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ONTOLOGY REPORT - ANNOTATIONS


Term:dorsomorphin
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Accession:CHEBI:78510 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Synonyms:exact_synonym: 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
 related_synonym: Formula=C24H25N5O;   InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2;   InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N;   SMILES=C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1;   compound C
 alt_id: MESH:C516138
 xref: CAS:866405-64-3 "ChemIDplus";   DrugBank:DB08597;   LINCS:LSM-3207
 xref_mesh: MESH:C516138
 xref: PDBeChem:TAK;   PMID:18026094 "Europe PMC";   PMID:18682835 "Europe PMC";   PMID:19996563 "Europe PMC";   PMID:20691279 "Europe PMC";   PMID:21384475 "Europe PMC";   PMID:21543851 "Europe PMC";   PMID:21988724 "Europe PMC";   PMID:23526253 "Europe PMC";   PMID:23936500 "Europe PMC";   PMID:24280125 "Europe PMC";   PMID:24396733 "Europe PMC";   Reaxys:11725482 "Reaxys"


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        pharmacological role 18687
          antagonist 15809
            bone morphogenetic protein receptor antagonist 5639
              dorsomorphin 5639
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organic heteropolycyclic compound 17427
                                    organic heterobicyclic compound 15905
                                      pyrazolopyrimidine 5674
                                        dorsomorphin 5639
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.