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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
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Accession:CHEBI:79091 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
Synonyms:related_synonym: ATP:protein phosphotransferase (MAPKK-activated) inhibitor;   ATP:protein phosphotransferase (MAPKK-activated) inhibitors;   Dp38 inhibitor;   Dp38 inhibitors;   EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors;   EC 2.7.11.24 inhibitor;   EC 2.7.11.24 inhibitors;   ERK inhibitor;   ERK inhibitors;   ERK1 inhibitor;   ERK1 inhibitors;   ERK2 inhibitor;   ERK2 inhibitors;   JNK inhibitor;   JNK inhibitors;   JNK3alpha1 inhibitor;   JNK3alpha1 inhibitors;   LeMPK3 inhibitor;   LeMPK3 inhibitors;   MAP kinase inhibitor;   MAP kinase inhibitors;   MAP-2 kinase inhibitor;   MAP-2 kinase inhibitors;   MAPK inhibitor;   MAPK inhibitors;   MBP kinase I inhibitor;   MBP kinase I inhibitors;   MBP kinase II inhibitor;   MBP kinase II inhibitors;   MEK inhibitor;   MEK inhibitors;   PMK-1 inhibitor;   PMK-1 inhibitors;   PMK-2 inhibitor;   PMK-2 inhibitors;   PMK-3 inhibitor;   PMK-3 inhibitors;   SAPK inhibitor;   SAPK inhibitors;   STK26 inhibitor;   STK26 inhibitors;   c-Jun N-terminal kinase inhibitor;   c-Jun N-terminal kinase inhibitors;   extracellular signal-regulated kinase inhibitor;   extracellular signal-regulated kinase inhibitors;   microtubule-associated protein 2 kinase inhibitor;   microtubule-associated protein 2 kinase inhibitors;   microtubule-associated protein kinase inhibitor;   microtubule-associated protein kinase inhibitors;   mitogen-activated protein kinase inhibitor;   mitogen-activated protein kinase inhibitors;   myelin basic protein kinase inhibitor;   myelin basic protein kinase inhibitors;   p38-2 inhibitor;   p38-2 inhibitors;   p38delta inhibitor;   p38delta inhibitors;   p42 mitogen-activated protein kinase inhibitor;   p42 mitogen-activated protein kinase inhibitors;   p42(mapk) inhibitor;   p42(mapk) inhibitors;   p44mpk inhibitor;   p44mpk inhibitors;   pp42 inhibitor;   pp42 inhibitors;   pp44(mapk) inhibitor;   pp44(mapk) inhibitors;   stress-activated protein kinase inhibitor;   stress-activated protein kinase inhibitors
 alt_id: CHEBI:75997
 xref: Wikipedia:MEK_inhibitor;   Wikipedia:Mitogen-activated_protein_kinase


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4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G IL6 interleukin 6 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MTNR1A melatonin receptor 1A affects binding EXP chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr 4:186,532,769...186,555,567
Ensembl chr 4:186,533,655...186,555,567
JBrowse link
G MTNR1B melatonin receptor 1B affects binding EXP chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr11:92,969,651...92,986,241
Ensembl chr11:92,969,651...92,985,066
Ensembl chr11:92,969,651...92,985,066
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions EXP chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr 6:2,999,816...3,019,876
Ensembl chr 6:2,987,987...3,021,850
Ensembl chr 6:2,987,987...3,021,850
JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
6-hydroxyluteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases chemical synthesis
EXP [CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CYP1A1 protein results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases chemical synthesis
multiple interactions
EXP CYP1B1 protein results in increased chemical synthesis of 6-hydroxyluteolin
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [MAP3K1 protein results in increased expression of ABCB1 mRNA]; pyrazolanthrone inhibits the reaction [Oxygen deficiency results in increased expression of ABCB1 mRNA]
pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]
CTD PMID:15604272, PMID:18474546 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO pyrazolanthrone inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:20600246 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions ISO crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]; pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein] CTD PMID:30580027 NCBI chr19:11,574,660...11,578,983
Ensembl chr19:11,574,660...11,579,008
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]] CTD PMID:31447676 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA] CTD PMID:18577375 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA] CTD PMID:23603059 NCBI chr 3:148,697,871...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP pyrazolanthrone binds to and results in increased activity of AHR protein CTD PMID:17959153 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [arsenic trioxide affects the localization of AIFM1 protein]
pyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of AIFM1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]
CTD PMID:18412143, PMID:20423716, PMID:24577723, PMID:25043952, PMID:29289695 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B multiple interactions ISO pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [arsenic trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [diallyl trisulfide results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein]
pyrazolanthrone results in decreased expression of AKT1 protein
CTD PMID:16046226, PMID:17341418, PMID:20534739, PMID:22020565, PMID:22696236, PMID:25939952, PMID:28087840 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AKT2 AKT serine/threonine kinase 2 multiple interactions ISO [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] CTD PMID:30580027 NCBI chr19:40,230,317...40,285,531
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase decreases expression EXP pyrazolanthrone results in decreased expression of ALOX5 protein CTD PMID:23539630 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G AMPD3 adenosine monophosphate deaminase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of AMPD3 mRNA] CTD PMID:17460151 NCBI chr11:10,450,388...10,507,579
Ensembl chr11:10,308,313...10,507,579
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOD apolipoprotein D multiple interactions EXP pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD protein] CTD PMID:21688324 NCBI chr 3:195,568,705...195,583,940
Ensembl chr 3:195,568,705...195,584,033
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein] CTD PMID:16648635, PMID:28004443 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) multiple interactions EXP pyrazolanthrone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of AQP1 protein] CTD PMID:21647617 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G AR androgen receptor multiple interactions EXP pyrazolanthrone affects the reaction [Quercetin inhibits the reaction [mibolerone results in increased expression of AR protein]] CTD PMID:20148354 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATF2 activating transcription factor 2 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]; pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ATF2 protein]
pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein]
CTD PMID:12393500, PMID:12663670, PMID:22003962, PMID:23591579, PMID:23836369, PMID:24469321, PMID:24525298, PMID:28975372, PMID:30768131 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G ATF3 activating transcription factor 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of ATF3 protein]
pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF3 protein]
CTD PMID:22003962, PMID:25531190 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA] CTD PMID:20920558 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions EXP pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in increased expression of BAD protein] CTD PMID:19747539 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAG3 BAG cochaperone 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein] CTD PMID:22020323 NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,370...119,677,819
Ensembl chr10:119,651,370...119,677,819
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [docetaxel results in increased activity of BAK1 protein] CTD PMID:17317842 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased activity of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of and results in increased localization of BAX protein]
pyrazolanthrone inhibits the reaction [bakuchiol affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of BAX protein]
CTD PMID:14514659, PMID:15034932, PMID:16046226, PMID:16972261, PMID:17292878, PMID:17317842, PMID:19428505, PMID:19540902, PMID:19954742, PMID:20423716, PMID:21420390, PMID:24036456, PMID:24577723, PMID:25043952, PMID:29289695, PMID:30653946, PMID:31044527 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of BBC3 protein] CTD PMID:30472098 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCAS2 BCAS2 pre-mRNA processing factor multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of BCAS2 mRNA] CTD PMID:17460151 NCBI chr 1:114,567,557...114,581,615
Ensembl chr 1:114,567,557...114,581,629
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases phosphorylation
EXP
ISO
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [fosbretabulin results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of BCL2 protein]
pyrazolanthrone results in decreased phosphorylation of BCL2 protein
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 mRNA]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BCL2 protein modified form]; pyrazolanthrone inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; pyrazolanthrone results in increased phosphorylation of and results in decreased activity of BCL2 protein
pyrazolanthrone inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
CTD PMID:14724571, PMID:17317842, PMID:17786558, PMID:18412143, PMID:19428505, PMID:19540902, PMID:19747539, PMID:19954742, PMID:20166895, PMID:20920558, PMID:21420390, PMID:23212307, PMID:23423712, PMID:24036456, PMID:24321340, PMID:24577723, PMID:24833599, PMID:25043952, PMID:25446857, PMID:30472098, PMID:30653946, PMID:30871965 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP
ISO
[pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BCL2L1 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BCL2L1 protein modified form]
CTD PMID:18281123, PMID:19540902, PMID:19747539, PMID:20166895, PMID:31044527 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BCL2L11 protein]
pyrazolanthrone inhibits the reaction [docetaxel results in increased degradation of BCL2L11 protein]; pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of BCL2L11 mRNA]; pyrazolanthrone inhibits the reaction [temozolomide results in increased expression of BCL2L11 mRNA]
CTD PMID:16166651, PMID:17317842, PMID:18766339, PMID:26418950 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions EXP pyrazolanthrone inhibits the reaction [BDNF protein results in increased expression of SOD2 protein] CTD PMID:22261313 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BECN1 beclin 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [decamethrin results in increased expression of BECN1 protein]
pyrazolanthrone promotes the reaction [polyphyllin I results in increased expression of BECN1 protein]
CTD PMID:26588882, PMID:28842171, PMID:31421117 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein multiple interactions ISO [pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of BGLAP protein] CTD PMID:26136938 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP pyrazolanthrone promotes the reaction [arsenic trioxide results in increased cleavage of BID protein] CTD PMID:16972261 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of BIRC2 mRNA] CTD PMID:12832416 NCBI chr11:102,347,182...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased expression of BIRC5 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BIRC5 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of BIRC5 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of BIRC5 protein] CTD PMID:16328441, PMID:19747539, PMID:21594580, PMID:22706169 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of BNIP3 protein] CTD PMID:24824807 NCBI chr10:131,967,683...131,982,013
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein] CTD PMID:21933187 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,291
JBrowse link
G CAPN1 calpain 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein] CTD PMID:29289695 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CAPN2 calpain 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CASP1 caspase 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [irinotecan results in increased cleavage of CASP1 protein]
pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]
CTD PMID:26431797, PMID:28004443 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) multiple interactions ISO pyrazolanthrone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein] CTD PMID:24140863 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP2 caspase 2 decreases activity EXP pyrazolanthrone results in decreased activity of CASP2 protein CTD PMID:17317842 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
EXP
ISO
[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Citrinin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Phytochemicals results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein]
pyrazolanthrone results in increased expression of CASP3 protein modified form
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [bakuchiol results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [satratoxin H results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; Taurine promotes the reaction [pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]
pyrazolanthrone results in decreased activity of CASP3 protein
pyrazolanthrone results in increased activity of CASP3 protein
CTD PMID:12393500, PMID:15034932, PMID:15095415, PMID:15254339, PMID:15501958, PMID:15767555, PMID:15831436, PMID:15850772, PMID:16061660, PMID:16310883, PMID:16322078, PMID:16357177, PMID:16712891, PMID:16787641, PMID:16843435, PMID:17292878, PMID:17341418, PMID:18281123, PMID:18703135, PMID:18767140, PMID:19193634, PMID:19361540, PMID:19631732, PMID:20632440, PMID:20830294, PMID:20920558, PMID:21165570, PMID:21295052, PMID:21600974, PMID:21843585, PMID:21843586, PMID:22654482, PMID:22863859, PMID:23082001, PMID:23212307, PMID:23405080, PMID:23416140, PMID:23578390, PMID:23836369, PMID:24036456, PMID:24111524, PMID:24157283, PMID:24577723, PMID:25043952, PMID:25078063, PMID:25305377, PMID:25446857, PMID:25882087, PMID:26588882, PMID:26630137, PMID:27539140, PMID:28383207, PMID:28391263, PMID:28474156, PMID:29289695, PMID:29968959, PMID:30259999, PMID:30871965, PMID:30928397, PMID:31044527, PMID:31421117, PMID:31447676, PMID:32574669, PMID:32652169 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP4 caspase 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Bortezomib results in increased cleavage of CASP4 protein] CTD PMID:16357177 NCBI chr11:104,942,866...104,968,596
Ensembl chr11:104,942,866...104,969,366
JBrowse link
G CASP6 caspase 6 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP6 protein]
pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP6 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]
CTD PMID:15501958, PMID:16310883, PMID:17341418, PMID:19954742 NCBI chr 4:109,688,628...109,703,445
Ensembl chr 4:109,688,622...109,703,583
JBrowse link
G CASP7 caspase 7 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP7 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP7 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP7 protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased activity of CASP7 protein]; pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP7 protein]
CTD PMID:20920558, PMID:21843585, PMID:21843586, PMID:23405080, PMID:24157283, PMID:25078063, PMID:25882087, PMID:27539140 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions EXP pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP8 protein]; pyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with Arsenic Trioxide] results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP8 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of CASP8 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:15501958, PMID:15767555, PMID:16061660, PMID:16972261, PMID:17145888, PMID:21138480, PMID:21165570, PMID:23212307, PMID:29968959 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity
EXP
ISO
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP9 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP9 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein]
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pyrazolanthrone results in increased activity of CASP9 protein
CTD PMID:15034932, PMID:15501958, PMID:15831436, PMID:16310883, PMID:16322078, PMID:17341418, PMID:17786558, PMID:20920558, PMID:21138480, PMID:21165570, PMID:21420390, PMID:21843586, PMID:23212307, PMID:27539140, PMID:29968959 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions EXP pyrazolanthrone promotes the reaction [Pyrogallol results in decreased expression of CAT protein] CTD PMID:20191265 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]]; pyrazolanthrone inhibits the reaction [Palmitates results in increased secretion of CCL2 protein]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; pyrazolanthrone promotes the reaction [Ozone results in increased expression of CCL2 mRNA]
pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of CCL2 protein]
CTD PMID:17460151, PMID:18303122, PMID:20354174, PMID:20712904, PMID:23958496, PMID:26641773, PMID:28087833, PMID:28505368 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCL8 C-C motif chemokine ligand 8 multiple interactions EXP pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CCL8 mRNA] CTD PMID:12832416 NCBI chr17:34,319,435...34,321,402
Ensembl chr17:34,319,435...34,321,402
JBrowse link
G CCN2 cellular communication network factor 2 multiple interactions EXP [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of CCN2 protein] CTD PMID:31044527 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CCNB1 protein] CTD PMID:23212307 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 mRNA]; pyrazolanthrone inhibits the reaction [kahweol results in decreased expression of CCND1 protein]; pyrazolanthrone inhibits the reaction [kahweol results in increased phosphorylation of CCND1 protein]
pyrazolanthrone results in decreased expression of CCND1 protein
CTD PMID:18593901, PMID:19801633, PMID:27424123 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCR2 C-C motif chemokine receptor 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein] CTD PMID:26163174 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
JBrowse link
G CD14 CD14 molecule multiple interactions EXP pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CD14 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:14729647, PMID:18180316 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CD207 CD207 molecule multiple interactions
decreases expression
EXP pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CD207 protein]
pyrazolanthrone results in decreased expression of CD207 protein
CTD PMID:15588916 NCBI chr 2:70,825,248...70,860,787
Ensembl chr 2:70,830,211...70,835,816
JBrowse link
G CD36 CD36 molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of CD36 mRNA] CTD PMID:21873422 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD80 CD80 molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD80 protein] CTD PMID:28235615 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
JBrowse link
G CD86 CD86 molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD86 protein] CTD PMID:28235615 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin affects the expression of CDC25C protein] CTD PMID:16179969 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDH1 cadherin 1 decreases expression
multiple interactions
EXP
ISO
pyrazolanthrone results in decreased expression of CDH1 protein
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]]
pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]
CTD PMID:15588916, PMID:31447676 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH5 cadherin 5 multiple interactions EXP pyrazolanthrone inhibits the reaction [Varenicline results in decreased expression of CDH5] CTD PMID:28842382 NCBI chr16:66,366,657...66,404,784
Ensembl chr16:66,366,622...66,404,784
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions
decreases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CDK1 protein]
pyrazolanthrone results in decreased expression of CDK1 protein
CTD PMID:18593901, PMID:23212307 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions
decreases activity
EXP pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of CDK2 protein]
pyrazolanthrone results in decreased activity of CDK2 protein
CTD PMID:12534346, PMID:19747539 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK5 cyclin dependent kinase 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]; pyrazolanthrone inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein] CTD PMID:24481447 NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897
JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA] CTD PMID:21736731 NCBI chr17:32,485,028...32,491,256
Ensembl chr17:32,486,993...32,491,253
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [EGF protein results in increased expression of CDKN1A mRNA]
pyrazolanthrone promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A protein]
pyrazolanthrone results in increased expression of CDKN1A protein
CTD PMID:15961274, PMID:16061660, PMID:16283431, PMID:19418558, PMID:31734849 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions EXP pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPA protein] CTD PMID:24376792 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta multiple interactions EXP pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB protein]; pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPB protein] CTD PMID:14729647, PMID:24376792 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CEBPD CCAAT enhancer binding protein delta multiple interactions EXP pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPD protein] CTD PMID:24376792 NCBI chr 8:47,736,913...47,738,164
Ensembl chr 8:47,736,913...47,738,164
JBrowse link
G CES3 carboxylesterase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of CES3 mRNA] CTD PMID:17460151 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of CHUK protein] CTD PMID:19616567 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CLDN4 claudin 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,693
JBrowse link
G CPEB1 cytoplasmic polyadenylation element binding protein 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of CPEB1 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CPEB1 mRNA] CTD PMID:21620800 NCBI chr15:82,543,201...82,648,795
Ensembl chr15:82,543,201...82,648,861
JBrowse link
G CPT1B carnitine palmitoyltransferase 1B increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of CPT1B mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of CPT1B mRNA]
CTD PMID:21873422 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465
JBrowse link
G CREB1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
EXP
ISO
pyrazolanthrone results in decreased phosphorylation of CREB1 protein
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]
CTD PMID:25605016, PMID:28087833 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRH corticotropin releasing hormone multiple interactions EXP pyrazolanthrone inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA] CTD PMID:28189027 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein] CTD PMID:19460412 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CSNK1D casein kinase 1 delta decreases activity EXP pyrazolanthrone results in decreased activity of CSNK1D protein CTD PMID:12534346 NCBI chr17:82,239,019...82,273,750
Ensembl chr17:82,239,023...82,273,731
JBrowse link
G CST3 cystatin C multiple interactions ISO 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of CST3 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of CST3 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased expression of CST3 protein]] CTD PMID:31447676 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473
JBrowse link
G CTF1 cardiotrophin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr16:30,895,824...30,903,560
Ensembl chr16:30,896,614...30,903,547
Ensembl chr16:30,896,614...30,903,547
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of CXCL1 protein] CTD PMID:28087833 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions EXP pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL10 mRNA] CTD PMID:12832416 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL3 C-X-C motif chemokine ligand 3 multiple interactions EXP pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CXCL3 mRNA] CTD PMID:12832416 NCBI chr 4:74,036,589...74,038,689
Ensembl chr 4:74,036,589...74,038,807
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases expression
EXP pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Diclofenac analog results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [IL1B results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Smoke results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Zinc results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Zinc results in increased expression of CXCL8 protein]; pyrazolanthrone results in decreased susceptibility to [Hydrogen Peroxide results in increased secretion of CXCL8 protein]
pyrazolanthrone results in decreased expression of CXCL8 protein
CTD PMID:12832416, PMID:16076765, PMID:16373669, PMID:19626664, PMID:20302854, PMID:20307528, PMID:20932985, PMID:21777978, PMID:21956143, PMID:23535185, PMID:24104198, PMID:25540590, PMID:26641773, PMID:27427241, PMID:27836898, PMID:30133131 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased expression of CYBA protein] CTD PMID:22245600 NCBI chr16:88,643,289...88,651,079
Ensembl chr16:88,643,289...88,651,054
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of CYCS protein]; pyrazolanthrone inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide affects the localization of CYCS protein]
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]
CTD PMID:16322078, PMID:16972261, PMID:19954742, PMID:30653946 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYGB cytoglobin multiple interactions EXP pyrazolanthrone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr17:76,527,356...76,557,692
Ensembl chr17:76,527,356...76,551,175
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]
CTD PMID:26209791, PMID:28697429, PMID:29567110 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression
multiple interactions
EXP
ISO
pyrazolanthrone results in increased expression of CYP17A1 mRNA
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]
pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]
CTD PMID:16269825, PMID:29567110 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP19A1 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]
CTD PMID:20096755, PMID:20678559, PMID:28571770, PMID:28697429 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases expression
increases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [pyrazolanthrone results in increased expression of CYP1A1 mRNA]
pyrazolanthrone results in decreased expression of CYP1A1 mRNA
pyrazolanthrone inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; pyrazolanthrone promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrazolanthrone promotes the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrazolanthrone promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]
CTD PMID:17959153, PMID:18078826 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression
multiple interactions
EXP pyrazolanthrone results in increased expression of CYP1A2 mRNA
pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [pyrazolanthrone results in increased expression of CYP1A2 mRNA]
CTD PMID:17959153 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA] CTD PMID:24830941 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] CTD PMID:17965521 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 multiple interactions
decreases expression
EXP pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of CYP4F11 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]
pyrazolanthrone results in decreased expression of CYP4F11 mRNA
CTD PMID:19812349 NCBI chr19:15,912,370...15,934,867
Ensembl chr19:15,912,367...15,934,867
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Tretinoin results in decreased expression of CYP7A1 mRNA]; pyrazolanthrone inhibits the reaction [Tretinoin results in decreased expression of CYP7A1 protein] CTD PMID:30709899 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [leflunomide results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of DDIT3 mRNA]; pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]
pyrazolanthrone inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of DDIT3 mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]
CTD PMID:17049495, PMID:17341418, PMID:19139269, PMID:20920558, PMID:24612139, PMID:26203587, PMID:28988120, PMID:30508555, PMID:31348969 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DIO1 iodothyronine deiodinase 1 multiple interactions EXP [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DOC2B double C2 domain beta multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of DOC2B mRNA] CTD PMID:17460151 NCBI chr17:142,789...181,650
Ensembl chr17:142,789...181,650
JBrowse link
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity EXP pyrazolanthrone results in decreased activity of DYRK1A protein CTD PMID:12534346 NCBI chr21:37,365,573...37,526,358
Ensembl chr21:37,365,573...37,526,358
JBrowse link
G EDN1 endothelin 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] CTD PMID:24376792 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRA endothelin receptor type A multiple interactions ISO pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein] CTD PMID:20561571 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EDNRB endothelin receptor type B multiple interactions ISO pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Smoke analog results in increased expression of EDNRB protein] CTD PMID:20561571, PMID:20716444, PMID:26496744 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G EGF epidermal growth factor multiple interactions EXP pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]; pyrazolanthrone promotes the reaction [EGF protein results in increased expression of CDKN1A mRNA] CTD PMID:15961274, PMID:21613822, PMID:22766066 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor decreases expression EXP
ISO
pyrazolanthrone results in decreased expression of EGFR mRNA; pyrazolanthrone results in decreased expression of EGFR protein CTD PMID:15923621, PMID:18332871 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of EGR1 mRNA]
CTD PMID:15688020, PMID:18316600 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 NCBI chr 2:37,099,210...37,157,065
Ensembl chr 2:37,099,210...37,157,065
JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein] CTD PMID:12660819, PMID:18316600, PMID:21642427 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604
JBrowse link
G ENDOG endonuclease G multiple interactions ISO pyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of ENDOG protein] CTD PMID:24577723 NCBI chr 9:128,818,402...128,822,676
Ensembl chr 9:128,818,500...128,822,676
JBrowse link
G EPOR erythropoietin receptor multiple interactions EXP pyrazolanthrone inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] CTD PMID:20189893 NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of ERN1 protein] CTD PMID:19139269 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,142...64,130,819
JBrowse link
G ETFA electron transfer flavoprotein subunit alpha multiple interactions EXP pyrazolanthrone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ETFA protein] CTD PMID:24394546 NCBI chr15:76,215,353...76,311,469
Ensembl chr15:76,215,353...76,311,472
JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions EXP pyrazolanthrone inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 NCBI chr 7:148,807,374...148,884,344
Ensembl chr 7:148,807,383...148,884,321
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions EXP pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein] CTD PMID:19944065 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of F3 mRNA] CTD PMID:16009787, PMID:19944065, PMID:20118172, PMID:27556861 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FADD Fas associated via death domain multiple interactions
decreases phosphorylation
EXP pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [polyphenon E results in increased phosphorylation of FADD protein]
pyrazolanthrone results in decreased phosphorylation of FADD protein
CTD PMID:16450001, PMID:21138480, PMID:23285096 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,163...70,207,390
Ensembl chr11:70,203,163...70,207,390
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases activity
increases expression
EXP pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP8 protein]
pyrazolanthrone results in increased activity of FAS protein
pyrazolanthrone results in increased expression of FAS protein
CTD PMID:16061660, PMID:16162944 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand multiple interactions EXP pyrazolanthrone affects the reaction [temozolomide results in increased expression of FASLG mRNA]; pyrazolanthrone inhibits the reaction [[sorafenib co-treated with Vitamin K 1] results in increased expression of FASLG protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of FASLG mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of FASLG protein] CTD PMID:20301194, PMID:21165570, PMID:26418950 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FBXO32 F-box protein 32 multiple interactions ISO pyrazolanthrone inhibits the reaction [Indican results in increased expression of FBXO32 protein] CTD PMID:30849338 NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206
JBrowse link
G FEM1B fem-1 homolog B multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of FEM1B mRNA] CTD PMID:17460151 NCBI chr15:68,277,745...68,295,862
Ensembl chr15:68,277,745...68,295,862
JBrowse link
G FGF1 fibroblast growth factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA] CTD PMID:15121739 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G FGF19 fibroblast growth factor 19 multiple interactions EXP pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA] CTD PMID:16269825 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of FGF2 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of FGF2 protein]
pyrazolanthrone inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]
CTD PMID:12832416, PMID:19176594, PMID:25290095, PMID:26800359, PMID:28087833 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G FGF7 fibroblast growth factor 7 multiple interactions EXP pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SCD protein]; pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of FGF7 protein] CTD PMID:15677771, PMID:16162944 NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775
Ensembl chr15:49,423,237...49,488,775
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of FN1 protein] CTD PMID:31447676 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with pyrazolanthrone] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein]; pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of FOS protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOS protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of FOS protein]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of FOS protein]
CTD PMID:22020770, PMID:24469321, PMID:24967690, PMID:28087833 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of FOSL1 mRNA]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of FOSL1 mRNA] CTD PMID:14565943 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G FOXO1 forkhead box O1 multiple interactions EXP pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein] CTD PMID:26385185 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ethanol results in increased phosphorylation of FOXO3 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of FOXO3 protein] CTD PMID:26470730 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO pyrazolanthrone inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; pyrazolanthrone inhibits the reaction [FSHB protein results in increased abundance of Progesterone] CTD PMID:22067323 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,016...30,235,261
JBrowse link
G GABPA GA binding protein transcription factor subunit alpha multiple interactions EXP pyrazolanthrone inhibits the reaction [Gallic Acid results in increased expression of GABPA protein] CTD PMID:16308312 NCBI chr21:25,734,972...25,772,460
Ensembl chr21:25,734,570...25,772,460
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GADD45A protein]; troglitazone inhibits the reaction [pyrazolanthrone results in increased expression of GADD45A mRNA]; troglitazone inhibits the reaction [pyrazolanthrone results in increased expression of GADD45A protein]
pyrazolanthrone inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA]
CTD PMID:15064713, PMID:20955365, PMID:25469469 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GADD45B growth arrest and DNA damage inducible beta multiple interactions EXP pyrazolanthrone inhibits the reaction [sorafenib results in increased expression of GADD45B mRNA]; pyrazolanthrone inhibits the reaction [sorafenib results in increased expression of GADD45B protein] CTD PMID:21062976 NCBI chr19:2,476,127...2,478,259
Ensembl chr19:2,476,122...2,478,259
JBrowse link
G GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of GALNT3 mRNA] CTD PMID:24614234 NCBI chr 2:165,747,588...165,796,352
Ensembl chr 2:165,747,588...165,794,659
JBrowse link
G GATA2 GATA binding protein 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein] CTD PMID:23940812 NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201
Ensembl chr 3:128,479,427...128,493,201
JBrowse link
G GCH1 GTP cyclohydrolase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of GCH1 mRNA] CTD PMID:12832416 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]; pyrazolanthrone inhibits the reaction [Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC protein]
pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA]; pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA]
CTD PMID:17460151, PMID:19328227, PMID:21469739, PMID:25881548 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
decreases activity
EXP pyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM protein]
pyrazolanthrone results in decreased activity of GCLM protein
CTD PMID:16972261, PMID:25881548 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GDF15 growth differentiation factor 15 multiple interactions EXP pyrazolanthrone promotes the reaction [silybin results in increased expression of GDF15 protein] CTD PMID:24440808 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GH1 growth hormone 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein] CTD PMID:26141394 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Amphetamine results in increased expression of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of and affects the localization of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of GJA1 mRNA]
pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of GJA1 protein]
CTD PMID:15194466, PMID:24449132, PMID:32045570 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GLB1 galactosidase beta 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]; pyrazolanthrone promotes the reaction [SB 203580 inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]]; SB 203580 promotes the reaction [pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]] CTD PMID:31734849 NCBI chr 3:32,996,617...33,097,146
Ensembl chr 3:32,996,609...33,097,202
JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha multiple interactions EXP pyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein] CTD PMID:20523355 NCBI chr17:4,932,277...4,935,023
Ensembl chr17:4,932,277...4,935,023
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD PMID:20166895, PMID:26218279 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene] CTD PMID:24353929 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GYPA glycophorin A (MNS blood group) multiple interactions EXP pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein] CTD PMID:20523355 NCBI chr 4:144,109,303...144,140,854
Ensembl chr 4:144,109,303...144,140,751
JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP pyrazolanthrone inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein] CTD PMID:25619392, PMID:28993908 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G H3-4 H3.4 histone multiple interactions EXP pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin results in increased phosphorylation of H3-4 protein] CTD PMID:16179969 NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,325
Ensembl chr 1:228,424,845...228,425,325
JBrowse link
G HAT1 histone acetyltransferase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Quercetin results in increased activity of HAT1 protein] CTD PMID:21165570 NCBI chr 2:171,922,425...171,983,686
Ensembl chr 2:171,922,448...171,983,686
JBrowse link
G HBEGF heparin binding EGF like growth factor multiple interactions EXP pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:19193634, PMID:26800359 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein] CTD PMID:20152896, PMID:28651835 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] CTD PMID:27616297 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
decreases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [butein results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [iron protoporphyrin IX results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; pyrazolanthrone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]
pyrazolanthrone results in decreased expression of HMOX1 mRNA
pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; pyrazolanthrone promotes the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]
pyrazolanthrone results in decreased expression of HMOX1 protein
CTD PMID:12637567, PMID:16171798, PMID:16439612, PMID:16631525, PMID:18078826, PMID:18289802, PMID:18332044, PMID:18404528, PMID:18636201, PMID:21469739, PMID:22056766, PMID:23318726, PMID:23535287, PMID:23845594, PMID:24140437, PMID:24423726, PMID:25449124, PMID:25881548, PMID:26291278, PMID:26385185, PMID:26404762, PMID:26542248, PMID:27393035, PMID:27777014, PMID:28087833, PMID:29426002, PMID:31790703 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha increases expression
multiple interactions
EXP pyrazolanthrone results in increased expression of HNF4A mRNA
pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of HNF4A mRNA]
CTD PMID:19883121 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G HPX hemopexin multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of HPX mRNA] CTD PMID:17460151 NCBI chr11:6,431,049...6,440,987
Ensembl chr11:6,431,049...6,442,617
JBrowse link
G HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA] CTD PMID:29567110 NCBI chr 9:96,235,306...96,313,987
Ensembl chr 9:96,235,306...96,302,176
JBrowse link
G HSF1 heat shock transcription factor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 NCBI chr 8:144,291,603...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA] CTD PMID:20920558 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,645
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions ISO pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of HSPA1A protein] CTD PMID:28087833 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA]
pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]
CTD PMID:17341418, PMID:20920558 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of HSPA6 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of HSPA6 protein] CTD PMID:15978632 NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP [sodium arsenite co-treated with pyrazolanthrone] promotes the reaction [HSPA9 protein binds to TP53 protein modified form] CTD PMID:22706169 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,416
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 mRNA]; pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]; pyrazolanthrone inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein] CTD PMID:21457723, PMID:24140437 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G HSPB8 heat shock protein family B (small) member 8 multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of HSPB8 mRNA] CTD PMID:17460151 NCBI chr12:119,178,931...119,194,746
Ensembl chr12:119,171,555...119,224,855
Ensembl chr12:119,171,555...119,224,855
Ensembl chr12:119,171,555...119,224,855
JBrowse link
G IBSP integrin binding sialoprotein multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of IBSP protein] CTD PMID:31051157 NCBI chr 4:87,799,554...87,812,435
Ensembl chr 4:87,799,554...87,812,435
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of ICAM1 mRNA]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1] CTD PMID:12832416, PMID:22166487 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; pyrazolanthrone inhibits the reaction [Eosine I Bluish results in increased expression of IFNG mRNA]
[pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; pyrazolanthrone results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides]
pyrazolanthrone inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
CTD PMID:16307444, PMID:16488514, PMID:21295052, PMID:22440610, PMID:23831309, PMID:26609140, PMID:29385629 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein] CTD PMID:17458902 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein] CTD PMID:19616567 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL10 interleukin 10 multiple interactions ISO pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL10 protein] CTD PMID:28235615 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL12B interleukin 12B multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]
pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:15778123, PMID:19101624 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL17A interleukin 17A multiple interactions ISO pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein] CTD PMID:29385629 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL18 interleukin 18 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]
pyrazolanthrone inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased expression of IL18 mRNA]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]
CTD PMID:20381601, PMID:26431797 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL10 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of FGF2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of GCH1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of ICAM1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1A mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTX3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SERPINB2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased secretion of CXCL8 protein]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of BIRC2 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CCL8 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CXCL3 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of JUN mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of SAA1 mRNA]
pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL1A protein]
CTD PMID:12832416, PMID:19782127 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of CYP4F11 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of FGF7 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [IL1B results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein]
pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL1B protein]
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; IL1B protein inhibits the reaction [pyrazolanthrone results in increased expression of THRA mRNA alternative form]; pyrazolanthrone affects the reaction [Fungal Polysaccharides results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of IL1B mRNA]
CTD PMID:12832416, PMID:15019843, PMID:15677771, PMID:16359550, PMID:16365456, PMID:16614379, PMID:17641275, PMID:18982426, PMID:19626664, PMID:19782127, PMID:19812349, PMID:20712904, PMID:21295052, PMID:21430222, PMID:21447443, PMID:22547200, PMID:22687552, PMID:22727857, PMID:22728154, PMID:23535185, PMID:24781252, PMID:26218279, PMID:26431797, PMID:27174766, PMID:27556861, PMID:28004443, PMID:31199065 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]; pyrazolanthrone inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 protein] CTD PMID:26003274 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [7-ketocholesterol results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Acids results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Acids results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of IL6 mRNA]; pyrazolanthrone promotes the reaction [cadmium acetate results in increased secretion of IL6 protein]
[pyrazolanthrone co-treated with Acrylamide] results in decreased expression of IL6 mRNA; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL6 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL6 protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; pyrazolanthrone promotes the reaction [Ozone results in increased expression of IL6 mRNA]
CTD PMID:12832416, PMID:17460151, PMID:18515973, PMID:19074641, PMID:19101624, PMID:19782127, PMID:20712904, PMID:21548952, PMID:22488045, PMID:22727857, PMID:22728154, PMID:23535185, PMID:24631921, PMID:25047101, PMID:25677194, PMID:27427241, PMID:28087833, PMID:28235615, PMID:28474156, PMID:29385629, PMID:29426002, PMID:29906494, PMID:30078834, PMID:30259999 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
pyrazolanthrone inhibits the reaction [GW8510 results in increased expression of INS2 mRNA]
pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK3 protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased uptake of Glucose]]
CTD PMID:17728140, PMID:22242153, PMID:24349194 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G INSR insulin receptor multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]
pyrazolanthrone inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]
CTD PMID:19345745, PMID:24349194, PMID:29793316 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]
CTD PMID:17728140, PMID:29793316 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,317...226,799,759
JBrowse link
G ITGA2B integrin subunit alpha 2b multiple interactions EXP pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP pyrazolanthrone promotes the reaction [arsenic disulfide analog results in increased expression of ITGAM mRNA]; pyrazolanthrone promotes the reaction [arsenic disulfide analog results in increased expression of ITGAM protein] CTD PMID:18778786 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
JBrowse link
G JAG1 jagged canonical Notch ligand 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of JAG1 mRNA] CTD PMID:21843347 NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases activity
decreases phosphorylation
increases degradation
decreases expression
EXP
ISO
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with pyrazolanthrone] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein]; [pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein]; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with Arsenic Trioxide] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Sorafenib co-treated with Vitamin K 1] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Estradiol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Leflunomide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Methyl Methanesulfonate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Quercetin affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Simvastatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of JUN mRNA]
pyrazolanthrone results in decreased activity of JUN protein
pyrazolanthrone results in increased degradation of JUN protein
pyrazolanthrone results in decreased expression of JUN protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Amphetamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Indolinone A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]]
pyrazolanthrone inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [monobutyl phthalate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Ozone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone promotes the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]
CTD PMID:12169099, PMID:12393500, PMID:12663670, PMID:12774022, PMID:12832416, PMID:15019843, PMID:15028728, PMID:15034932, PMID:15194466, PMID:15196213, PMID:15252869, PMID:15322261, PMID:15342272, PMID:15677771, PMID:15838870, PMID:15850772, PMID:15923621, PMID:15930183, PMID:16041517, PMID:16061660, PMID:16166651, PMID:16322078, PMID:16337876, PMID:16357177, PMID:16407847, PMID:16872482, PMID:16932349, PMID:17125918, PMID:17460151, PMID:17950587, PMID:18021293, PMID:18593901, PMID:18633430, PMID:18982426, PMID:19002563, PMID:19225867, PMID:19292871, PMID:19418558, PMID:19768117, PMID:19812349, PMID:20148354, PMID:20301194, PMID:20338993, PMID:20632440, PMID:21062976, PMID:21165570, PMID:21911303, PMID:22003962, PMID:22020770, PMID:22166487, PMID:22288910, PMID:23082001, PMID:23103562, PMID:23219847, PMID:23836369, PMID:24111524, PMID:24469321, PMID:24967690, PMID:25200491, PMID:26209791, PMID:26514923, PMID:26630137, PMID:28087833, PMID:28474156, PMID:28697429, PMID:28988120, PMID:30133131, PMID:30709899, PMID:30768131, PMID:31306638, PMID:32738922 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein] CTD PMID:24830941 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622
JBrowse link
G KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of KCNE4 mRNA] CTD PMID:17460151 NCBI chr 2:223,052,190...223,055,637
Ensembl chr 2:223,051,814...223,198,399
JBrowse link
G KLF5 Kruppel like factor 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLF5 mRNA] CTD PMID:17460151 NCBI chr13:73,054,976...73,077,538
Ensembl chr13:73,054,976...73,077,541
JBrowse link
G KLHL2 kelch like family member 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLHL2 mRNA] CTD PMID:17460151 NCBI chr 4:165,207,561...165,323,156
Ensembl chr 4:165,207,561...165,323,156
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions EXP pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR protein] CTD PMID:22388943 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G LEP leptin multiple interactions EXP pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LEPR leptin receptor affects response to substance ISO LEPR protein affects the susceptibility to pyrazolanthrone CTD PMID:22933112 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LPL lipoprotein lipase increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of LPL mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of LPL mRNA]
CTD PMID:21873422 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [MAP3K1 protein results in increased expression of ABCB1 mRNA] CTD PMID:15604272 NCBI chr 5:56,815,543...56,896,152
Ensembl chr 5:56,815,549...56,896,152
JBrowse link
G MAP3K6 mitogen-activated protein kinase kinase kinase 6 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MAP3K6 mRNA] CTD PMID:17460151 NCBI chr 1:27,355,179...27,368,037
Ensembl chr 1:27,354,067...27,366,961
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:15342272, PMID:17458902, PMID:19135517, PMID:21933187, PMID:22727857, PMID:24349194, PMID:26136938, PMID:26359795, PMID:26609140, PMID:28087833, PMID:30317802 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions
decreases phosphorylation
increases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK14 protein]
pyrazolanthrone results in decreased phosphorylation of MAPK14 protein
pyrazolanthrone results in increased expression of MAPK14 protein
CTD PMID:15964311, PMID:16046226 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK3 protein]]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]
[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:15342272, PMID:17458902, PMID:19135517, PMID:21933187, PMID:22727857, PMID:24349194, PMID:26136938, PMID:26359795, PMID:26609140, PMID:28087833, PMID:30317802, PMID:30580027 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases expression
decreases phosphorylation
decreases activity
EXP
ISO
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of MAPK8 protein]; pyrazolanthrone inhibits the reaction [benzyl isothiocyanate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [dracorhodin analog results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased expression of MAPK8 protein modified form]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK8 protein]
pyrazolanthrone results in increased expression of MAPK8 protein
pyrazolanthrone results in decreased phosphorylation of MAPK8 protein
pyrazolanthrone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paroxetine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK8 protein]
[pyrazolanthrone co-treated with 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride] inhibits the reaction [Folic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone affects the reaction [TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of MAPK8 protein]; pyrazolanthrone results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
pyrazolanthrone results in decreased activity of MAPK8 protein
CTD PMID:12534346, PMID:14610070, PMID:15322261, PMID:15767555, PMID:15831436, PMID:15964311, PMID:16041517, PMID:16046226, PMID:16151469, PMID:16374168, PMID:16442704, PMID:16648635, PMID:16687388, PMID:16777994, PMID:16864444, PMID:17185352, PMID:17651887, PMID:17728140, PMID:18347188, PMID:18412143, PMID:18495191, PMID:18506790, PMID:18728404, PMID:18840457, PMID:19038359, PMID:19135517, PMID:19436114, PMID:20206247, PMID:20534739, PMID:20632440, PMID:20678559, PMID:21112663, PMID:21219922, PMID:21626648, PMID:21843586, PMID:21933187, PMID:22085843, PMID:22696236, PMID:24833599, PMID:25531190, PMID:26385185, PMID:27174766, PMID:28474156, PMID:29906494, PMID:30259999, PMID:30768131, PMID:31176653, PMID:31348969, PMID:31421117, PMID:31447676, PMID:31587482, PMID:31734849, PMID:32574669 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
decreases phosphorylation
decreases activity
EXP
ISO
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased expression of MAPK9 protein modified form]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone results in decreased phosphorylation of MAPK9 protein
pyrazolanthrone inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK9 protein]
pyrazolanthrone results in decreased activity of MAPK9 protein
CTD PMID:12534346, PMID:15322261, PMID:15831436, PMID:16151469, PMID:16687388, PMID:16777994, PMID:17651887, PMID:18347188, PMID:18412143, PMID:18728404, PMID:18840457, PMID:19038359, PMID:19135517, PMID:20206247, PMID:20678559, PMID:21843586, PMID:22085843, PMID:22696236, PMID:25531190, PMID:26385185, PMID:27174766, PMID:28474156, PMID:29906494, PMID:31348969, PMID:31421117 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 decreases activity ISO pyrazolanthrone results in decreased activity of MAPKAPK2 protein CTD PMID:15196213 NCBI chr 1:206,684,905...206,734,283
Ensembl chr 1:206,684,944...206,734,283
Ensembl chr 1:206,684,944...206,734,283
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member multiple interactions EXP pyrazolanthrone inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:23082001, PMID:25078063 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G MCM2 minichromosome maintenance complex component 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [trichostatin A results in decreased expression of MCM2 protein] CTD PMID:23770000 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436
JBrowse link
G MIF macrophage migration inhibitory factor multiple interactions EXP pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein] CTD PMID:16872482 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MIR21 microRNA 21 affects expression
multiple interactions
EXP pyrazolanthrone affects the expression of MIR21 mRNA
pyrazolanthrone affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]
CTD PMID:24434654 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIR328 microRNA 328 increases expression EXP pyrazolanthrone results in increased expression of MIR328 mRNA CTD PMID:25605016 NCBI chr16:67,202,321...67,202,395
Ensembl chr16:67,202,321...67,202,395
JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of and results in increased activity of MMP1 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of MMP1 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 protein] CTD PMID:12832416, PMID:20004183, PMID:24469321 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
JBrowse link
G MMP12 matrix metallopeptidase 12 multiple interactions EXP pyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions EXP pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]; pyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein] CTD PMID:16948116, PMID:20004183, PMID:20338993 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP14 matrix metallopeptidase 14 multiple interactions EXP pyrazolanthrone inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA] CTD PMID:19661247 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,027
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [resveratrol results in decreased expression of MMP2]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone promotes the reaction [resveratrol results in decreased expression of and results in decreased activity of MMP2 protein]
pyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]
CTD PMID:16213474, PMID:20599481, PMID:24841706, PMID:25605016, PMID:27060453, PMID:28722351 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein] CTD PMID:12832416, PMID:16778083, PMID:19361540, PMID:20004183 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases activity
EXP
ISO
[kahweol acetate co-treated with pyrazolanthrone] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; pyrazolanthrone affects the reaction [TNF protein results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in decreased expression of MMP9]; pyrazolanthrone inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; pyrazolanthrone promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]
pyrazolanthrone inhibits the reaction [RELA protein binds to MMP9 promoter]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pyrazolanthrone promotes the reaction [Doxorubicin results in increased expression of MMP9 mRNA]
pyrazolanthrone results in decreased activity of MMP9 protein
CTD PMID:16213474, PMID:19447859, PMID:20152819, PMID:21354279, PMID:22033475, PMID:22705379, PMID:22926441, PMID:23774252, PMID:24841706, PMID:25200491, PMID:26514923, PMID:26807887, PMID:27060453, PMID:28722351, PMID:30133131, PMID:30590137, PMID:30766661 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MT1X metallothionein 1X multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MT1 mRNA] CTD PMID:17460151 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP pyrazolanthrone inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC protein]; pyrazolanthrone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]; pyrazolanthrone promotes the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA] CTD PMID:21544845, PMID:22766066, PMID:25177032, PMID:30935901, PMID:31944254 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
EXP
ISO
pyrazolanthrone results in increased expression of MYC protein
pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]
MYC affects the reaction [pyrazolanthrone results in increased expression of BAX protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of MYC protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of TP53 protein]
CTD PMID:15034932, PMID:19418558 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYH2 myosin heavy chain 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MYH2 mRNA] CTD PMID:17460151 NCBI chr17:10,521,148...10,549,658
Ensembl chr17:10,521,148...10,549,700
JBrowse link
G MYH6 myosin heavy chain 6 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of MYH6 mRNA] CTD PMID:21873422 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273
JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of MYH7 mRNA] CTD PMID:21873422 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased expression of NCF1 protein] CTD PMID:22245600 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
decreases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
pyrazolanthrone inhibits the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of NFE2L2 protein]
pyrazolanthrone results in decreased expression of NFE2L2 protein
CTD PMID:16631525, PMID:17640564, PMID:23535287, PMID:25449124, PMID:25649257, PMID:28087833, PMID:29426002, PMID:30928397, PMID:31790703 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO
pyrazolanthrone affects the reaction [sodium arsenite affects the expression of NFKB1 protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]
pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of NFKB1 protein]
CTD PMID:18507870, PMID:22547200, PMID:29528074, PMID:30259999 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
pyrazolanthrone inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:18507870, PMID:22245600 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NGF nerve growth factor multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF protein]
pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein]
CTD PMID:17651887, PMID:19954754 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
JBrowse link
G NGFR nerve growth factor receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein] CTD PMID:17651887 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein]
pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]
CTD PMID:28004443, PMID:30259999 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Phosgene results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]
CTD PMID:16417967, PMID:16488514, PMID:17570326, PMID:18507870, PMID:19376148, PMID:19497418, PMID:20004183, PMID:20423716, PMID:20712904, PMID:21818760, PMID:22227475, PMID:22547200, PMID:23268108, PMID:23500011, PMID:23727179, PMID:23735482, PMID:24239652, PMID:26218279, PMID:30259999 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NPPB natriuretic peptide B multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB mRNA] CTD PMID:21873422 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NQO1 mRNA]
CTD PMID:18752316, PMID:29426002 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA] CTD PMID:19593819 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression EXP pyrazolanthrone results in increased expression of NR1H3 mRNA CTD PMID:19883121 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]] CTD PMID:28505368 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]] CTD PMID:15249158 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of NR4A1 mRNA] CTD PMID:17460151 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G OPTN optineurin multiple interactions ISO pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of OPTN protein] CTD PMID:28776281 NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308
JBrowse link
G OSM oncostatin M multiple interactions EXP pyrazolanthrone inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:21548952 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851
JBrowse link
G OSTM1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA] CTD PMID:30580027 NCBI chr 6:108,041,409...108,074,741
Ensembl chr 6:108,041,409...108,165,854
JBrowse link
G PAPPA pappalysin 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA] CTD PMID:24781252 NCBI chr 9:116,153,752...116,402,321
Ensembl chr 9:116,153,791...116,402,321
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of PARP1 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased expression of PARP1 protein modified form]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of PARP1 protein]; pyrazolanthrone results in increased susceptibility to [[TNFSF10 protein co-treated with kahweol acetate] results in increased cleavage of PARP1 protein]
pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PARP1 protein]; pyrazolanthrone inhibits the reaction [bakuchiol results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]
pyrazolanthrone inhibits the reaction [3-dinitrobenzene results in increased cleavage of PARP1 protein]
CTD PMID:14724571, PMID:15501958, PMID:16151469, PMID:16328441, PMID:16407847, PMID:17292878, PMID:18281123, PMID:19477251, PMID:19777565, PMID:20403343, PMID:21165570, PMID:21843586, PMID:23082001, PMID:23405080, PMID:24036456, PMID:24577723, PMID:25043952, PMID:25446857, PMID:25939952, PMID:27539140, PMID:28087840, PMID:28283887, PMID:29968959, PMID:30871965, PMID:31421117 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions
decreases expression
ISO pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]
pyrazolanthrone results in decreased expression of PCNA protein
CTD PMID:18593901, PMID:19418558 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDGFRB platelet derived growth factor receptor beta decreases expression ISO pyrazolanthrone results in decreased expression of PDGFRB mRNA; pyrazolanthrone results in decreased expression of PDGFRB protein CTD PMID:18332871 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PDK4 mRNA] CTD PMID:17460151 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions ISO pyrazolanthrone inhibits the reaction [Valproic Acid results in increased activity of PLAT protein] CTD PMID:23378038 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions EXP pyrazolanthrone inhibits the reaction [TNF protein results in increased activity of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of PLAU protein]; pyrazolanthrone promotes the reaction [resveratrol results in decreased expression of PLAU protein] CTD PMID:19874453, PMID:23437203 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLAUR plasminogen activator, urokinase receptor multiple interactions EXP pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] CTD PMID:22261521 NCBI chr19:43,646,095...43,670,197
Ensembl chr19:43,646,095...43,670,547
JBrowse link
G PLCB1 phospholipase C beta 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA] CTD PMID:19225867 NCBI chr20:8,132,266...8,884,900
Ensembl chr20:8,077,251...8,968,360
JBrowse link
G PLCB3 phospholipase C beta 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA] CTD PMID:19225867 NCBI chr11:64,251,530...64,269,452
Ensembl chr11:64,251,530...64,269,398
Ensembl chr11:64,251,530...64,269,398
JBrowse link
G PLCD1 phospholipase C delta 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA] CTD PMID:19225867 NCBI chr 3:38,007,496...38,029,642
Ensembl chr 3:38,007,496...38,029,642
Ensembl chr 3:38,007,496...38,029,642
JBrowse link
G PLIN3 perilipin 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA] CTD PMID:20628022 NCBI chr19:4,838,341...4,867,667
Ensembl chr19:4,838,341...4,867,694
JBrowse link
G PLXNA2 plexin A2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PLXNA2 mRNA] CTD PMID:17460151 NCBI chr 1:208,022,242...208,244,384
Ensembl chr 1:208,022,242...208,244,384
JBrowse link
G PON1 paraoxonase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of PON1 mRNA]; pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA]; pyrazolanthrone inhibits the reaction [GW 4064 results in decreased expression of PON1 mRNA] CTD PMID:16269825 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PON2 paraoxonase 2 decreases expression ISO pyrazolanthrone results in decreased expression of PON2 protein CTD PMID:15544923 NCBI chr 7:95,404,862...95,435,028
Ensembl chr 7:95,404,862...95,435,329
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
increases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of PPARA mRNA]
pyrazolanthrone results in increased expression of PPARA mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARA mRNA]
CTD PMID:19883121, PMID:21873422 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions EXP pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of PPARD protein] CTD PMID:17341418 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of PPARG mRNA; pyrazolanthrone results in increased expression of PPARG protein
pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PPARG protein]
CTD PMID:17372590, PMID:28283887 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of PPARGC1A mRNA
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A mRNA]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]]
CTD PMID:21873422, PMID:31447676 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRF1 perforin 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of PRF1 protein] CTD PMID:20082299 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
JBrowse link
G PRKCD protein kinase C delta multiple interactions EXP pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein] CTD PMID:16872482 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
G PROCR protein C receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased cleavage of PROCR protein] CTD PMID:24632454 NCBI chr20:35,172,072...35,215,989
Ensembl chr20:35,172,072...35,216,240
JBrowse link
G PSAT1 phosphoserine aminotransferase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PSAT1 mRNA] CTD PMID:17460151 NCBI chr 9:78,297,125...78,330,093
Ensembl chr 9:78,297,125...78,330,093
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions EXP pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of PTEN protein] CTD PMID:20534739 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G PTGDS prostaglandin D2 synthase multiple interactions ISO pyrazolanthrone affects the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGDS mRNA] CTD PMID:20382172 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [Sodium Fluoride results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]]
pyrazolanthrone inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Phosgene results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Sodium Selenite inhibits the reaction [pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:12832416, PMID:17084486, PMID:18481333, PMID:18507870, PMID:18596194, PMID:18840457, PMID:19376214, PMID:19808956, PMID:20004183, PMID:21262218, PMID:21818760, PMID:21911040, PMID:22288910, PMID:22547200, PMID:22728154, PMID:22767315, PMID:23268108, PMID:23376440, PMID:23416140, PMID:23500011, PMID:23727179, PMID:23735482, PMID:24239652, PMID:24967690, PMID:25199686, PMID:25888188, PMID:26218279, PMID:27818125 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTX3 pentraxin 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTX3 mRNA] CTD PMID:12832416 NCBI chr 3:157,436,850...157,443,633
Ensembl chr 3:157,436,850...157,443,633
JBrowse link
G RAD51 RAD51 recombinase multiple interactions EXP pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA] CTD PMID:22579953 NCBI chr15:40,694,774...40,732,340
Ensembl chr15:40,694,774...40,732,340
JBrowse link
G RAPGEF4 Rap guanine nucleotide exchange factor 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of RAPGEF4 mRNA] CTD PMID:17460151 NCBI chr 2:172,735,282...173,052,893
Ensembl chr 2:172,735,274...173,052,893
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 protein] CTD PMID:14729647 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G REG3G regenerating family member 3 gamma multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of REG3G mRNA] CTD PMID:17460151 NCBI chr 2:79,025,664...79,028,502
Ensembl chr 2:79,025,686...79,028,505
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
EXP
ISO
pyrazolanthrone affects the reaction [sodium arsenite affects the expression of RELA protein]; pyrazolanthrone inhibits the reaction [Acids results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [sodium arsenite affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]
pyrazolanthrone results in decreased expression of RELA protein
pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of RELA protein]; pyrazolanthrone inhibits the reaction [RELA protein binds to MMP9 promoter]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of RELA protein]; pyrazolanthrone inhibits the reaction [TNF protein affects the localization of RELA protein]
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Cisplatin inhibits the reaction [TNF protein affects the localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Cyclosporine affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of RELA protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of RELA protein]
CTD PMID:18507870, PMID:19074641, PMID:19616567, PMID:20534739, PMID:21295052, PMID:22547200, PMID:22706169, PMID:23103562, PMID:23774252, PMID:23958496, PMID:25540590, PMID:25677194, PMID:25888188, PMID:28474156, PMID:29426002, PMID:29528074, PMID:30133131 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RIOX2 ribosomal oxygenase 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein] CTD PMID:24434654 NCBI chr 3:97,941,818...97,972,431
Ensembl chr 3:97,941,818...97,972,457
JBrowse link
G ROBO1 roundabout guidance receptor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein] CTD PMID:25030704 NCBI chr 3:78,597,239...79,767,998
Ensembl chr 3:78,597,239...79,767,998
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions
decreases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [arsenite results in decreased phosphorylation of RPS6KB1 protein]; pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of RPS6KB1 protein]
pyrazolanthrone results in decreased activity of RPS6KB1 protein
CTD PMID:12534346, PMID:20589738, PMID:31051157 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions ISO
EXP
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of RUNX2 mRNA]
pyrazolanthrone inhibits the reaction [Ethanol results in increased activity of RUNX2 protein]
pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]
CTD PMID:26136938, PMID:31306638, PMID:32198086 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G RXRA retinoid X receptor alpha multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of RXRA protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of RXRA protein]
CTD PMID:16038797, PMID:16184197 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G S100A4 S100 calcium binding protein A4 multiple interactions EXP pyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein] CTD PMID:16948116 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G SAA1 serum amyloid A1 multiple interactions EXP pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of SAA1 mRNA] CTD PMID:12832416 NCBI chr11:18,266,264...18,269,967
Ensembl chr11:18,266,260...18,269,977
JBrowse link
G SCD stearoyl-CoA desaturase multiple interactions EXP pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SCD protein] CTD PMID:16162944 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SERPINA7 serpin family A member 7 multiple interactions ISO pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein] CTD PMID:29385629 NCBI chr  X:106,032,435...106,038,727
Ensembl chr  X:106,032,435...106,038,727
JBrowse link
G SERPINB2 serpin family B member 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SERPINB2 mRNA] CTD PMID:12832416 NCBI chr18:63,887,705...63,903,890
Ensembl chr18:63,871,692...63,903,888
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in decreased expression of SERPINE1 mRNA]
pyrazolanthrone inhibits the reaction [Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 protein]
CTD PMID:17379280, PMID:23378038 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 decreases activity EXP pyrazolanthrone results in decreased activity of SGK1 protein CTD PMID:12534346 NCBI chr 6:134,169,246...134,318,112
Ensembl chr 6:134,169,246...134,318,112
JBrowse link
G SHC1 SHC adaptor protein 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [diallyl trisulfide results in increased phosphorylation of SHC1 protein] CTD PMID:21616139, PMID:22020565 NCBI chr 1:154,962,298...154,974,492
Ensembl chr 1:154,962,298...154,974,395
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]
pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]]; pyrazolanthrone inhibits the reaction [Silicon Dioxide results in decreased expression of SIRT1 protein]
CTD PMID:22669716, PMID:31082419 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Rotenone results in decreased activity of SLC18A2 protein] CTD PMID:25496994 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430
JBrowse link
G SLC27A1 solute carrier family 27 member 1 multiple interactions
increases expression
ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC27A1 mRNA]
pyrazolanthrone results in increased expression of SLC27A1 mRNA
CTD PMID:21873422 NCBI chr19:17,468,745...17,506,169
Ensembl chr19:17,468,769...17,506,168
JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein]
[pyrazolanthrone co-treated with 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride] inhibits the reaction [Folic Acid results in increased phosphorylation of SMAD3 protein]
CTD PMID:19418558, PMID:31447676 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G SNAI1 snail family transcriptional repressor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein] CTD PMID:27060453 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [BDNF protein results in increased expression of SOD2 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:12832416, PMID:22261313 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX2 SRY-box transcription factor 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SOX2 protein] CTD PMID:23219847 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G SOX9 SRY-box transcription factor 9 multiple interactions EXP pyrazolanthrone promotes the reaction [resveratrol results in increased expression of SOX9] CTD PMID:24841706 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] CTD PMID:26385185 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SP7 Sp7 transcription factor multiple interactions ISO pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of SP7 protein] CTD PMID:31306638 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]
pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein]
CTD PMID:15121739, PMID:31051157 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
increases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SQSTM1 protein]
pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]
pyrazolanthrone inhibits the reaction [methylmercuric chloride results in increased expression of SQSTM1 protein]
pyrazolanthrone results in decreased expression of SQSTM1 protein
pyrazolanthrone results in increased expression of SQSTM1 protein
CTD PMID:24833599, PMID:25881548, PMID:27393035, PMID:27667695, PMID:28842171 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein] CTD PMID:16162944 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein] CTD PMID:22388943 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link
G SRRT serrate, RNA effector molecule multiple interactions EXP pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SRRT protein] CTD PMID:23219847 NCBI chr 7:100,874,971...100,888,664
Ensembl chr 7:100,875,103...100,888,664
JBrowse link
G ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Tretinoin results in increased expression of ST8SIA3 mRNA] CTD PMID:17069899 NCBI chr18:57,352,557...57,368,931
Ensembl chr18:57,352,557...57,371,731
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]
pyrazolanthrone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein]
CTD PMID:29567110, PMID:32199951 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] CTD PMID:26609140 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of and affects the localization of STAT3 protein]
CTD PMID:19429262, PMID:22696236, PMID:24349194, PMID:27174766, PMID:30871965 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 protein] CTD PMID:16308312 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
JBrowse link
G SYT11 synaptotagmin 11 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of SYT11 mRNA] CTD PMID:17460151 NCBI chr 1:155,859,502...155,885,199
Ensembl chr 1:155,859,567...155,885,199
JBrowse link
G TAC1 tachykinin precursor 1 multiple interactions ISO pyrazolanthrone promotes the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:18809416 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
JBrowse link
G TALDO1 transaldolase 1 multiple interactions ISO pyrazolanthrone affects the reaction [TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]] CTD PMID:19436114 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
G TARDBP TAR DNA binding protein multiple interactions EXP pyrazolanthrone promotes the reaction [Paraquat results in increased expression of TARDBP protein modified form] CTD PMID:22879928 NCBI chr 1:11,012,654...11,030,528
Ensembl chr 1:11,012,662...11,030,528
Ensembl chr 1:11,012,662...11,030,528
Ensembl chr 1:11,012,662...11,030,528
JBrowse link
G TAT tyrosine aminotransferase multiple interactions EXP pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA] CTD PMID:15744361 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
G TERT telomerase reverse transcriptase multiple interactions EXP [pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA] CTD PMID:23382840 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]
CTD PMID:16365456, PMID:21613822, PMID:25358858, PMID:31447676 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THPO thrombopoietin multiple interactions EXP pyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr 3:184,371,935...184,379,688
Ensembl chr 3:184,371,935...184,381,968
JBrowse link
G THRA thyroid hormone receptor alpha increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of THRA mRNA alternative form
[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; IL1B protein inhibits the reaction [pyrazolanthrone results in increased expression of THRA mRNA alternative form]
CTD PMID:17641275 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein] CTD PMID:27060453 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein] CTD PMID:27060453 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO
pyrazolanthrone affects the reaction [TNF protein results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of HNF4A mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of PPARA mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased activity of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of F3 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [TNF protein affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of OPTN protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased expression of XAF1 mRNA]; pyrazolanthrone inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Cisplatin inhibits the reaction [TNF protein affects the localization of RELA protein]]; pyrazolanthrone inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Ozone results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Acetaminophen]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; pyrazolanthrone inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased expression of TNF mRNA]; pyrazolanthrone promotes the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]
CTD PMID:12774022, PMID:14644621, PMID:15302094, PMID:15322261, PMID:16271621, PMID:16488514, PMID:17185352, PMID:17460151, PMID:17464197, PMID:18577375, PMID:19812349, PMID:19874453, PMID:19883121, PMID:20118172, PMID:20166895, PMID:20371967, PMID:20712904, PMID:20932985, PMID:21447443, PMID:22705379, PMID:22728154, PMID:22926441, PMID:23103562, PMID:23268108, PMID:23535185, PMID:23774252, PMID:23831309, PMID:24525298, PMID:25047101, PMID:25677194, PMID:26691871, PMID:28087840, PMID:28474156, PMID:28483571, PMID:28776281, PMID:29426002, PMID:29673704, PMID:29906494, PMID:30078834, PMID:30259999, PMID:31199065, PMID:31447676 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions EXP pyrazolanthrone inhibits the reaction [[arsenic trioxide co-treated with Buthionine Sulfoximine] results in increased expression of TNFRSF10B protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of TNFRSF10B protein] CTD PMID:17145888, PMID:26203587 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b multiple interactions ISO pyrazolanthrone inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein] CTD PMID:24333336, PMID:24813642, PMID:25234201, PMID:25290095, PMID:25677506 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions EXP pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of TNFSF10 mRNA]; pyrazolanthrone results in increased susceptibility to [[TNFSF10 protein co-treated with kahweol acetate] results in increased cleavage of PARP1 protein] CTD PMID:17545621, PMID:20403343 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]; pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein] CTD PMID:30580027 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G TNNI2 troponin I2, fast skeletal type multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of TNNI2 mRNA] CTD PMID:17460151 NCBI chr11:1,838,981...1,841,678
Ensembl chr11:1,838,981...1,841,680
JBrowse link
G TOP1 DNA topoisomerase I multiple interactions EXP [pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein] CTD PMID:15923621 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases phosphorylation
increases expression
decreases expression
EXP
ISO
[sodium arsenite co-treated with pyrazolanthrone] promotes the reaction [HSPA9 protein binds to TP53 protein modified form]; MYC affects the reaction [pyrazolanthrone results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein modified form]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Capsaicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased stability of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Pyrogallol results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of TP53 protein]
pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein]
pyrazolanthrone results in increased phosphorylation of TP53 protein
pyrazolanthrone promotes the reaction [TRP53 gene mutant form results in decreased susceptibility to sodium arsenite]
pyrazolanthrone results in increased expression of TP53 protein; pyrazolanthrone results in increased expression of TP53 protein modified form
pyrazolanthrone results in decreased expression of TP53 protein
CTD PMID:15034932, PMID:16046226, PMID:16061660, PMID:16166651, PMID:16450001, PMID:17292493, PMID:20191265, PMID:22706169, PMID:25305377, PMID:25939952, PMID:26630137, PMID:28842171, PMID:31734849, PMID:32238696 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions ISO [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] CTD PMID:30580027 NCBI chr11:36,483,769...36,510,313
Ensembl chr11:36,483,769...36,510,272
JBrowse link
G TRHR thyrotropin releasing hormone receptor multiple interactions EXP pyrazolanthrone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TRHR protein] CTD PMID:22889935 NCBI chr 8:109,086,585...109,121,565
Ensembl chr 8:109,086,621...109,119,584
Ensembl chr 8:109,086,621...109,119,584
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein] CTD PMID:27060453 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636
JBrowse link
G UBA7 ubiquitin like modifier activating enzyme 7 decreases expression EXP pyrazolanthrone results in decreased expression of UBA7 protein CTD PMID:25649257 NCBI chr 3:49,805,205...49,813,953
Ensembl chr 3:49,805,209...49,813,953
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA] CTD PMID:17256720 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of VCAM1 mRNA]; pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:16271621, PMID:19609071, PMID:28483571 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VDR vitamin D receptor multiple interactions EXP pyrazolanthrone inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein] CTD PMID:18596194, PMID:19176594, PMID:23968725, PMID:28651835 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VIM vimentin multiple interactions EXP pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of VIM protein] CTD PMID:27060453 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G XAF1 XIAP associated factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased expression of XAF1 mRNA] CTD PMID:23103562 NCBI chr17:6,755,408...6,775,647
Ensembl chr17:6,755,447...6,775,647
JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of XIAP protein] CTD PMID:23423712 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976
Ensembl chr  X:123,859,724...123,913,976
JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A multiple interactions ISO pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of ZC3H12A protein] CTD PMID:26865670 NCBI chr 1:37,474,518...37,484,377
Ensembl chr 1:37,474,580...37,484,377
JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G CCNA2 cyclin A2 affects expression EXP aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB2 cyclin B2 affects expression EXP aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045
JBrowse link
G CDC45 cell division cycle 45 affects expression EXP aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr22:19,479,294...19,520,612
Ensembl chr22:19,479,457...19,520,612
JBrowse link
G CDK1 cyclin dependent kinase 1 affects expression EXP aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B affects expression EXP aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305
JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C affects expression EXP aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634
JBrowse link
G CHEK1 checkpoint kinase 1 affects expression EXP aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr11:125,624,910...125,676,256
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 affects expression EXP aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CTNNB1 catenin beta 1 decreases expression ISO aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G DDIT3 DNA damage inducible transcript 3 affects expression EXP aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DUSP1 dual specificity phosphatase 1 affects expression EXP aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G E2F1 E2F transcription factor 1 affects expression EXP aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G E2F2 E2F transcription factor 2 affects expression EXP aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 1:23,505,696...23,531,250
Ensembl chr 1:23,506,438...23,531,233
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha affects expression EXP aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit affects expression EXP aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KIF20B kinesin family member 20B affects expression EXP aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr10:89,701,590...89,774,934
Ensembl chr10:89,701,610...89,774,939
JBrowse link
G MCM3 minichromosome maintenance complex component 3 affects expression EXP aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881
JBrowse link
G MCM6 minichromosome maintenance complex component 6 affects expression EXP aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G UHRF1 ubiquitin like with PHD and ring finger domains 1 affects expression EXP aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr19:4,903,080...4,962,154
Ensembl chr19:4,903,080...4,962,154
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
cobimetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L11 BCL2 like 11 multiple interactions
increases expression
EXP 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in increased expression of BCL2L11 protein alternative form]; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in increased expression of BCL2L11 protein]; [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with cobimetinib] results in decreased phosphorylation of BCL2L11 protein alternative form; cobimetinib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of BCL2L11 protein alternative form]
cobimetinib results in increased expression of BCL2L11 protein; cobimetinib results in increased expression of BCL2L11 protein alternative form
CTD PMID:22084396 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase increases response to substance
multiple interactions
EXP BRAF protein mutant form results in increased susceptibility to cobimetinib
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [BRAF protein mutant form results in increased susceptibility to cobimetinib]
CTD PMID:22084396 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929
Ensembl chr 7:140,719,327...140,924,929
JBrowse link
G CCND1 cyclin D1 decreases expression
multiple interactions
EXP cobimetinib results in decreased expression of CCND1 protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in decreased expression of CCND1 protein]
CTD PMID:22084396 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G GPT glutamic--pyruvic transaminase increases secretion ISO cobimetinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G KRAS KRAS proto-oncogene, GTPase increases response to substance
multiple interactions
EXP KRAS protein mutant form results in increased susceptibility to cobimetinib
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [KRAS protein mutant form results in increased susceptibility to cobimetinib]; cobimetinib promotes the reaction [KRAS protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine]
CTD PMID:22084396 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP cobimetinib results in decreased phosphorylation of MAPK1 protein CTD PMID:22084396 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP cobimetinib results in decreased phosphorylation of MAPK3 protein CTD PMID:22084396 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NRAS NRAS proto-oncogene, GTPase increases response to substance EXP NRAS protein mutant form results in increased susceptibility to cobimetinib CTD PMID:22084396 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP cobimetinib results in increased cleavage of PARP1 protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in increased cleavage of PARP1 protein]; cobimetinib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased cleavage of PARP1 protein]
CTD PMID:22084396 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP cobimetinib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein] CTD PMID:22084396 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
diosmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP diosmetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP diosmetin results in decreased activity of CYP1A1 protein CTD PMID:10781868, PMID:21482471 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP diosmetin results in decreased activity of CYP1A2 protein CTD PMID:28867436 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP diosmetin results in decreased activity of CYP1B1 protein CTD PMID:10781868, PMID:21482471 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP diosmetin results in decreased activity of CYP2C19 protein CTD PMID:28867436 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity EXP diosmetin results in decreased activity of CYP2C8 protein CTD PMID:28867436 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP diosmetin results in decreased activity of CYP2C9 protein CTD PMID:28867436 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP diosmetin results in decreased activity of CYP2E1 protein CTD PMID:28867436 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions EXP diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:16934226 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:16934226 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PKM pyruvate kinase M1/2 increases activity EXP diosmetin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr15:72,199,029...72,231,389
Ensembl chr15:72,199,029...72,231,822
JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions ISO [diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,013
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:28867436 NCBI chr12:21,264,600...21,403,663
Ensembl chr12:21,264,600...21,419,594
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16934226 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO
EXP
Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions ISO Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
CTD PMID:21477647, PMID:32061149 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]
CTD PMID:21477647, PMID:23665045, PMID:32061149 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647, PMID:23665045 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]
CTD PMID:23665045, PMID:32061149 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
CTD PMID:23665045, PMID:32061149 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647, PMID:23665045 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]
CTD PMID:23665045, PMID:32061149 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
doramapimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO BIRB 796 results in increased expression of ABCC2 mRNA CTD PMID:21328587 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ACTG2 actin gamma 2, smooth muscle increases expression ISO BIRB 796 results in increased expression of ACTG2 mRNA CTD PMID:24303162 NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865
JBrowse link
G ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression ISO BIRB 796 results in increased expression of ADH7 mRNA CTD PMID:24303162 NCBI chr 4:99,412,263...99,435,342
Ensembl chr 4:99,412,261...99,435,737
JBrowse link
G AHSG alpha 2-HS glycoprotein decreases expression ISO BIRB 796 results in decreased expression of AHSG mRNA CTD PMID:21328587 NCBI chr 3:186,613,060...186,621,318
Ensembl chr 3:186,613,060...186,621,318
JBrowse link
G AK5 adenylate kinase 5 increases expression ISO BIRB 796 results in increased expression of AK5 mRNA CTD PMID:24303162 NCBI chr 1:77,281,908...77,559,966
Ensembl chr 1:77,282,019...77,559,966
JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 increases expression ISO BIRB 796 results in increased expression of AKR1B7 mRNA CTD PMID:21328587 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875
JBrowse link
G APOA4 apolipoprotein A4 decreases expression ISO BIRB 796 results in decreased expression of APOA4 mRNA CTD PMID:21328587 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G C1QA complement C1q A chain decreases expression ISO BIRB 796 results in decreased expression of C1QA mRNA CTD PMID:21328587 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,636,628...22,639,678
JBrowse link
G C1QB complement C1q B chain decreases expression ISO BIRB 796 results in decreased expression of C1QB mRNA CTD PMID:21328587 NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637
JBrowse link
G CA3 carbonic anhydrase 3 decreases expression ISO BIRB 796 results in decreased expression of CAR3 mRNA CTD PMID:21328587 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CD5L CD5 molecule like decreases expression ISO BIRB 796 results in decreased expression of CD5L mRNA CTD PMID:21328587 NCBI chr 1:157,827,068...157,841,844
Ensembl chr 1:157,830,911...157,898,256
JBrowse link
G CD74 CD74 molecule decreases expression ISO BIRB 796 results in decreased expression of CD74 mRNA CTD PMID:21328587 NCBI chr 5:150,400,041...150,412,936
Ensembl chr 5:150,400,041...150,412,929
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 decreases expression ISO BIRB 796 results in decreased expression of CEACAM1 mRNA CTD PMID:24303162 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CES3 carboxylesterase 3 increases expression ISO BIRB 796 results in increased expression of CES3 mRNA CTD PMID:21328587 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149
JBrowse link
G CLEC1B C-type lectin domain family 1 member B decreases expression ISO BIRB 796 results in decreased expression of CLEC1B mRNA CTD PMID:21328587 NCBI chr12:9,986,119...10,001,894
Ensembl chr12:9,985,642...10,013,424
JBrowse link
G CTSS cathepsin S decreases expression ISO BIRB 796 results in decreased expression of CTSS mRNA CTD PMID:21328587 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,188...150,765,792
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions EXP BIRB 796 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases secretion EXP BIRB 796 results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP BIRB 796 inhibits the reaction [Dinitrofluorobenzene results in increased secretion of CXCL8 protein]; BIRB 796 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein] CTD PMID:14997032, PMID:19427879 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 multiple interactions EXP BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein] CTD PMID:14997032 NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 multiple interactions EXP BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein] CTD PMID:14997032 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 increases expression ISO BIRB 796 results in increased expression of CYP2A5 mRNA CTD PMID:21328587 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases expression ISO BIRB 796 results in increased expression of CYP2A4 mRNA CTD PMID:21328587 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G EGR1 early growth response 1 increases expression ISO BIRB 796 results in increased expression of EGR1 mRNA CTD PMID:21328587 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G FCGR2B Fc fragment of IgG receptor IIb decreases expression ISO BIRB 796 results in decreased expression of FCGR2B mRNA CTD PMID:21328587 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,147...161,678,654
JBrowse link
G FGF8 fibroblast growth factor 8 decreases expression ISO BIRB 796 results in decreased expression of FGF8 mRNA CTD PMID:24303162 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,130...101,780,369
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO BIRB 796 results in decreased expression of G6PC mRNA CTD PMID:21328587 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO BIRB 796 results in increased expression of GCLC mRNA CTD PMID:21328587 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GPX2 glutathione peroxidase 2 increases expression ISO BIRB 796 results in increased expression of GPX2 mRNA CTD PMID:21328587 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,905
JBrowse link
G GRM8 glutamate metabotropic receptor 8 increases expression ISO BIRB 796 results in increased expression of GRM8 mRNA CTD PMID:24303162 NCBI chr 7:126,438,598...127,252,941
Ensembl chr 7:126,438,598...127,253,093
Ensembl chr 7:126,438,598...127,253,093
JBrowse link
G GSTM2 glutathione S-transferase mu 2 increases expression ISO BIRB 796 results in increased expression of GSTM2 mRNA CTD PMID:21328587 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTM3 glutathione S-transferase mu 3 increases expression ISO BIRB 796 results in increased expression of GSTM3 mRNA CTD PMID:21328587 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 decreases expression ISO BIRB 796 results in decreased expression of H2-AB1 mRNA CTD PMID:21328587 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HP haptoglobin decreases expression ISO BIRB 796 results in decreased expression of HP mRNA CTD PMID:21328587 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055
JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase decreases expression ISO BIRB 796 results in decreased expression of HPD mRNA CTD PMID:24303162 NCBI chr12:121,839,527...121,888,611
Ensembl chr12:121,839,527...121,863,596
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP BIRB 796 inhibits the reaction [Dinitrofluorobenzene results in increased expression of ICAM1 protein] CTD PMID:19427879 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G KCNK1 potassium two pore domain channel subfamily K member 1 decreases expression ISO BIRB 796 results in decreased expression of KCNK1 mRNA CTD PMID:24303162 NCBI chr 1:233,614,106...233,672,514
Ensembl chr 1:233,614,106...233,672,514
JBrowse link
G LMOD1 leiomodin 1 increases expression ISO BIRB 796 results in increased expression of LMOD1 mRNA CTD PMID:24303162 NCBI chr 1:201,896,456...201,946,548
Ensembl chr 1:201,896,456...201,946,588
JBrowse link
G MEIG1 meiosis/spermiogenesis associated 1 increases expression ISO BIRB 796 results in increased expression of MEIG1 mRNA CTD PMID:21328587 NCBI chr10:14,954,228...14,988,050
Ensembl chr10:14,959,388...14,988,050
JBrowse link
G MT1X metallothionein 1X increases expression ISO BIRB 796 results in increased expression of MT1 mRNA CTD PMID:21328587 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MYBPC1 myosin binding protein C1 decreases expression ISO BIRB 796 results in decreased expression of MYBPC1 mRNA CTD PMID:24303162 NCBI chr12:101,594,849...101,695,841
Ensembl chr12:101,568,353...101,686,028
JBrowse link
G MYH11 myosin heavy chain 11 increases expression ISO BIRB 796 results in increased expression of MYH11 mRNA CTD PMID:24303162 NCBI chr16:15,703,135...15,857,032
Ensembl chr16:15,703,135...15,857,028
JBrowse link
G MYH3 myosin heavy chain 3 increases expression ISO BIRB 796 results in increased expression of MYH3 mRNA CTD PMID:24303162 NCBI chr17:10,628,527...10,678,347
Ensembl chr17:10,628,526...10,657,309
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO BIRB 796 results in increased expression of NQO1 mRNA CTD PMID:21328587 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OR51E2 olfactory receptor family 51 subfamily E member 2 increases expression ISO BIRB 796 results in increased expression of OLR59 mRNA CTD PMID:24303162 NCBI chr11:4,680,171...4,697,853
Ensembl chr11:4,680,171...4,697,854
JBrowse link
G OTOG otogelin decreases expression ISO BIRB 796 results in decreased expression of OTOG mRNA CTD PMID:24303162 NCBI chr11:17,547,259...17,646,044
Ensembl chr11:17,547,373...17,647,150
JBrowse link
G PFN2 profilin 2 increases expression ISO BIRB 796 results in increased expression of PFN2 mRNA CTD PMID:21328587 NCBI chr 3:149,964,904...149,970,895
Ensembl chr 3:149,964,904...150,050,788
JBrowse link
G PON1 paraoxonase 1 decreases expression ISO BIRB 796 results in decreased expression of PON1 mRNA CTD PMID:24303162 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression ISO BIRB 796 results in increased expression of PPARG mRNA CTD PMID:21328587 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRM2 protamine 2 increases expression ISO BIRB 796 results in increased expression of PRM2 mRNA CTD PMID:21328587 NCBI chr16:11,275,639...11,276,480
Ensembl chr16:11,275,639...11,276,480
JBrowse link
G RGS4 regulator of G protein signaling 4 increases expression ISO BIRB 796 results in increased expression of RGS4 mRNA CTD PMID:24303162 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression ISO BIRB 796 results in increased expression of SLC7A11 mRNA CTD PMID:21328587 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 decreases expression ISO BIRB 796 results in decreased expression of SPOCK2 mRNA CTD PMID:24303162 NCBI chr10:72,059,034...72,095,313
Ensembl chr10:72,059,034...72,089,032
JBrowse link
G SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 decreases expression ISO BIRB 796 results in decreased expression of SPSB1 mRNA CTD PMID:21328587 NCBI chr 1:9,292,894...9,369,532
Ensembl chr 1:9,292,894...9,369,532
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression ISO BIRB 796 results in increased expression of SRXN1 mRNA CTD PMID:21328587 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G STMN2 stathmin 2 increases expression ISO BIRB 796 results in increased expression of STMN2 mRNA CTD PMID:24303162 NCBI chr 8:79,611,117...79,666,162
Ensembl chr 8:79,610,814...79,666,175
Ensembl chr 8:79,610,814...79,666,175
JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 decreases expression ISO BIRB 796 results in decreased expression of VSIG4 mRNA CTD PMID:21328587 NCBI chr  X:66,021,738...66,040,092
Ensembl chr  X:66,021,738...66,040,125
JBrowse link
G ZNF324B zinc finger protein 324B increases expression ISO BIRB 796 results in increased expression of ZFP324 mRNA CTD PMID:21328587 NCBI chr19:58,451,611...58,457,833
Ensembl chr19:58,451,611...58,457,833
JBrowse link
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases response to substance
increases metabolic processing
decreases activity
increases expression
EXP CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA
CTD PMID:18454852, PMID:19601638, PMID:21482471 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases metabolic processing
increases expression
decreases activity
EXP CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein
CTD PMID:19601638, PMID:21482471 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
isoorientin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:22446813 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP homoorientin results in decreased phosphorylation of AKT1 protein
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]
CTD PMID:24374571 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] CTD PMID:22446813 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G IL6 interleukin 6 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:22446813 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein] CTD PMID:24374571 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein] CTD PMID:24374571 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MPO myeloperoxidase multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:22446813 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:22446813 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
luteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP Luteolin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Luteolin co-treated with Cisplatin] results in increased expression of ABCC2 protein; Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:23770416 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions ISO Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC4 protein] CTD PMID:23770416 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) affects activity EXP Luteolin affects the activity of ABCG2 protein CTD PMID:20403331 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Luteolin inhibits the reaction [cobaltous chloride results in increased activity of ACHE protein] CTD PMID:31362009 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Luteolin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:19747501 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions EXP Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA] CTD PMID:19557821 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP
ISO
Luteolin binds to and results in decreased activity of AHR protein
Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
CTD PMID:14644660, PMID:20450880 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
EXP
ISO
Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased phosphorylation of AKT1 protein
Luteolin results in increased phosphorylation of AKT1 protein
Luteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein]; Luteolin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
[Luteolin co-treated with Hydrogen Peroxide] results in increased expression of AKT1 protein; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased expression of AKT1 protein
CTD PMID:18591783, PMID:18720166, PMID:19344998, PMID:20153296, PMID:20685402, PMID:21782929, PMID:22926442, PMID:25448439, PMID:27474067, PMID:27525270, PMID:32035215 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions EXP Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) multiple interactions EXP Luteolin inhibits the reaction [Tunicamycin results in increased expression of ASNS mRNA] CTD PMID:32407927 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein modified form] CTD PMID:32407927 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression
ISO
EXP
Luteolin inhibits the reaction [Methamphetamine results in increased expression of ATG5 protein]
Luteolin results in increased expression of ATG5 protein
CTD PMID:32035215, PMID:32268164 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of BAX protein]
Luteolin results in increased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of BAX protein]
CTD PMID:21601631, PMID:27474067, PMID:27525270, PMID:32035215, PMID:32268164 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of BCL2 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2 protein]; Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein] CTD PMID:19557821, PMID:25448439, PMID:27474067, PMID:32268164 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions
EXP Luteolin results in decreased expression of BCL2L1 protein
Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2L1 protein]
CTD PMID:21601631, PMID:25448439 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
ISO
EXP
Luteolin inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]
Luteolin results in increased expression of BECN1 protein
CTD PMID:32035215, PMID:32268164 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15334063 NCBI chr11:102,347,182...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G CASP1 caspase 1 multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases cleavage
increases activity
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased cleavage of CASP3 protein]; [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Luteolin results in increased expression of and results in increased cleavage of CASP3 protein
Luteolin results in increased expression of CASP3 protein
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
Luteolin results in increased activity of CASP3 protein
Luteolin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased expression of CASP3 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of CASP3 protein modified form]
CTD PMID:16140950, PMID:18331776, PMID:19397994, PMID:21074525, PMID:21601631, PMID:23770416, PMID:24525192, PMID:27474067, PMID:27489195, PMID:27525270, PMID:31288002, PMID:32035215, PMID:32268164, PMID:32407927 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 increases activity EXP Luteolin results in increased activity of CASP7 protein CTD PMID:21074525 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions EXP
ISO
[Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]
CTD PMID:15334063, PMID:16140950, PMID:24525192, PMID:27525270 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity
increases cleavage
EXP Luteolin results in increased activity of CASP9 protein
Luteolin results in increased cleavage of CASP9 protein
CTD PMID:18331776, PMID:19397994, PMID:21601631, PMID:27474067, PMID:27489195 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase affects activity
decreases activity
multiple interactions
EXP
ISO
Luteolin affects the activity of CAT protein
Luteolin results in decreased activity of CAT protein
Fluorouracil promotes the reaction [Luteolin results in decreased activity of CAT protein]; Luteolin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Luteolin promotes the reaction [Fluorouracil results in decreased activity of CAT protein]
CTD PMID:18503759, PMID:31288002 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Luteolin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCN5 cellular communication network factor 5 decreases expression EXP Luteolin results in decreased expression of CCN5 mRNA CTD PMID:19397994 NCBI chr20:44,714,204...44,728,041
Ensembl chr20:44,714,844...44,728,509
JBrowse link
G CCNA2 cyclin A2 decreases expression EXP Luteolin results in decreased expression of CCNA2 protein CTD PMID:22926442 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP Luteolin results in decreased expression of CCNB1 mRNA; Luteolin results in decreased expression of CCNB1 protein CTD PMID:18331776, PMID:19397994, PMID:22926442 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression
ISO Fluorouracil promotes the reaction [Luteolin results in decreased expression of CCND1 protein]; Luteolin promotes the reaction [Fluorouracil results in decreased expression of CCND1 protein] CTD PMID:31288002 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CD40 CD40 molecule multiple interactions EXP Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Calcimycin results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CD74 CD74 molecule decreases expression EXP Luteolin results in decreased expression of CD74 mRNA CTD PMID:18818744 NCBI chr 5:150,400,041...150,412,936
Ensembl chr 5:150,400,041...150,412,929
JBrowse link
G CDH1 cadherin 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of CDH1 protein] CTD PMID:27474067, PMID:32268164 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH2 cadherin 2 multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of CDH2 protein] CTD PMID:27474067 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDH5 cadherin 5 multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of CDH5 mRNA] CTD PMID:32035215 NCBI chr16:66,366,657...66,404,784
Ensembl chr16:66,366,622...66,404,784
JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP Luteolin results in decreased expression of CDK1 protein CTD PMID:22926442 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases activity
decreases expression
EXP Luteolin results in decreased activity of CDK2 protein
Luteolin results in decreased expression of CDK2 protein
CTD PMID:11322924, PMID:22926442 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
EXP
ISO
Luteolin results in increased expression of CDKN1A mRNA; Luteolin results in increased expression of CDKN1A protein
Fluorouracil promotes the reaction [Luteolin results in increased expression of CDKN1A protein]; Luteolin promotes the reaction [Fluorouracil results in increased expression of CDKN1A protein]
CTD PMID:11322924, PMID:11790449, PMID:19397994, PMID:22926442, PMID:31288002, PMID:32268164 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Luteolin results in increased expression of CDKN1B protein CTD PMID:11322924 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C decreases expression EXP Luteolin results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Luteolin inhibits the reaction [chromium hexavalent ion results in increased activity of CHUK protein] CTD PMID:25448439 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CSF2 colony stimulating factor 2 decreases expression
multiple interactions
EXP
ISO
Luteolin results in decreased expression of CSF2 mRNA
Luteolin inhibits the reaction [Calcimycin results in increased expression of CSF2 mRNA]
CTD PMID:10718847, PMID:17950587 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP Luteolin results in decreased expression of CTNNB1 protein CTD PMID:32268164 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
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G CXCL12 C-X-C motif chemokine ligand 12 multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of CXCL12 mRNA] CTD PMID:32035215 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of CXCL8 protein] CTD PMID:25448439, PMID:30133131 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 multiple interactions ISO Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA] CTD PMID:19426678 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
decreases activity
EXP
ISO
Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Dust analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Particulate Matter analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of CYP1A1 mRNA]
Luteolin results in increased expression of CYP1A1 mRNA
Luteolin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
Luteolin results in decreased activity of CYP1A1 protein
CTD PMID:16263508, PMID:17090139, PMID:20403331, PMID:20930378, PMID:21482471, PMID:23994263, PMID:29584932 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP Luteolin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity
increases expression
EXP Luteolin results in decreased activity of CYP1B1 protein
Luteolin results in increased expression of CYP1B1 mRNA
CTD PMID:21482471, PMID:23994263 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP Luteolin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Luteolin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr10:94,938,6