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ONTOLOGY REPORT - ANNOTATIONS


Term:8-(4-chlorophenylthio)-cGMP
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Accession:CHEBI:84638 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP in which the hydrogen at position 2 on the purine fragment is replaced by a 4-chlorophenylthio group.
Synonyms:exact_synonym: 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda(5)-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one
 related_synonym: 8-((4-Chlorophenyl)thio)cyclic-3',5'-GMP;   8-(4-chlorophenylthio)-3',5'-cyclic GMP;   8-(4-chlorophenylthio)-cyclic GMP;   8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate;   8-(4-chlorophenylthio)guanosine 3',5'-cyclic phosphate;   8-pCPT-cGMP;   Formula=C16H15ClN5O7PS;   InChI=1S/C16H15ClN5O7PS/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24)/t8-,10-,11-,14-/m1/s1;   InChIKey=ZDJHIEHUVPCEDK-IDTAVKCVSA-N;   SMILES=Nc1nc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Sc3ccc(Cl)cc3)nc2c(=O)[nH]1
 xref: CAS:54364-02-2 "ChemIDplus"
 xref_mesh: MESH:C055656
 xref: PMID:24481877 "Europe PMC";   PMID:24534906 "Europe PMC";   PMID:24605759 "SUBMITTER";   Reaxys:1199328 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:91239


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8-(4-chlorophenylthio)-cGMP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:6480464
G Arhgef17 Rho guanine nucleotide exchange factor 17 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6480464
G Scnn1a sodium channel epithelial 1 subunit alpha JBrowse link 4 157,834,339 157,860,472 RGD:6480464
G Scnn1b sodium channel epithelial 1 subunit beta JBrowse link 1 191,829,547 191,883,991 RGD:6480464
G Scnn1g sodium channel epithelial 1 subunit gamma JBrowse link 1 191,704,397 191,738,271 RGD:6480464
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:6480464
G Vasp vasodilator-stimulated phosphoprotein JBrowse link 1 80,170,608 80,185,882 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        pharmacological role 18798
          agonist 18170
            protein kinase agonist 8497
              8-(4-chlorophenylthio)-cGMP 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      chalcogen 19334
                        oxygen atom 19295
                          oxygen molecular entity 19295
                            hydroxides 19048
                              oxoacid 18111
                                pnictogen oxoacid 9840
                                  phosphorus oxoacid 8659
                                    phosphoric acids 7332
                                      phosphoric acid 7332
                                        phosphoric acid derivative 6983
                                          phosphate 6983
                                            organic phosphate 6982
                                              carbohydrate phosphate 1508
                                                phospho sugar 1443
                                                  aldose phosphate 1441
                                                    aldopentose phosphate 1435
                                                      ribose phosphate 1429
                                                        ribonucleotide 1388
                                                          purine ribonucleotide 1361
                                                            guanyl ribonucleotide 128
                                                              3',5'-cyclic GMP 74
                                                                8-(4-chlorophenylthio)-cGMP 13
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.