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ONTOLOGY REPORT - ANNOTATIONS


Term:CZC-25146
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Accession:CHEBI:78414 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(morpholin-4-yl)phenyl and 2-(methanesulfonylamino)phenyl substituents. It is an inhibitor of the Parkinson's disease kinase LRRK2.
Synonyms:exact_synonym: N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide
 related_synonym: Formula=C22H25ClN6O4S;   InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);   InChIKey=CLGWUCNXOBLWFM-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
 xref: PMID:21812418 "SUBMITTER";   PMID:24725412 "SUBMITTER";   Reaxys:19687577 "Reaxys"


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  CHEBI ontology 225
    role 225
      application 191
        refrigerant 69
          ammonia 69
            organic amino compound 69
              secondary amino compound 24
                CZC-25146 0
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  CHEBI ontology 225
    subatomic particle 225
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                  main group element atom 218
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                          hydrides 113
                            inorganic hydride 75
                              pnictogen hydride 74
                                nitrogen hydride 74
                                  azane 69
                                    ammonia 69
                                      organic amino compound 69
                                        aromatic amine 30
                                          aminopyrimidine 1
                                            CZC-25146 0
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