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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor
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Accession:CHEBI:85113 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cGMP-dependent protein kinase (EC 2.7.11.12).
Synonyms:related_synonym: 3':5'-cyclic GMP-dependent protein kinase inhibitor;   3':5'-cyclic GMP-dependent protein kinase inhibitors;   ATP:protein phosphotransferase (cGMP-dependent) inhibitor;   ATP:protein phosphotransferase (cGMP-dependent) inhibitors;   EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitors;   EC 2.7.11.12 inhibitor;   EC 2.7.11.12 inhibitors;   PKG 1alpha inhibitor;   PKG 1alpha inhibitors;   PKG 1beta inhibitor;   PKG 1beta inhibitors;   PKG II inhibitor;   PKG II inhibitors;   PKG inhibitor;   PKG inhibitors;   STK23 inhibitor;   STK23 inhibitors;   cGMP-dependent protein kinase Ibeta inhibitor;   cGMP-dependent protein kinase Ibeta inhibitors;   cGMP-dependent protein kinase inhibitor;   cGMP-dependent protein kinase inhibitors;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitor;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitors
 xref: Wikipedia:CGMP-dependent_protein_kinase


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KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL4A2 collagen type IV alpha 2 chain multiple interactions
decreases expression
EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein
CTD PMID:21307347 NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,615
JBrowse link
G COL4A3 collagen type IV alpha 3 chain decreases expression
multiple interactions
EXP KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]
CTD PMID:21307347 NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122
JBrowse link
G ITGAV integrin subunit alpha V multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,840
JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 880
    role 860
      biological role 860
        inhibitor 524
          enzyme inhibitor 325
            EC 2.* (transferase) inhibitor 100
              EC 2.7.* (P-containing group transferase) inhibitor 73
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 35
                  EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 4
                    KT 5823 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 880
    role 860
      biological role 860
        inhibitor 524
          enzyme inhibitor 325
            EC 2.* (transferase) inhibitor 100
              EC 2.7.* (P-containing group transferase) inhibitor 73
                protein kinase inhibitor 61
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 35
                    EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 4
                      KT 5823 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.