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Accession:CHEBI:7862 term browser browse the term
Definition:A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.
Synonyms:exact_synonym: 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
 related_synonym: 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline;   3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol;   6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol;   6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol;   Formula=C16H24N2O;   InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18);   InChIKey=WYWIFABBXFUGLM-UHFFFAOYSA-N;   SMILES=Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C;   oxymetazolina;   oxymetazolinum
 xref: CAS:1491-59-4 "KEGG COMPOUND";   CAS:1491-59-4 "NIST Chemistry WebBook";   DrugBank:DB00935;   Drug_Central:2032 "DrugCentral";   HMDB:HMDB0015070;   KEGG:C07363;   KEGG:D08322;   LINCS:LSM-2353
 xref_mesh: MESH:D010109
 xref: PMID:10487000 "Europe PMC";   PMID:21177487 "Europe PMC";   PMID:23679077 "Europe PMC";   PMID:23988443 "Europe PMC";   PMID:4003266 "Europe PMC";   Patent:DE1117588;   Reaxys:886303 "Reaxys";   Wikipedia:Oxymetazoline
 cyclic_relationship: is_conjugate_base_of CHEBI:77716

show annotations for term's descendants       view all columns           Sort by:
oxymetazoline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:6480464
G Adra1d adrenoceptor alpha 1D JBrowse link 3 124,129,558 124,145,566 RGD:6480464
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:6480464
G Adra2b adrenoceptor alpha 2B JBrowse link 3 119,805,941 119,809,987 RGD:6480464
G Adra2c adrenoceptor alpha 2C JBrowse link 14 80,730,307 80,732,010 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            nasal decongestant 550
              oxymetazoline 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic molecule 19431
                              organic cyclic compound 19197
                                organic heterocyclic compound 18267
                                  organic heteromonocyclic compound 16348
                                    diazoline 68
                                      imidazolines 68
                                        oxymetazoline 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.