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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron dextran
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Accession:CHEBI:78291 term browser browse the term
Definition:Please consider adding concept for iron dextran. CAS# 9004-66-4. Thank you.
Synonyms:related_synonym: Iron dextran complex
 xref: CAS:9004-66-4;   KEGG:C13774;   KEGG:D02141
 xref_mesh: MESH:D007505


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iron dextran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; GW 6471 inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; tin protoporphyrin IX promotes the reaction [Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]] CTD PMID:20709802 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Iron-Dextran Complex affects the reaction [AHR affects the susceptibility to Tetrachlorodibenzodioxin] CTD PMID:9443932 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; [pirinixic acid results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Iron-Dextran Complex results in decreased expression of BGLAP mRNA CTD PMID:29122540 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions
affects expression
ISO Diltiazem inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]; Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; [pirinixic acid results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; GW 6471 inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; tin protoporphyrin IX inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]] CTD PMID:20709802 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases expression
decreases activity
increases activity
ISO
EXP
Iron-Dextran Complex promotes the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [mezerein results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
Iron-Dextran Complex results in increased expression of CAT protein
Iron-Dextran Complex results in decreased activity of CAT protein
Iron-Dextran Complex results in increased activity of CAT protein
CTD PMID:12065085, PMID:24120471, PMID:28700905 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO Iron-Dextran Complex results in increased expression of COL1A1 protein
Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]
CTD PMID:27095094 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression EXP Iron-Dextran Complex results in increased expression of CYBA protein CTD PMID:15086920 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP Iron-Dextran Complex results in increased expression of CYBB protein CTD PMID:28700905, PMID:29990562 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO Iron-Dextran Complex inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Iron-Dextran Complex results in decreased activity of CYP1A1 protein
CTD PMID:9443932 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Iron-Dextran Complex inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Iron-Dextran Complex results in decreased activity of CYP1A2 protein
CTD PMID:9443932 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression
ISO Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein] CTD PMID:27095094 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression
ISO [Iron-Dextran Complex co-treated with Tetrachlorodibenzodioxin] results in increased expression of GSTM1 protein
Iron-Dextran Complex results in increased expression of GSTM1 protein
CTD PMID:9443932 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
increases expression
ISO Diltiazem promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]; Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]; Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] CTD PMID:27095094 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]; tin protoporphyrin IX promotes the reaction [Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]]
Iron-Dextran Complex results in increased expression of HMOX1 mRNA; Iron-Dextran Complex results in increased expression of HMOX1 protein
CTD PMID:20709802, PMID:23525258 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il6 interleukin 6 increases expression EXP Iron-Dextran Complex results in increased expression of IL6 mRNA CTD PMID:29122540 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Iron-Dextran Complex results in increased phosphorylation of MAPK1 protein CTD PMID:28700905 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP Iron-Dextran Complex results in increased phosphorylation of MAPK3 protein CTD PMID:28700905 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Iron-Dextran Complex results in increased expression of NOS2 protein CTD PMID:28700905 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Iron-Dextran Complex results in increased expression of and results in increased phosphorylation of NOS3 protein CTD PMID:29990562 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity
ISO Iron-Dextran Complex promotes the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [Hydrogen Peroxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [mezerein results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
Iron-Dextran Complex results in increased activity of ODC1 protein
CTD PMID:12065085 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
increases expression
ISO Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein] CTD PMID:27095094 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Iron-Dextran Complex results in increased expression of SOD1 protein CTD PMID:29990562 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Iron-Dextran Complex results in decreased expression of SOD2 protein CTD PMID:28700905 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tfr2 transferrin receptor 2 increases expression ISO Iron-Dextran Complex results in increased expression of TFR2 protein CTD PMID:27095094 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion EXP Iron-Dextran Complex results in increased secretion of TGFB1 protein CTD PMID:23525258 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Iron-Dextran Complex results in decreased expression of TNFRSF11B mRNA CTD PMID:29122540 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression EXP Iron-Dextran Complex results in increased expression of TNFSF11 mRNA CTD PMID:29122540 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO Iron-Dextran Complex promotes the reaction [Tetrachlorodibenzodioxin results in decreased activity of UROD protein] CTD PMID:9443932 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              iron dextran 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            iron dextran 30
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.