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ONTOLOGY REPORT - ANNOTATIONS


Term:CZC-25146
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Accession:CHEBI:78414 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(morpholin-4-yl)phenyl and 2-(methanesulfonylamino)phenyl substituents. It is an inhibitor of the Parkinson's disease kinase LRRK2.
Synonyms:exact_synonym: N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide
 related_synonym: Formula=C22H25ClN6O4S;   InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);   InChIKey=CLGWUCNXOBLWFM-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
 xref: PMID:21812418 "SUBMITTER";   PMID:24725412 "SUBMITTER";   Reaxys:19687577 "Reaxys"


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  CHEBI ontology 0
    role 0
      application 0
        refrigerant 0
          ammonia 0
            organic amino compound 0
              secondary amino compound 0
                CZC-25146 0
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  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    main group molecular entity 0
                      s-block molecular entity 0
                        hydrogen molecular entity 0
                          hydrides 0
                            inorganic hydride 0
                              pnictogen hydride 0
                                nitrogen hydride 0
                                  azane 0
                                    ammonia 0
                                      organic amino compound 0
                                        aromatic amine 0
                                          aminopyrimidine 0
                                            CZC-25146 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.