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ONTOLOGY REPORT - ANNOTATIONS


Term:ceritinib
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Accession:CHEBI:78432 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.
Synonyms:exact_synonym: 5-chloro-N(2)-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N(4)-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
 related_synonym: Formula=C28H36ClN5O3S;   InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34);   InChIKey=VERWOWGGCGHDQE-UHFFFAOYSA-N;   SMILES=N=1C(=NC(=C(C1)Cl)NC=2C(=CC=CC2)S(C(C)C)(=O)=O)NC=3C=C(C(=CC3OC(C)C)C4CCNCC4)C;   ZYKADIA;   ceritinibum
 xref: CAS:1032900-25-6 "ChemIDplus";   Drug_Central:4866 "DrugCentral";   LINCS:LSM-36374
 xref_mesh: MESH:C586847
 xref: PMID:24670165 "Europe PMC";   PMID:24675041 "Europe PMC";   PMID:24789171 "Europe PMC";   PMID:24856155 "Europe PMC";   PMID:24891360 "Europe PMC";   PMID:24963575 "Europe PMC";   PMID:24963576 "Europe PMC";   PMID:24980964 "Europe PMC";   PMID:24984564 "Europe PMC";   PMID:24998601 "Europe PMC";   PMID:25002599 "Europe PMC";   Reaxys:18383989 "Reaxys";   Wikipedia:Ceritinib


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ceritinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pharmaceutical 19081
          drug 19081
            antineoplastic agent 16550
              ceritinib 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        aromatic amine 13576
                                          aminopyrimidine 1042
                                            ceritinib 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.