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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
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Accession:CHEBI:79091 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
Synonyms:related_synonym: ATP:protein phosphotransferase (MAPKK-activated) inhibitor;   ATP:protein phosphotransferase (MAPKK-activated) inhibitors;   Dp38 inhibitor;   Dp38 inhibitors;   EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors;   EC 2.7.11.24 inhibitor;   EC 2.7.11.24 inhibitors;   ERK inhibitor;   ERK inhibitors;   ERK1 inhibitor;   ERK1 inhibitors;   ERK2 inhibitor;   ERK2 inhibitors;   JNK inhibitor;   JNK inhibitors;   JNK3alpha1 inhibitor;   JNK3alpha1 inhibitors;   LeMPK3 inhibitor;   LeMPK3 inhibitors;   MAP kinase inhibitor;   MAP kinase inhibitors;   MAP-2 kinase inhibitor;   MAP-2 kinase inhibitors;   MAPK inhibitor;   MAPK inhibitors;   MBP kinase I inhibitor;   MBP kinase I inhibitors;   MBP kinase II inhibitor;   MBP kinase II inhibitors;   MEK inhibitor;   MEK inhibitors;   PMK-1 inhibitor;   PMK-1 inhibitors;   PMK-2 inhibitor;   PMK-2 inhibitors;   PMK-3 inhibitor;   PMK-3 inhibitors;   SAPK inhibitor;   SAPK inhibitors;   STK26 inhibitor;   STK26 inhibitors;   c-Jun N-terminal kinase inhibitor;   c-Jun N-terminal kinase inhibitors;   extracellular signal-regulated kinase inhibitor;   extracellular signal-regulated kinase inhibitors;   microtubule-associated protein 2 kinase inhibitor;   microtubule-associated protein 2 kinase inhibitors;   microtubule-associated protein kinase inhibitor;   microtubule-associated protein kinase inhibitors;   mitogen-activated protein kinase inhibitor;   mitogen-activated protein kinase inhibitors;   myelin basic protein kinase inhibitor;   myelin basic protein kinase inhibitors;   p38-2 inhibitor;   p38-2 inhibitors;   p38delta inhibitor;   p38delta inhibitors;   p42 mitogen-activated protein kinase inhibitor;   p42 mitogen-activated protein kinase inhibitors;   p42(mapk) inhibitor;   p42(mapk) inhibitors;   p44mpk inhibitor;   p44mpk inhibitors;   pp42 inhibitor;   pp42 inhibitors;   pp44(mapk) inhibitor;   pp44(mapk) inhibitors;   stress-activated protein kinase inhibitor;   stress-activated protein kinase inhibitors
 alt_id: CHEBI:75997
 xref: Wikipedia:MEK_inhibitor;   Wikipedia:Mitogen-activated_protein_kinase


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anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] CTD PMID:23816505 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] CTD PMID:23816505 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      biological role 227
        inhibitor 113
          enzyme inhibitor 107
            EC 2.* (transferase) inhibitor 25
              EC 2.7.* (P-containing group transferase) inhibitor 20
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10
                  EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor 5
                    1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea 0
                    2-(2-amino-3-methoxyphenyl)chromen-4-one 0
                    3-fluoro-5-morpholin-4-yl-N-[1-(2-pyridin-4-ylethyl)-1H-indol-6-yl]benzamide 0
                    4-methyl-N-[3-(morpholin-4-yl)phenyl]-3-[3-(piperidin-4-yl)-1,2-benzoxazol-6-yl]benzamide 0
                    4-phenoxy-N-(pyridin-2-ylmethyl)benzamide 0
                    9-(4-hydroxyphenyl)-2,7-phenanthroline 0
                    CH5126766 0
                    G-573 0
                    N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 0
                    N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide 0
                    N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide 0
                    N-cyclopropyl-3-\{4-[(cyclopropylmethyl)carbamoyl]phenyl\}-4-methylbenzamide 0
                    N-cyclopropyl-3-\{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydropyrazolo[3,4-b]pyridin-4-yl]amino\}-4-methylbenzamide 0
                    PH 797804 0
                    RO4927350 0
                    SB 203580 0
                    SB-202190 0
                    SB-239063 0
                    SB-245391 0
                    SB-284851-BT 0
                    SB220025 0
                    U0126 + 0
                    U0126.EtOH 0
                    VX-745 0
                    auraptene 0
                    binimetinib 0
                    c-Jun N-terminal kinase inhibitor + 5
                    cercosporamide 0
                    cobimetinib 0
                    cobimetinib fumarate 0
                    doramapimod 0
                    hypothemycin 0
                    pamapimod 0
                    selumetinib 0
                    talmapimod 0
                    trametinib + 0
                    trametinib dimethyl sulfoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      biological role 227
        inhibitor 113
          enzyme inhibitor 107
            EC 2.* (transferase) inhibitor 25
              EC 2.7.* (P-containing group transferase) inhibitor 20
                protein kinase inhibitor 13
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10
                    EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor 5
                      1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea 0
                      2-(2-amino-3-methoxyphenyl)chromen-4-one 0
                      3-fluoro-5-morpholin-4-yl-N-[1-(2-pyridin-4-ylethyl)-1H-indol-6-yl]benzamide 0
                      4-methyl-N-[3-(morpholin-4-yl)phenyl]-3-[3-(piperidin-4-yl)-1,2-benzoxazol-6-yl]benzamide 0
                      4-phenoxy-N-(pyridin-2-ylmethyl)benzamide 0
                      9-(4-hydroxyphenyl)-2,7-phenanthroline 0
                      CH5126766 0
                      G-573 0
                      N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 0
                      N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide 0
                      N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide 0
                      N-cyclopropyl-3-\{4-[(cyclopropylmethyl)carbamoyl]phenyl\}-4-methylbenzamide 0
                      N-cyclopropyl-3-\{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydropyrazolo[3,4-b]pyridin-4-yl]amino\}-4-methylbenzamide 0
                      PH 797804 0
                      RO4927350 0
                      SB 203580 0
                      SB-202190 0
                      SB-239063 0
                      SB-245391 0
                      SB-284851-BT 0
                      SB220025 0
                      U0126 + 0
                      U0126.EtOH 0
                      VX-745 0
                      auraptene 0
                      binimetinib 0
                      c-Jun N-terminal kinase inhibitor + 5
                      cercosporamide 0
                      cobimetinib 0
                      cobimetinib fumarate 0
                      doramapimod 0
                      hypothemycin 0
                      pamapimod 0
                      selumetinib 0
                      talmapimod 0
                      trametinib + 0
                      trametinib dimethyl sulfoxide 0
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