10:66,586,924...66,602,987
JBrowse link
G Zfp36 zinc finger protein 36 decreases expression EXP Toxaphene results in decreased expression of ZFP36 mRNA CTD PMID:23153324 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
G Zfyve1 zinc finger FYVE-type containing 1 increases expression EXP Toxaphene results in increased expression of ZFYVE1 mRNA CTD PMID:23153324 NCBI chr 6:107,031,411...107,080,590
Ensembl chr 6:107,031,412...107,080,524
JBrowse link
G Zfyve26 zinc finger FYVE-type containing 26 increases expression EXP Toxaphene results in increased expression of ZFYVE26 mRNA CTD PMID:23153324 NCBI chr 6:102,409,235...102,472,962
Ensembl chr 6:102,409,881...102,472,926
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        agrochemical 14499
          toxaphene 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pesticide 16430
          acaricide 9730
            toxaphene 63
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.