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ONTOLOGY REPORT - ANNOTATIONS


Term:triprolidine
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Accession:CHEBI:84116 term browser browse the term
Definition:An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.
Synonyms:exact_synonym: 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine
 related_synonym: (E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine;   Formula=C19H22N2;   InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+;   InChIKey=CBEQULMOCCWAQT-WOJGMQOQSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1ccccn1;   trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene;   trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene;   trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine;   tripolidina;   triprolidinum
 xref: CAS:486-12-4 "ChemIDplus";   CAS:486-12-4 "NIST Chemistry WebBook";   DrugBank:DB00427;   Drug_Central:2763 "DrugCentral";   HMDB:HMDB0014571;   KEGG:D08648
 xref_mesh: MESH:D014311
 xref: PMID:1362947 "Europe PMC";   PMID:1362948 "Europe PMC";   PMID:3944383 "Europe PMC";   PMID:6509877 "Europe PMC";   PMID:7258744 "Europe PMC";   PMID:8529817 "Europe PMC";   Patent:US2712020;   Patent:US2712023;   Reaxys:87215 "Reaxys";   Wikipedia:Triprolidine
 cyclic_relationship: is_conjugate_base_of CHEBI:84117


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triprolidine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6480464
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        pharmacological role 18800
          antagonist 16202
            histamine antagonist 4567
              H1-receptor antagonist 4096
                triprolidine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    main group molecular entity 19630
                      s-block molecular entity 19390
                        hydrogen molecular entity 19379
                          hydrides 18296
                            inorganic hydride 17209
                              pnictogen hydride 17171
                                nitrogen hydride 17006
                                  azane 16699
                                    ammonia 16696
                                      organic amino compound 16695
                                        tertiary amino compound 8556
                                          N-alkylpyrrolidine 1096
                                            triprolidine 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.