Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor
go back to main search page
Accession:CHEBI:85113 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cGMP-dependent protein kinase (EC 2.7.11.12).
Synonyms:related_synonym: 3':5'-cyclic GMP-dependent protein kinase inhibitor;   3':5'-cyclic GMP-dependent protein kinase inhibitors;   ATP:protein phosphotransferase (cGMP-dependent) inhibitor;   ATP:protein phosphotransferase (cGMP-dependent) inhibitors;   EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitors;   EC 2.7.11.12 inhibitor;   EC 2.7.11.12 inhibitors;   PKG 1alpha inhibitor;   PKG 1alpha inhibitors;   PKG 1beta inhibitor;   PKG 1beta inhibitors;   PKG II inhibitor;   PKG II inhibitors;   PKG inhibitor;   PKG inhibitors;   STK23 inhibitor;   STK23 inhibitors;   cGMP-dependent protein kinase Ibeta inhibitor;   cGMP-dependent protein kinase Ibeta inhibitors;   cGMP-dependent protein kinase inhibitor;   cGMP-dependent protein kinase inhibitors;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitor;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitors
 xref: Wikipedia:CGMP-dependent_protein_kinase


show annotations for term's descendants           Sort by:
 
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein multiple interactions EXP KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ARHGEF17 Rho guanine nucleotide exchange factor 17 multiple interactions EXP KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]] CTD PMID:23195829 NCBI chr11:73,305,961...73,369,388
Ensembl chr11:73,308,276...73,369,388
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO KT 5823 inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]]
CTD PMID:19428112, PMID:22850435 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G CASP3 caspase 3 multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 multiple interactions EXP KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:10860942 NCBI chr11:62,908,675...62,921,861
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREBBP CREB binding protein multiple interactions ISO KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]] CTD PMID:22850435 NCBI chr16:3,725,054...3,880,727
Ensembl chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12184995, PMID:16389725 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDN3 endothelin 3 multiple interactions ISO KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr20:59,300,415...59,325,992
Ensembl chr20:59,300,443...59,325,992
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]] CTD PMID:23274518 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions ISO KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411, PMID:17290048 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 protein] CTD PMID:23274518 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases activity EXP KT 5823 results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK1 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]]
CTD PMID:16389725, PMID:17828804, PMID:22850435 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK3 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]]
CTD PMID:16389725, PMID:17828804, PMID:22850435 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPKAPK5 MAPK activated protein kinase 5 decreases activity EXP KT 5823 results in decreased activity of MAPKAPK5 protein CTD PMID:12534346 NCBI chr12:111,842,228...111,902,222
Ensembl chr12:111,842,228...111,902,222
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MYC protein] CTD PMID:17828804 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:27774770 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions EXP KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] CTD PMID:15733978 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 multiple interactions EXP KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]]; KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G RHOA ras homolog family member A multiple interactions EXP KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO KT 5823 inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] CTD PMID:20453393 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 multiple interactions EXP
ISO
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]; KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]
CTD PMID:20177073 NCBI chr11:101,451,470...101,584,007
Ensembl chr11:101,451,564...101,872,562
JBrowse link
G TXN thioredoxin multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                  EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 27
                    KT 5823 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                protein kinase inhibitor 14047
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                    EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 27
                      KT 5823 27
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.