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Accession:CHEBI:82701 term browser browse the term
Definition:A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.
Synonyms:exact_synonym: 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one
 related_synonym: 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one;   CAL-101;   Formula=C22H18FN7O;   GS-1101;   InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1;   InChIKey=IFSDAJWBUCMOAH-HNNXBMFYSA-N;   SMILES=CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1;   ZYDELIG
 xref: CAS:870281-82-6 "ChemIDplus";   Drug_Central:4878 "DrugCentral";   LINCS:LSM-1205
 xref_mesh: MESH:C552946
 xref: PMID:24376763 "Europe PMC";   PMID:24450857 "Europe PMC";   PMID:24450858 "Europe PMC";   PMID:24463402 "Europe PMC";   PMID:24615776 "Europe PMC";   PMID:24615777 "Europe PMC";   PMID:24615778 "Europe PMC";   PMID:24619588 "Europe PMC";   PMID:24659719 "Europe PMC";   PMID:24795031 "Europe PMC";   PMID:25093123 "Europe PMC";   PMID:25187123 "Europe PMC";   PMID:25274697 "Europe PMC";   Reaxys:12464214 "Reaxys";   Wikipedia:Idelalisib

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idelalisib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 JBrowse link 14 83,559,397 83,572,481 RGD:6480464

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  CHEBI ontology 19654
    role 19598
      biological role 19596
        biochemical role 19125
          apoptosis inducer 10818
            idelalisib 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                organic heterocyclic compound 18151
                                  organic heteropolycyclic compound 17415
                                    organic heterobicyclic compound 15891
                                      imidazopyrimidine 5406
                                        purines 5404
                                          idelalisib 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.