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ONTOLOGY REPORT - ANNOTATIONS


Term:promethazine
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Accession:CHEBI:8461 term browser browse the term
Definition:A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Synonyms:exact_synonym: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
 related_synonym: (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine;   10-(2-Dimethylaminopropyl)phenothiazine;   10-[2-(dimethylamino)propyl]phenothiazine;   Formula=C17H20N2S;   InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3;   InChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N;   N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine;   N-(2'-dimethylamino-2'-methyl)ethylphenothiazine;   SMILES=CC(CN1c2ccccc2Sc2ccccc12)N(C)C;   proazamine;   prometazina;   promethazinum
 xref: Beilstein:88554 "Beilstein";   CAS:60-87-7 "ChemIDplus";   CAS:60-87-7 "KEGG COMPOUND";   CAS:60-87-7 "NIST Chemistry WebBook";   DrugBank:DB01069;   Drug_Central:2286 "DrugCentral";   Gmelin:337077 "Gmelin";   HMDB:HMDB0015202;   KEGG:C07404;   KEGG:D00494;   LINCS:LSM-4440
 xref_mesh: MESH:D011398
 xref: Patent:US2530451;   Patent:US2607773;   Reaxys:88554 "Reaxys";   Wikipedia:Promethazine
 cyclic_relationship: is_conjugate_base_of CHEBI:61214


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promethazine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:6480464
G Aurka aurora kinase A JBrowse link 3 170,364,177 170,380,278 RGD:6480464
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:6480464
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6480464
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:6480464
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase JBrowse link 3 120,373,604 120,404,910 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 JBrowse link 18 1,789,796 1,857,271 RGD:6480464
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mad1l1 mitotic arrest deficient 1 like 1 JBrowse link 12 16,410,083 16,721,232 RGD:6480464
G Mad2l1 mitotic arrest deficient 2 like 1 JBrowse link 4 97,530,993 97,543,179 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Pgam1 phosphoglycerate mutase 1 JBrowse link 1 261,158,204 261,165,814 RGD:6480464
G Pkm pyruvate kinase M1/2 JBrowse link 8 64,480,963 64,502,957 RGD:6480464
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:6480464
G Rad17 RAD17 checkpoint clamp loader component JBrowse link 2 30,634,353 30,664,618 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rbl2 RB transcriptional corepressor like 2 JBrowse link 19 17,300,088 17,346,865 RGD:6480464
G Slc22a5 solute carrier family 22 member 5 JBrowse link 10 39,201,101 39,228,090 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6480464
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Ubd ubiquitin D JBrowse link 20 1,876,175 1,878,126 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          drug 19179
            anti-allergic agent 3778
              promethazine 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    main group molecular entity 19598
                      s-block molecular entity 19361
                        hydrogen molecular entity 19350
                          hydrides 18280
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17003
                                  azane 16693
                                    ammonia 16690
                                      organic amino compound 16689
                                        tertiary amino compound 8527
                                          tertiary amine 600
                                            promethazine 46
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.