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Accession:CHEBI:78538 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Synonyms:exact_synonym: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
 related_synonym: 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid;   Formula=C14H7Cl2NO3;   Fx-1006;   InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19);   InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1;   tafamidisum
 xref: CAS:594839-88-0 "ChemIDplus";   CAS:594839-88-0 "KEGG DRUG";   Drug_Central:4192 "DrugCentral";   KEGG:D09673
 xref_mesh: MESH:C547076
 xref: PDBeChem:3MI;   PMID:22378262 "Europe PMC";   PMID:22645360 "Europe PMC";   PMID:22645721 "Europe PMC";   PMID:22843282 "Europe PMC";   PMID:23569001 "Europe PMC";   PMID:23834402 "Europe PMC";   PMID:23974642 "Europe PMC";   PMID:24000164 "Europe PMC";   PMID:24101373 "Europe PMC";   PMID:24749898 "Europe PMC";   PMID:24998820 "Europe PMC";   PMID:24998822 "Europe PMC";   PMID:24998826 "Europe PMC";   PMID:25003808 "Europe PMC";   PMID:25022953 "Europe PMC";   Patent:WO2011131661;   Patent:WO2013060668;   Reaxys:9496624 "Reaxys";   Wikipedia:Tafamidis
 cyclic_relationship: is_conjugate_acid_of CHEBI:79344

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tafamidis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:6480464

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  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          drug 19179
            central nervous system drug 16385
              tafamidis 1
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  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                carbocyclic compound 17533
                                  benzenoid aromatic compound 17061
                                    benzenes 16782
                                      chlorobenzenes 12678
                                        dichlorobenzene 9743
                                          tafamidis 1
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