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Accession:CHEBI:78414 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(morpholin-4-yl)phenyl and 2-(methanesulfonylamino)phenyl substituents. It is an inhibitor of the Parkinson's disease kinase LRRK2.
Synonyms:exact_synonym: N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide
 related_synonym: Formula=C22H25ClN6O4S;   InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);   InChIKey=CLGWUCNXOBLWFM-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
 xref: PMID:21812418 "SUBMITTER";   PMID:24725412 "SUBMITTER";   Reaxys:19687577 "Reaxys"

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  CHEBI ontology 21038
    role 21018
      application 20451
        refrigerant 17606
          ammonia 17221
            organic amino compound 17220
              secondary amino compound 6437
                CZC-25146 0
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    subatomic particle 21032
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              atomic nucleus 21032
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                  main group element atom 20874
                    main group molecular entity 20874
                      s-block molecular entity 20359
                        hydrogen molecular entity 20267
                          hydrides 19091
                            inorganic hydride 17587
                              pnictogen hydride 17538
                                nitrogen hydride 17354
                                  azane 17224
                                    ammonia 17221
                                      organic amino compound 17220
                                        aromatic amine 14019
                                          aminopyrimidine 1073
                                            CZC-25146 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.