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Accession:CHEBI:78510 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Synonyms:exact_synonym: 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
 related_synonym: Formula=C24H25N5O;   InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2;   InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N;   SMILES=C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1;   compound C
 alt_id: MESH:C516138
 xref: CAS:866405-64-3 "ChemIDplus";   DrugBank:DB08597;   LINCS:LSM-3207
 xref_mesh: MESH:C516138
 xref: PDBeChem:TAK;   PMID:18026094 "Europe PMC";   PMID:18682835 "Europe PMC";   PMID:19996563 "Europe PMC";   PMID:20691279 "Europe PMC";   PMID:21384475 "Europe PMC";   PMID:21543851 "Europe PMC";   PMID:21988724 "Europe PMC";   PMID:23526253 "Europe PMC";   PMID:23936500 "Europe PMC";   PMID:24280125 "Europe PMC";   PMID:24396733 "Europe PMC";   Reaxys:11725482 "Reaxys"

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  CHEBI ontology 23760
    role 23649
      biological role 23612
        pharmacological role 20970
          antagonist 17232
            bone morphogenetic protein receptor antagonist 6082
              dorsomorphin 6082
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  CHEBI ontology 23760
    subatomic particle 23709
      composite particle 23709
        hadron 23709
          baryon 23709
            nucleon 23709
              atomic nucleus 23709
                atom 23709
                  main group element atom 23528
                    p-block element atom 23528
                      carbon group element atom 23239
                        carbon atom 23216
                          organic molecular entity 23216
                            organic molecule 23078
                              organic cyclic compound 22095
                                organic heterocyclic compound 20732
                                  organic heteropolycyclic compound 19854
                                    organic heterobicyclic compound 17258
                                      pyrazolopyrimidine 6119
                                        dorsomorphin 6082
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.