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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzidine
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Accession:CHEBI:80495 term browser browse the term
Definition:A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.
Synonyms:exact_synonym: biphenyl-4,4'-diamine
 related_synonym: (1,1'-biphenyl)-4,4'-diamine;   4,4'-bianiline;   4,4'-biphenyldiamine;   4,4'-biphenylenediamine;   4,4'-diamino-1,1'-biphenyl;   4,4'-diaminobiphenyl;   4,4'-diaminodiphenyl;   4,4'-diphenylenediamine;   C.I. azoic diazo component 112;   Formula=C12H12N2;   InChI=1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2;   InChIKey=HFACYLZERDEVSX-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1)C=2C=CC(=CC2)N)N;   p,p'-bianiline;   p,p'-diaminodiphenyl;   p-diaminodiphenyl
 xref: CAS:92-87-5;   HMDB:HMDB0041835;   KEGG:C16444
 xref_mesh: MESH:C029876
 xref: PMID:15317128;   PMID:21089809;   PMID:23766236;   PMID:25151432;   PMID:25281283;   PMID:25757908;   PMID:7341968;   Reaxys:742770;   Wikipedia:Benzidine


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benzidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO benzidine results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Bik BCL2-interacting killer increases expression ISO benzidine results in increased expression of BIK mRNA CTD PMID:26198647 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO benzidine results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO benzidine results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Lpo lactoperoxidase increases metabolic processing ISO LPO protein results in increased metabolism of benzidine CTD PMID:15606142 NCBI chr10:75,100,385...75,120,247
Ensembl chr10:75,100,385...75,120,247
JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of benzidine CTD PMID:9288889 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nat1 N-acetyltransferase 1 increases activity ISO NAT1 protein results in increased activity of benzidine CTD PMID:15450435 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 affects response to substance ISO NAT2 gene polymorphism affects the susceptibility to benzidine CTD PMID:16003747 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of benzidine CTD PMID:11159734 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of benzidine CTD PMID:11159734 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO benzidine results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO benzidine results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO benzidine results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tp53 tumor protein p53 increases expression ISO benzidine results in increased expression of TP53 protein mutant form CTD PMID:15748509, PMID:17690521 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases metabolic processing ISO UGT2B7 protein results in increased metabolism of benzidine CTD PMID:15615884 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            benzidine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        aromatic amine 13634
                                          anilines 12341
                                            substituted aniline 11837
                                              benzidine 15
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