Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:paromomycin
go back to main search page
Accession:CHEBI:7934 term browser browse the term
Definition:An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.
Synonyms:related_synonym: (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside;   Aminosidin;   Catenulin;   Formula=C23H45N5O14;   Hydroxymycin;   InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1;   InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N;   Monomycin A;   Paromomycin I;   R-400;   SMILES=NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O;   Zygomycin A1;   aminosidine;   crestomycin;   estomycin;   neomycin E;   paromomicina;   paromomycine;   paromomycinum;   paucimycin;   paucimycinum
 alt_id: CHEBI:44703
 xref: CAS:7542-37-2 "ChemIDplus";   CAS:7542-37-2 "KEGG COMPOUND";   DrugBank:DB01421;   Drug_Central:2067 "DrugCentral";   KEGG:C00832;   KEGG:D07467
 xref_mesh: MESH:D010303
 xref: PDBeChem:PAR;   PMID:18447603 "Europe PMC";   PMID:18947845 "Europe PMC";   PMID:8036682 "Europe PMC";   Patent:US2895876;   Patent:US2916485;   Reaxys:72285 "Reaxys"


show annotations for term's descendants       view all columns           Sort by:
 
paromomycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        antimicrobial agent 17211
          carbohydrate-containing antibiotic 2546
            aminoglycoside antibiotic 2529
              paromomycin 1
                lividomycin A 0
                lividomycin B + 0
                paromomycin sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            heteroorganic entity 19055
                              organochalcogen compound 18781
                                organooxygen compound 18694
                                  carbohydrates and carbohydrate derivatives 12101
                                    carbohydrate 12101
                                      carbohydrate derivative 11727
                                        glycosyl compound 10788
                                          glycoside 9139
                                            aminoglycoside 8351
                                              aminoglycoside antibiotic 2529
                                                paromomycin 1
                                                  lividomycin A 0
                                                  lividomycin B + 0
                                                  paromomycin sulfate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.