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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:olodaterol
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Accession:CHEBI:82700 term browser browse the term
Definition:A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.
Synonyms:exact_synonym: 6-hydroxy-8-[(1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl]-2H-1,4-benzoxazin-3(4H)-one
 related_synonym: BI 1744;   Formula=C21H26N2O5;   InChI=1S/C21H26N2O5/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26)/t18-/m0/s1;   InChIKey=COUYJEVMBVSIHV-SFHVURJKSA-N;   SMILES=COc1ccc(CC(C)(C)NC[C@H](O)c2cc(O)cc3NC(=O)COc23)cc1
 xref: CAS:868049-49-4;   Drug_Central:4814;   KEGG:D10145
 xref_mesh: MESH:C549647
 xref: PMID:20096576;   PMID:20371707;   PMID:21839850;   PMID:24158691;   PMID:24247039;   PMID:24269928;   PMID:24307202;   PMID:24966672;   PMID:25045258;   PMID:25114521;   PMID:25187881;   Reaxys:12431799;   Wikipedia:Olodaterol
 cyclic_relationship: is_conjugate_base_of CHEBI:83312


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olodaterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions
affects expression
increases expression
ISO Cycloheximide inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]; EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [olodaterol affects the expression of ADRB2 mRNA]; olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689, PMID:24705868 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression
ISO 2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; N(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]; olodaterol inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]; olodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]; olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689, PMID:22796455 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO olodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            bronchodilator agent 3710
              olodaterol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        secondary amino compound 6516
                                          olodaterol 3
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