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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:probenecid
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Accession:CHEBI:8426 term browser browse the term
Definition:A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Synonyms:exact_synonym: 4-(dipropylsulfamoyl)benzoic acid
 related_synonym: 4-((Dipropylamino)sulfonyl)benzoic acid;   4-(Di-n-propylsulfamoyl)benzoesaeure;   4-(N,N-Dipropylsulfamoyl)benzoesaeure;   Formula=C13H19NO4S;   InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16);   InChIKey=DBABZHXKTCFAPX-UHFFFAOYSA-N;   Probenecid Acid;   SMILES=CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O;   p-(Dipropylsulfamoyl)benzoic acid;   probenecida;   probenecide;   probenecidum
 xref: Beilstein:2815775;   CAS:57-66-9;   DrugBank:DB01032;   Drug_Central:2268;   KEGG:C07372;   KEGG:D00475;   LINCS:LSM-4140
 xref_mesh: MESH:D011339
 xref: PMID:21861129;   PMID:21938493;   PMID:22321288;   PMID:22561103;   PMID:22582566;   PMID:22681402;   PMID:22854641;   PMID:23129053;   PMID:509935;   Patent:US2608507;   Reaxys:2815775;   Wikipedia:Probenecid


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probenecid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 multiple interactions ISO Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
affects activity
EXP
ISO
Probenecid results in decreased activity of ABCC1 protein
[Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
Probenecid affects the activity of ABCC1 protein
[Probenecid results in decreased activity of ABCC1 protein] which results in decreased export of 10-nitro-oleic acid metabolite; Probenecid affects the reaction [ABCC1 protein results in increased transport of Valproic Acid]; Probenecid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673, PMID:9334814, PMID:12893836, PMID:15066675, PMID:15585369, PMID:15652236, PMID:15804283, PMID:15916776, PMID:16101123, PMID:29158255 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases export
multiple interactions
increases activity
EXP
ISO
ABCC2 protein results in increased export of Probenecid
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Probenecid promotes the reaction [ABCC2 protein affects the transport of docetaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Etoposide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine]; Probenecid promotes the reaction [ABCC2 protein results in decreased susceptibility to Paclitaxel]
[Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of resveratrol metabolite; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium
Probenecid results in increased activity of ABCC2 protein
CTD PMID:11477083, PMID:12608533, PMID:12704183, PMID:15849751, PMID:15904671, PMID:17478601, PMID:19853032, PMID:20089784, PMID:27450509 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide] CTD PMID:12704183 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Probenecid inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]
Probenecid affects the reaction [ABCC4 protein affects the uptake of Cyclic AMP analog]
CTD PMID:11856762, PMID:28587784 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO Probenecid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions ISO Probenecid inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione] CTD PMID:11880368 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX protein] CTD PMID:24768735 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 protein] CTD PMID:24768735 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Card10 caspase recruitment domain family, member 10 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CARD10 mRNA CTD PMID:25406165 NCBI chr 7:119,998,639...120,028,632
Ensembl chr 7:119,999,472...120,027,026
JBrowse link
G Casp1 caspase 1 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CASP1 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CASP1 mRNA CTD PMID:25406165 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 protein] CTD PMID:24768735 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of CAT protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of CAT protein] CTD PMID:24768735 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
Probenecid inhibits the reaction [Uric Acid results in increased expression of CCL2 protein]
Probenecid analog results in increased expression of CCL2 mRNA
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CCL2 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CCL2 mRNA
CTD PMID:16113518, PMID:24104198, PMID:25406165 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Probenecid promotes the reaction [10-nitro-oleic acid results in decreased expression of CCND1 protein] CTD PMID:29158255 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Probenecid promotes the reaction [10-nitro-oleic acid results in increased expression of CDKN1A protein] CTD PMID:29158255 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA] CTD PMID:24768735 NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of CYBA mRNA] CTD PMID:23325087 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYC1 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYC1 protein] CTD PMID:24768735 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP2C8 protein affects the metabolism of Carbamazepine] CTD PMID:15915352 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of FADD mRNA CTD PMID:25406165 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Faslg Fas ligand multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of FASL mRNA CTD PMID:25406165 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GFAP protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GFAP protein] CTD PMID:25064079 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Probenecid inhibits the reaction [cidofovir results in increased secretion of HAVCR1 protein] CTD PMID:29738843 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA CTD PMID:25406165 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of NOX4 mRNA] CTD PMID:23325087 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein CTD PMID:25406165 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Ocln occludin multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein] CTD PMID:25064079 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Panx1 Pannexin 1 decreases activity
multiple interactions
ISO Probenecid results in decreased activity of PANX1 protein
Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
CTD PMID:19023039, PMID:19213873 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Probenecid promotes the reaction [10-nitro-oleic acid results in increased cleavage of PARP1 protein] CTD PMID:29158255 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ren renin multiple interactions ISO Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein] CTD PMID:7040495 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC18A2 protein CTD PMID:19653878 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646, PMID:22967667 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions
affects activity
ISO Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]
Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]
Probenecid affects the activity of SLC22A12 protein
CTD PMID:14694169, PMID:14747372, PMID:21272127, PMID:22865646, PMID:22967667 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 protein] CTD PMID:22865646, PMID:22967667 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO Probenecid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:221,327,608...221,344,367
Ensembl chr 1:221,328,711...221,343,889
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions
decreases activity
ISO Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
Probenecid results in decreased activity of SLC22A9 protein
CTD PMID:17132213, PMID:28629854 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:22865646, PMID:22967667 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein] CTD PMID:22865646, PMID:22967667 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases activity
ISO
EXP
Probenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]; Probenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]; Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
Probenecid results in decreased activity of SLC22A6 protein
Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]
Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]
CTD PMID:10336520, PMID:11602689, PMID:12472777, PMID:12606766, PMID:19643159, PMID:21561794, PMID:22865646, PMID:22967667, PMID:23856525, PMID:27989701, PMID:28629854, PMID:28890383, PMID:29045746, PMID:31364238, PMID:31830554, PMID:32003934, PMID:32305507 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity
decreases expression
ISO
EXP
Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]; Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
Probenecid results in decreased activity of SLC22A8 protein
Probenecid results in decreased expression of SLC22A8 mRNA; Probenecid results in decreased expression of SLC22A8 protein
Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]
CTD PMID:10224140, PMID:11306713, PMID:15319347, PMID:16006492, PMID:19643159, PMID:23129053, PMID:27989701, PMID:28629854, PMID:28890383, PMID:29045746, PMID:31364238, PMID:31830554, PMID:32003934, PMID:32305507 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein] CTD PMID:25064079 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein] CTD PMID:22967667 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Probenecid inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slc5a8 solute carrier family 5 member 8 decreases activity ISO Probenecid results in decreased activity of SLC5A8 protein CTD PMID:15090606 NCBI chr 7:29,434,175...29,476,807
Ensembl chr 7:29,435,444...29,477,947
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein] CTD PMID:19653878, PMID:25064079, PMID:25406165 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein] CTD PMID:27989701 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Tas2r118 taste receptor, type 2, member 118 multiple interactions ISO Probenecid binds to and results in decreased activity of TAS2R16 protein; Probenecid inhibits the reaction [salicin results in increased activity of TAS2R16 protein] CTD PMID:21629661 NCBI chr 4:51,002,218...51,003,117
Ensembl chr 4:51,002,218...51,003,117
JBrowse link
G Tas2r138 taste receptor, type 2, member 138 multiple interactions
decreases activity
ISO Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Propylthiouracil results in increased activity of TAS2R38 protein]
Probenecid results in decreased activity of TAS2R38 protein
CTD PMID:21629661 NCBI chr 4:68,831,221...68,832,216
Ensembl chr 4:68,831,221...68,832,216
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein] CTD PMID:23325087 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein CTD PMID:19653878, PMID:25406165 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein] CTD PMID:25064079 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNA CTD PMID:25406165 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TNF mRNA CTD PMID:25406165 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects response to substance ISO UGT1A3 affects the susceptibility to Probenecid CTD PMID:17880178 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects response to substance ISO UGT1A9 affects the susceptibility to Probenecid CTD PMID:17880178 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance ISO UGT2B7 affects the susceptibility to Probenecid CTD PMID:17880178 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Umod uromodulin multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein] CTD PMID:22865646 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            renal agent 406
              uricosuric drug 392
                probenecid 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        aromatic carboxylic acid 10896
                                          benzoic acids 10866
                                            probenecid 59
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.