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ONTOLOGY REPORT - ANNOTATIONS


Term:eliglustat
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Accession:CHEBI:82752 term browser browse the term
Definition:A carboxamide obtained by formal condensation of the carboxy group of octanoic acid with the primary amino group of (1R,2R)-2-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(pyrrolidin-1-yl)propan-1-ol. A ceramide glucosyltransferase inhibitor used (as its tartrate salt) for treatment of Gaucher's disease.
Synonyms:exact_synonym: N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]octanamide
 related_synonym: Formula=C23H36N2O4;   Genz-99067;   InChI=1S/C23H36N2O4/c1-2-3-4-5-6-9-22(26)24-19(17-25-12-7-8-13-25)23(27)18-10-11-20-21(16-18)29-15-14-28-20/h10-11,16,19,23,27H,2-9,12-15,17H2,1H3,(H,24,26)/t19-,23-/m1/s1;   InChIKey=FJZZPCZKBUKGGU-AUSIDOKSSA-N;   SMILES=CCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2OCCOc2c1
 xref: CAS:491833-29-5 "ChemIDplus";   CAS:491833-29-5 "KEGG DRUG";   Drug_Central:4834 "DrugCentral";   KEGG:D09893
 xref_mesh: MESH:C522917
 xref: PMID:20439622 "Europe PMC";   PMID:20713962 "Europe PMC";   PMID:20864621 "Europe PMC";   PMID:20872320 "Europe PMC";   PMID:22563139 "Europe PMC";   PMID:24816856 "Europe PMC";   PMID:24835462 "Europe PMC";   PMID:25239269 "Europe PMC";   Reaxys:21475293 "Reaxys";   Wikipedia:Eliglustat
 cyclic_relationship: is_conjugate_base_of CHEBI:83355


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eliglustat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    chemical entity 19746
      atom 19744
        nonmetal atom 19616
          nitrogen atom 18402
            nitrogen molecular entity 18402
              organonitrogen compound 18194
                carboxamide 16811
                  eliglustat 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic group 18426
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18306
                                    carbonyl compound 18306
                                      carboxylic acid 17973
                                        carboacyl group 17082
                                          univalent carboacyl group 17082
                                            carbamoyl group 16811
                                              carboxamide 16811
                                                eliglustat 1
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