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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rac-1,2-dichloropropane
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Accession:CHEBI:82163 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-1,2-dichloropropane. It is used as a fumigant to control nematodes in soil and insects in stored grain.
Synonyms:related_synonym: (+-)-1,2-dichloropropane;   (2RS)-1,2-dichloropropane;   rac-(2R)-1,2-dichloropropane;   rac-1,2-DCP;   rac-CH3CHClCH2Cl;   rac-alpha,beta-dichloropropane;   rac-alpha,beta-propylene dichloride;   rac-dichloro-1,2 propane;   rac-propylene dichloride
 xref: CAS:78-87-5;   KEGG:C19034
 xref_mesh: MESH:C004765
 xref: PMID:21070183;   PMID:28527381;   PMID:29863124;   PMID:29973469;   PMID:30240022;   PPDB:1191;   Pesticides:1\,2-dichloropropane;   Reaxys:1718880


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rac-1,2-dichloropropane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of ACAT1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of ACAT1 protein]
CTD PMID:32435916 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Acot2 acyl-CoA thioesterase 2 multiple interactions
increases expression
ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ACOT2 protein] CTD PMID:32435916 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Aicda activation-induced cytidine deaminase affects expression ISO propylene dichloride affects the expression of AICDA mRNA CTD PMID:30452740 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of ALDH1B1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ALDH1B1 protein]
CTD PMID:32435916 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of CAR3 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CAR3 protein]
CTD PMID:32435916 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Ces3a carboxylesterase 3a decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of CES3B protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CES3B protein]
CTD PMID:32435916 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of propylene dichloride CTD PMID:1664256 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of ECH1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ECH1 protein]
CTD PMID:32435916 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of FTCD protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of FTCD protein]
CTD PMID:32435916 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of FTH1 protein
1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased expression of FTH1 protein]
CTD PMID:32435916 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of FTL1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of FTL1 protein]
CTD PMID:32435916 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP propylene dichloride results in increased expression of GPT protein CTD PMID:1980407 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
ISO propylene dichloride results in increased expression of GSTM1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of GSTM1 protein]
CTD PMID:32435916 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO propylene dichloride results in increased phosphorylation of H2AX protein
1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]
CTD PMID:28300663 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Inmt indolethylamine N-methyltransferase multiple interactions
decreases expression
ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of INMT protein] CTD PMID:32435916 NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
JBrowse link
G Krt8 keratin 8 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of KRT8 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of KRT8 protein]
CTD PMID:32435916 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Otc ornithine transcarbamylase increases activity EXP propylene dichloride results in increased activity of OTC protein CTD PMID:2744274 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Rgn regucalcin multiple interactions
decreases expression
ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of RGN protein] CTD PMID:32435916 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Tnf tumor necrosis factor increases expression ISO propylene dichloride results in increased expression of TNF mRNA CTD PMID:30452740 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 affects localization ISO propylene dichloride affects the localization of TP53BP1 protein CTD PMID:28300663 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Ubp1 upstream binding protein 1 decreases expression
multiple interactions
ISO propylene dichloride results in decreased expression of UBP1 protein
1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of UBP1 protein]
CTD PMID:32435916 NCBI chr 8:122,196,576...122,241,368
Ensembl chr 8:122,197,027...122,240,357
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        agrochemical 14499
          rac-1,2-dichloropropane 21
            D-D mixture 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  halohydrocarbon 13956
                                    haloalkane 11674
                                      chloroalkane 9140
                                        1,2-dichloropropane 21
                                          (S)-1,2-dichloropropane 21
                                            rac-1,2-dichloropropane 21
                                              D-D mixture 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.