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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenhexamid
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Accession:CHEBI:81853 term browser browse the term
Definition:An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol.
Synonyms:exact_synonym: N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide
 related_synonym: 2',3'-dichloro-4'-hydroxy-1-methylcyclohexanecarboxanilide;   Formula=C14H17Cl2NO2;   InChI=1S/C14H17Cl2NO2/c1-14(7-3-2-4-8-14)13(19)17-9-5-6-10(18)12(16)11(9)15/h5-6,18H,2-4,7-8H2,1H3,(H,17,19);   InChIKey=VDLGAVXLJYLFDH-UHFFFAOYSA-N;   KBR-2738;   N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexane-1-carboxamide;   SMILES=CC1(CCCCC1)C(=O)Nc1ccc(O)c(Cl)c1Cl;   Teldor;   fenhexamide
 alt_id: MESH:C451426
 xref: AGR:IND500627165;   CAS:126833-17-8;   KEGG:C18593
 xref_mesh: MESH:C451426
 xref: PMID:17390774;   PMID:19285148;   PMID:22045588;   PMID:23052036;   PMID:23139232;   PPDB:298;   Patent:EP339418;   Patent:US5059623;   Pesticides:fenhexamid;   Reaxys:8996658


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fenhexamid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
affects binding
ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to AR protein
CTD PMID:21310686, PMID:23436777 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of ATM mRNA CTD PMID:25461557 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of BCL2 protein]
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BCL2 mRNA
CTD PMID:23052036 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
ISO ESR1 protein affects the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCND1 protein]
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCND1 mRNA; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCND1 protein
CTD PMID:23052036, PMID:23436777, PMID:26344002 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCNE1 protein] CTD PMID:26344002 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CDC25A mRNA CTD PMID:25461557 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain multiple interactions ISO [systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of COL18A1 mRNA CTD PMID:25461557 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CTSD protein] CTD PMID:26344002 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
decreases expression
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR1 protein; ESR1 protein affects the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of CCND1 mRNA]; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to and results in increased activity of ESR1 protein; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased activity of ESR1 protein]
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of ESR1 mRNA
CTD PMID:20143881, PMID:23052036, PMID:23436777, PMID:26812056 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
increases activity
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR2 protein; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of ESR2 mRNA
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased activity of ESR2 protein
CTD PMID:23436777, PMID:26812056 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor multiple interactions ISO [systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of ETS2 mRNA CTD PMID:25461557 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of ITGA4 mRNA CTD PMID:25461557 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itgav integrin subunit alpha V increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of ITGAV mRNA CTD PMID:25461557 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO [systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of ITGB1 mRNA CTD PMID:25461557 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Mir200a microRNA 200a increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR200A mRNA CTD PMID:23052036 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of BCL2 protein]; MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein]; wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:23052036 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir22 microRNA 22 increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR22 mRNA CTD PMID:23052036 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions
decreases expression
ISO MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein]
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 mRNA; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein
CTD PMID:23052036 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression
multiple interactions
ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PDGFA mRNA
[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased expression of PDGFA mRNA
CTD PMID:25461557 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of PDGFB mRNA CTD PMID:25461557 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pgr progesterone receptor decreases expression
affects binding
increases expression
ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PGR mRNA
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to PGR protein
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PGR mRNA
CTD PMID:23052036, PMID:23436777, PMID:32278787 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PTEN mRNA CTD PMID:23052036 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions
decreases expression
ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide promotes the reaction [Estradiol results in decreased expression of RARB mRNA]
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of RARB mRNA
CTD PMID:23436777 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions
ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of RB1 mRNA
[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] affects the expression of RB1 mRNA
CTD PMID:25461557 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of TIMP1 mRNA CTD PMID:25461557 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of TIMP3 mRNA CTD PMID:25461557 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of VMP1 mRNA] CTD PMID:23052036 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        inhibitor 18223
          sterol biosynthesis inhibitor 2900
            fenhexamid 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  fenhexamid 29
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