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Accession:CHEBI:79090 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-activated protein kinase (MAPK) alpha and beta.
Synonyms:exact_synonym: 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
 related_synonym: 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole;   Formula=C20H14FN3O;   InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24);   InChIKey=QHKYPYXTTXKZST-UHFFFAOYSA-N;   SB202190;   SMILES=Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
 xref: CAS:152121-30-7 "ChemIDplus";   PMID:11040446 "Europe PMC";   PMID:16183336 "Europe PMC";   PMID:18995898 "Europe PMC";   PMID:21853067 "Europe PMC";   PMID:22253611 "Europe PMC";   PMID:22986232 "Europe PMC";   PMID:24455679 "Europe PMC";   PMID:9632706 "Europe PMC";   PMID:9738669 "Europe PMC";   Reaxys:10467168 "Reaxys"

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.