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ONTOLOGY REPORT - ANNOTATIONS


Term:CZC-25146
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Accession:CHEBI:78414 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(morpholin-4-yl)phenyl and 2-(methanesulfonylamino)phenyl substituents. It is an inhibitor of the Parkinson's disease kinase LRRK2.
Synonyms:exact_synonym: N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide
 related_synonym: Formula=C22H25ClN6O4S;   InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);   InChIKey=CLGWUCNXOBLWFM-UHFFFAOYSA-N;   SMILES=COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
 xref: PMID:21812418 "SUBMITTER";   PMID:24725412 "SUBMITTER";   Reaxys:19687577 "Reaxys"


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  CHEBI ontology 19734
    role 19680
      application 19336
        refrigerant 17097
          ammonia 16696
            organic amino compound 16695
              secondary amino compound 6383
                CZC-25146 0
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  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    main group molecular entity 19614
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18289
                            inorganic hydride 17210
                              pnictogen hydride 17172
                                nitrogen hydride 17008
                                  azane 16699
                                    ammonia 16696
                                      organic amino compound 16695
                                        aromatic amine 13604
                                          aminopyrimidine 1051
                                            CZC-25146 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.