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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:climbazole
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Accession:CHEBI:83499 term browser browse the term
Definition:A racemate composed of equimolar amounts of (R)- and (S)-climbazole. It is a topically applied antifungal agent used to treat human fungal skin infections.
Synonyms:exact_synonym: rac-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
 related_synonym: (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one;   1-(p-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl -2-butanone;   Climbazolum;   Formula=C15H17ClN2O2;   climbazol
 xref: CAS:38083-17-9
 xref_mesh: MESH:C108286
 xref: PMID:11552297;   PMID:11824557;   PMID:18950734;   PMID:21272039;   PMID:23542433;   PMID:23958691;   PMID:23982925;   PMID:24811958;   PMID:25794970;   PMID:27378240;   Patent:DE102012203240;   Pesticides:climbazole;   Reaxys:618020;   Wikipedia:Climbazole


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climbazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP climbazole results in increased expression of CYP2B1 mRNA; climbazole results in increased expression of CYP2B1 protein CTD PMID:11552297, PMID:11824557 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP climbazole results in increased expression of CYP3A2 protein CTD PMID:11552297, PMID:11824557 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP climbazole results in increased expression of CYP4A1 protein CTD PMID:11552297 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        xenobiotic 18413
          climbazole 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        hemiaminal 460
                                          hemiaminal ether 388
                                            1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one 3
                                              (R)-climbazole 3
                                                climbazole 3
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