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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:probucol
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Accession:CHEBI:8427 term browser browse the term
Definition:A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Synonyms:exact_synonym: 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol)
 related_synonym: 4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol);   Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole;   Biphenabid;   Bisbid;   Bisphenabid;   DH-581;   Formula=C31H48O2S2;   InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3;   InChIKey=FYPMFJGVHOHGLL-UHFFFAOYSA-N;   Lesterol;   Lorelco;   Lurselle;   SMILES=CC(C)(Sc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)Sc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C;   Serterol;   Superlipid;   probucolum
 xref: CAS:23288-49-5;   DrugBank:DB01599;   Drug_Central:2269;   HMDB:HMDB0015537;   KEGG:C07373;   KEGG:D00476;   LINCS:LSM-3617
 xref_mesh: MESH:D011341
 xref: PMID:22305809;   PMID:23107872;   PMID:23167559;   PMID:23334712;   PMID:23363981;   PMID:23378294;   PMID:23443157;   PMID:23741215;   Patent:CN101423484;   Patent:CN101455842;   Patent:CN102973535;   Patent:FR1561853;   Patent:US3576883;   Patent:US3862332;   Reaxys:2026253;   Wikipedia:Probucol


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probucol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Probucol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Probucol inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoe apolipoprotein E affects response to substance
decreases response to substance
multiple interactions
ISO APOE protein affects the susceptibility to Probucol
APOE protein results in decreased susceptibility to Probucol
Probucol promotes the reaction [APOE gene mutant form results in increased expression of C1QC mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of CXCR4 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of DOCK2 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of FCER1G mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of ITGB2 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of LILRB3 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of LY86 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of SELPLG mRNA]
CTD PMID:10998462, PMID:19394937 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Probucol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; Probucol inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Probucol inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763, PMID:28734741 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Probucol inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:11291592, PMID:26111763 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] CTD PMID:26111763 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C1qc complement C1q C chain multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of C1QC mRNA] CTD PMID:19394937 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]] CTD PMID:19967051 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cfl1 cofilin 1 multiple interactions ISO Probucol inhibits the reaction [methylmercury II affects the localization of and results in decreased phosphorylation of CFL1 protein] CTD PMID:27241350 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Cttn cortactin multiple interactions ISO Probucol inhibits the reaction [methylmercury II results in increased expression of CTTN mRNA] CTD PMID:27241350 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of CXCR4 mRNA] CTD PMID:19394937 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dock2 dedicator of cytokinesis 2 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of DOCK2 mRNA] CTD PMID:19394937 NCBI chr10:19,181,512...19,603,171 JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Probucol inhibits the reaction [Copper results in increased activity of F3 protein] CTD PMID:7600656 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of FCER1G mRNA] CTD PMID:19394937 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions EXP Probucol promotes the reaction [Dietary Fats results in decreased expression of GATA4 protein modified form] CTD PMID:30240538 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein] CTD PMID:28881715 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
ISO
EXP
Probucol inhibits the reaction [methylmercuric chloride results in decreased activity of GPX1 protein]; Probucol promotes the reaction [methylmercury II results in decreased expression of GPX1 mRNA]
Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]; Probucol inhibits the reaction [Doxorubicin results in decreased expression of GPX1 protein]
Probucol results in increased activity of GPX1 protein
CTD PMID:7805190, PMID:19770487, PMID:27241350, PMID:28734741 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Probucol results in increased expression of HMOX1 mRNA
NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]
HMOX1 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]
CTD PMID:23942037, PMID:28881715 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO Probucol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone] CTD PMID:23942037 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:28881715 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:28881715 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of ITGB2 mRNA] CTD PMID:19394937 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Probucol results in decreased activity of KCNH2 protein SNP CTD PMID:15043509 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Limk1 LIM domain kinase 1 multiple interactions ISO Probucol inhibits the reaction [methylmercury II results in increased expression of LIMK1 mRNA] CTD PMID:27241350 NCBI chr12:25,036,630...25,070,538
Ensembl chr12:25,036,605...25,070,539
JBrowse link
G Ly86 lymphocyte antigen 86 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of LY86 mRNA] CTD PMID:19394937 NCBI chr17:28,104,535...28,191,447
Ensembl chr17:28,104,589...28,191,436
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of MMP2 protein] CTD PMID:17964422 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:17964422 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
NFE2L2 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]
NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]
CTD PMID:23942037, PMID:28881715 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression EXP Probucol results in increased expression of NPHS1 mRNA CTD PMID:11012881 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein] CTD PMID:28881715 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Probucol inhibits the reaction [Fluorouracil results in decreased expression of PCNA protein] CTD PMID:19272435 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 mRNA]; Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 protein] CTD PMID:19272435 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pirb paired Ig-like receptor B multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of LILRB3 mRNA] CTD PMID:19394937 NCBI chr 1:64,074,097...64,081,568
Ensembl chr 1:64,074,231...64,081,438
JBrowse link
G Sele selectin E multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selplg selectin P ligand multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of SELPLG mRNA] CTD PMID:19394937 NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
JBrowse link
G Snca synuclein alpha multiple interactions ISO Probucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] CTD PMID:16239214 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
EXP [Probucol co-treated with Doxorubicin] results in increased activity of SOD2 protein; Probucol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 mRNA]; Probucol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]
Probucol results in increased activity of SOD2 protein
CTD PMID:10912462 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] CTD PMID:28734741 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Probucol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Probucol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
[cilostazol co-treated with Probucol] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]; Probucol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of SELE protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]]
Probucol decreases expression of Tnf mRNA in liver, protein in serum
NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:16769766, PMID:17964422, PMID:19967051, PMID:28881715, PMID:19220660 RGD:2312478 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]] CTD PMID:16769766, PMID:19967051 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

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  CHEBI ontology 19816
    role 19764
      chemical role 19288
        antioxidant 14226
          probucol 43
Path 2
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organosulfur compound 15223
                                  thioacetal 295
                                    dithioacetal 46
                                      dithioketal 46
                                        probucol 43
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.