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ONTOLOGY REPORT - ANNOTATIONS


Term:monascin
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Accession:CHEBI:82621 term browser browse the term
Definition:An organic heterotricyclic compound that is 3a,4,8,9a-tetrahydro-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione that is substituted at positions 3, 6, and 9a by hexanoyl, (1E)-prop-1-en-1-yl and methyl groups, respectively (the 3S,3aR,9aR diastereoisomer). One of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mould rice), it is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.
Synonyms:exact_synonym: (3S,3aR,9aR)-3-hexanoyl-9a-methyl-6-[(1E)-prop-1-en-1-yl]-3a,4,8,9a-tetrahydro-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione
 related_synonym: Formula=C21H26O5;   InChI=1S/C21H26O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10,16,18H,4,6-7,9,11-12H2,1-3H3/b8-5+/t16-,18+,21-/m1/s1;   InChIKey=XXKNHBAFFJINCK-RVEJDSBJSA-N;   SMILES=CCCCCC(=O)[C@@H]1[C@H]2CC3=C(COC(\\C=C\\C)=C3)C(=O)[C@]2(C)OC1=O;   monascusone B
 xref: CAS:21516-68-7 "ChemIDplus"
 xref_mesh: MESH:C517880
 xref: PMID:17191930 "Europe PMC";   PMID:20666456 "Europe PMC";   PMID:21080714 "Europe PMC";   PMID:21777645 "Europe PMC";   PMID:22041455 "Europe PMC";   PMID:23237237 "Europe PMC";   PMID:23360447 "Europe PMC";   PMID:23673903 "Europe PMC";   PMID:23848565 "Europe PMC";   PMID:23954466 "Europe PMC";   PMID:24275089 "Europe PMC";   PMID:24865672 "Europe PMC";   Reaxys:51355 "Reaxys"


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monascin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Glo1 glyoxalase 1 JBrowse link 20 9,273,589 9,291,608 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6480464
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G S100b S100 calcium binding protein B JBrowse link 20 13,130,633 13,142,856 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antineoplastic agent 16877
              monascin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic ester 13965
                                        lactone 5868
                                          gamma-lactone 1198
                                            monascin 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.