Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:78414 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(morpholin-4-yl)phenyl and 2-(methanesulfonylamino)phenyl substituents. It is an inhibitor of the Parkinson's disease kinase LRRK2.
Synonyms:exact_synonym: N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide
 related_synonym: Formula=C22H25ClN6O4S;   InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);   InChIKey=CLGWUCNXOBLWFM-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
 xref: PMID:21812418 "SUBMITTER";   PMID:24725412 "SUBMITTER";   Reaxys:19687577 "Reaxys"

show annotations for term's descendants       view all columns           Sort by:

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 829
    role 806
      application 437
        refrigerant 193
          ammonia 192
            organic amino compound 192
              secondary amino compound 25
                CZC-25146 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 829
    subatomic particle 813
      composite particle 813
        hadron 813
          baryon 813
            nucleon 813
              atomic nucleus 813
                atom 813
                  main group element atom 801
                    main group molecular entity 799
                      s-block molecular entity 680
                        hydrogen molecular entity 673
                          hydrides 310
                            inorganic hydride 203
                              pnictogen hydride 199
                                nitrogen hydride 199
                                  azane 192
                                    ammonia 192
                                      organic amino compound 192
                                        aromatic amine 24
                                          aminopyrimidine 0
                                            CZC-25146 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.