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ONTOLOGY REPORT - ANNOTATIONS


Term:pentobarbital
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Accession:CHEBI:7983 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Synonyms:exact_synonym: 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: 5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione;   5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;   5-ethyl-5-(1-methylbutyl)barbituric acid;   5-ethyl-5-(sec-pentyl)barbituric acid;   Formula=C11H18N2O3;   InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);   InChIKey=WEXRUCMBJFQVBZ-UHFFFAOYSA-N;   Nembutal;   Pentobarbitone;   SMILES=CCCC(C)C1(CC)C(=O)NC(=O)NC1=O
 alt_id: CHEBI:102327
 xref: Beilstein:87067;   CAS:76-74-4;   DrugBank:DB00312;   Drug_Central:2095;   Gmelin:281792;   HMDB:HMDB0014457;   KEGG:C07422;   KEGG:D00499;   LINCS:LSM-1566
 xref_mesh: MESH:D010424
 xref: PMID:15324906;   PMID:15801854;   PMID:15857133;   PMID:16720246;   PMID:1977910;   PMID:19879734;   PMID:2215478;   PMID:23246494;   PMID:23345614;   PMID:23526799;   PMID:23663566;   PMID:2579237;   PMID:3599019;   PMID:3654008;   PMID:6864729;   PMID:7154009;   PMID:9016329;   PMID:9412440;   PMID:9599235;   Reaxys:87067;   VSDB:3000;   Wikipedia:Pentobarbital


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pentobarbital term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 87,503,017 87,713,323 RGD:6480464
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G APAF1 apoptotic peptidase activating factor 1 JBrowse link 12 98,645,141 98,735,433 RGD:6480464
G APP amyloid beta precursor protein JBrowse link 21 25,880,550 26,171,128 RGD:6480464
G BCL10 BCL10 immune signaling adaptor JBrowse link 1 85,265,776 85,276,632 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G BDNF brain derived neurotrophic factor JBrowse link 11 27,654,893 27,722,030 RGD:6480464
G BLK BLK proto-oncogene, Src family tyrosine kinase JBrowse link 8 11,493,991 11,564,599 RGD:6480464
G BNIP3 BCL2 interacting protein 3 JBrowse link 10 131,967,683 131,982,013 RGD:6480464
G CACNA1I calcium voltage-gated channel subunit alpha1 I JBrowse link 22 39,570,753 39,689,737 RGD:6480464
G CASP14 caspase 14 JBrowse link 19 15,049,480 15,058,293 RGD:6480464
G CASP7 caspase 7 JBrowse link 10 113,679,162 113,730,909 RGD:6480464
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6480464
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6480464
G CCND3 cyclin D3 JBrowse link 6 41,934,933 42,048,894 RGD:6480464
G CD27 CD27 molecule JBrowse link 12 6,444,867 6,451,718 RGD:6480464
G CD40LG CD40 ligand JBrowse link X 136,648,158 136,660,390 RGD:6480464
G CDK2 cyclin dependent kinase 2 JBrowse link 12 55,966,830 55,972,789 RGD:6480464
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:6480464
G CHEK2 checkpoint kinase 2 JBrowse link 22 28,687,743 28,741,866 RGD:6480464
G CNR1 cannabinoid receptor 1 JBrowse link 6 88,139,864 88,167,349 RGD:6480464
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 12 93,677,342 93,894,840 RGD:6480464
G CRH corticotropin releasing hormone JBrowse link 8 66,176,376 66,178,464 RGD:6480464
G CRHR1 corticotropin releasing hormone receptor 1 JBrowse link 17 45,784,280 45,835,828 RGD:6480464
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 JBrowse link 15 74,748,845 74,756,607 RGD:6480464
G DFFA DNA fragmentation factor subunit alpha JBrowse link 1 10,456,522 10,472,529 RGD:6480464
G DRD2 dopamine receptor D2 JBrowse link 11 113,409,595 113,475,398 RGD:6480464
G FASLG Fas ligand JBrowse link 1 172,659,008 172,666,876 RGD:6480464
G FOLH1 folate hydrolase 1 JBrowse link 11 49,145,092 49,208,642 RGD:6480464
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 14 75,278,828 75,282,230 RGD:6480464
G FSHB follicle stimulating hormone subunit beta JBrowse link 11 30,231,014 30,235,194 RGD:6480464
G FST follistatin JBrowse link 5 53,480,338 53,487,134 RGD:6480464
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 JBrowse link 5 161,847,191 161,899,971 RGD:6480464
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 JBrowse link 4 46,243,548 46,390,300 RGD:6480464
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 JBrowse link 4 46,918,900 46,993,581 RGD:6480464
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 5 161,685,721 161,702,592 RGD:6480464
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 4 46,993,560 47,438,409 RGD:6480464
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 JBrowse link 5 161,288,429 161,548,404 RGD:6480464
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 JBrowse link 15 26,543,546 26,773,763 RGD:6480464
G GABRD gamma-aminobutyric acid type A receptor subunit delta JBrowse link 1 2,019,345 2,030,758 RGD:6480464
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 151,953,124 151,974,692 RGD:6480464
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 JBrowse link 5 162,067,465 162,155,539 RGD:6480464
G GAL galanin and GMAP prepropeptide JBrowse link 11 68,684,544 68,691,175 RGD:6480464
G GAP43 growth associated protein 43 JBrowse link 3 115,623,510 115,721,485 RGD:6480464
G GAST gastrin JBrowse link 17 41,712,331 41,715,969 RGD:6480464
G GHRL ghrelin and obestatin prepropeptide JBrowse link 3 10,285,666 10,292,947 RGD:6480464
G GJB1 gap junction protein beta 1 JBrowse link X 71,215,212 71,225,516 RGD:6480464
G GNAI1 G protein subunit alpha i1 JBrowse link 7 80,134,831 80,226,181 RGD:6480464
G GNAO1 G protein subunit alpha o1 JBrowse link 16 56,191,489 56,357,444 RGD:6480464
G GNAS GNAS complex locus JBrowse link 20 58,839,681 58,911,196 RGD:6480464
G GNRHR gonadotropin releasing hormone receptor JBrowse link 4 67,737,118 67,754,388 RGD:6480464
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 4 157,220,120 157,370,583 RGD:6480464
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 9 137,139,092 137,168,759 RGD:6480464
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 16 9,753,404 10,182,928 RGD:6480464
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 12 13,537,337 13,982,012 RGD:6480464
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C JBrowse link 17 74,842,021 74,860,843 RGD:6480464
G HCRTR1 hypocretin receptor 1 JBrowse link 1 31,617,689 31,632,518 RGD:6480464
G HCRTR2 hypocretin receptor 2 JBrowse link 6 55,106,460 55,284,698 RGD:6480464
G HSPB1 heat shock protein family B (small) member 1 JBrowse link 7 76,302,673 76,304,292 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G ITGAE integrin subunit alpha E JBrowse link 17 3,714,628 3,803,766 RGD:6480464
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 1 58,780,791 58,784,047 RGD:6480464
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link 19 12,791,486 12,793,315 RGD:6480464
G JUND JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 19 18,279,694 18,281,622 RGD:6480464
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link 21 34,446,688 34,512,210 RGD:6480464
G KCNH2 potassium voltage-gated channel subfamily H member 2 JBrowse link 7 150,944,956 150,978,321 RGD:6480464
G KRAS KRAS proto-oncogene, GTPase JBrowse link 12 25,205,246 25,250,929 RGD:6480464
G LHB luteinizing hormone subunit beta JBrowse link 19 49,015,980 49,017,091 RGD:6480464
G LTBR lymphotoxin beta receptor JBrowse link 12 6,375,160 6,391,571 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MCL1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 1 150,574,551 150,579,738 RGD:6480464
G MED1 mediator complex subunit 1 JBrowse link 17 39,404,285 39,451,281 RGD:6480464
G MPO myeloperoxidase JBrowse link 17 58,269,855 58,280,935 RGD:6480464
G MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 3 38,138,661 38,143,022 RGD:6480464
G NPPA natriuretic peptide A JBrowse link 1 11,845,709 11,847,783 RGD:6480464
G NPY neuropeptide Y JBrowse link 7 24,284,190 24,291,862 RGD:6480464
G NPY1R neuropeptide Y receptor Y1 JBrowse link 4 163,323,962 163,344,832 RGD:6480464
G NR1I2 nuclear receptor subfamily 1 group I member 2 JBrowse link 3 119,780,484 119,818,485 RGD:6480464
G NR1I3 nuclear receptor subfamily 1 group I member 3 JBrowse link 1 161,229,666 161,238,623 RGD:6480464
G NR4A1 nuclear receptor subfamily 4 group A member 1 JBrowse link 12 52,022,832 52,059,507 RGD:6480464
G NTRK3 neurotrophic receptor tyrosine kinase 3 JBrowse link 15 87,859,749 88,256,796 RGD:6480464
G PDYN prodynorphin JBrowse link 20 1,978,756 1,994,285 RGD:6480464
G PENK proenkephalin JBrowse link 8 56,440,957 56,446,641 RGD:6480464
G PGR progesterone receptor JBrowse link 11 101,029,624 101,130,681 RGD:6480464
G POMC proopiomelanocortin JBrowse link 2 25,160,853 25,168,851 RGD:6480464
G POR cytochrome p450 oxidoreductase JBrowse link 7 75,915,155 75,986,855 RGD:6480464
G PRL prolactin JBrowse link 6 22,287,246 22,302,897 RGD:6480464
G RAC1 Rac family small GTPase 1 JBrowse link 7 6,374,527 6,403,967 RGD:6480464
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,751 48,481,890 RGD:6480464
G REN renin JBrowse link 1 204,154,819 204,166,337 RGD:6480464
G SLC13A3 solute carrier family 13 member 3 JBrowse link 20 46,557,828 46,684,485 RGD:6480464
G SLC2A1 solute carrier family 2 member 1 JBrowse link 1 42,925,353 42,958,868 RGD:6480464
G SUMO1 small ubiquitin like modifier 1 JBrowse link 2 202,206,171 202,238,597 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TNFRSF11A TNF receptor superfamily member 11a JBrowse link 18 62,325,287 62,391,288 RGD:6480464
G TNFRSF11B TNF receptor superfamily member 11b JBrowse link 8 118,923,557 118,951,885 RGD:6480464
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 12 6,328,771 6,342,076 RGD:6480464
G TNFSF11 TNF superfamily member 11 JBrowse link 13 42,562,736 42,608,013 RGD:6480464
G TNFSF12 TNF superfamily member 12 JBrowse link 17 7,549,058 7,557,881 RGD:6480464
G TNFSF13 TNF superfamily member 13 JBrowse link 17 7,558,292 7,561,608 RGD:6480464
G TNFSF14 TNF superfamily member 14 JBrowse link 19 6,658,126 6,670,595 RGD:6480464
G TNFSF4 TNF superfamily member 4 JBrowse link 1 173,183,729 173,462,208 RGD:6480464
G TRAF2 TNF receptor associated factor 2 JBrowse link 9 136,881,933 136,926,615 RGD:6480464
G TRAF3 TNF receptor associated factor 3 JBrowse link 14 102,777,449 102,911,500 RGD:6480464
G UPP1 uridine phosphorylase 1 JBrowse link 7 48,088,308 48,108,736 RGD:6480464
G XIAP X-linked inhibitor of apoptosis JBrowse link X 123,859,708 123,913,972 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23909
    role 23797
      biological role 23760
        biophysical role 12896
          membrane transport modulator 12641
            GABA modulator 4706
              barbiturates 4435
                pentobarbital 109
Path 2
Term Annotations click to browse term
  CHEBI ontology 23909
    subatomic particle 23860
      composite particle 23860
        hadron 23860
          baryon 23860
            nucleon 23860
              atomic nucleus 23860
                atom 23860
                  main group element atom 23681
                    p-block element atom 23681
                      carbon group element atom 23401
                        carbon atom 23358
                          organic molecular entity 23358
                            organic molecule 23222
                              organic cyclic compound 22248
                                organic heterocyclic compound 20780
                                  organic heteromonocyclic compound 17277
                                    diazines 12263
                                      pyrimidines 12056
                                        pyrimidone 8788
                                          barbiturates 4435
                                            pentobarbital 109
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.