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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:non-proteinogenic alpha-amino acid
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Accession:CHEBI:83925 term browser browse the term
Definition:Any alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
Synonyms:related_synonym: non-proteinogenic alpha-amino acids


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(N(omega)-L-arginino)succinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
decreases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Argininosuccinic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
(S)-3,5-dihydroxyphenylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases activity ISO BDNF protein results in decreased activity of 3,5-dihydroxyphenylglycine CTD PMID:20554863 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP
ISO
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein] CTD PMID:16600209 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions
affects localization
ISO
EXP
3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL]
3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA; 3,5-dihydroxyphenylglycine affects the localization of FMR1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]
CTD PMID:15028757, PMID:20393458 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases phosphorylation
EXP 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein] CTD PMID:16600209 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions
increases activity
EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenyl borate inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenylborane inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium; [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein; Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; Potassium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; Sodium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] CTD PMID:14622174, PMID:15893642 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
increases activity
ISO
EXP
[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM5 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]
CTD PMID:15608073, PMID:17179862 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Map2 microtubule-associated protein 2 increases phosphorylation
multiple interactions
EXP 3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein
[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein; Ammonia inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein]
CTD PMID:15893642 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein
3,5-dihydroxyphenylglycine promotes the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]
CTD PMID:16600209, PMID:30205134 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]
3,5-dihydroxyphenylglycine promotes the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16600209, PMID:30205134 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgll monoglyceride lipase multiple interactions ISO 3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL] CTD PMID:20393458 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
(S)-alpha-methyl-4-carboxyphenylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcg protein kinase C, gamma multiple interactions EXP (S)-alpha-methyl-4-carboxyphenylglycine inhibits the reaction [long-term potentiation affects localization of Prkcg protein in hippocampus] RGD PMID:10501452 RGD:28867228 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
(S)-AMPA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions
increases activity
EXP [ZM 241385 binds to and results in decreased activity of ADORA2A protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; ZM 241385 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2A protein] CTD PMID:16601261 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora2b adenosine A2B receptor increases activity
multiple interactions
EXP alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2B protein
[isoalloxazine binds to and results in decreased activity of ADORA2B protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; isoalloxazine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2B protein]
CTD PMID:16601261 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased expression of BDNF protein CTD PMID:11279263 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions EXP 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]; Cadmium Chloride inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; omega-agatoxin-Aa4b inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; staurosporine aglycone inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]] CTD PMID:24995437 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP FG 9041 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein]; GYKI 52466 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein] CTD PMID:14622123 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases response to substance EXP GDNF protein results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid CTD PMID:15893467 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of KLC2 protein] inhibits the reaction [GRIA1 protein binds to KLC2 protein] CTD PMID:20534517 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in increased expression of GRIA2 protein] CTD PMID:28663055 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [chromium mesoporphyrin results in decreased activity of HMOX1 protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid CTD PMID:16601261 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression EXP alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased expression of HNRNPAB protein CTD PMID:21471000 NCBI chr10:34,955,713...34,961,662
Ensembl chr10:34,955,716...34,961,608
JBrowse link
G Klc2 kinesin light chain 2 multiple interactions
increases phosphorylation
EXP [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of KLC2 protein] inhibits the reaction [GRIA1 protein binds to KLC2 protein] CTD PMID:20534517 NCBI chr 1:220,492,174...220,502,397
Ensembl chr 1:220,492,176...220,502,272
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein] CTD PMID:28663055 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
EXP 1-naphthylacetylspermine inhibits the reaction [TNF protein results in increased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid] CTD PMID:21276434 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
1-methyltryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido2 indoleamine 2,3-dioxygenase 2 decreases activity ISO 1-methyltryptophan results in decreased activity of IDO2 protein CTD PMID:32289347 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
2-amino-5-phosphonopentanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcg protein kinase C, gamma multiple interactions EXP D-2-amino-5-phosphonopentanoic acid inhibits the reaction [pertussis toxin increases expression of Prkcg protein in spinal cord] RGD PMID:12560106 RGD:28867224 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
3,3',5'-triiodo-L-thyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases activity
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein] CTD PMID:16135673 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions
increases metabolic processing
ISO [DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine] CTD PMID:21565810 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
decreases activity
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]; Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]] CTD PMID:26004626 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein]; Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
EXP Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein
alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein]
CTD PMID:16135673 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA] CTD PMID:17198541 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
affects binding
EXP 2,4-dichlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-nonylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-octylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; bisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; Pentachlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrachlorodian inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein] CTD PMID:16617682 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Triiodothyronine, Reverse results in decreased expression of PPARA mRNA CTD PMID:17198541 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA] CTD PMID:17198541 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]; Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA] CTD PMID:17198541 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein]; Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein CTD PMID:16135673 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Triiodothyronine, Reverse inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases activity
multiple interactions
affects binding
ISO Triiodothyronine, Reverse results in increased activity of THRB protein
Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein]
Triiodothyronine, Reverse binds to THRB protein
CTD PMID:21543282, PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein] CTD PMID:16135673 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
3,3',5'-triiodothyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases activity
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein] CTD PMID:16135673 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions
increases metabolic processing
ISO [DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine] CTD PMID:21565810 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
decreases activity
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]; Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]] CTD PMID:26004626 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein]; Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
EXP Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein
alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein]
CTD PMID:16135673 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA] CTD PMID:17198541 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
affects binding
EXP 2,4-dichlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-nonylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-octylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; bisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; Pentachlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrachlorodian inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein] CTD PMID:16617682 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Triiodothyronine, Reverse results in decreased expression of PPARA mRNA CTD PMID:17198541 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA] CTD PMID:17198541 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]; Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA] CTD PMID:17198541 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein]; Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein CTD PMID:16135673 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Triiodothyronine, Reverse inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases activity
multiple interactions
affects binding
ISO Triiodothyronine, Reverse results in increased activity of THRB protein
Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein]
Triiodothyronine, Reverse binds to THRB protein
CTD PMID:21543282, PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein]
3,3',5-triiodothyronine increases expression of Tnf protein in serum
CTD PMID:16135673, PMID:15019085 RGD:14995431 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
3,3',5-triiodo-L-thyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Triiodothyronine results in increased expression of ABCA1 mRNA CTD PMID:25172293 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Triiodothyronine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Triiodothyronine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression EXP Triiodothyronine results in increased expression of ABCC5 mRNA CTD PMID:29357290 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcf3 ATP binding cassette subfamily F member 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ABCF3 mRNA CTD PMID:14761676 NCBI chr11:84,026,206...84,037,938
Ensembl chr11:84,026,207...84,037,938
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases expression
increases activity
EXP Triiodothyronine inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Triiodothyronine inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]
Triiodothyronine results in increased expression of ACACA mRNA
Triiodothyronine results in increased activity of ACACA protein
CTD PMID:1973097 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acbd4 acyl-CoA binding domain containing 4 decreases expression ISO Triiodothyronine results in decreased expression of ACBD4 mRNA CTD PMID:23397585 NCBI chr10:91,186,131...91,200,081
Ensembl chr10:91,187,593...91,196,572
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Triiodothyronine results in increased expression of and results in increased activity of ACE protein CTD PMID:1659346 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression
decreases expression
EXP Triiodothyronine results in increased expression of ACOT1 mRNA
Triiodothyronine results in decreased expression of ACOT1 mRNA
CTD PMID:15953391, PMID:28299817 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO Triiodothyronine results in increased expression of ACSL1 mRNA CTD PMID:30209975 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 increases expression EXP Triiodothyronine results in increased expression of ACSL5 mRNA CTD PMID:15953391 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Acvrl1 activin A receptor like type 1 increases expression ISO Triiodothyronine results in increased expression of ACVRL1 mRNA CTD PMID:25172293 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Adam11 ADAM metallopeptidase domain 11 increases expression ISO Triiodothyronine results in increased expression of ADAM11 mRNA CTD PMID:25172293 NCBI chr10:90,731,260...90,749,221
Ensembl chr10:90,731,148...90,749,217
JBrowse link
G Adam12 ADAM metallopeptidase domain 12 increases expression ISO Triiodothyronine results in increased expression of ADAM12 mRNA CTD PMID:23397585 NCBI chr 1:205,951,840...206,286,294
Ensembl chr 1:205,956,342...206,282,575
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 decreases expression ISO Triiodothyronine results in decreased expression of ADAM15 mRNA CTD PMID:23397585 NCBI chr 2:188,661,831...188,672,337
Ensembl chr 2:188,661,699...188,672,247
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADAM19 mRNA CTD PMID:14761676 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582
JBrowse link
G Add2 adducin 2 increases expression ISO Triiodothyronine results in increased expression of ADD2 mRNA CTD PMID:23397585 NCBI chr 4:117,691,294...117,887,556
Ensembl chr 4:117,743,710...117,882,464
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Triiodothyronine results in increased expression of ADRB1 mRNA; Triiodothyronine results in increased expression of ADRB1 protein CTD PMID:10217540, PMID:11090638 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO bicalutamide inhibits the reaction [Triiodothyronine results in increased expression of ADRB2 protein]
Triiodothyronine results in increased expression of ADRB2 mRNA; Triiodothyronine results in increased expression of ADRB2 protein
CTD PMID:18454446 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases expression
decreases expression
EXP Amiodarone inhibits the reaction [Triiodothyronine results in decreased expression of ADRB3 protein]
Triiodothyronine results in increased expression of ADRB3 protein
Triiodothyronine results in decreased expression of ADRB3 mRNA; Triiodothyronine results in decreased expression of ADRB3 protein
CTD PMID:8836703, PMID:10217540 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Triiodothyronine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA] CTD PMID:28478156 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO Triiodothyronine results in increased expression of AKAP12 mRNA CTD PMID:23397585 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Akirin2 akirin 2 increases expression ISO Triiodothyronine results in increased expression of AKIRIN2 mRNA CTD PMID:23397585 NCBI chr 5:50,001,945...50,016,544
Ensembl chr 5:50,002,184...50,016,539
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Triiodothyronine results in increased expression of AKR1C2 mRNA CTD PMID:15507505 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Triiodothyronine results in increased expression of AKR1C3 mRNA CTD PMID:15507505 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine results in increased phosphorylation of AKT1 protein]; AKT1 protein affects the reaction [Triiodothyronine affects the expression of TTN mRNA] CTD PMID:16021636, PMID:18096819 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Triiodothyronine binds to ALB protein CTD PMID:21517007 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNA CTD PMID:14761676 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression EXP Triiodothyronine results in increased expression of ALDH3A2 mRNA CTD PMID:15953391 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP Triiodothyronine affects the reaction [Propylthiouracil affects the expression of AMH mRNA] CTD PMID:7819453 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503
JBrowse link
G Angptl8 angiopoietin-like 8 multiple interactions ISO [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein]; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 protein; [THRB protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr 8:22,855,495...22,858,565
Ensembl chr 8:22,856,539...22,858,565
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Triiodothyronine results in increased expression of APOA1 protein CTD PMID:6816881 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions EXP Triiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein] CTD PMID:6816881 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoe apolipoprotein E multiple interactions EXP Triiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein] CTD PMID:6816881 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein decreases expression
multiple interactions
ISO Triiodothyronine results in decreased expression of APP mRNA; Triiodothyronine results in decreased expression of APP protein
Tretinoin promotes the reaction [Triiodothyronine results in decreased secretion of APP protein]
CTD PMID:17199430 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Triiodothyronine results in increased expression of AQP1 mRNA CTD PMID:25172293 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp8 aquaporin 8 increases expression EXP Triiodothyronine results in increased expression of AQP8 mRNA CTD PMID:15953391 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676
JBrowse link
G Arhgef25 Rho guanine nucleotide exchange factor 25 decreases expression ISO Triiodothyronine results in decreased expression of ARHGEF25 mRNA CTD PMID:23397585 NCBI chr 7:70,469,304...70,476,633
Ensembl chr 7:70,469,312...70,476,340
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression ISO Triiodothyronine results in increased expression of ARL4D mRNA CTD PMID:25172293 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression EXP Triiodothyronine results in increased expression of ARRDC3 mRNA CTD PMID:28299817 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Aspg asparaginase increases expression EXP Triiodothyronine results in increased expression of ASPG mRNA CTD PMID:29357290 NCBI chr 6:136,682,279...136,701,673
Ensembl chr 6:136,682,126...136,701,628
JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression ISO Triiodothyronine results in decreased expression of ASPM mRNA CTD PMID:23397585 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Atg5 autophagy related 5 increases expression
affects response to substance
ISO Triiodothyronine results in increased expression of ATG5 mRNA; Triiodothyronine results in increased expression of ATG5 protein
ATG5 protein affects the susceptibility to Triiodothyronine
CTD PMID:30209975 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Triiodothyronine results in increased expression of ATG7 mRNA CTD PMID:30209975 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 increases expression ISO Triiodothyronine results in increased expression of ATP1B2 mRNA CTD PMID:25172293 NCBI chr10:56,205,622...56,211,879
Ensembl chr10:56,205,625...56,211,891
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
increases expression
EXP THRB protein promotes the reaction [Triiodothyronine results in increased expression of ATP2A2 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA] CTD PMID:11577024 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO
EXP
Triiodothyronine results in decreased expression of BAD protein CTD PMID:16021636 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO
EXP
Triiodothyronine results in decreased expression of BAX protein CTD PMID:16021636 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Triiodothyronine promotes the reaction [tamibarotene results in decreased expression of BCL2 mRNA]
Triiodothyronine results in increased expression of BCL2 protein
CTD PMID:11201846, PMID:16021636 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO Triiodothyronine promotes the reaction [tamibarotene results in increased expression of BCL2A1A mRNA] CTD PMID:11201846 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO
EXP
Triiodothyronine results in increased expression of BCL2L1 protein CTD PMID:16021636 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP Triiodothyronine results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP2 mRNA CTD PMID:14761676 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions
decreases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA] CTD PMID:14761676 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Capns1 calpain, small subunit 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of CAPNS1 mRNA CTD PMID:14761676 NCBI chr 1:91,058,528...91,064,880 JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
EXP
ISO
Triiodothyronine results in decreased expression of CASP3 protein
THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]
CTD PMID:16021636, PMID:32223187 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [Triiodothyronine results in decreased activity of CAT protein] CTD PMID:12516873, PMID:23391542 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccdc71 coiled-coil domain containing 71 decreases expression ISO Triiodothyronine results in decreased expression of CCDC71 mRNA CTD PMID:23397585 NCBI chr 8:117,236,933...117,251,573
Ensembl chr 8:117,246,376...117,250,280
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of CCL5 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of CCL5 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of CCL5 mRNA] CTD PMID:14761676 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 increases expression ISO
EXP
Triiodothyronine results in increased expression of CCNA2 protein CTD PMID:16021636 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO
EXP
Triiodothyronine results in increased expression of CCND1 protein
Triiodothyronine results in increased expression of CCND1 mRNA; Triiodothyronine results in increased expression of CCND1 protein
THRB protein promotes the reaction [Triiodothyronine results in increased expression of CCND1 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of CCND1 mRNA]
CTD PMID:16021636, PMID:20638743, PMID:28315333 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression ISO
EXP
Triiodothyronine results in increased expression of CCNE1 protein
Triiodothyronine results in increased expression of CCNE1 mRNA; Triiodothyronine results in increased expression of CCNE1 protein
CTD PMID:16021636 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdc45 cell division cycle 45 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDC45 mRNA CTD PMID:14761676 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1A mRNA; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of CDKN1A mRNA]; Triiodothyronine analog inhibits the reaction [CDKN1A protein binds to PCNA protein]; Triiodothyronine inhibits the reaction [CDKN1A protein binds to PCNA protein] CTD PMID:14761676, PMID:22383522 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
EXP
ISO
Triiodothyronine results in decreased expression of CDKN1B mRNA; Triiodothyronine results in decreased expression of CDKN1B protein
THRB protein promotes the reaction [Triiodothyronine results in decreased expression of CDKN1B protein]
CTD PMID:16021636, PMID:20638743 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Ces2c carboxylesterase 2C increases expression EXP Triiodothyronine results in increased expression of CES2C mRNA CTD PMID:28299817 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
decreases expression
EXP Phenelzine inhibits the reaction [Triiodothyronine results in decreased expression of CGA mRNA]; Triiodothyronine inhibits the reaction [Phenelzine results in increased expression of CGA mRNA] CTD PMID:20148560 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO Triiodothyronine analog results in increased phosphorylation of CHEK1 protein CTD PMID:22383522 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chst1 carbohydrate sulfotransferase 1 increases expression ISO Triiodothyronine results in increased expression of CHST1 mRNA CTD PMID:25172293 NCBI chr 3:81,441,785...81,512,829
Ensembl chr 3:81,498,022...81,512,807
JBrowse link
G Clu clusterin increases expression EXP Triiodothyronine results in increased expression of CLU mRNA CTD PMID:7531505 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions
increases expression
EXP ciglitazone inhibits the reaction [Triiodothyronine results in increased expression of COL10A1 mRNA]; troglitazone inhibits the reaction [Triiodothyronine results in increased expression of COL10A1 mRNA] CTD PMID:16023420 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP Triiodothyronine promotes the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
Triiodothyronine results in increased expression of COL1A1 mRNA
CTD PMID:18031379 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Triiodothyronine results in increased expression of COL6A3 mRNA CTD PMID:15507505 NCBI chr 9:97,926,784...98,004,643
Ensembl chr 9:97,926,787...98,004,546
JBrowse link
G Coq10b coenzyme Q10B increases expression EXP Triiodothyronine results in increased expression of COQ10B mRNA CTD PMID:29357290 NCBI chr 9:61,655,963...61,675,880
Ensembl chr 9:61,655,963...61,675,873
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
increases expression
ISO Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein] CTD PMID:30209975 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions
ISO
EXP
Triiodothyronine results in increased expression of CPT1A mRNA
Triiodothyronine results in increased expression of CPT1A mRNA; Triiodothyronine results in increased expression of CPT1A protein
resveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]
Resveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CPT1A mRNA]
CTD PMID:23209300, PMID:25048947 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO Triiodothyronine results in increased expression of CPT1B mRNA CTD PMID:30209975 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cracr2b calcium release activated channel regulator 2B decreases expression ISO Triiodothyronine results in decreased expression of CRACR2B mRNA CTD PMID:23397585 NCBI chr 1:214,439,810...214,445,876
Ensembl chr 1:214,440,503...214,445,874
JBrowse link
G Crat carnitine O-acetyltransferase increases expression EXP Triiodothyronine results in increased expression of CRAT mRNA CTD PMID:15953391 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Csad cysteine sulfinic acid decarboxylase increases expression EXP Triiodothyronine results in increased expression of CSAD mRNA CTD PMID:15953391 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]] CTD PMID:9664232 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Ctse cathepsin E increases expression EXP Triiodothyronine results in increased expression of CTSE mRNA CTD PMID:15953391 NCBI chr13:48,426,833...48,449,493
Ensembl chr13:48,426,820...48,449,490
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA] CTD PMID:32223187 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein] CTD PMID:21726595 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein] CTD PMID:21726595 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Triiodothyronine affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Triiodothyronine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Triiodothyronine results in increased expression of CYP1A1 mRNA
CTD PMID:28478156 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of CYP1A2 mRNA
Triiodothyronine affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Triiodothyronine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 protein]
CTD PMID:28478156 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of CYP24A1 mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of CYP24A1 mRNA]
CTD PMID:21815645 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
increases expression
EXP Triiodothyronine results in increased activity of CYP2E1 protein
Triiodothyronine results in increased expression of CYP2E1 protein
CTD PMID:14631868 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Triiodothyronine results in decreased expression of CYP8B1 mRNA CTD PMID:10393316, PMID:29357290 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Triiodothyronine results in increased expression of DBP mRNA CTD PMID:25172293 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression EXP Triiodothyronine results in increased expression of DECR2 mRNA CTD PMID:15953391 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Dio1 iodothyronine deiodinase 1 affects abundance
multiple interactions
increases expression
affects metabolic processing
increases chemical synthesis
ISO
EXP
DIO1 gene SNP affects the abundance of Triiodothyronine
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]
[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine]
DIO1 protein affects the metabolism of Triiodothyronine
Arsenic affects the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]; Pentachlorophenol inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]
DIO1 protein results in increased chemical synthesis of Triiodothyronine
CTD PMID:15254343, PMID:16131326, PMID:17105838, PMID:18288313, PMID:21565810, PMID:23397585, PMID:24001430, PMID:25646720, PMID:27420076, PMID:28167136, PMID:29357290 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
increases expression
increases chemical synthesis
ISO
EXP
2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; [DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine; kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]
Triiodothyronine results in increased expression of DIO2 mRNA
DIO2 protein results in increased chemical synthesis of Triiodothyronine
CTD PMID:17327447, PMID:17615150, PMID:23397585, PMID:25646720, PMID:26004626 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of DIO3 mRNA
[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine
CTD PMID:23397585 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DMBT1 mRNA CTD PMID:14761676 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705
JBrowse link
G Dmpk DM1 protein kinase increases expression EXP Triiodothyronine results in increased expression of DMPK mRNA CTD PMID:15953391 NCBI chr 1:79,988,096...79,999,358
Ensembl chr 1:79,989,019...79,999,364
JBrowse link
G Dmtn dematin actin binding protein increases expression ISO Triiodothyronine results in increased expression of DMTN mRNA CTD PMID:25172293 NCBI chr15:52,292,762...52,320,385
Ensembl chr15:52,292,765...52,320,385
JBrowse link
G Dusp2 dual specificity phosphatase 2 multiple interactions
decreases expression
ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of DUSP2 mRNA] CTD PMID:14761676 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Triiodothyronine results in increased expression of DYNC1LI2 mRNA CTD PMID:23397585 NCBI chr19:740,007...762,897
Ensembl chr19:740,028...762,897
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Triiodothyronine results in increased expression of ECH1 mRNA CTD PMID:15953391 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Efcab3 EF-hand calcium binding domain 3 decreases expression ISO Triiodothyronine results in decreased expression of EFCAB3 mRNA CTD PMID:23397585 NCBI chr10:93,304,559...93,332,849
Ensembl chr10:93,305,969...93,332,702
JBrowse link
G Egf epidermal growth factor multiple interactions EXP
ISO
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11742803, PMID:16150908 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Triiodothyronine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30209975 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eml2 EMAP like 2 increases expression ISO Triiodothyronine results in increased expression of EML2 mRNA CTD PMID:23397585 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012
JBrowse link
G Eno1 enolase 1 increases expression ISO Triiodothyronine results in increased expression of ENO1 mRNA CTD PMID:15507505 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO Triiodothyronine results in increased expression of EPAS1 mRNA CTD PMID:25172293 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EPB41L3 mRNA CTD PMID:14761676 NCBI chr 9:117,314,935...117,666,408
Ensembl chr 9:117,538,009...117,666,410
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO Tamoxifen inhibits the reaction [Triiodothyronine results in decreased expression of ESR1 mRNA] CTD PMID:19942988 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP [Arsenic co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of ESR2 mRNA; [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in increased expression of ESR2 mRNA; [enzacamene co-treated with Estradiol co-treated with Triiodothyronine] affects the expression of ESR2 mRNA; [Estradiol co-treated with Triiodothyronine] inhibits the reaction [bisphenol A results in decreased expression of ESR2 mRNA]; [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA]; [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA CTD PMID:27338438 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase increases expression EXP Triiodothyronine results in increased expression of ETHE1 mRNA CTD PMID:28299817 NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097
JBrowse link
G Eva1c eva-1 homolog C increases expression ISO Triiodothyronine results in increased expression of EVA1C mRNA CTD PMID:25172293 NCBI chr11:31,001,697...31,075,784
Ensembl chr11:31,002,451...31,075,809
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP Triiodothyronine results in increased expression of FABP4 mRNA CTD PMID:15953391 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP Triiodothyronine results in increased expression of FABP5 mRNA CTD PMID:15953391 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fads2 fatty acid desaturase 2 increases expression EXP Triiodothyronine results in increased expression of FADS2 mRNA CTD PMID:15953391 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Fam171b family with sequence similarity 171, member B decreases expression ISO Triiodothyronine results in decreased expression of FAM171B mRNA CTD PMID:23397585 NCBI chr 3:71,210,048...71,265,419
Ensembl chr 3:71,210,301...71,262,615
JBrowse link
G Fam83h family with sequence similarity 83, member H increases expression ISO Triiodothyronine results in increased expression of FAM83H mRNA CTD PMID:23397585 NCBI chr 7:117,062,748...117,070,936
Ensembl chr 7:117,062,692...117,070,936
JBrowse link
G Fasn fatty acid synthase increases expression EXP Triiodothyronine results in increased expression of FASN mRNA CTD PMID:15953391 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Triiodothyronine results in increased expression of FDFT1 mRNA CTD PMID:15953391 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP Triiodothyronine results in increased expression of FDPS mRNA CTD PMID:15953391 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions ISO Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16150908 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
Triiodothyronine inhibits the reaction [FGF2 protein results in increased phosphorylation of STAT1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]; Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:11742803, PMID:12805413, PMID:16150908 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf7 fibroblast growth factor 7 decreases expression ISO Triiodothyronine results in decreased expression of FGF7 mRNA CTD PMID:15507505 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16150908 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression
multiple interactions
ISO
EXP
Triiodothyronine results in increased expression of FGFR1 mRNA
Triiodothyronine results in increased expression of FGFR1 mRNA; Triiodothyronine results in increased expression of FGFR1 protein
Cycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]
CTD PMID:12805413, PMID:16150908 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Triiodothyronine results in increased expression of FGFR2 mRNA CTD PMID:16150908 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO Triiodothyronine results in increased expression of FGFR3 mRNA CTD PMID:16150908 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fkbp10 FKBP prolyl isomerase 10 decreases expression ISO Triiodothyronine results in decreased expression of FKBP10 mRNA CTD PMID:23397585 NCBI chr10:88,326,337...88,338,199
Ensembl chr10:88,326,080...88,338,207
JBrowse link
G Flrt1 fibronectin leucine rich transmembrane protein 1 increases expression ISO Triiodothyronine results in increased expression of FLRT1 mRNA CTD PMID:25172293 NCBI chr 1:222,340,481...222,417,915
Ensembl chr 1:222,344,713...222,350,173
JBrowse link
G Foxo6 forkhead box O6 increases expression ISO Triiodothyronine results in increased expression of FOXO6 mRNA CTD PMID:25172293 NCBI chr 5:139,208,153...139,227,288
Ensembl chr 5:139,208,046...139,227,196
JBrowse link
G Fpgs folylpolyglutamate synthase increases expression EXP Triiodothyronine results in increased expression of FPGS mRNA CTD PMID:15953391 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP FSHB protein promotes the reaction [Triiodothyronine results in increased expression of INHBB mRNA]; Triiodothyronine promotes the reaction [FSHB protein results in increased expression of INHBB mRNA] CTD PMID:7531505 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 increases expression EXP Triiodothyronine results in increased expression of FXYD2 mRNA CTD PMID:15953391 NCBI chr 8:49,710,334...49,717,492
Ensembl chr 8:49,710,477...49,716,955
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression
ISO (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA] CTD PMID:21815645 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Triiodothyronine results in increased expression of GAP43 mRNA; Triiodothyronine results in increased expression of GAP43 protein CTD PMID:15708448 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gba glucosylceramidase beta increases activity EXP Triiodothyronine results in increased activity of GBA protein CTD PMID:9101438 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression EXP Triiodothyronine results in increased expression of GCH1 mRNA CTD PMID:15953391 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gh1 growth hormone 1 multiple interactions
increases expression
EXP
ISO
Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Amiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; bisphenol A promotes the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; Butyric Acid inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Dexamethasone promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Polybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Polybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]; Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]; Triiodothyronine results in increased expression of and results in increased secretion of GH protein; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]
Triiodothyronine results in increased expression of GH mRNA; Triiodothyronine results in increased expression of GH1 mRNA; Triiodothyronine results in increased expression of GH1 protein
CTD PMID:2211641, PMID:2910914, PMID:10720163, PMID:15240998, PMID:17090972, PMID:17928132, PMID:22201216, PMID:24001430, PMID:27420076 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Ghrh growth hormone releasing hormone multiple interactions EXP Triiodothyronine promotes the reaction [Dexamethasone results in increased expression of GHRH mRNA] CTD PMID:17090972 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Triiodothyronine results in increased expression of GJA1 protein CTD PMID:15685554 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression EXP Triiodothyronine results in increased expression of GPCPD1 mRNA CTD PMID:15953391 NCBI chr 3:125,169,131...125,213,598
Ensembl chr 3:125,169,135...125,213,607
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP Triiodothyronine results in increased expression of GPD2 mRNA CTD PMID:29357290 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 increases expression ISO Triiodothyronine results in increased expression of GRIK4 mRNA CTD PMID:23397585 NCBI chr 8:46,804,134...47,237,546
Ensembl chr 8:46,806,147...47,094,352
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTA2 protein] CTD PMID:7532609 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTP1 protein] CTD PMID:7532609 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Triiodothyronine results in decreased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Triiodothyronine results in increased expression of H1-5 mRNA CTD PMID:23397585 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO Triiodothyronine analog results in increased phosphorylation of H2AX protein
Triiodothyronine analog promotes the reaction [Cisplatin results in increased expression of H2AX protein]
CTD PMID:22383522 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression EXP Triiodothyronine results in increased expression of HBA-A1 mRNA CTD PMID:15953391 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Triiodothyronine results in increased expression of HBB mRNA CTD PMID:15953391 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 increases expression EXP Triiodothyronine results in increased expression of HBG1 mRNA CTD PMID:15953391 NCBI chr 1:168,992,841...168,994,219
Ensembl chr 1:168,992,722...168,994,253
JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 increases expression ISO Triiodothyronine results in increased expression of HCN2 mRNA CTD PMID:25172293 NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215
JBrowse link
G Hdc histidine decarboxylase decreases expression EXP Triiodothyronine results in decreased expression of HDC mRNA CTD PMID:29357290 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 increases expression ISO Triiodothyronine results in increased expression of HEG1 mRNA CTD PMID:25172293 NCBI chr11:70,234,248...70,322,966
Ensembl chr11:70,236,888...70,322,690
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Triiodothyronine results in increased expression of HIF1A mRNA CTD PMID:15507505 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Triiodothyronine results in increased expression of HIGD1A mRNA CTD PMID:15953391 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998
JBrowse link
G Hira histone cell cycle regulator increases expression ISO Triiodothyronine results in increased expression of HIRA mRNA CTD PMID:23397585 NCBI chr11:86,168,196...86,276,430
Ensembl chr11:86,168,196...86,276,430
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Triiodothyronine results in increased expression of HMGCS1 mRNA CTD PMID:15953391 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Triiodothyronine results in increased expression of HMGCS2 mRNA CTD PMID:23397585 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 increases expression ISO Triiodothyronine results in increased expression of HNRNPH3 mRNA CTD PMID:23397585 NCBI chr20:27,167,926...27,178,172
Ensembl chr20:27,169,267...27,216,941
JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor increases expression ISO Triiodothyronine results in increased expression of HR mRNA CTD PMID:25172293, PMID:26096596 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276
JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone decreases expression ISO Triiodothyronine results in decreased expression of HSCB mRNA CTD PMID:23397585 NCBI chr12:51,878,267...51,888,645
Ensembl chr12:51,878,153...51,888,669
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA] CTD PMID:21726595
G Hunk hormonally upregulated Neu-associated kinase increases expression ISO Triiodothyronine results in increased expression of HUNK mRNA CTD PMID:25172293 NCBI chr11:30,550,141...30,663,465
Ensembl chr11:30,550,141...30,663,465
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases expression EXP Triiodothyronine results in increased expression of IDH1 mRNA CTD PMID:15953391 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
increases secretion
EXP Estradiol inhibits the reaction [Triiodothyronine results in increased expression of IGF1 mRNA]; Estradiol inhibits the reaction [Triiodothyronine results in increased secretion of IGF1 protein] CTD PMID:7684602 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Triiodothyronine results in increased expression of IGFBP2 mRNA CTD PMID:15953391 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Iglon5 IgLON family member 5 increases expression ISO Triiodothyronine results in increased expression of IGLON5 mRNA CTD PMID:25172293 NCBI chr 1:98,440,186...98,457,942
Ensembl chr 1:98,440,186...98,455,920
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein] CTD PMID:32223187 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein] CTD PMID:32223187 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbb inhibin subunit beta B multiple interactions
increases expression
EXP FSHB protein promotes the reaction [Triiodothyronine results in increased expression of INHBB mRNA]; Triiodothyronine promotes the reaction [FSHB protein results in increased expression of INHBB mRNA] CTD PMID:7531505 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 protein CTD PMID:27605626 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression EXP Triiodothyronine results in increased expression of INSIG1 mRNA CTD PMID:15953391 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of IRF1 mRNA CTD PMID:14761676 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Triiodothyronine promotes the reaction [tamibarotene results in increased expression of ITGAM protein] CTD PMID:11201846 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itgb5 integrin subunit beta 5 increases expression
decreases expression
ISO Triiodothyronine results in increased expression of ITGB5 mRNA
Triiodothyronine results in decreased expression of ITGB5 mRNA
CTD PMID:23397585 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase increases expression ISO Triiodothyronine results in increased expression of ITPK1 mRNA CTD PMID:25172293 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Triiodothyronine results in increased expression of ITPR1 mRNA CTD PMID:15953391 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Kantr KDM5C adjacent transcript increases expression ISO Triiodothyronine results in increased expression of KANTR mRNA CTD PMID:25172293 NCBI chr  X:22,369,521...22,399,881
Ensembl chr  X:22,369,521...22,399,901
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO Triiodothyronine results in increased expression of KCNA1 mRNA CTD PMID:25172293 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases expression ISO Triiodothyronine results in decreased expression of KCNA4 mRNA CTD PMID:25172293 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein CTD PMID:27605626 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Triiodothyronine results in decreased expression of KCTD12 mRNA CTD PMID:25172293 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kif1b kinesin family member 1B increases expression EXP Triiodothyronine results in increased expression of KIF1B mRNA CTD PMID:15953391 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression
increases expression
ISO Triiodothyronine results in decreased expression of KLF9 mRNA
Triiodothyronine results in increased expression of KLF9 mRNA
CTD PMID:15507505, PMID:23397585, PMID:26096596 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Krt13 keratin 13 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT13 mRNA CTD PMID:14761676 NCBI chr10:88,032,130...88,036,040
Ensembl chr10:88,032,130...88,036,040
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO
EXP
Amiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]; desethylamiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]
Triiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein]
CTD PMID:9071962, PMID:9712728 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lgi4 leucine-rich repeat LGI family, member 4 increases expression ISO Triiodothyronine results in increased expression of LGI4 mRNA CTD PMID:25172293 NCBI chr 1:89,491,588...89,502,939
Ensembl chr 1:89,491,654...89,502,974
JBrowse link
G Lhx3 LIM homeobox 3 decreases expression ISO Triiodothyronine results in decreased expression of LHX3 mRNA CTD PMID:23397585 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Linc00176 long intergenic non-protein coding RNA 176 decreases expression ISO Triiodothyronine results in decreased expression of C20ORF204 mRNA CTD PMID:23397585 NCBI chr 3:177,163,038...177,166,874
Ensembl chr 3:177,164,359...177,166,737
JBrowse link
G Lipe lipase E, hormone sensitive type increases expression ISO Triiodothyronine results in increased expression of LIPE mRNA CTD PMID:30209975 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression ISO Triiodothyronine results in decreased expression of LMCD1 mRNA CTD PMID:25172293 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Lpin3 lipin 3 increases expression ISO Triiodothyronine results in increased expression of LPIN3 mRNA CTD PMID:25172293 NCBI chr 3:156,874,805...156,899,601
Ensembl chr 3:156,886,454...156,899,436
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Triiodothyronine results in increased expression of LPL mRNA CTD PMID:15953391 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lss lanosterol synthase increases expression EXP Triiodothyronine results in increased expression of LSS mRNA CTD PMID:15953391 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA CTD PMID:14761676 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Lyrm9 LYR motif containing 9 decreases expression ISO Triiodothyronine results in decreased expression of LYRM9 mRNA CTD PMID:23397585 NCBI chr10:66,099,478...66,113,559
Ensembl chr10:66,099,531...66,113,559
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
increases expression
multiple interactions
ISO Triiodothyronine results in increased lipidation of MAP1LC3B protein
Triiodothyronine results in increased expression of MAP1LC3B mRNA
bafilomycin A1 promotes the reaction [Triiodothyronine results in increased lipidation of MAP1LC3B protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased lipidation of MAP1LC3B protein]
CTD PMID:30209975 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
ISO
EXP
tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Triiodothyronine results in increased expression of MAPK1 mRNA
Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MAPK1 mRNA]
CTD PMID:12805413, PMID:16150908, PMID:17174366, PMID:28315333 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression
ISO
EXP
tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Triiodothyronine results in increased expression of MAPK3 mRNA
Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MAPK3 mRNA]
CTD PMID:12805413, PMID:16150908, PMID:17174366, PMID:28315333 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mbp myelin basic protein increases expression ISO Triiodothyronine results in increased expression of MBP protein alternative form CTD PMID:15345905 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Triiodothyronine results in increased expression of ME1 mRNA CTD PMID:15953391, PMID:29357290 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Meioc meiosis specific with coiled-coil domain decreases expression ISO Triiodothyronine results in decreased expression of MEIOC mRNA CTD PMID:23397585 NCBI chr10:90,622,954...90,641,883
Ensembl chr10:90,622,992...90,642,151
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A increases expression ISO Triiodothyronine results in increased expression of MFSD2A mRNA CTD PMID:25172293 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link
G Mier3 MIER family member 3 decreases expression ISO Triiodothyronine results in decreased expression of MIER3 mRNA CTD PMID:23397585 NCBI chr 2:43,266,301...43,295,175
Ensembl chr 2:43,266,739...43,294,889
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of MKI67 mRNA
U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MKI67 mRNA]
CTD PMID:28315333 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmd2 monocyte to macrophage differentiation-associated 2 increases expression EXP Triiodothyronine results in increased expression of MMD2 mRNA CTD PMID:29357290 NCBI chr12:14,021,724...14,078,121
Ensembl chr12:14,021,727...14,078,134
JBrowse link
G Mmp11 matrix metallopeptidase 11 multiple interactions
increases expression
ISO (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of MMP11 mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of MMP11 mRNA] CTD PMID:21815645 NCBI chr20:13,670,051...13,678,834
Ensembl chr20:13,670,066...13,678,089
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Triiodothyronine inhibits the reaction [TGFB1 protein results in increased secretion of MMP2 protein] CTD PMID:18031379 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased activity of MPO protein CTD PMID:7503757 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Triiodothyronine results in decreased phosphorylation of MTOR protein CTD PMID:30209975 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
increases expression
EXP S100A6 protein inhibits the reaction [Triiodothyronine results in increased expression of MYH6 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024, PMID:15578571, PMID:15652358 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
decreases expression
EXP Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
Triiodothyronine results in decreased expression of MYH7 mRNA
CTD PMID:11577024, PMID:15578571 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Naglt1 Na+ dependent glucose transporter 1 increases expression EXP Triiodothyronine results in increased expression of NAGLT1 mRNA CTD PMID:15953391 NCBI chr20:45,095,232...45,107,532
Ensembl chr20:45,094,791...45,107,555
JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 decreases expression ISO Triiodothyronine results in decreased expression of NCAPG2 mRNA CTD PMID:23397585 NCBI chr 6:144,291,313...144,362,454
Ensembl chr 6:144,291,974...144,363,947
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein; bisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein] CTD PMID:22227104 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Triiodothyronine promotes the reaction [NCOA2 protein binds to THRA protein]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]; Triiodothyronine promotes the reaction [THRA protein binds to NCOA2 protein]; Triiodothyronine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:29146198, PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein] CTD PMID:22227104 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein] CTD PMID:22227104 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression EXP Triiodothyronine results in increased expression of NDUFA5 mRNA CTD PMID:15953391 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Nefl neurofilament light decreases expression ISO Triiodothyronine results in decreased expression of NEFL mRNA CTD PMID:25172293 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium decreases expression ISO Triiodothyronine results in decreased expression of NEFM mRNA CTD PMID:25172293 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
EXP Triiodothyronine results in increased activity of NFKB1 protein
Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of NFKB1 protein]
CTD PMID:15019085 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nnat neuronatin decreases expression EXP Triiodothyronine results in decreased expression of NNAT mRNA CTD PMID:29357290 NCBI chr 3:154,043,873...154,046,334
Ensembl chr 3:154,043,873...154,046,330
JBrowse link
G Npnt nephronectin increases expression ISO Triiodothyronine results in increased expression of NPNT mRNA CTD PMID:25172293 NCBI chr 2:238,001,767...238,068,886
Ensembl chr 2:238,002,990...238,068,694
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP Triiodothyronine results in increased expression of NR0B2 mRNA CTD PMID:29357290 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA] CTD PMID:21726595 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nrgn neurogranin increases expression EXP Triiodothyronine results in increased expression of NRGN mRNA; Triiodothyronine results in increased expression of NRGN protein CTD PMID:15708448 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Nrp1 neuropilin 1 increases expression EXP Triiodothyronine results in increased expression of NRP1 mRNA CTD PMID:15953391 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Triiodothyronine results in increased expression of NSDHL mRNA CTD PMID:15953391 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor increases expression EXP Triiodothyronine results in increased expression of NSMF mRNA CTD PMID:15953391 NCBI chr 3:2,262,173...2,270,996
Ensembl chr 3:2,262,253...2,270,995
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression
increases activity
EXP Triiodothyronine results in increased expression of NT5E mRNA
Triiodothyronine results in increased activity of NT5E protein
CTD PMID:15543949 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nudt7 nudix hydrolase 7 increases expression EXP Triiodothyronine results in increased expression of NUDT7 mRNA CTD PMID:15953391 NCBI chr19:46,455,745...46,470,070
Ensembl chr19:46,455,761...46,482,050
JBrowse link
G Nup214 nucleoporin 214 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NUP214 mRNA CTD PMID:14761676 NCBI chr 3:9,227,869...9,236,878
NCBI chr 3:10,993,584...11,070,638
Ensembl chr 3:9,227,823...9,236,736
Ensembl chr 3:9,227,823...9,236,736
JBrowse link
G Ocln occludin increases expression EXP Triiodothyronine results in increased expression of OCLN mRNA CTD PMID:15953391 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Olr59 olfactory receptor 59 increases expression EXP Triiodothyronine results in increased expression of OLR59 mRNA CTD PMID:28299817 NCBI chr 1:167,906,030...167,940,688
Ensembl chr 1:167,906,061...167,911,961
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Triiodothyronine results in increased expression of OSGIN1 mRNA CTD PMID:25172293 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
affects binding
EXP 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine binds to P4HB protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to P4HB protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Polychlorinated Biphenyls metabolite inhibits the reaction [Triiodothyronine binds to P4HB protein] CTD PMID:17928132, PMID:18515855, PMID:19374345, PMID:22201216 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Padi4 peptidyl arginine deiminase 4 increases expression EXP Triiodothyronine results in increased expression of PADI4 mRNA CTD PMID:15953391 NCBI chr 5:159,260,675...159,293,906
Ensembl chr 5:159,260,675...159,293,673
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 decreases expression ISO Triiodothyronine results in decreased expression of PARP4 mRNA CTD PMID:23397585 NCBI chr15:36,809,362...36,911,167 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
EXP
ISO
SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]
CTD PMID:21815645, PMID:23209300, PMID:30209975 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
affects binding
ISO Triiodothyronine results in increased expression of PCNA protein
THRB protein promotes the reaction [Triiodothyronine results in increased expression of PCNA protein]
Triiodothyronine analog inhibits the reaction [CDKN1A protein binds to PCNA protein]; Triiodothyronine analog inhibits the reaction [POLD3 protein binds to PCNA protein]; Triiodothyronine inhibits the reaction [CDKN1A protein binds to PCNA protein]
Triiodothyronine analog binds to PCNA protein; Triiodothyronine binds to PCNA protein
CTD PMID:17174366, PMID:20638743, PMID:22383522 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 decreases expression ISO Triiodothyronine results in decreased expression of PCSK1 mRNA CTD PMID:15291740 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 decreases expression ISO Triiodothyronine results in decreased expression of PCSK2 mRNA CTD PMID:15585599 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions
increases expression
ISO
EXP
resveratrol promotes the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
resveratrol promotes the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
CTD PMID:23209300 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdp2 pyruvate dehyrogenase phosphatase catalytic subunit 2 increases expression EXP Triiodothyronine results in increased expression of PDP2 mRNA CTD PMID:29357290 NCBI chr19:597,427...601,556
Ensembl chr19:597,427...601,469
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO Triiodothyronine results in increased expression of PEG10 mRNA CTD PMID:23397585 NCBI chr 4:29,795,524...29,804,517 JBrowse link
G Pex5 peroxisomal biogenesis factor 5 increases expression ISO Triiodothyronine results in increased expression of PEX5 mRNA CTD PMID:23397585 NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674
JBrowse link
G Pfkp phosphofructokinase, platelet increases expression ISO Triiodothyronine results in increased expression of PFKP mRNA CTD PMID:15507505 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 increases expression ISO Triiodothyronine results in increased expression of PHOSPHO1 mRNA CTD PMID:25172293 NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression ISO Triiodothyronine results in increased expression of PIK3CD mRNA CTD PMID:25172293 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pla2g6 phospholipase A2 group VI increases expression EXP Triiodothyronine results in increased expression of PLA2G6 mRNA CTD PMID:15953391 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Pld5 phospholipase D family, member 5 increases expression ISO Triiodothyronine results in increased expression of PLD5 mRNA CTD PMID:23397585 NCBI chr13:94,025,696...94,355,219
Ensembl chr13:94,025,369...94,355,219
JBrowse link
G Plin2 perilipin 2 increases expression EXP Triiodothyronine results in increased expression of PLIN2 mRNA CTD PMID:15953391 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Plin3 perilipin 3 multiple interactions ISO [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein] CTD PMID:24262987 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Plxnc1 plexin C1 increases expression ISO Triiodothyronine results in increased expression of PLXNC1 mRNA CTD PMID:23397585 NCBI chr 7:35,848,083...36,000,969
Ensembl chr 7:35,850,398...36,000,906
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression
decreases phosphorylation
ISO Triiodothyronine results in increased expression of PNPLA2 mRNA
Triiodothyronine results in decreased phosphorylation of PNPLA2 protein
CTD PMID:30209975 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
JBrowse link
G Podxl podocalyxin-like increases expression EXP Triiodothyronine results in increased expression of PODXL mRNA CTD PMID:15953391 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit multiple interactions ISO Triiodothyronine analog inhibits the reaction [POLD3 protein binds to PCNA protein] CTD PMID:22383522 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of POLG mRNA CTD PMID:14761676 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 increases expression EXP Triiodothyronine results in increased expression of POMT1 mRNA CTD PMID:15953391 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [GW 7647 results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; [Triiodothyronine co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA CTD PMID:19631232, PMID:25048947 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Triiodothyronine inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA] CTD PMID:25048947 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP
ISO
Triiodothyronine results in increased expression of PPARGC1A mRNA CTD PMID:23209300, PMID:30209975 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prdm16 PR/SET domain 16 increases expression ISO Triiodothyronine results in increased expression of PRDM16 mRNA CTD PMID:30209975 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein decreases expression ISO Triiodothyronine results in decreased expression of PRELP mRNA CTD PMID:25172293 NCBI chr13:50,749,526...50,773,934
Ensembl chr13:50,749,514...50,761,355
JBrowse link
G Prickle2 prickle planar cell polarity protein 2 decreases expression ISO Triiodothyronine results in decreased expression of PRICKLE2 mRNA CTD PMID:25172293 NCBI chr 4:124,238,167...124,584,176
Ensembl chr 4:124,238,167...124,338,176
JBrowse link
G Prl prolactin decreases expression
increases secretion
multiple interactions
EXP Triiodothyronine results in decreased expression of PRL mRNA; Triiodothyronine results in decreased expression of PRL protein
Triiodothyronine results in increased secretion of PRL protein
bisphenol A inhibits the reaction [Triiodothyronine results in increased secretion of PRL protein]; Chlorodiphenyl (54% Chlorine) promotes the reaction [Triiodothyronine results in increased secretion of PRL protein]
CTD PMID:3734668, PMID:17615682 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prokr1 prokineticin receptor 1 increases expression ISO Triiodothyronine results in increased expression of PROKR1 mRNA CTD PMID:25172293 NCBI chr 4:119,375,790...119,386,551
Ensembl chr 4:119,375,778...119,386,590
JBrowse link
G Psca prostate stem cell antigen multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA protein]
Triiodothyronine results in increased expression of PSCA mRNA; Triiodothyronine results in increased expression of PSCA protein
CTD PMID:14761676 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
JBrowse link
G Rab23 RAB23, member RAS oncogene family decreases expression ISO Triiodothyronine results in decreased expression of RAB23 mRNA CTD PMID:23397585 NCBI chr 9:38,469,784...38,496,185
Ensembl chr 9:38,470,298...38,495,176
JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO Triiodothyronine results in increased expression of RAB3B mRNA CTD PMID:15507505 NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP Triiodothyronine results in increased expression of RARB mRNA CTD PMID:15708448 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
EXP Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of RELA protein] CTD PMID:15019085 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retsat retinol saturase increases expression EXP Triiodothyronine results in increased expression of RETSAT mRNA CTD PMID:15953391 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301
JBrowse link
G RGD1306063 similar to HT021 increases expression EXP Triiodothyronine results in increased expression of RGD1306063 mRNA CTD PMID:15953391 NCBI chr15:12,869,217...12,889,144
Ensembl chr15:12,872,408...12,889,108
JBrowse link
G RGD1307603 similar to hypothetical protein MGC37914 decreases expression EXP Triiodothyronine results in decreased expression of RGD1307603 mRNA CTD PMID:29357290 NCBI chr 1:219,309,593...219,312,240
Ensembl chr 1:219,309,592...219,312,240
JBrowse link
G RGD1564801 similar to hepatic multiple inositol polyphosphate phosphatase increases expression EXP Triiodothyronine results in increased expression of RGD1564801 mRNA CTD PMID:15953391 NCBI chr 1:75,151,956...75,154,325
Ensembl chr 1:75,152,883...75,154,325
JBrowse link
G Rhov ras homolog family member V increases expression ISO Triiodothyronine results in increased expression of RHOV mRNA CTD PMID:23397585 NCBI chr 3:111,078,642...111,087,347
Ensembl chr 3:111,078,619...111,087,347
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Triiodothyronine analog results in increased phosphorylation of RPA2 protein CTD PMID:22383522 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Triiodothyronine results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:30209975 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rxrb retinoid X receptor beta increases expression EXP Triiodothyronine results in increased expression of RXRB mRNA CTD PMID:15708448 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma increases expression EXP Triiodothyronine results in increased expression of RXRG mRNA CTD PMID:15708448 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a6 S100 calcium binding protein A6 multiple interactions EXP S100A6 protein inhibits the reaction [Triiodothyronine results in increased expression of MYH6 mRNA] CTD PMID:15652358 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Triiodothyronine results in increased expression of SC5D mRNA CTD PMID:15953391 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP Triiodothyronine results in increased expression of SCD1 mRNA CTD PMID:15953391 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina6 serpin family A member 6 increases expression EXP Triiodothyronine results in increased expression of SERPINA6 mRNA CTD PMID:29357290 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
JBrowse link
G Serpina7 serpin family A member 7 affects binding ISO Triiodothyronine binds to SERPINA7 protein CTD PMID:20804816, PMID:21517007 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 increases expression EXP Triiodothyronine results in increased expression of SIGMAR1 mRNA CTD PMID:15953391 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
affects response to substance
EXP SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]; SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
Triiodothyronine results in increased expression of SIRT1 mRNA
SIRT1 protein affects the susceptibility to Triiodothyronine
CTD PMID:23209300 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP Triiodothyronine results in increased expression of SLC10A2 mRNA CTD PMID:28299817 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 mRNA]; resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 protein]
Triiodothyronine results in decreased expression of SLC15A1 mRNA; Triiodothyronine results in decreased expression of SLC15A1 protein
CTD PMID:26394120 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions
increases uptake
ISO bisphenol A inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; bosutinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Dasatinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Desipramine inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Genistein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Imatinib Mesylate inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Indocyanine Green inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Meclofenamic Acid inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Phloretin inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression ISO Triiodothyronine results in increased expression of SLC16A3 mRNA CTD PMID:15507505 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of SLC16A6 mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of SLC16A6 mRNA]
CTD PMID:21815645 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression ISO Triiodothyronine results in increased expression of SLC1A2 mRNA CTD PMID:25172293 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc25a25 solute carrier family 25 member 25 increases expression EXP Triiodothyronine results in increased expression of SLC25A25 mRNA CTD PMID:29357290 NCBI chr 3:11,442,396...11,476,186
Ensembl chr 3:11,442,397...11,452,529
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Triiodothyronine results in increased expression of SLC2A1 mRNA CTD PMID:15507505 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 protein CTD PMID:27605626 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions EXP [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA CTD PMID:17485832 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression EXP Triiodothyronine results in increased expression of SLC38A2 mRNA CTD PMID:29357290 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slc43a2 solute carrier family 43 member 2 increases expression ISO Triiodothyronine results in increased expression of SLC43A2 mRNA CTD PMID:25172293 NCBI chr10:63,676,317...63,719,283
Ensembl chr10:63,677,396...63,719,283
JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of SLC51B mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of SLC51B mRNA]
CTD PMID:21815645 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Sned1 sushi, nidogen and EGF-like domains 1 increases expression ISO Triiodothyronine results in increased expression of SNED1 mRNA CTD PMID:25172293 NCBI chr 9:100,380,487...100,439,125
Ensembl chr 9:100,380,515...100,437,056
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
ISO Triiodothyronine inhibits the reaction [Paraquat results in decreased expression of SOD1 mRNA]; Triiodothyronine inhibits the reaction [THRA protein results in increased expression of SOD1 mRNA]; Triiodothyronine inhibits the reaction [THRB protein results in increased expression of SOD1 mRNA]
Triiodothyronine results in decreased expression of SOD1 mRNA
CTD PMID:16738222 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spen spen family transcriptional repressor increases expression ISO Triiodothyronine results in increased expression of SPEN mRNA CTD PMID:23397585 NCBI chr 5:160,015,573...160,070,915
Ensembl chr 5:160,015,454...160,070,965
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression ISO Triiodothyronine results in increased expression of SPTLC2 mRNA CTD PMID:23397585 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO [THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein; Ammonium Chloride inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]
Triiodothyronine results in increased expression of SQSTM1 mRNA
CTD PMID:24262987, PMID:30209975 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
decreases activity
EXP SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]; SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA] CTD PMID:23209300 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 decreases expression ISO Triiodothyronine results in decreased expression of SFRS3 mRNA CTD PMID:23397585 NCBI chr20:6,288,285...6,298,218
Ensembl chr20:6,288,267...6,298,213
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA] CTD PMID:21726595 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stard8 StAR-related lipid transfer domain containing 8 increases expression ISO Triiodothyronine results in increased expression of STARD8 mRNA CTD PMID:25172293 NCBI chr  X:68,713,157...68,785,046
Ensembl chr  X:68,713,123...68,785,052
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Triiodothyronine inhibits the reaction [FGF2 protein results in increased phosphorylation of STAT1 protein] CTD PMID:16150908 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression ISO Triiodothyronine results in increased expression of STAT5A mRNA CTD PMID:25172293 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression EXP Triiodothyronine results in increased expression of STAT5B mRNA CTD PMID:15953391 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Stk19 serine/threonine kinase 19 increases expression ISO Triiodothyronine results in increased expression of STK19 mRNA CTD PMID:23397585 NCBI chr20:4,317,440...4,517,128 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation
multiple interactions
affects sulfation
ISO SULT1A1 protein results in increased sulfation of Triiodothyronine
Triiodothyronine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
SULT1A1 gene polymorphism affects the sulfation of Triiodothyronine
CTD PMID:11739018, PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP Triiodothyronine results in increased expression of SULT2A1 mRNA CTD PMID:15953391 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of Triiodothyronine CTD PMID:12039030 NCBI chr 7:124,958,546...124,982,602
Ensembl chr 7:124,958,546...124,982,566
JBrowse link
G Taf5l TATA-box binding protein associated factor 5 like increases expression ISO Triiodothyronine results in increased expression of TAF5L mRNA CTD PMID:23397585 NCBI chr19:56,781,854...56,801,005
Ensembl chr19:56,781,859...56,799,445
JBrowse link
G Tcim transcriptional and immune response regulator multiple interactions
increases expression
ISO SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of TCIM mRNA] CTD PMID:21815645 NCBI chr16:72,401,526...72,403,180
Ensembl chr16:72,401,887...72,403,179
JBrowse link
G Tex264 testis expressed 264 increases expression EXP Triiodothyronine results in increased expression of TEX264 mRNA CTD PMID:29357290 NCBI chr 8:115,360,706...115,388,299
Ensembl chr 8:115,360,713...115,388,266
JBrowse link
G Tfeb transcription factor EB increases expression ISO Triiodothyronine results in increased expression of TFEB mRNA CTD PMID:25172293 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Triiodothyronine inhibits the reaction [TGFB1 protein results in increased secretion of MMP2 protein]; Triiodothyronine promotes the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:18031379 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgoln2 trans-golgi network protein 2 decreases expression
increases expression
ISO Triiodothyronine results in decreased expression of TGOLN2 mRNA
Triiodothyronine results in increased expression of TGOLN2 mRNA
CTD PMID:23397585 NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
affects binding
increases expression
increases activity
decreases expression
ISO
EXP
2,2',4,4'-tetrabromodiphenyl ether analog affects the reaction [Triiodothyronine binds to THRA protein]; [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein]; [THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 protein; Ammonium Chloride inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine binds to THRA protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to THRA protein]; bisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; bisphenol F inhibits the reaction [Triiodothyronine binds to THRA protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; daidzein promotes the reaction [Triiodothyronine results in increased activity of THRA protein]; Genistein promotes the reaction [Triiodothyronine results in increased activity of THRA protein]; KB 130015 inhibits the reaction [Triiodothyronine binds to and results in increased activity of THRA protein]; pentabromodiphenyl ether analog inhibits the reaction [Triiodothyronine binds to THRA protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to THRA protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; tetrachlorodian inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]]; tribromodiphenyl ether 28 analog affects the reaction [Triiodothyronine binds to THRA protein]; Triiodothyronine binds to and results in increased activity of THRA protein; Triiodothyronine inhibits the reaction [THRA protein results in increased expression of SOD1 mRNA]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRA protein]; Triiodothyronine promotes the reaction [THRA protein binds to NCOA2 protein]
Triiodothyronine results in increased expression of THRA mRNA
2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine results in increased expression of THRA mRNA]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]
[bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Triiodothyronine] results in increased expression of THRA mRNA; Polybrominated Biphenyls inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine binds to THRA protein]; THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; Triiodothyronine binds to and results in increased activity of THRA protein
Triiodothyronine results in decreased expression of THRA mRNA
Triiodothyronine results in increased expression of THRA mRNA; Triiodothyronine results in increased expression of THRA protein
CTD PMID:7684602, PMID:9664232, PMID:11806713, PMID:12414890, PMID:12588052, PMID:15680168, PMID:15708448, PMID:16021636, PMID:16023420, PMID:16738222, PMID:19672399, PMID:21396401, PMID:21726595, PMID:22015988, PMID:22086976, PMID:23112079, PMID:23402801, PMID:24076165, PMID:24262987, PMID:24819616, PMID:25646720, PMID:27993100, PMID:28167136, PMID:29146198, PMID:29688519, PMID:31566444, PMID:32223187 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
decreases expression
affects binding
increases response to substance
increases activity
increases expression
ISO
EXP
2,2',4,4'-tetrabromodiphenyl ether analog affects the reaction [Triiodothyronine binds to THRB protein]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,3,4,7,8-pentachlorodibenzofuran inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; 2,4,6-tribromophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,4,6-trichlorophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,4,6-triiodophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 4-nonylphenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; 6-OH-BDE-47 inhibits the reaction [Triiodothyronine binds to THRB protein]; [THRB protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Amiodarone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bis(4-hydroxyphenyl)sulfone analog inhibits the reaction [Triiodothyronine binds to THRB protein]; bis(4-hydroxyphenyl)sulfone analog inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine binds to THRB protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bisphenol A analog inhibits the reaction [Triiodothyronine binds to THRB protein]; bisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to THRB protein]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bisphenol F inhibits the reaction [Triiodothyronine binds to THRB protein]; cyhalothrin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; daidzein promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; deoxynivalenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; desethylamiodarone inhibits the reaction [Triiodothyronine binds to THRB protein alternative form]; Genistein promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; KB 130015 inhibits the reaction [Triiodothyronine binds to and results in increased activity of THRB protein]; methoxyacetic acid promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; pentabromodiphenyl ether analog inhibits the reaction [Triiodothyronine binds to THRB protein]; pentabromophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; systhane inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; T-2 Toxin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to THRB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetrachlorodian analog inhibits the reaction [Triiodothyronine binds to THRB protein]; tetrachlorodian inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [Triiodothyronine binds to THRB protein]; Tretinoin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tribromodiphenyl ether 28 analog affects the reaction [Triiodothyronine binds to THRB protein]; Triclosan inhibits the reaction [Triiodothyronine binds to THRB protein]; Triiodothyronine binds to and results in increased activity of THRB protein; Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]; Triiodothyronine inhibits the reaction [THRB protein results in increased expression of SOD1 mRNA]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]; Triiodothyronine promotes the reaction [THRB protein binds to NCOA2 protein]; Zearalenone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]
Triiodothyronine results in decreased expression of THRB mRNA
THRB protein results in increased susceptibility to Triiodothyronine
THRB protein promotes the reaction [Triiodothyronine results in decreased expression of CDKN1B protein]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of CCND1 protein]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of PCNA protein]
Triiodothyronine results in increased expression of THRB mRNA; Triiodothyronine results in increased expression of THRB protein
[bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of THRB mRNA; [bisphenol A co-treated with Triiodothyronine] results in increased expression of THRB mRNA; Butyric Acid inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; desethylamiodarone inhibits the reaction [Triiodothyronine binds to THRB protein]; Polybrominated Biphenyls inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of ATP2A2 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]
CTD PMID:2211641, PMID:8137729, PMID:11577024, PMID:11806713, PMID:12414890, PMID:12538616, PMID:12588052, PMID:15103026, PMID:15598685, PMID:15680168, PMID:15708448, PMID:16021636, PMID:16738222, PMID:18486176, PMID:18584933, PMID:18795168, PMID:19457453, PMID:19672399, PMID:20638743, PMID:20737425, PMID:21396401, PMID:22015988, PMID:22227104, PMID:23112079, PMID:23402801, PMID:24262987, PMID:25646720, PMID:27410513, PMID:27420076, PMID:27993100, PMID:28167136, PMID:28531659, PMID:28973306, PMID:29146198, PMID:29409039, PMID:29688519, PMID:29763311, PMID:31077750, PMID:31476497, PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions
increases expression
EXP
ISO
Triiodothyronine inhibits the reaction [Amiodarone results in increased expression of THRSP mRNA]
Triiodothyronine results in increased expression of THRSP mRNA
CTD PMID:2721112, PMID:10357836, PMID:15953391, PMID:28478156 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Tmem184b transmembrane protein 184B multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMEM184B mRNA CTD PMID:14761676 NCBI chr 7:120,593,336...120,636,592
Ensembl chr 7:120,593,336...120,636,592
JBrowse link
G Tmem44 transmembrane protein 44 increases expression ISO Triiodothyronine results in increased expression of TMEM44 mRNA CTD PMID:23397585 NCBI chr11:73,737,323...73,774,149
Ensembl chr11:73,738,433...73,774,190
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]
THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]
CTD PMID:15019085, PMID:32223187 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TNFRSF9 protein]
Triiodothyronine results in increased expression of TNFRSF9 mRNA; Triiodothyronine results in increased expression of TNFRSF9 protein
CTD PMID:14761676 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of TOMM20 protein
Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of TOMM20 protein]
CTD PMID:30209975 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 protein]
Triiodothyronine results in increased expression of TRAF1 mRNA; Triiodothyronine results in increased expression of TRAF1 protein
CTD PMID:14761676 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Trim46 tripartite motif-containing 46 increases expression ISO Triiodothyronine results in increased expression of TRIM46 mRNA CTD PMID:23397585 NCBI chr 2:188,548,608...188,561,617
Ensembl chr 2:188,548,644...188,561,360
JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression
multiple interactions
increases secretion
ISO
EXP
Triiodothyronine results in decreased expression of TSHB mRNA
[Triiodothyronine co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TSHB mRNA alternative form
TSHB protein results in increased secretion of Triiodothyronine
CTD PMID:7827627, PMID:9092800, PMID:11288978, PMID:27420076, PMID:28167136 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ttbk1 tau tubulin kinase 1 increases expression ISO Triiodothyronine results in increased expression of TTBK1 mRNA CTD PMID:25172293 NCBI chr 9:16,862,305...16,899,399
Ensembl chr 9:16,862,248...16,902,199
JBrowse link
G Ttn titin multiple interactions
affects expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine affects the expression of TTN mRNA]; AKT1 protein affects the reaction [Triiodothyronine affects the expression of TTN mRNA] CTD PMID:18096819 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Ttr transthyretin affects binding ISO Triiodothyronine binds to TTR protein CTD PMID:20804816, PMID:21517007 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
increases expression
ISO
EXP
(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]; [Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA
Triiodothyronine results in increased expression of UCP1 mRNA; Triiodothyronine results in increased expression of UCP1 protein
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]
CTD PMID:11742803, PMID:26972250, PMID:30209975 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 protein]; Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [carboprostacyclin results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA] CTD PMID:12588052, PMID:25048947 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases activity EXP Triiodothyronine results in increased activity of UGCG protein CTD PMID:9101438 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression
multiple interactions
EXP Triiodothyronine results in decreased expression of UGT1A1 mRNA
Vitamin A inhibits the reaction [Triiodothyronine results in decreased expression of UGT1A1 mRNA]
CTD PMID:11299074 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions
EXP Triiodothyronine results in increased expression of UGT1A6 mRNA
Vitamin A inhibits the reaction [Triiodothyronine results in increased expression of UGT1A6 mRNA]
CTD PMID:11299074 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Utp20 UTP20 small subunit processome component multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of UTP20 mRNA CTD PMID:14761676 NCBI chr 7:29,296,360...29,378,105
Ensembl chr 7:29,296,963...29,378,080
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of VDAC1 protein
Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of VDAC1 protein]
CTD PMID:30209975 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Wls Wnt ligand secretion mediator increases expression ISO Triiodothyronine results in increased expression of WLS mRNA CTD PMID:23397585 NCBI chr 2:266,315,036...266,431,220
Ensembl chr 2:266,315,036...266,432,558
JBrowse link
G Zc3h7b zinc finger CCCH-type containing 7B decreases expression ISO Triiodothyronine results in decreased expression of ZC3H7B mRNA CTD PMID:23397585 NCBI chr 7:122,978,999...123,027,166
Ensembl chr 7:122,979,021...123,027,150
JBrowse link
G Zfp113 zinc finger protein 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ZNF3 mRNA CTD PMID:14761676 NCBI chr12:19,287,541...19,298,172
Ensembl chr12:19,288,403...19,294,888
JBrowse link
G Zfp664 zinc finger protein 664 increases expression ISO Triiodothyronine results in increased expression of ZNF664 mRNA CTD PMID:23397585 NCBI chr12:36,201,327...36,203,396 JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 increases expression ISO Triiodothyronine results in increased expression of ZMIZ1 mRNA CTD PMID:23397585 NCBI chr16:1,749,191...1,954,633
Ensembl chr16:1,749,191...1,954,614
JBrowse link
3,3'-diiodothyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine] CTD PMID:21565810 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO 3,3'-diiodothyronine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
3-(5-fluorouracil-1-yl)-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 affects response to substance ISO GRIA3 protein affects the susceptibility to 5-fluorowillardiine CTD PMID:15264227 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
3-cyanoalanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein] CTD PMID:29129814 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein] CTD PMID:29129814 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Usp5 ubiquitin specific peptidase 5 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of USP5 protein] CTD PMID:29129814 NCBI chr 4:157,332,735...157,347,803
Ensembl chr 4:157,332,740...157,347,803
JBrowse link
3-hydroxykynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [KMO protein results in increased hydroxylation of Kynurenine] which results in increased chemical synthesis of 3-hydroxykynurenine CTD PMID:32243540 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
3-nitrotyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO [Asbestos, Crocidolite co-treated with IL1B protein] results in increased abundance of 3-nitrotyrosine; [Asbestos, Serpentine co-treated with IL1B protein] results in increased abundance of 3-nitrotyrosine CTD PMID:9698594 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
acivicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA] CTD PMID:14766015 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
decreases activity
ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione CTD PMID:15629191, PMID:19419996 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
alliin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsd cathepsin D multiple interactions EXP alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] CTD PMID:29305303 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions
ISO alliin results in decreased secretion of FGF2 protein
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD PMID:16351512 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP
ISO
alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
CTD PMID:16640830, PMID:29305303 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:16640830 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] CTD PMID:29305303 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] CTD PMID:29305303 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO alliin results in decreased secretion of VEGFA protein CTD PMID:16351512 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
allysine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 increases oxidation
affects binding
ISO ALDH7A1 protein results in increased oxidation of allysine
allysine binds to ALDH7A1 protein
CTD PMID:21185811 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
JBrowse link
alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA] CTD PMID:22215663 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA] CTD PMID:22215663 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Igf1 insulin-like growth factor 1 increases uptake
multiple interactions
EXP IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD PMID:1928324 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein] CTD PMID:22215663 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions ISO SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid] CTD PMID:22215663 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity
ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein
CTD PMID:7053299, PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Prl prolactin increases expression
increases secretion
ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein
CTD PMID:1867878, PMID:7265421 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
Betanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP betanin inhibits the reaction [Paraquat results in decreased activity of CAT protein] CTD PMID:24799198 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP betanin inhibits the reaction [Fructose results in increased expression of CCN2 protein] CTD PMID:25559852 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP betanin inhibits the reaction [Paraquat results in increased expression of CYP3A2 mRNA] CTD PMID:24799198 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP betanin inhibits the reaction [Fructose results in increased expression of TGFB1 protein] CTD PMID:25559852 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein CTD PMID:28549670 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Dpep1 dipeptidase 1 decreases activity ISO Cilastatin results in decreased activity of DPEP1 protein CTD PMID:30664745 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Cilazapril CTD PMID:15498266 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cilazapril results in increased expression of ADIPOQ protein CTD PMID:19789415 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Cilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA] CTD PMID:15331931 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] CTD PMID:15331931 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP Cilazapril results in decreased expression of FGF2 mRNA; Cilazapril results in decreased expression of FGF2 protein CTD PMID:9640960 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Nppa natriuretic peptide A multiple interactions
affects secretion
ISO [Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein
Cilazapril affects the secretion of NPPA protein
CTD PMID:1457087 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Ren renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2425185 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Cilazapril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:15331931 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
D-penicillamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase increases activity
multiple interactions
ISO Penicillamine results in increased activity of AHCY protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]
CTD PMID:22945834 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression
decreases expression
EXP Penicillamine results in increased expression of ALOX12 mRNA
Penicillamine results in decreased expression of ALOX12 mRNA
CTD PMID:19575532 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Penicillamine results in increased expression of ALOX5AP mRNA CTD PMID:19575532 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Anxa1 annexin A1 decreases expression
increases expression
EXP Penicillamine results in decreased expression of ANXA1 mRNA
Penicillamine results in increased expression of ANXA1 mRNA
CTD PMID:19575532 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa4 annexin A4 increases expression
decreases expression
EXP Penicillamine results in increased expression of ANXA4 mRNA
Penicillamine results in decreased expression of ANXA4 mRNA
CTD PMID:19575532 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
ISO Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Penicillamine results in increased metabolism of APP protein
CTD PMID:10940226, PMID:12963085, PMID:17964426 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Penicillamine results in increased metabolism of and results in increased activity of ATF6 protein CTD PMID:19722195 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein] CTD PMID:21242307 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO [Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA]
CTD PMID:21242307, PMID:22945834, PMID:24368744 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bbc3 Bcl-2 binding component 3 decreases expression ISO Penicillamine results in decreased expression of BBC3 protein CTD PMID:22843330 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Penicillamine results in decreased expression of BCL2 mRNA; Penicillamine results in decreased expression of BCL2 protein CTD PMID:22843330 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]] CTD PMID:20946909 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G C1s complement C1s multiple interactions ISO Penicillamine inhibits the reaction [C4A protein binds to C1S protein]; Penicillamine inhibits the reaction [C4B protein binds to C1S protein] CTD PMID:8435078 NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609
JBrowse link
G C3 complement C3 increases expression EXP Penicillamine results in increased expression of C3 mRNA CTD PMID:19575532 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C4a complement C4A multiple interactions ISO Penicillamine inhibits the reaction [C4A protein binds to C1S protein] CTD PMID:8435078 NCBI chr20:2,651,599...2,678,183
Ensembl chr20:2,651,599...2,678,141
JBrowse link
G C4b complement C4B (Chido blood group) multiple interactions ISO Penicillamine inhibits the reaction [C4B protein binds to C1S protein] CTD PMID:8435078 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]
Penicillamine results in increased cleavage of CASP3 protein
Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
CTD PMID:12963085, PMID:19722195, PMID:20946909, PMID:22843330 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]] CTD PMID:20946909 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO Penicillamine results in decreased expression of CAT mRNA
[Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein
CTD PMID:22843330, PMID:24368744 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Penicillamine results in increased expression of CCL3 mRNA CTD PMID:22843330 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO
EXP
Penicillamine results in increased expression of CCL4 mRNA CTD PMID:19575532, PMID:22843330 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression EXP Penicillamine results in increased expression of CCL5 mRNA CTD PMID:19575532 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression
decreases expression
EXP Penicillamine results in increased expression of CCR5 mRNA
Penicillamine results in decreased expression of CCR5 mRNA
CTD PMID:19575532 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd14 CD14 molecule decreases expression
increases expression
EXP Penicillamine results in decreased expression of CD14 mRNA
Penicillamine results in increased expression of CD14 mRNA
CTD PMID:19575532 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd163 CD163 molecule decreases expression
increases expression
EXP Penicillamine results in decreased expression of CD163 mRNA
Penicillamine results in increased expression of CD163 mRNA
CTD PMID:19575532 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd38 CD38 molecule increases expression EXP Penicillamine results in increased expression of CD38 mRNA CTD PMID:19575532 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd52 CD52 molecule decreases expression EXP Penicillamine results in decreased expression of CD52 mRNA CTD PMID:19575532 NCBI chr 5:152,322,910...152,324,469
Ensembl chr 5:152,322,916...152,324,469
JBrowse link
G Clu clusterin multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cp ceruloplasmin decreases expression
multiple interactions
ISO Penicillamine results in decreased expression of CP protein
Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]
CTD PMID:24013775, PMID:24368744 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions
EXP
ISO
Penicillamine results in decreased expression of CPT1A mRNA
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]
CTD PMID:19575532, PMID:22945834 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crp C-reactive protein decreases expression ISO Penicillamine results in decreased expression of CRP protein CTD PMID:241598 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 increases expression EXP Penicillamine results in increased expression of CSF2 mRNA CTD PMID:19575532 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression
decreases expression
EXP Penicillamine results in increased expression of CXCR4 mRNA
Penicillamine results in decreased expression of CXCR4 mRNA
CTD PMID:19575532 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Penicillamine results in increased expression of CYP1A1 mRNA CTD PMID:22843330 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Penicillamine results in increased expression of CYP2E1 mRNA CTD PMID:22843330 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Penicillamine results in increased expression of DDIT3 mRNA; Penicillamine results in increased expression of DDIT3 protein CTD PMID:19722195, PMID:22843330 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO Penicillamine results in decreased expression of DNMT3A mRNA CTD PMID:22945834 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA] CTD PMID:22945834 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Penicillamine results in decreased expression of DUSP1 mRNA CTD PMID:19575532 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression EXP Penicillamine results in increased expression of DUSP6 mRNA CTD PMID:19575532 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Egr1 early growth response 1 increases expression EXP
ISO
Penicillamine results in increased expression of EGR1 mRNA CTD PMID:19575532, PMID:22843330 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Penicillamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:22843330 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Penicillamine results in increased phosphorylation of EIF2S1 protein CTD PMID:22843330 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eln elastin affects localization ISO Penicillamine affects the localization of ELN protein CTD PMID:3954958 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Fcnb ficolin B increases expression EXP Penicillamine results in increased expression of FCNB mRNA CTD PMID:19575532 NCBI chr 3:6,617,816...6,626,193
Ensembl chr 3:6,617,751...6,626,284
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression ISO Penicillamine results in increased expression of FMO1 mRNA CTD PMID:22843330 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression ISO Penicillamine results in increased expression of FMO5 mRNA CTD PMID:22843330 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Penicillamine results in increased expression of FN1 mRNA CTD PMID:19575532 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Penicillamine results in increased expression of GADD45A mRNA CTD PMID:22843330 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gatm glycine amidinotransferase increases expression EXP Penicillamine results in increased expression of GATM mRNA CTD PMID:19575532 NCBI chr 3:114,711,570...114,728,155
Ensembl chr 3:114,711,562...114,728,410
JBrowse link
G Gstm3 glutathione S-transferase mu 3 increases expression ISO Penicillamine results in increased expression of GSTM3 mRNA CTD PMID:22843330 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Penicillamine results in increased expression of GSTM3 mRNA CTD PMID:22843330 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
ISO [Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein
Penicillamine results in increased expression of HMOX1 mRNA
Penicillamine analog results in decreased expression of HMOX1 protein
CTD PMID:19323979, PMID:21242307, PMID:22843330 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hp haptoglobin decreases expression ISO Penicillamine results in decreased expression of HP protein CTD PMID:241598 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Penicillamine results in increased expression of HSPA1A mRNA; Penicillamine results in increased expression of HSPA1A protein CTD PMID:22843330 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Penicillamine results in increased expression of HSPA1L mRNA CTD PMID:22843330 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO Penicillamine results in increased expression of HSPA2 mRNA CTD PMID:22843330 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Penicillamine results in increased expression of HSPA5 protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]
CTD PMID:19722195, PMID:22843330, PMID:22945834 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma increases expression EXP Penicillamine results in increased expression of IFNG mRNA CTD PMID:19575532 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il10 interleukin 10 increases expression EXP Penicillamine results in increased expression of IL10 mRNA CTD PMID:19575532 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 decreases expression
increases expression
EXP Penicillamine results in decreased expression of IL13 mRNA
Penicillamine results in increased expression of IL13 mRNA
CTD PMID:19575532 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 increases expression EXP Penicillamine results in increased expression of IL15 mRNA CTD PMID:19575532 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Penicillamine results in increased expression of IL1B mRNA CTD PMID:19575532 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il21 interleukin 21 increases expression EXP Penicillamine results in increased expression of IL21 mRNA CTD PMID:21227906 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Penicillamine results in increased expression of IL23A protein CTD PMID:19575532 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il3ra interleukin 3 receptor subunit alpha increases expression EXP Penicillamine results in increased expression of IL3RA mRNA CTD PMID:19575532 NCBI chr12:18,534,762...18,542,508
Ensembl chr12:18,534,767...18,540,166
JBrowse link
G Il4 interleukin 4 increases expression EXP Penicillamine results in increased expression of IL4 mRNA CTD PMID:9182889, PMID:21227906 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases expression EXP
ISO
Penicillamine results in increased expression of IL6 protein CTD PMID:19575532, PMID:21227906 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Klf4 Kruppel like factor 4 increases expression EXP Penicillamine results in increased expression of KLF4 mRNA CTD PMID:19575532 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Lgals1 galectin 1 increases expression EXP Penicillamine results in increased expression of LGALS1 mRNA CTD PMID:19575532 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects response to substance ISO HLA-A gene polymorphism affects the susceptibility to Penicillamine CTD PMID:3459889 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Loxl2 lysyl oxidase-like 2 decreases activity ISO Penicillamine results in decreased activity of LOXL2 protein CTD PMID:16023247 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
ISO PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein] CTD PMID:22843330 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mpo myeloperoxidase decreases secretion
multiple interactions
ISO Penicillamine results in decreased secretion of MPO protein
Penicillamine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Penicillamine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]
CTD PMID:6324512, PMID:25614581 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression EXP Penicillamine results in increased expression of NFE2L2 mRNA CTD PMID:19575532 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Penicillamine results in increased expression of NOS2 mRNA CTD PMID:22843330 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression EXP Penicillamine results in increased expression of NR4A1 mRNA CTD PMID:19575532 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Penicillamine results in increased cleavage of PARP1 protein CTD PMID:22843330 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions
ISO Penicillamine results in increased expression of PMAIP1 mRNA; Penicillamine results in increased expression of PMAIP1 protein
PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein]
CTD PMID:22843330 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA] CTD PMID:22945834 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] CTD PMID:4087275 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression EXP Penicillamine results in increased expression of PTGER2 mRNA CTD PMID:19575532 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Penicillamine results in increased expression of PTGS1 mRNA CTD PMID:22843330 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases response to substance ISO HLA-DRB1 gene polymorphism results in increased susceptibility to Penicillamine CTD PMID:6420562 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Penicillamine results in increased expression of S100A4 mRNA CTD PMID:19575532 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression EXP Penicillamine results in increased expression of S100A6 mRNA CTD PMID:19575532 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G S100a8 S100 calcium binding protein A8 decreases expression
increases expression
EXP Penicillamine results in decreased expression of S100A8 mRNA
Penicillamine results in increased expression of S100A8 mRNA
CTD PMID:19575532 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression
increases expression
EXP Penicillamine results in decreased expression of S100A9 mRNA
Penicillamine results in increased expression of S100A9 mRNA
CTD PMID:19575532 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression EXP Penicillamine results in decreased expression of SELENBP1 mRNA CTD PMID:19575532 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression EXP Penicillamine results in increased expression of SLC11A1 mRNA CTD PMID:19575532 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression
increases expression
EXP Penicillamine results in decreased expression of SLC28A2 mRNA
Penicillamine results in increased expression of SLC28A2 mRNA
CTD PMID:19575532 NCBI chr 3:114,355,003...114,647,382
Ensembl chr 3:114,355,798...114,647,382
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression
increases expression
EXP Penicillamine results in decreased expression of SLC30A1 mRNA
Penicillamine results in increased expression of SLC30A1 mRNA
CTD PMID:19575532 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
increases expression
ISO [Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to Oxaliplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]; Penicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA] CTD PMID:22914438 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) decreases expression EXP Penicillamine results in decreased expression of SLC4A1 mRNA CTD PMID:19575532 NCBI chr10:90,296,144...90,312,401
Ensembl chr10:90,296,141...90,312,386
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity ISO Penicillamine analog results in decreased activity of SOD1 protein CTD PMID:19323979 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO Penicillamine results in increased expression of SP1 mRNA CTD PMID:22914438 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA] CTD PMID:22945834 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stx3 syntaxin 3 increases expression
decreases expression
EXP Penicillamine results in increased expression of STX3 mRNA
Penicillamine results in decreased expression of STX3 mRNA
CTD PMID:19575532 NCBI chr 1:228,137,781...228,195,004
Ensembl chr 1:228,149,867...228,194,977
JBrowse link
G Tfrc transferrin receptor increases expression EXP Penicillamine results in increased expression of TFRC mRNA CTD PMID:19575532 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Penicillamine results in increased expression of TNF protein
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]
CTD PMID:19575532, PMID:22945834 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
ISO Penicillamine results in increased expression of TP53 protein
Penicillamine results in decreased expression of TP53 mRNA
CTD PMID:22843330 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Penicillamine results in increased splicing of XBP1 mRNA CTD PMID:19722195 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
domoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
increases localization
multiple interactions
ISO domoic acid results in increased expression of BAX mRNA
domoic acid results in increased localization of BAX protein
Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein]
CTD PMID:18293405, PMID:19200344 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO domoic acid affects the expression of BCL2 mRNA CTD PMID:18293405 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein] CTD PMID:19200344 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO domoic acid results in increased expression of GCLC mRNA; domoic acid results in increased expression of GCLC protein CTD PMID:23315585 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
decreases response to substance
affects response to substance
ISO domoic acid results in increased expression of GCLM mRNA; domoic acid results in increased expression of GCLM protein
[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone; [GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to Hydrogen Peroxide; GCLM protein results in decreased susceptibility to domoic acid; GCLM results in decreased susceptibility to domoic acid
GCLM affects the susceptibility to domoic acid
CTD PMID:17804861, PMID:19200344, PMID:23315585 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases phosphorylation EXP domoic acid results in increased phosphorylation of GRIA1 protein CTD PMID:19564213 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Pvalb parvalbumin increases expression ISO domoic acid results in increased expression of PVALB protein CTD PMID:26797589 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Wdr35 WD repeat domain 35 increases expression
multiple interactions
EXP domoic acid results in increased expression of WDR35 mRNA; domoic acid results in increased expression of WDR35 protein
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline inhibits the reaction [domoic acid results in increased expression of WDR35 protein]; Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein]
CTD PMID:23289926 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622
JBrowse link
glufosinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein multiple interactions
increases expression
ISO Dizocilpine Maleate inhibits the reaction [phosphinothricin results in increased expression of ARC mRNA] CTD PMID:30557575 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO phosphinothricin results in increased expression of FOS protein CTD PMID:27031874 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO phosphinothricin results in increased expression of GFAP mRNA; phosphinothricin results in increased expression of GFAP protein CTD PMID:27031874 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glul glutamate-ammonia ligase increases expression
multiple interactions
ISO phosphinothricin results in increased expression of GLUL mRNA
phosphinothricin results in increased expression of and results in increased activity of GLUL protein
CTD PMID:27031874 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Nefh neurofilament heavy affects expression EXP phosphinothricin affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Peg3 paternally expressed 3 decreases expression ISO phosphinothricin results in decreased expression of PEG3 mRNA CTD PMID:25477793 NCBI chr 1:70,210,810...70,237,450
Ensembl chr 1:70,222,964...70,237,443
JBrowse link
G Pten phosphatase and tensin homolog affects expression ISO phosphinothricin affects the expression of PTEN mRNA CTD PMID:25477793 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
homocysteic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [homocysteic acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein CTD PMID:19046382 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression EXP homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions
ISO homocysteic acid results in increased activity of SP1 protein
mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]
CTD PMID:11261509 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity
ISO mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Homocysteine results in increased expression of ACADM mRNA; Homocysteine results in increased expression of ACADM protein CTD PMID:26993217 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Ache acetylcholinesterase increases activity ISO Homocysteine results in increased activity of ACHE protein CTD PMID:16375580 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]
Homocysteine results in increased expression of ACTA2 mRNA; Homocysteine results in increased expression of ACTA2 protein
CTD PMID:21647593 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahcy adenosylhomocysteinase multiple interactions ISO [Arsenic results in increased expression of and results in increased activity of AHCY protein] which results in increased chemical synthesis of Homocysteine CTD PMID:18487201 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein] CTD PMID:20305681 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of APOA1 mRNA; Homocysteine results in decreased expression of APOA1 protein
Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]
CTD PMID:18540024 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G App amyloid beta precursor protein increases abundance ISO APP protein results in increased abundance of Homocysteine CTD PMID:16837103 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions EXP Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter] CTD PMID:8550827 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the expression of BAX mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX protein]; Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein]
Homocysteine results in increased expression of BAX mRNA
Folic Acid inhibits the reaction [Homocysteine results in increased expression of BAX mRNA]
Homocysteine affects the expression of BAX mRNA; Homocysteine affects the expression of BAX protein
CTD PMID:16757814, PMID:29250709, PMID:31721048 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
EXP Folic Acid inhibits the reaction [Homocysteine results in decreased activity of BCHE protein] CTD PMID:16442260 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
ISO
EXP
Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 protein]; Zeranol inhibits the reaction [Homocysteine results in decreased expression of BCL2 protein]
Homocysteine affects the expression of BCL2 mRNA; Homocysteine affects the expression of BCL2 protein
[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA; [Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein]
CTD PMID:16757814, PMID:22169520, PMID:29250709 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO Homocysteine results in decreased expression of BIRC2 mRNA; Homocysteine results in decreased expression of BIRC2 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]
CTD PMID:19343037 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple in