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ONTOLOGY REPORT - ANNOTATIONS


Term:toxaphene
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Accession:CHEBI:77850 term browser browse the term
Definition:A highly complex mixture of several hundred polychlorinated compounds obtained by chlorination of camphene to an overall chlorine content of 67-69% by weight and having an overall empirical formula of C10H10Cl8 (including optical isomers, it could theoretically contain over 32,000 congeners). Toxaphene was used from the mid-1940s as an agricultural insecticide (mostly in the USA, particularly on corn and soybeans). Use increased with the phasing out of DDT in the 1970s (it became the most heavily manufactured pesticide in the US) but it is now banned due to concerns about toxicity and carcinogenicity. Total production since its first use is estimated at around 500,000 tons. In the environment, most of the components of toxaphene get metabolised, but from 10 to >100 resist biodegradation, depending on the medium and the specialisation of the enzyme system. Breathing, drinking or eating high levels of toxaphene can damage the lungs, kidneys, and nervous system.
Synonyms:related_synonym: Toxaphen;   camphechlor;   camphechlore;   chlorinated camphene;   chlorocamphene;   polychlorocamphene
 xref: CAS:8001-35-2 "ChemIDplus";   CAS:8001-35-2 "KEGG COMPOUND";   KEGG:C15470
 xref_mesh: MESH:D014112
 xref: PMID:11254057 "Europe PMC";   PMID:15295903 "Europe PMC";   PMID:20221755 "Europe PMC";   PMID:21470655 "Europe PMC";   PMID:21863113 "Europe PMC";   PMID:22162326 "Europe PMC";   PMID:22366425 "Europe PMC";   PMID:22498080 "Europe PMC";   PMID:23859873 "Europe PMC";   PMID:23939819 "Europe PMC";   PMID:24056452 "Europe PMC";   PMID:24164036 "Europe PMC";   PMID:24274290 "Europe PMC";   PMID:385896 "Europe PMC";   Patent:US2565471;   Reaxys:8188730 "Reaxys";   Wikipedia:Toxaphene


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toxaphene term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 JBrowse link 20 11,060,584 11,144,806 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Arl4a ADP-ribosylation factor like GTPase 4A JBrowse link 6 59,945,926 59,950,586 RGD:6480464
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:6480464
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:6480464
G Cab39l calcium binding protein 39-like JBrowse link 15 39,745,124 39,849,022 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cdca8 cell division cycle associated 8 JBrowse link 5 142,911,310 142,933,536 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cfd complement factor D JBrowse link 7 12,634,216 12,635,939 RGD:6480464
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Esrra estrogen related receptor, alpha JBrowse link 1 222,168,729 222,178,842 RGD:6480464
G Fmn2 formin 2 JBrowse link 13 92,569,256 92,887,302 RGD:6480464
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:6480464
G Glis2 GLIS family zinc finger 2 JBrowse link 10 11,154,459 11,177,063 RGD:6480464
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:6480464
G Kbtbd2 kelch repeat and BTB domain containing 2 JBrowse link 4 87,088,759 87,111,576 RGD:6480464
G Kctd9 potassium channel tetramerization domain containing 9 JBrowse link 15 44,411,591 44,439,645 RGD:6480464
G Kif22 kinesin family member 22 JBrowse link 1 198,461,406 198,476,430 RGD:6480464
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6480464
G Ldhb lactate dehydrogenase B JBrowse link 4 176,701,980 176,719,999 RGD:6480464
G Ldhc lactate dehydrogenase C JBrowse link 1 102,914,875 102,931,843 RGD:6480464
G Ldhd lactate dehydrogenase D JBrowse link 19 43,826,989 43,848,937 RGD:6480464
G Lin7c lin-7 homolog C, crumbs cell polarity complex component JBrowse link 3 101,010,923 101,018,235 RGD:6480464
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 JBrowse link 7 69,213,098 69,263,251 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:6480464
G Nnmt nicotinamide N-methyltransferase JBrowse link 8 52,918,437 52,938,172 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6480464
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:6480464
G Rab34 RAB34, member RAS oncogene family JBrowse link 10 65,448,111 65,452,178 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Sema3c semaphorin 3C JBrowse link 4 14,318,276 14,490,438 RGD:6480464
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:6480464
G Slc10a7 solute carrier family 10, member 7 JBrowse link 19 32,857,984 33,081,359 RGD:6480464
G Slmap sarcolemma associated protein JBrowse link 16 2,112,271 2,227,336 RGD:6480464
G Tbc1d13 TBC1 domain family, member 13 JBrowse link 3 8,701,849 8,718,400 RGD:6480464
G Tenm2 teneurin transmembrane protein 2 JBrowse link 10 20,846,091 21,791,771 RGD:6480464
G Tff1 trefoil factor 1 JBrowse link 20 9,892,124 9,895,984 RGD:6480464
G Tmem63a transmembrane protein 63a JBrowse link 13 99,219,585 99,253,176 RGD:6480464
G Trim29 tripartite motif-containing 29 JBrowse link 8 47,674,321 47,699,065 RGD:6480464
G Tshb thyroid stimulating hormone subunit beta JBrowse link 2 205,207,799 205,215,199 RGD:6480464
G Tubb6 tubulin, beta 6 class V JBrowse link 18 63,130,542 63,140,181 RGD:6480464
G Ube4b ubiquitination factor E4B JBrowse link 5 166,156,033 166,259,069 RGD:6480464
G Upb1 beta-ureidopropionase 1 JBrowse link 20 14,167,383 14,193,724 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Wsb1 WD repeat and SOCS box-containing 1 JBrowse link 10 66,586,905 66,602,984 RGD:6480464
G Zfp36 zinc finger protein 36 JBrowse link 1 85,380,088 85,382,565 RGD:6480464
G Zfyve1 zinc finger FYVE-type containing 1 JBrowse link 6 107,031,411 107,080,590 RGD:6480464
G Zfyve26 zinc finger FYVE-type containing 26 JBrowse link 6 102,409,235 102,472,962 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        agrochemical 13335
          toxaphene 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pesticide 15811
          acaricide 8870
            toxaphene 62
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.