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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenindione
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Accession:CHEBI:8066 term browser browse the term
Definition:A beta-diketone that has formula C15H10O2.
Synonyms:exact_synonym: 2-phenyl-1H-indene-1,3(2H)-dione
 related_synonym: 2-Phenyl-1,3-indandione;   2-phenyl-1,3(2H)-Indenedione;   2-phenyl-1,3-diketohydrindene;   Formula=C15H10O2;   InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H;   InChIKey=NFBAXHOPROOJAW-UHFFFAOYSA-N;   PID;   SMILES=O=C1C(C(=O)c2ccccc12)c1ccccc1;   fenindiona;   phenindionum
 xref: Beilstein:1911699;   CAS:83-12-5;   DrugBank:DB00498;   Drug_Central:2130;   KEGG:C07584;   KEGG:D08354;   LINCS:LSM-5784
 xref_mesh: MESH:D010630
 xref: Wikipedia:Phenindione


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phenindione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite CTD PMID:21613233 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tp53 tumor protein p53 increases degradation ISO Phenindione results in increased degradation of TP53 protein CTD PMID:14634213 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions
ISO Phenindione results in decreased activity of VKORC1 protein
Phenindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
CTD PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity
ISO Phenindione inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Phenindione results in decreased activity of VKORC1L1 protein
CTD PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      application 19395
        pharmaceutical 19266
          drug 19266
            hematologic agent 4362
              anticoagulant 4156
                phenindione 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19801
    subatomic particle 19797
      composite particle 19797
        hadron 19797
          baryon 19797
            nucleon 19797
              atomic nucleus 19797
                atom 19797
                  main group element atom 19684
                    p-block element atom 19684
                      carbon group element atom 19583
                        carbon atom 19572
                          organic molecular entity 19572
                            organic group 18520
                              organic divalent group 18513
                                organodiyl group 18513
                                  carbonyl group 18415
                                    carbonyl compound 18415
                                      ketone 16154
                                        diketone 1157
                                          beta-diketone 878
                                            phenindione 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.